Gene

KWMTBOMO08820  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007701

Annotation

abnormal_wing_disc-like_protein_[Bombyx_mori]

Location

Bomo_Chr15(+):5934352-5934993      View in EpiBrowser

Full name

Nucleoside diphosphate kinase      

Alternative Name

Abnormal wing disks protein
Killer of prune protein

Location in the cell

Cytoplasmic   Reliability : 2.228

CDS

ATGGCGGAACAACGTGAGCGTACTTTTATTATGGTTAAGCCTGATGGTGTACAACGTGGTCTTGTGGGCACCATTATTGAACGTTTCGAAAAGAAAGGCTTCAAACTAGTCGGTTTGAAATTCGTATGGCCATCAGAAGAACTTCTCCAGCAACACTACAGCGATTTGGCATCCCGGCCTTTCTTCCCTGGTCTAGTAAAGTACATGAGTTCAGGACCTGTGGTCCCTATGGTATGGGAGGGCCTTAATGTTGTGAAGACTGGCCGTCAAATGCTTGGCGCAACTAACCCAGCTGACTCGCAGCCCGGCACTATCCGCGGTGATCTCTGCATTCAAGTTGGGCGTAACATCATCCATGGTTCGGACAGCGTTGAATCTGCTAAAAAGGAAATAGGCCTCTGGTTTACGGACAAAGAAGTTGTGGGCTGGACACCTGCAAATGAAAACTGGGTTTATGAGTAA

Protein

MAEQRERTFIMVKPDGVQRGLVGTIIERFEKKGFKLVGLKFVWPSEELLQQHYSDLASRPFFPGLVKYMSSGPVVPMVWEGLNVVKTGRQMLGATNPADSQPGTIRGDLCIQVGRNIIHGSDSVESAKKEIGLWFTDKEVVGWTPANENWVYE

Description

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).

Catalytic Activity

a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Cofactor

Mg(2+)

Subunit

Homohexamer.

Miscellaneous

Mutations cause abnormal tissue morphology and necrosis and widespread aberrant differentiation.

Similarity

Belongs to the NDK family.

Keywords

3D-structure   Acetylation   ATP-binding   Complete proteome   Cytoplasm   Cytoskeleton   Direct protein sequencing   Kinase   Magnesium   Metal-binding   Microtubule   Nucleotide metabolism   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Nucleoside diphosphate kinase

Uniprot

Q1HPI5   H9JDV4   A0A3S2NSB7   E3SRH2   A0A170QHP8   I4DJ21   + More
A0A194QMH0   A0A194PS06   A0A2A4JIZ8   A0A2H1VK95   A0A2W1BB94   I4DML6   H8YI03   S4P4M4   A0A3G1T1K4   A0A212FEK6   Q8MUR5   A0A0L7KXM5   D6WHK2   A0A0T6B1P4   A0A0A7BYH5   A0A1S3DHQ1   Q0PXX9   U5ELM6   A0A2M4A0G9   A0A2M4A0J5   A0A1B0D3Q5   A0A182WLI1   T1EA13   A0A182F9R5   A0A182YEK8   A0A182QJ33   A0A182P0N1   A0A182M9A4   K7QJQ7   A0A1Q3FWR1   A0A2M4C1E2   A0A2M4C1H6   A0A2M4AWP1   B6DDT8   B3MSX7   W5JV72   A0A182NK61   A0A182V070   A0A182UBS7   A0A182WWY7   A0A182KQD4   Q7QIX6   A0A182I2I6   A0A182JND1   A0A2M4CI12   A8E6J4   B4PP18   B3P511   B4N8T2   B4QT92   A0A084VDH9   J3JZ25   A0A182RP58   N6UB03   A0A1L8DKD9   A0A3B0JL30   A0A0B4LHX6   B4KCG6   W8C3P8   T1DIW5   B4IJ26   A0A0B4LJ12   P08879   A0A0J7KSF4   A0A026WVX5   A0A1W4W6Y4   B5DW72   A0A2M3YYQ7   A0A067QR89   A0A0C9RVE7   A0A034WTB1   A0A182IPA3   R4UKI3   A0A0K8VUG3   B4M0X8   B4G2Y5   A0A023EHG0   A0A0P6IJK1   Q16MB4   A0A023EHV4   E9IUS3   E2AQV0   A0A1L8EIF7   A0A1W4WP60   A0A182GKP0   A0A1L8EII8   B4JH64   A0A1L8EIA0   A0A1D1YPU1   A0A151WHF8   Q6XI71   A0A1I8M733   A0A151JSH4   A0A195F0E8  

