Gene

KWMTBOMO08840

Pre Gene Modal

BGIBMGA007854

Annotation

PREDICTED:_kynurenine_formamidase-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr15(-):6203799-6218247      View in EpiBrowser

Full name

Kynurenine formamidase      

Alternative Name

Arylformamidase
N-formylkynurenine formamidase

Location in the cell

Nuclear   Reliability : 1.41

CDS

ATGGAATTTGTGGATTTGGAAAGAGAATACACACCGGTGTTGTGGTCGAACCGGTTATATACCCCGGAGCATCGCCTCAACTTGCACATCAACCTTGTAACAGCAGAGAGCGAAATAGCCACAAATAACGTTCCACACAAATTGGAGATTGAGTACGGATCAACGCCCGGACAGAAGCTGGACATTTTCGGTACCGACCTCCCGAATGAATCTCCAATTCTCGTGTTCATTCACGGTGGATACTGGCCGGACGTGTCTCGTGAAATATCACGTTATCCAGCAAAATCCCTCTACCCCGCCGGCGTTAAGACGATAATTGTTGGTTATGATCTCTGTCCCGCGGTCACGCTTGCTGAGGTCGTCAATCAGATACAGAACGCTGCGAGATACATCTTCGAATACGCTGAGAAGATGAATTCTAGAGGCGTTTACTTCGCGGGACACGGAACGGGAGCGCATCTGGTAGCGAAACTCCTGGCCAGTTCCGAATTCTTCGAAAACACGCCCGATTCACACCACCTCCAGGGAGCCTTCCTTATTTCAGGACTGTACGACTTACGGGAAGTCGTAAATACATCAGTCAACAGATCCGTGCAACTGCCTCACGAGTGGGCGGTGCCGCTGTCCCCGCAATTCGATTGTTTCTCCCACTTACAGTCGCGAAGGATCAGAATTTACATTTTTGCGGCCCAAAACGACAGCCCGACTTTCAAGAGGCAATCGAGAGAGTTCTATGAGCTTTTACACAATACGTGCTTGATGCAGAACATGTATTTGGAGATCAAAGACGATATGGATCATCACGAAATAGTCGAGTGCTTCGCGAACAGCAACAACTACCTTAAGAACTTGTTGATTCATGATATTCGTAAGCACATATGA

Protein

MEFVDLEREYTPVLWSNRLYTPEHRLNLHINLVTAESEIATNNVPHKLEIEYGSTPGQKLDIFGTDLPNESPILVFIHGGYWPDVSREISRYPAKSLYPAGVKTIIVGYDLCPAVTLAEVVNQIQNAARYIFEYAEKMNSRGVYFAGHGTGAHLVAKLLASSEFFENTPDSHHLQGAFLISGLYDLREVVNTSVNRSVQLPHEWAVPLSPQFDCFSHLQSRRIRIYIFAAQNDSPTFKRQSREFYELLHNTCLMQNMYLEIKDDMDHHEIVECFANSNNYLKNLLIHDIRKHI

Description

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Required for elimination of toxic metabolites.
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.

Catalytic Activity

H2O + N-formyl-L-kynurenine = formate + H(+) + L-kynurenine

Subunit

Homodimer.

Similarity

Belongs to the kynurenine formamidase family.

Uniprot

H9JEA7   A0A194PQ23   A0A2A4JKB9   C6KEF1   A0A2A4JIQ8   A0A194QN01   + More
A0A2W1B8N3   A0A212F2A7   A0A437AZ89   S4PP32   A0A0L7LV95   A0A2H1WNA8   H9JEA9   A0A1Y1MDP1   A0A067QLT8   U5ES04   A0A182QFV9   A0A182NEL5   A0A1W4XRI6   A0A1W4XFU9   A0A182G908   J3JUE8   U4U0B4   A0A182GZ03   A0A139WAT7   A0A1B6HEY5   A0A182PJ14   A0A182RG95   A0A182YFY2   Q1HRC1   V4ALI9   A0A1S4F7T3   Q0IFP1   A0A084VPT3   W5J900   A0A182VUS7   A0A190EFG9   B0W291   A0A182F5B4   Q7QKH2   A0A182MAI7   A0A182XIN4   U5EY00   A0A1S3KC92   A0A1S4H142   A0A182V8R0   A0A088A2A3   A0A1Q3FQI6   J3JZ36   A0A0P4ZP14   A0A1Y1MBD2   A0A182L5E7   A0A210QA33   A0A0P5FR89   A0A182HG53   A0A182J6H1   A0A232ELZ4   A0A182UBW5   A0A0P6B396   A0A1J1J319   A0A0L8GC40   A0A0P4XK47   E9GB07   A0A023F6Q9   A0A161M607   A0A2A3E9X7   A0A0P4VIP9   R4G805   A0A151XB44   A0A0P5C209   U4U343   A0A0J7P476   A0A224XKW5   A0A0P5XCD8   A0A195EQR9   A0A2R7WTW1   A0A0L8GC20   A0A1J1HHH1   N6TRP6   A0A0P5HH37   A0A1S3KCT5   A0A195DHX2   A0A195D3R2   A0A0P4ZJW9   A0A1B0CQ20   A0A0M9A453   A0A158NQK7   A0A0L7R3B9   E2BMI6   A0A0N8APU3   A0A182K2L6   F4WK97   A0A2J7QX32   E4WT97   H3BDX0   A0A210Q8U8   A0A1L8E2F9   E1ZXE8   A0A402F3Q9  

