Gene

KWMTBOMO08839

Annotation

serine_protease_inhibitor_21_[Bombyx_mori]

Location

Bomo_Chr15(+):6189748-6202135      View in EpiBrowser

Full name

Serine protease inhibitor 3/4       + More
Antichymotrypsin-2      
Antitrypsin      
Alaserpin      

Alternative Name

Antichymotrypsin II
Serpin-1

Location in the cell

Cytoplasmic   Reliability : 1.115

CDS

ATGGATACGAAGTCGTTCTCCTCGACAATAGCAAAGTTCTCAGTCAAGTTTTGCAATGAGCTAAACGGTGATAAAGATGTGGTCTCGTCACCGTTGTCAGCGGAATACTTATTGGCGCTGATAGCTTTGGGTTCAACGGACACCGCACACGAAGAGCTCTTAACAAGCCTCGATTTTCCAGATGACAACACGATACGCACGCTTTTCACTGCGGCCTCTGCTAAATTGAAAACTATTAAGGGTATTAATTTAAGTTTAGCAAACAAGATATACGTTAAATCGTGCGATTATGAACTCAATTCGCAACTGAAGAAAGACGCCGTGGACGTGTTTGATGCGGAATTGGAGAAAGTCGATTTCGGAGACAGCGCTGCTGCTGCTAAACTGATCAACGGCTGGGTCGAAAGTAAAACAAATGAACGAATTAAAAATCTGGTTTCCAATAGCAGCCTCAATTCTGACACGCAAGTCGTTCTGATCAACGCTCTCTACTTTAAGGGTTCATGGAAAAACCAATTTAACCCTAAGAGCACCGTGGAGCATCCGTTCTATATTAACAACGAAACATCTGTGAAAATTCCCATGATGTACCAAGAAGACAAATTTAAGTACGACAACAACACTGAGCTCAACGCCCAGATCTTAGAAATGGCGTATGAAGGTAACGAGGCCAGCATGGTAATTGTATTACCGAACGAAATTGATGGCCTTGATCAAGTCCTACGGAAACTAGCCGACGGCTTCGATCTCATCGCAGTATGGGAGAAGCTGATCTCAACAAAACTACAAGTCATAATACCCAAATTCAAGACTGAAACTGAAATAGACCTTACGCATGTTTTCTCAAAGTTGGGCATTAATGCGATCTTCCGTCGCGAAAATTCTGGTGTGTCGAAGATCTTGGATAACAACGAGTCGTTGTATATCTCGAAGGCCATACAAAAAGCCTTCATTGAAGTGAATGAAGAAGGAGCCGAAGCGGCTGCTGCCACTCATATGGTGTTAAGAAAGCGGCGTGCTCATTATCCCGCTCCGATCGTCCGGGCTGATCGACCTTTTCTTTATTTCCTCATTGGGCCTGATCACACGATGCTGTTCGTCGGTCTGTACCAAGGACGTACATAA

Protein

MDTKSFSSTIAKFSVKFCNELNGDKDVVSSPLSAEYLLALIALGSTDTAHEELLTSLDFPDDNTIRTLFTAASAKLKTIKGINLSLANKIYVKSCDYELNSQLKKDAVDVFDAELEKVDFGDSAAAAKLINGWVESKTNERIKNLVSNSSLNSDTQVVLINALYFKGSWKNQFNPKSTVEHPFYINNETSVKIPMMYQEDKFKYDNNTELNAQILEMAYEGNEASMVIVLPNEIDGLDQVLRKLADGFDLIAVWEKLISTKLQVIIPKFKTETEIDLTHVFSKLGINAIFRRENSGVSKILDNNESLYISKAIQKAFIEVNEEGAEAAAATHMVLRKRRAHYPAPIVRADRPFLYFLIGPDHTMLFVGLYQGRT

Miscellaneous

The N-terminal section (1-336) is identical to the N-terminal section of the silk moth antitrypsin I (17-352).

Similarity

Belongs to the serpin family.

Keywords

Alternative splicing   Direct protein sequencing   Protease inhibitor   Serine protease inhibitor   Signal   Complete proteome   Reference proteome   Secreted   3D-structure   Glycoprotein  

Feature

chain  Serine protease inhibitor 3/4
splice variant  In isoform 2.

