Gene
KWMTBOMO08805
Pre Gene Modal
BGIBMGA007877
Annotation
hypothetical_protein_KGM_03390_[Danaus_plexippus]
Full name
Mediator of RNA polymerase II transcription subunit 18
Alternative Name
Mediator complex subunit 18
Location in the cell
Nuclear Reliability : 2.356
Sequence
CDS
ATGTCGGCAAACGCTGCACCTATAACAGCTACAGATAGCTTATCGCAAGCTTTAAAAGCGAACATTATACCAAATCAGGAATACTTACTTCAGGGCTCAGTGTTGGACTCGGCAGTAGAAGTTTTACTTCACCGATTACGTGGTCTTTGTGACAATGTTGATGCTGGGCCAGAAACATTTGATGACCAGGAAGTGTGTTTCAGTCTACGGGATCCTAATCATCATCAGGCTCCCCCTCTCATGTTGCGTGTTCGTAAAGCATTAGATGCTCGAGACATGCCATTTCAGTTACGATACATTGGGCAGCCTGATTTGGGGGACAAAAATAGGCCAACAGTTGTCCGTTCCAGTCTTGATATAGCCTGCAGTGGAATGCTCATTGAATTTTTAAATGAGCTAGGATGCCGAATTGAATTTGAATACAGTGTAAAAGGTTACATGTTTAGAAAAGGTCGTATGAAAATTACTGTAGCAAAAGTGTTTAAGATTTCTCAAAATTCAATGCCACCTGAACCTATCTCACAGAGCTATCTTGTGGAGCTTTCTGTTCTTGCACCACAAGGCCAGGACGCTATCGGCGAGGATATGCGAGCCTTCGCCGACCAACTCAGGCCTCTAGTGCAGCTCGACAAAATCGACTACAAGAGACTCGGGCACATGTCGGTTTCATAG
Protein
MSANAAPITATDSLSQALKANIIPNQEYLLQGSVLDSAVEVLLHRLRGLCDNVDAGPETFDDQEVCFSLRDPNHHQAPPLMLRVRKALDARDMPFQLRYIGQPDLGDKNRPTVVRSSLDIACSGMLIEFLNELGCRIEFEYSVKGYMFRKGRMKITVAKVFKISQNSMPPEPISQSYLVELSVLAPQGQDAIGEDMRAFADQLRPLVQLDKIDYKRLGHMSVS
Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Subunit
Component of the Mediator complex.
Similarity
Belongs to the Mediator complex subunit 18 family.
Keywords
Activator
Complete proteome
Nucleus
Reference proteome
Transcription
Transcription regulation
Feature
chain Mediator of RNA polymerase II transcription subunit 18
Uniprot
A0A212F0X8
H9JED0
A0A1E1WIA5
A0A437AYH9
A0A194QT40
A0A2H1W0Z3
+ More
A0A2A4K3V6 A0A194PQC7 S4NQM2 A0A026WD48 A0A2J7QR47 A0A154PFM4 A0A067QTY3 A0A2A3E7N4 A0A087ZR21 A0A195DZS4 E2A173 A0A310SVG6 A0A151XIU0 A0A0J7L775 A0A195CR28 A0A195AVL1 A0A195FM21 A0A158NES6 A0A2P8ZJN0 F4WEE3 A0A1B6J9L2 A0A1B6FEI2 A0A1B6K5N5 A0A1B6GT03 A0A1W4X724 E0VHT4 A0A1B6LXQ7 A0A1B6D4W9 A0A0C9RB37 A0A0C9PVU2 U5ERX0 E2B791 D6WG94 A0A0N1IU43 A0A3Q0IW85 J3JW15 A0A1Y1LG21 A0A182GYT1 A0A2R7WLU0 Q17IN5 A0A232FA42 K7IZQ7 A0A1Q3F3Q4 B0WF60 A0A2H8TT06 J9KA52 A0A2S2R8M0 A0A1B0DM62 E9IAB6 A0A069DQX9 A0A023F4H9 A0A1L8DI36 A0A1L8DHS2 A0A084VSI5 A0A224XWX7 A0A182IQ30 A0A1B0CG53 A0A182M029 A0A182RYW4 A0A182WFW3 A0A182K5A1 W5JNY2 A0A182PJA2 A0A1S4H5B9 A0A2M4BZK9 A0A182KKB8 A0A182WUN8 A0A182HVT7 Q7QGX9 A0A182VLZ6 A0A182YKM9 A0A182QK85 A0A0L0BRM1 A0A3B0J948 A0A182NC98 A0A182FKD2 T1H324 A0A1B0ASX0 A0A1A9XYE0 A0A1A9UUW9 A0A1A9ZLQ6 D3TRB3 A0A1A9X033 B4GXR8 Q29HG3 A0A0A1WF95 E9HC81 A0A0P5YSR4 A0A0K8W4I4 A0A034WPI7 A0A0C9Q874 A0A1J1ICC2 A0A1I8PSN2