EC Number

2.7.4.6

Pubmed

19121390    22651552    26354079    28756777    23468937    23622113    + More
22118469    26227816    18362917    19820115    25244985    23126268    19178717    17994087    20920257    23761445    20966253    12364791    14747013    17210077    17550304    24438588    22516182    23537049    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    24495485    24330624    26109357    26109356    2849580    12537569    12099695    8500545    2175255    1320004    7559441    18327897    8081741    7669763    24508170    15632085    24845553    25348373    24945155    17510324    26483478    21282665    20798317    14525923    25315136   

EMBL

DQ443417    ABF51506.1    BABH01002865    RSAL01000266    RVE43271.1    GU073317    + More
ADE75591.1    KT984956    AMY63175.1    AK401289    BAM17911.1    KQ461195    KPJ06722.1    KQ459596    KPI95534.1    NWSH01001323    PCG71688.1    ODYU01003012    SOQ41243.1    KZ150372    PZC71134.1    AK402534    BAM19156.1    JF690666    AEC12435.1    GAIX01005904    JAA86656.1    MG992433    AXY94871.1    AGBW02008937    OWR52127.1    AF514332    AAM53644.1    JTDY01004756    KOB67796.1    KQ971331    EEZ99726.1    LJIG01016195    KRT81331.1    KC966938    AHV85212.1    DQ673407    ABG81980.1    GANO01001340    JAB58531.1    GGFK01000983    MBW34304.1    GGFK01000982    MBW34303.1    AJVK01011006    GAMD01001428    JAB00163.1    AXCN02000429    AXCM01001237    JQ085374    JQ085375    AFU52975.1    GFDL01003026    JAV32019.1    GGFJ01009982    MBW59123.1    GGFJ01010016    MBW59157.1    GGFK01011895    MBW45216.1    EU934298    ACI30076.1    CH902623    EDV30367.2    ADMH02000262    ETN67208.1    AAAB01008807    EAA04524.4    APCN01000164    GGFL01000812    MBW64990.1    BT030786    ABV82168.1    CM000160    EDW99254.1    CH954182    EDV52925.1    CH964232    EDW81533.2    CM000364    EDX15154.1    ATLV01011337    KE524664    KFB36023.1    BT128506    AEE63463.1    APGK01041853    KB740998    KB632355    ENN75817.1    ERL93384.1    GFDF01007156    JAV06928.1    OUUW01000005    SPP81032.1    AE014297    AHN57624.1    CH933806    EDW14785.2    GAMC01005979    JAC00577.1    GALA01000706    JAA94146.1    CH480846    EDW50979.1    KX531763    AHN57623.1    ANY27573.1    X13107    AY113576    LBMM01003772    KMQ93159.1    KK107078    EZA60210.1    CM000070    EDY68117.2    GGFM01000610    MBW21361.1    KK853114    KDR11183.1    GBYB01012880    JAG82647.1    GAKP01001380    JAC57572.1    KC740805    AGM32629.1    GDHF01009787    JAI42527.1    CH940650    EDW67389.2    CH479179    EDW24180.1    GAPW01005141    JAC08457.1    GDIQ01003407    JAN91330.1    CH477869    EAT35464.1    JXUM01024999    GAPW01005142    KQ560708    JAC08456.1    KXJ81204.1    GL766032    EFZ15678.1    GL441834    EFN64212.1    GFDG01000364    JAV18435.1    JXUM01071189    KQ562648    KXJ75411.1    GFDG01000363    JAV18436.1    CH916369    EDV92755.1    GFDG01000362    JAV18437.1    GDJX01011285    JAT56651.1    KQ983120    KYQ47247.1    AY231961    AAR09984.1    KQ978530    KYN30292.1    KQ981866    KYN34055.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000218220    UP000007151    + More
UP000037510    UP000007266    UP000079169    UP000092462    UP000075920    UP000069272    UP000076408    UP000075886    UP000075885    UP000075883    UP000007801    UP000000673    UP000075884    UP000075903    UP000075902    UP000076407    UP000075882    UP000007062    UP000075840    UP000075881    UP000002282    UP000008711    UP000007798    UP000000304    UP000030765    UP000075900    UP000019118    UP000030742    UP000268350    UP000000803    UP000009192    UP000001292    UP000036403    UP000053097    UP000192221    UP000001819    UP000027135    UP000075880    UP000008792    UP000008744    UP000008820    UP000069940    UP000249989    UP000000311    UP000192223    UP000001070    UP000075809    UP000095301    UP000078492    UP000078541   