EC Number

3.5.1.9

Pubmed

19121390    26354079    19754707    28756777    22118469    23622113    + More
26227816    28004739    24845553    26483478    22516182    23537049    18362917    19820115    25244985    17204158    23254933    17510324    24438588    20920257    23761445    12364791    20966253    28812685    28648823    21292972    25474469    27129103    21347285    20798317    21719571    21097902    9215903   

EMBL

BABH01002833    KQ459596    KPI95546.1    NWSH01001283    PCG71850.1    GQ183897    + More
ACS66705.1    PCG71851.1    KQ461195    KPJ06734.1    KZ150220    PZC72109.1    AGBW02010781    OWR47862.1    RSAL01000249    RVE43512.1    GAIX01000467    JAA92093.1    JTDY01000021    KOB79382.1    ODYU01009469    SOQ53934.1    BABH01002838    BABH01002839    BABH01002840    GEZM01034617    JAV83701.1    KK853274    KDR09098.1    GANO01002587    JAB57284.1    AXCN02000850    JXUM01048555    KQ561567    KXJ78141.1    BT126861    AEE61823.1    KB630055    KB630056    KB630208    ERL83365.1    ERL83367.1    ERL83475.1    JXUM01098528    KQ564427    KXJ72302.1    KQ971380    KYB25017.1    GECU01034501    JAS73205.1    DQ440173    ABF18206.1    KB199651    ESP05049.1    CH477306    EAT44101.1    ATLV01015034    KE524999    KFB39977.1    ADMH02002093    ETN59279.1    KP881330    ALQ52681.1    DS231825    EDS28155.1    AAAB01008797    EAA03628.4    AXCM01004322    GANO01002267    JAB57604.1    GFDL01005263    JAV29782.1    BT128517    AEE63474.1    GDIP01214349    LRGB01002076    JAJ09053.1    KZS09367.1    GEZM01035656    JAV83139.1    NEDP02004470    OWF45559.1    GDIQ01259020    JAJ92704.1    APCN01004115    NNAY01003463    OXU19366.1    GDIP01034395    JAM69320.1    CVRI01000067    CRL06829.1    KQ422595    KOF74596.1    GDIP01249797    JAI73604.1    GL732537    EFX83454.1    GBBI01001666    JAC17046.1    GEMB01001942    JAS01233.1    KZ288311    PBC28520.1    GDKW01001846    JAI54749.1    ACPB03019872    GAHY01001812    JAA75698.1    KQ982335    KYQ57520.1    GDIP01176804    JAJ46598.1    KB631855    ERL86758.1    LBMM01000146    KMR04739.1    GFTR01004712    JAW11714.1    GDIP01074172    JAM29543.1    KQ982021    KYN30558.1    KK855326    PTY22025.1    KOF74597.1    CVRI01000004    CRK87453.1    APGK01057597    KB741280    ENN70981.1    GDIQ01228116    JAK23609.1    KQ980824    KYN12495.1    KQ976885    KYN07538.1    GDIP01211702    JAJ11700.1    AJWK01022926    KQ435762    KOX75479.1    ADTU01023371    KQ414663    KOC65362.1    GL449233    EFN83095.1    GDIQ01254715    JAJ97009.1    GL888199    EGI65321.1    NEVH01009397    PNF33146.1    FN653016    CBY06998.1    AFYH01017047    NEDP02004580    OWF45109.1    GFDF01001187    JAV12897.1    GL435038    EFN74125.1    BDOT01000098    GCF51165.1   