A0A2A4K3V6 A0A194PQC7 S4NQM2 A0A026WD48 A0A2J7QR47 A0A154PFM4 A0A067QTY3 A0A2A3E7N4 A0A087ZR21 A0A195DZS4 E2A173 A0A310SVG6 A0A151XIU0 A0A0J7L775 A0A195CR28 A0A195AVL1 A0A195FM21 A0A158NES6 A0A2P8ZJN0 F4WEE3 A0A1B6J9L2 A0A1B6FEI2 A0A1B6K5N5 A0A1B6GT03 A0A1W4X724 E0VHT4 A0A1B6LXQ7 A0A1B6D4W9 A0A0C9RB37 A0A0C9PVU2 U5ERX0 E2B791 D6WG94 A0A0N1IU43 A0A3Q0IW85 J3JW15 A0A1Y1LG21 A0A182GYT1 A0A2R7WLU0 Q17IN5 A0A232FA42 K7IZQ7 A0A1Q3F3Q4 B0WF60 A0A2H8TT06 J9KA52 A0A2S2R8M0 A0A1B0DM62 E9IAB6 A0A069DQX9 A0A023F4H9 A0A1L8DI36 A0A1L8DHS2 A0A084VSI5 A0A224XWX7 A0A182IQ30 A0A1B0CG53 A0A182M029 A0A182RYW4 A0A182WFW3 A0A182K5A1 W5JNY2 A0A182PJA2 A0A1S4H5B9 A0A2M4BZK9 A0A182KKB8 A0A182WUN8 A0A182HVT7 Q7QGX9 A0A182VLZ6 A0A182YKM9 A0A182QK85 A0A0L0BRM1 A0A3B0J948 A0A182NC98 A0A182FKD2 T1H324 A0A1B0ASX0 A0A1A9XYE0 A0A1A9UUW9 A0A1A9ZLQ6 D3TRB3 A0A1A9X033 B4GXR8 Q29HG3 A0A0A1WF95 E9HC81 A0A0P5YSR4 A0A0K8W4I4 A0A034WPI7 A0A0C9Q874 A0A1J1ICC2 A0A1I8PSN2
Pubmed
22118469
19121390
26354079
23622113
24508170
30249741
+ More
24845553 20798317 21347285 29403074 21719571 20566863 18362917 19820115 22516182 23537049 28004739 26483478 17510324 28648823 20075255 21282665 26334808 25474469 24438588 20920257 23761445 12364791 20966253 25244985 26108605 20353571 17994087 15632085 25830018 21292972 25348373
24845553 20798317 21347285 29403074 21719571 20566863 18362917 19820115 22516182 23537049 28004739 26483478 17510324 28648823 20075255 21282665 26334808 25474469 24438588 20920257 23761445 12364791 20966253 25244985 26108605 20353571 17994087 15632085 25830018 21292972 25348373
EMBL
AGBW02011012
OWR47377.1
BABH01002893
GDQN01004366
JAT86688.1
RSAL01000266
+ More
RVE43258.1 KQ461195 KPJ06706.1 ODYU01005599 SOQ46596.1 NWSH01000179 PCG78706.1 KQ459596 KPI95517.1 GAIX01011479 JAA81081.1 KK107260 QOIP01000001 EZA53987.1 RLU26510.1 NEVH01011982 PNF31056.1 KQ434893 KZC10663.1 KK853274 KDR09100.1 KZ288344 PBC27710.1 KQ979999 KYN18331.1 GL435707 EFN72840.1 KQ759804 OAD62809.1 KQ982080 KYQ60225.1 LBMM01000427 KMQ98379.1 KQ977381 KYN03193.1 KQ976736 KYM76097.1 KQ981490 KYN41302.1 ADTU01013629 PYGN01000035 PSN56706.1 GL888103 EGI67430.1 GECU01011887 