Uniprot

C0J8H0   E2GHX4   A0A0M4JBR8   Q9NGS0   H9JDX3   Q5MGH1   + More
A0A2H1VAC5   Q5MGH2   A0A2A4JPH1   A0A3S2NC81   A0A194PIN8   A0A2A4JQC6   A0A2A4JPB5   J7HI16   B2X122   A0A2A4JR25   A0A2A4JQ63   A0A1E1W229   A0A1E1WB01   A0A1E1W071   A0A212EXP2   A0A1L7B973   A0A437BU62   O02377   G9F9J6   A0A1L7B974   A0A212ELH5   A0A3S2M7J7   A0A3G1T1E7   A0A0M4K7J2   Q5MGH0   C7ASM3   C7ASM7   P80034   C7ASM4   C7ASM6   Q25492   A3KEZ7   A0A2H1VE36   A0A385XRT7   C7ASM2   P22922   F5B4G8   C7ASM9   B4XHA1   B4XHA0   Q25495   B4XH99   Q60FS0   A0A212FD15   A0A194R1A3   A3KEZ8   I4DJC8   H9JKA2   Q25500   K4P392   A0A194PZ13   Q5MGH0-2   B0FZ68   Q25501   B0FZ61   B0FZ67   B0FZ60   A0A1Y1KX43   C5I794   Q8IS86   Q25498   A0A3S2TR38   A0A1W4XBF6   A0A1Y1L0U1   Q25526   P14754   Q8IS84   B0FZ63   B0FZ64   B0FZ62   A0A1W4X0J8   B0FZ66   A0A1W4XA23   B0FZ65   Q25491   A0A1L7B975   Q25494   Q25499   A0A385XRR7   B4XH98   Q25497   Q25496   Q25493   G9F9J1   Q8IS85   A0A1W4XBF1   A0A1W4XB61   C5I795   A0A1Y1KVX7   A0A1W4X0K9   A0A1Y1KYH2   A0A1Y1KQA5  

Pubmed

19150649    19121390    16023793    26354079    22118469    11439248    + More
18342903    21104446    1761030    8910411    30237077    2277028    1368515    19524698    22651552    28004739    19481148    8276850    10368276    2463253    14728663   

EMBL

EU935622    ACG61184.1    HM357255    ADN52338.1    KR003725    ALD62503.1    + More
AF242200    AAF61252.1    BABH01002639    BABH01002640    AY829815    AAV91429.1    ODYU01001314    SOQ37342.1    AY829814    AAV91428.1    NWSH01000840    PCG73901.1    RSAL01000236    RVE43711.1    KQ459602    KPI93286.1    PCG73908.1    PCG73905.1    JN400442    AFQ01141.1    EF584499    ABU62829.1    PCG73903.1    PCG73906.1    GDQN01010075    GDQN01007015    JAT80979.1    JAT84039.1    GDQN01006900    JAT84154.1    GDQN01010691    JAT80363.1    AGBW02011729    OWR46227.1    KY094503    APT69915.1    RSAL01000008    RVE53905.1    U79184    AAB58491.1    JN033741    AEW46894.1    KY385636    APT69917.1    AGBW02014057    OWR42342.1    RSAL01000018    RVE52837.1    MG992370    AXY94808.1    KR003729    ALD62507.1    AY829816    AY829817    AAV91430.1    FJ613794    FJ613796    ACT36273.1    ACT36275.1    FJ613797    ACT36277.1    ACT36279.1    FJ613795    ACT36274.1    ACT36278.1    U58361    AAC47338.1    AB295498    BAF48334.1    ODYU01002062    SOQ39103.1    MG753798    AYC12555.1    FJ613793    ACT36272.1    D00738    HQ615869    ADT63775.1    ACT36276.1    EU040210    ABW17158.1    EU040209    ABW17157.1    AAC47341.1    EU040208    ABW17156.1    AB189029    BAD52261.1    AGBW02009121    OWR51607.1    KQ460883    KPJ11294.1    AB295499    BAF48335.1    AK401396    BAM18018.1    BABH01041150    AAC47335.1    JX524148    AFV46312.1    KQ459586    KPI97989.1    EU368832    ABY68555.1    AAC47339.1    ABY68562.1    ABY68556.1    ABY68563.1    GEZM01073934    JAV64730.1    FJ763763    ACR56864.1    AY148483    AAN71632.1    AAC47342.1    RVE52836.1    GEZM01073937    JAV64727.1    L20793    AAA29334.1    M23438    L20792    AY148485    AAN71634.1    ABY68560.1    ABY68559.1    ABY68561.1    ABY68557.1    ABY68558.1    AAC47334.1    KY385635    APT69916.1    AAC47332.1    AAC47340.1    MG753799    AYC12556.1    EU040207    ABW17155.1    AAC47333.1    AAC47336.1    AAC47337.1    JN033736    AEW46889.1    AY148484    AAN71633.1    FJ763764    ACR56865.1    GEZM01073936    JAV64728.1    GEZM01073929    JAV64735.1    GEZM01076851    GEZM01076849    JAV63593.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000053240    + More
UP000192223   