PRIDE

Q1HPI5    H9JDV4    A8E6J4    P08879    Q6XI71   

Pfam

PF00334   NDK

Interpro

IPR023005   Nucleoside_diP_kinase_AS        + More
IPR036850   NDK-like_dom_sf       
IPR001564   Nucleoside_diP_kinase       
IPR034907   NDK-like_dom       

SUPFAM

SSF54919   SSF54919       

Gene 3D

3.30.70.141    

ProteinModelPortal

Q1HPI5   H9JDV4   A0A3S2NSB7   E3SRH2   A0A170QHP8   I4DJ21   + More
A0A194QMH0   A0A194PS06   A0A2A4JIZ8   A0A2H1VK95   A0A2W1BB94   I4DML6   H8YI03   S4P4M4   A0A3G1T1K4   A0A212FEK6   Q8MUR5   A0A0L7KXM5   D6WHK2   A0A0T6B1P4   A0A0A7BYH5   A0A1S3DHQ1   Q0PXX9   U5ELM6   A0A2M4A0G9   A0A2M4A0J5   A0A1B0D3Q5   A0A182WLI1   T1EA13   A0A182F9R5   A0A182YEK8   A0A182QJ33   A0A182P0N1   A0A182M9A4   K7QJQ7   A0A1Q3FWR1   A0A2M4C1E2   A0A2M4C1H6   A0A2M4AWP1   B6DDT8   B3MSX7   W5JV72   A0A182NK61   A0A182V070   A0A182UBS7   A0A182WWY7   A0A182KQD4   Q7QIX6   A0A182I2I6   A0A182JND1   A0A2M4CI12   A8E6J4   B4PP18   B3P511   B4N8T2   B4QT92   A0A084VDH9   J3JZ25   A0A182RP58   N6UB03   A0A1L8DKD9   A0A3B0JL30   A0A0B4LHX6   B4KCG6   W8C3P8   T1DIW5   B4IJ26   A0A0B4LJ12   P08879   A0A0J7KSF4   A0A026WVX5   A0A1W4W6Y4   B5DW72   A0A2M3YYQ7   A0A067QR89   A0A0C9RVE7   A0A034WTB1   A0A182IPA3   R4UKI3   A0A0K8VUG3   B4M0X8   B4G2Y5   A0A023EHG0   A0A0P6IJK1   Q16MB4   A0A023EHV4   E9IUS3   E2AQV0   A0A1L8EIF7   A0A1W4WP60   A0A182GKP0   A0A1L8EII8   B4JH64   A0A1L8EIA0   A0A1D1YPU1   A0A151WHF8   Q6XI71   A0A1I8M733   A0A151JSH4   A0A195F0E8  

PDB

1NSQ     E-value=7.55304e-72,     Score=682

KEGG

100101186    K00940 nucleoside-diphosphate kinase [EC:2.7.4.6] | (RefSeq) abnormal wing disc-like protein

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00240    Pyrimidine metabolism - Bombyx mori (domestic silkworm)
00983    Drug metabolism - other enzymes - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004550   GO:0006183   GO:0005524   GO:0006228   GO:0006241   GO:0004519   GO:0006468   GO:0005737   GO:0009117   GO:0007424   GO:0018105   GO:0006165   GO:0000287   GO:0016301   GO:0046777   GO:0005886   GO:0007017   GO:0007427   GO:0005880   GO:0005874   GO:0008017   GO:0000278   GO:0005525   GO:0035152   GO:0034332   GO:0016334   GO:0016021   GO:0016817   GO:0008270   GO:0043565   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  
Cytoskeleton  

Length:

153

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05455

Exp number, first 60 AAs:

0.0018

Total prob of N-in:

0.28055

outside

1  -  153

 

 

Pi

192.949459

Theta

152.511759

Tajima's D

0.782539

CLR

0

CSRT

0.598270086495675

Interpretation

Uncertain