JAS95819.1 GECZ01021255 JAS48514.1 GECU01000982 JAT06725.1 GECZ01004211 JAS65558.1 AAZO01002431 DS235171 EEB12857.1 GEBQ01011572 JAT28405.1 GEDC01016557 JAS20741.1 GBYB01005535 JAG75302.1 GBYB01005593 JAG75360.1 GANO01002637 JAB57234.1 GL446149 EFN88452.1 KQ971329 EFA01136.1 KQ435709 KOX79974.1 APGK01050039 BT127433 KB741165 KB632352 AEE62395.1 ENN73395.1 ERL93301.1 GEZM01058189 JAV71808.1 JXUM01098060 KQ564391 KXJ72352.1 KK855040 PTY20459.1 CH477238 NNAY01000551 OXU27724.1 GFDL01012878 JAV22167.1 DS231915 EDS26036.1 GFXV01005569 MBW17374.1 ABLF02025434 GGMS01017204 MBY86407.1 AJVK01016693 GL761997 EFZ22487.1 GBGD01002832 JAC86057.1 GBBI01002281 JAC16431.1 GFDF01008090 JAV05994.1 GFDF01008091 JAV05993.1 ATLV01016038 KE525054 KFB40929.1 GFTR01003763 JAW12663.1 AXCP01008426 AJWK01010758 AXCM01007054 ADMH02001012 ETN64459.1 AAAB01008823 GGFJ01009321 MBW58462.1 APCN01001416 AXCN02001762 JRES01001470 KNC22638.1 OUUW01000003 SPP78425.1 CAQQ02126420 JXJN01003019 CCAG010001567 EZ423965 ADD20241.1 CH479196 EDW27545.1 CH379064 EAL31795.1 GBXI01017137 JAC97154.1 GL732619 EFX70656.1 GDIP01054077 GDIQ01055078 JAM49638.1 JAN39659.1 GDHF01006549 JAI45765.1 GAKP01001441 JAC57511.1 GBYB01010418 JAG80185.1 CVRI01000047 CRK97402.1
RVE43258.1 KQ461195 KPJ06706.1 ODYU01005599 SOQ46596.1 NWSH01000179 PCG78706.1 KQ459596 KPI95517.1 GAIX01011479 JAA81081.1 KK107260 QOIP01000001 EZA53987.1 RLU26510.1 NEVH01011982 PNF31056.1 KQ434893 KZC10663.1 KK853274 KDR09100.1 KZ288344 PBC27710.1 KQ979999 KYN18331.1 GL435707 EFN72840.1 KQ759804 OAD62809.1 KQ982080 KYQ60225.1 LBMM01000427 KMQ98379.1 KQ977381 KYN03193.1 KQ976736 KYM76097.1 KQ981490 KYN41302.1 ADTU01013629 PYGN01000035 PSN56706.1 GL888103 EGI67430.1 GECU01011887 JAS95819.1 GECZ01021255 JAS48514.1 GECU01000982 JAT06725.1 GECZ01004211 JAS65558.1 AAZO01002431 DS235171 EEB12857.1 GEBQ01011572 JAT28405.1 GEDC01016557 JAS20741.1 GBYB01005535 JAG75302.1 GBYB01005593 JAG75360.1 GANO01002637 JAB57234.1 GL446149 EFN88452.1 KQ971329 EFA01136.1 KQ435709 KOX79974.1 APGK01050039 BT127433 KB741165 KB632352 AEE62395.1 ENN73395.1 ERL93301.1 GEZM01058189 JAV71808.1 JXUM01098060 KQ564391 KXJ72352.1 KK855040 PTY20459.1 CH477238 NNAY01000551 OXU27724.1 GFDL01012878 JAV22167.1 DS231915 EDS26036.1 GFXV01005569 MBW17374.1 ABLF02025434 GGMS01017204 MBY86407.1 AJVK01016693 GL761997 EFZ22487.1 