Proteomes

UP000005204    UP000053268    UP000218220    UP000053240    UP000007151    UP000283053    + More
UP000037510    UP000027135    UP000075886    UP000075884    UP000192223    UP000069940    UP000249989    UP000030742    UP000007266    UP000075885    UP000075900    UP000076408    UP000030746    UP000008820    UP000030765    UP000000673    UP000075920    UP000002320    UP000069272    UP000007062    UP000075883    UP000076407    UP000085678    UP000075903    UP000005203    UP000076858    UP000075882    UP000242188    UP000075840    UP000075880    UP000215335    UP000075902    UP000183832    UP000053454    UP000000305    UP000242457    UP000015103    UP000075809    UP000036403    UP000078541    UP000019118    UP000078492    UP000078542    UP000092461    UP000053105    UP000005205    UP000053825    UP000008237    UP000075881    UP000007755    UP000235965    UP000008672    UP000000311    UP000288954   

PRIDE

H9JEA7    H9JEA9   

Pfam

PF07859   Abhydrolase_3        + More
PF00595   PDZ
PF04189   Gcd10p

Interpro

IPR029058   AB_hydrolase        + More
IPR013094   AB_hydrolase_3       
IPR027519   KFase_ver/fungi-typ       
IPR036034   PDZ_sf       
IPR017423   TRM6       
IPR001478   PDZ       

SUPFAM

SSF53474   SSF53474        + More
SSF50156   SSF50156       

Gene 3D

3.40.50.1820    

ProteinModelPortal

H9JEA7   A0A194PQ23   A0A2A4JKB9   C6KEF1   A0A2A4JIQ8   A0A194QN01   + More
A0A2W1B8N3   A0A212F2A7   A0A437AZ89   S4PP32   A0A0L7LV95   A0A2H1WNA8   H9JEA9   A0A1Y1MDP1   A0A067QLT8   U5ES04   A0A182QFV9   A0A182NEL5   A0A1W4XRI6   A0A1W4XFU9   A0A182G908   J3JUE8   U4U0B4   A0A182GZ03   A0A139WAT7   A0A1B6HEY5   A0A182PJ14   A0A182RG95   A0A182YFY2   Q1HRC1   V4ALI9   A0A1S4F7T3   Q0IFP1   A0A084VPT3   W5J900   A0A182VUS7   A0A190EFG9   B0W291   A0A182F5B4   Q7QKH2   A0A182MAI7   A0A182XIN4   U5EY00   A0A1S3KC92   A0A1S4H142   A0A182V8R0   A0A088A2A3   A0A1Q3FQI6   J3JZ36   A0A0P4ZP14   A0A1Y1MBD2   A0A182L5E7   A0A210QA33   A0A0P5FR89   A0A182HG53   A0A182J6H1   A0A232ELZ4   A0A182UBW5   A0A0P6B396   A0A1J1J319   A0A0L8GC40   A0A0P4XK47   E9GB07   A0A023F6Q9   A0A161M607   A0A2A3E9X7   A0A0P4VIP9   R4G805   A0A151XB44   A0A0P5C209   U4U343   A0A0J7P476   A0A224XKW5   A0A0P5XCD8   A0A195EQR9   A0A2R7WTW1   A0A0L8GC20   A0A1J1HHH1   N6TRP6   A0A0P5HH37   A0A1S3KCT5   A0A195DHX2   A0A195D3R2   A0A0P4ZJW9   A0A1B0CQ20   A0A0M9A453   A0A158NQK7   A0A0L7R3B9   E2BMI6   A0A0N8APU3   A0A182K2L6   F4WK97   A0A2J7QX32   E4WT97   H3BDX0   A0A210Q8U8   A0A1L8E2F9   E1ZXE8   A0A402F3Q9  

PDB

4E15     E-value=4.08913e-23,     Score=266

KEGG

101745043    K01432 arylformamidase [EC:3.5.1.9] | (RefSeq) kynurenine formamidase-like

PATHWAY

00380    Tryptophan metabolism - Bombyx mori (domestic silkworm)
00630    Glyoxylate and dicarboxylate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016787   GO:0019441   GO:0004061   GO:0016021   GO:0005737   GO:0031515   GO:0030488   GO:0005634   GO:0005829   GO:0034354   GO:0008152   GO:0015074   GO:0016817   GO:0008270   GO:0043565   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  
Cytosol  
Nucleus  

Length:

293

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0361600000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01997

outside

1  -  293

 

 

Pi

197.697802

Theta

156.940352

Tajima's D

0.80643

CLR

0.271407

CSRT

0.612669366531673

Interpretation

Uncertain