PRIDE

C0J8H0    Q9NGS0    H9JDX3    C7ASM3    C7ASM7    P80034    + More
C7ASM4    C7ASM6    P22922    C7ASM9    H9JKA2    P14754   

Pfam

PF00079   Serpin

Interpro

IPR000215   Serpin_fam        + More
IPR023796   Serpin_dom       
IPR042185   Serpin_sf_2       
IPR042178   Serpin_sf_1       
IPR023795   Serpin_CS       
IPR036186   Serpin_sf       

SUPFAM

SSF56574   SSF56574       

Gene 3D

2.30.39.10     3.30.497.10    

ProteinModelPortal

C0J8H0   E2GHX4   A0A0M4JBR8   Q9NGS0   H9JDX3   Q5MGH1   + More
A0A2H1VAC5   Q5MGH2   A0A2A4JPH1   A0A3S2NC81   A0A194PIN8   A0A2A4JQC6   A0A2A4JPB5   J7HI16   B2X122   A0A2A4JR25   A0A2A4JQ63   A0A1E1W229   A0A1E1WB01   A0A1E1W071   A0A212EXP2   A0A1L7B973   A0A437BU62   O02377   G9F9J6   A0A1L7B974   A0A212ELH5   A0A3S2M7J7   A0A3G1T1E7   A0A0M4K7J2   Q5MGH0   C7ASM3   C7ASM7   P80034   C7ASM4   C7ASM6   Q25492   A3KEZ7   A0A2H1VE36   A0A385XRT7   C7ASM2   P22922   F5B4G8   C7ASM9   B4XHA1   B4XHA0   Q25495   B4XH99   Q60FS0   A0A212FD15   A0A194R1A3   A3KEZ8   I4DJC8   H9JKA2   Q25500   K4P392   A0A194PZ13   Q5MGH0-2   B0FZ68   Q25501   B0FZ61   B0FZ67   B0FZ60   A0A1Y1KX43   C5I794   Q8IS86   Q25498   A0A3S2TR38   A0A1W4XBF6   A0A1Y1L0U1   Q25526   P14754   Q8IS84   B0FZ63   B0FZ64   B0FZ62   A0A1W4X0J8   B0FZ66   A0A1W4XA23   B0FZ65   Q25491   A0A1L7B975   Q25494   Q25499   A0A385XRR7   B4XH98   Q25497   Q25496   Q25493   G9F9J1   Q8IS85   A0A1W4XBF1   A0A1W4XB61   C5I795   A0A1Y1KVX7   A0A1W4X0K9   A0A1Y1KYH2   A0A1Y1KQA5  

PDB

1SEK     E-value=7.46468e-61,     Score=592

KEGG

100272186    no KO assigned | (RefSeq) serpin-21; serine protease inhibitor 21

GO

GO:0005615   GO:0008233   GO:0004867   GO:0009617  

PANTHER

PTHR11461  

Subcellular location

Secreted  
  

Length:

374

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.78642

Exp number, first 60 AAs:

0.01098

Total prob of N-in:

0.01981

outside

1  -  374

 

 

Pi

340.153597

Theta

177.038307

Tajima's D

2.860521

CLR

0.049713

CSRT

0.970501474926254

Interpretation

Uncertain