GBGD01002832 JAC86057.1 GBBI01002281 JAC16431.1 GFDF01008090 JAV05994.1 GFDF01008091 JAV05993.1 ATLV01016038 KE525054 KFB40929.1 GFTR01003763 JAW12663.1 AXCP01008426 AJWK01010758 AXCM01007054 ADMH02001012 ETN64459.1 AAAB01008823 GGFJ01009321 MBW58462.1 APCN01001416 AXCN02001762 JRES01001470 KNC22638.1 OUUW01000003 SPP78425.1 CAQQ02126420 JXJN01003019 CCAG010001567 EZ423965 ADD20241.1 CH479196 EDW27545.1 CH379064 EAL31795.1 GBXI01017137 JAC97154.1 GL732619 EFX70656.1 GDIP01054077 GDIQ01055078 JAM49638.1 JAN39659.1 GDHF01006549 JAI45765.1 GAKP01001441 JAC57511.1 GBYB01010418 JAG80185.1 CVRI01000047 CRK97402.1
Proteomes
UP000007151
UP000005204
UP000283053
UP000053240
UP000218220
UP000053268
+ More
UP000053097 UP000279307 UP000235965 UP000076502 UP000027135 UP000242457 UP000005203 UP000078492 UP000000311 UP000075809 UP000036403 UP000078542 UP000078540 UP000078541 UP000005205 UP000245037 UP000007755 UP000192223 UP000009046 UP000008237 UP000007266 UP000053105 UP000079169 UP000019118 UP000030742 UP000069940 UP000249989 UP000008820 UP000215335 UP000002358 UP000002320 UP000007819 UP000092462 UP000030765 UP000075880 UP000092461 UP000075883 UP000075900 UP000075920 UP000075881 UP000000673 UP000075885 UP000075882 UP000076407 UP000075840 UP000007062 UP000075903 UP000076408 UP000075886 UP000037069 UP000268350 UP000075884 UP000069272 UP000015102 UP000092460 UP000092443 UP000078200 UP000092445 UP000092444 UP000091820 UP000008744 UP000001819 UP000000305 UP000183832 UP000095300
UP000053097 UP000279307 UP000235965 UP000076502 UP000027135 UP000242457 UP000005203 UP000078492 UP000000311 UP000075809 UP000036403 UP000078542 UP000078540 UP000078541 UP000005205 UP000245037 UP000007755 UP000192223 UP000009046 UP000008237 UP000007266 UP000053105 UP000079169 UP000019118 UP000030742 UP000069940 UP000249989 UP000008820 UP000215335 UP000002358 UP000002320 UP000007819 UP000092462 UP000030765 UP000075880 UP000092461 UP000075883 UP000075900 UP000075920 UP000075881 UP000000673 UP000075885 UP000075882 UP000076407 UP000075840 UP000007062 UP000075903 UP000076408 UP000075886 UP000037069 UP000268350 UP000075884 UP000069272 UP000015102 UP000092460 UP000092443 UP000078200 UP000092445 UP000092444 UP000091820 UP000008744 UP000001819 UP000000305 UP000183832 UP000095300
PRIDE
Pfam
PF09637 Med18
Interpro
IPR019095
Mediator_Med18
ProteinModelPortal
A0A212F0X8
H9JED0
A0A1E1WIA5
A0A437AYH9
A0A194QT40
A0A2H1W0Z3
+ More
A0A2A4K3V6 A0A194PQC7 S4NQM2 A0A026WD48 A0A2J7QR47 A0A154PFM4 A0A067QTY3 A0A2A3E7N4 A0A087ZR21 A0A195DZS4 E2A173 A0A310SVG6 A0A151XIU0 A0A0J7L775 A0A195CR28 A0A195AVL1 A0A195FM21 A0A158NES6 A0A2P8ZJN0 F4WEE3 A0A1B6J9L2 A0A1B6FEI2 A0A1B6K5N5 A0A1B6GT03 A0A1W4X724 E0VHT4 A0A1B6LXQ7 A0A1B6D4W9 A0A0C9RB37 A0A0C9PVU2 U5ERX0 E2B791 D6WG94 A0A0N1IU43 A0A3Q0IW85 J3JW15 A0A1Y1LG21 A0A182GYT1 A0A2R7WLU0 Q17IN5 A0A232FA42 K7IZQ7 A0A1Q3F3Q4 B0WF60 A0A2H8TT06 J9KA52 A0A2S2R8M0 A0A1B0DM62 E9IAB6 A0A069DQX9 A0A023F4H9 A0A1L8DI36 A0A1L8DHS2 A0A084VSI5 A0A224XWX7 A0A182IQ30 A0A1B0CG53 A0A182M029 A0A182RYW4 A0A182WFW3 A0A182K5A1 W5JNY2 A0A182PJA2 A0A1S4H5B9 A0A2M4BZK9 A0A182KKB8 A0A182WUN8 A0A182HVT7 Q7QGX9 A0A182VLZ6 A0A182YKM9 A0A182QK85 A0A0L0BRM1 A0A3B0J948 A0A182NC98 A0A182FKD2 T1H324 A0A1B0ASX0 A0A1A9XYE0 A0A1A9UUW9 A0A1A9ZLQ6 D3TRB3 A0A1A9X033 B4GXR8 Q29HG3 A0A0A1WF95 E9HC81 A0A0P5YSR4 A0A0K8W4I4 A0A034WPI7 A0A0C9Q874 A0A1J1ICC2 A0A1I8PSN2
A0A2A4K3V6 A0A194PQC7 S4NQM2 A0A026WD48 A0A2J7QR47 A0A154PFM4 A0A067QTY3 A0A2A3E7N4 A0A087ZR21 A0A195DZS4 E2A173 A0A310SVG6 A0A151XIU0 A0A0J7L775 A0A195CR28 A0A195AVL1 A0A195FM21 A0A158NES6 A0A2P8ZJN0 F4WEE3 A0A1B6J9L2 A0A1B6FEI2 A0A1B6K5N5 A0A1B6GT03 A0A1W4X724 E0VHT4 A0A1B6LXQ7 A0A1B6D4W9 A0A0C9RB37 A0A0C9PVU2 U5ERX0 E2B791 D6WG94 A0A0N1IU43 A0A3Q0IW85 J3JW15 A0A1Y1LG21 A0A182GYT1 A0A2R7WLU0 Q17IN5 A0A232FA42 K7IZQ7 A0A1Q3F3Q4 B0WF60 A0A2H8TT06 J9KA52 A0A2S2R8M0 A0A1B0DM62 E9IAB6 A0A069DQX9 A0A023F4H9 A0A1L8DI36 A0A1L8DHS2 A0A084VSI5 A0A224XWX7 A0A182IQ30 A0A1B0CG53 A0A182M029 A0A182RYW4 A0A182WFW3 A0A182K5A1 W5JNY2 A0A182PJA2 A0A1S4H5B9 A0A2M4BZK9 A0A182KKB8 A0A182WUN8 A0A182HVT7 Q7QGX9 A0A182VLZ6 A0A182YKM9 A0A182QK85 A0A0L0BRM1 A0A3B0J948 A0A182NC98 A0A182FKD2 T1H324 A0A1B0ASX0 A0A1A9XYE0 A0A1A9UUW9 A0A1A9ZLQ6 D3TRB3 A0A1A9X033 B4GXR8 Q29HG3 A0A0A1WF95 E9HC81 A0A0P5YSR4 A0A0K8W4I4 A0A034WPI7 A0A0C9Q874 A0A1J1ICC2 A0A1I8PSN2
Ontologies
GO
PANTHER
Topology
Subcellular location
Nucleus
Length:
223
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00182
Exp number, first 60 AAs:
0.00024
Total prob of N-in:
0.08008
outside
1 - 223
Population Genetic Test Statistics
Pi
180.801328
Theta
174.075408
Tajima's D
0.053232
CLR
0.593728
CSRT
0.381930903454827
Interpretation
Possibly Positive selection
