Gene

KWMTBOMO08799

Pre Gene Modal

BGIBMGA007878

Annotation

autophagy_5-like_[Bombyx_mori]

Location

Bomo_Chr15(-):5495341-5497687      View in EpiBrowser

Full name

Autophagy protein 5      

Alternative Name

APG5-like

Location in the cell

Cytoplasmic   Reliability : 2.177

CDS

ATGGCCAACGACAGGGAGGTACTTCGAGAAATATGGGATGGAAAACTACCGATATGTTTTCATCTTGCTCAAGAAGAAATAATGGAAATTCAACAACCTGATCCATTTTACGTTATGGTGCCTCGACTTAGCTACTTTCCTCTTGTCATCGATAAGATGAAACGTCACTTTCTCCGATTCATATCACAAGAGAATTCTGATAGTGAAATGTGGTTGGACTTTAATGGGCAACCCTTGAAATGGCACTATCCCATAGGATTTTTGTACGATTTGTATTGTGGTAATGATCCTCAACTACCCTGGACTTTGACAGTACACTTCACAAAGTTCCCTGAAGACATTCTTCTTCATTGCCCAAACAAAGATGTAGTAGAAGCACATTATATGTCTACAGTGAAAGAGGCTGATGTACTGAAACACAGAGGACAAGTGATGTCAACTATGCAAAAAAAGGATCACAATCAGTTATGGCTTGGATTACAAAATGACAAGTTTGATCAGTTTTGGGCTATCAACAGACGTCTTATGGAGTCACATGGTGATAATGATGGATTCAAACACATACCACTTAGGATTTATACTGATGATGGTGTATACAATCAACGCCTTGTCTGTCCTAAAAATACTGATAATAGTAGAAAAACGCTACAACAGATGATCTCCGAGCTATATCCAGAAAAATCAAATGTTAATCTAAGAACTCATGGTGTAATCATACCTCCAGAAACTCCTCTGCAGTGGCTTTCAGAACATCTCAGTTACCCTGACAACTTTTTACATTTGTGTTTATGCTGA

Protein

MANDREVLREIWDGKLPICFHLAQEEIMEIQQPDPFYVMVPRLSYFPLVIDKMKRHFLRFISQENSDSEMWLDFNGQPLKWHYPIGFLYDLYCGNDPQLPWTLTVHFTKFPEDILLHCPNKDVVEAHYMSTVKEADVLKHRGQVMSTMQKKDHNQLWLGLQNDKFDQFWAINRRLMESHGDNDGFKHIPLRIYTDDGVYNQRLVCPKNTDNSRKTLQQMISELYPEKSNVNLRTHGVIIPPETPLQWLSEHLSYPDNFLHLCLC

Description

Involved in autophagic vesicle formation.
Involved in autophagic vesicle formation. Conjugation with Atg12, through a ubiquitin-like conjugating system involving Atg7 as an E1-like activating enzyme and Atg10 as an E2-like conjugating enzyme, is essential for its function. The Atg12-Atg5 conjugate acts as an E3-like enzyme which is required for lipidation of Atg8 and its association to the vesicle membranes (By similarity).

Subunit

Conjugated with ATG12.

Similarity

Belongs to the ATG5 family.

Keywords

Autophagy   Complete proteome   Cytoplasm   Isopeptide bond   Membrane   Protein transport   Reference proteome   Transport   Ubl conjugation  

Feature

chain  Autophagy protein 5

Uniprot

B7TZ42   A0A3S2NSB0   S4NY94   A0A1E1WSD6   A0A194QME3   A0A142FH18   + More
A0A2H1W0G2   A0A2A4K4V0   A0A194PPY9   A0A212F101   H9JED1   A0A0L7LGC0   A0A1E1WPQ9   A0A1E1WJ12   A0A084WQA8   Q17IN4   A0A1Y1MN24   A0A182WFW0   A0A182KKC5   Q7QGY1   A0A1Q3G268   A0A0A7A838   A0A2J7PC63   A0A154P8G5   D6W8J7   A0A067QVF6   A0A2P8XND1   E9J914   A0A232EIX1   E2AEP3   A0A0N0U7D4   A0A158NUG6   A0A195BU31   K7IRC9   A0A2A3EFU4   A0A088ACH4   A0A195FWY4   A0A151J127   A0A0C9RCT0   A0A0T6AZE4   A0A310SHI4   F4X811   A0A151WFW6   A0A026WGU7   A0A1W4XBE2   A0A0L7R5A5   E2BV18   U5EVK4   A0A3L8DQD0   N6UJ75   A0A3Q8C034   A0A2M4BWV6   A0A1B6MBH7   A0A2M4AWA5   A0A2M4CTK6   A0A1B6JMT8   A0A182FKD5   A0A0A9Z9U2   A0A1B0CG54   A0A1B6EIZ2   A0A1L8DV62   A0A2R5LDV6   A0A1L8DV69   A0A131XU97   A0A0V0GAY1   A0A023F9Z9   A0A224XHW2   A0A1B6DE50   A0A293MYB1   A0A069DR74   E0VWT9   A0A1E1X3C7   A0A0N7Z9D4   R4FNU1   A0A2R7X1W2   L7M5J6   A0A131XAE9   A0A131YKY0   G3MNQ6   A0A0K8TSS0   A0A0K8V270   A0A1I8N7E4   Q3MQ12   Q3MQ19   Q9W3R7   Q3MQ20   B4IHL0   Q3MQ14   A0A1I8PKD9   A0A1W4V6X8   A0A3B0JCS4   B4N2C6   A0A423TW72   A0A0N7ZCD9   B4GVP8   Q3MQ15   Q3MQ17   A0A2C9JR67   A0A1A9XYE1   A0A1A9UUY2  

Pubmed

19470186    23622113    26354079    22118469    19121390    26227816    + More
24438588    17510324    28004739    20966253    12364791    14747013    17210077    18362917    19820115    24845553    29403074    21282665    28648823    20798317    21347285    20075255    21719571    24508170    30249741    23537049    25401762    29652888    25474469    26334808    20566863    28503490    27129103    25576852    28049606    26830274    22216098    26369729    25315136    17994087    17550304    18057021    10731132    12537572    12537569    15296714    15632085    23185243    15562597   

EMBL

FJ418152    ACJ54280.1    RSAL01000266    RVE43255.1    GAIX01013890    JAA78670.1    + More
GDQN01001095    JAT89959.1    KQ461195    KPJ06702.1    KT895433    AMQ76404.1    ODYU01005599    SOQ46600.1    NWSH01000179    PCG78692.1    KQ459596    KPI95511.1    AGBW02011012    OWR47381.1    BABH01002901    JTDY01001240    KOB74434.1    GDQN01002157    JAT88897.1    GDQN01004082    JAT86972.1    ATLV01025452    ATLV01025453    ATLV01025454    ATLV01025455    ATLV01025456    ATLV01025457    KE525389    KFB52402.1    CH477238    EAT46526.1    GEZM01026293    JAV87062.1    AAAB01008823    EAA05542.4    GFDL01001206    JAV33839.1    KF670694    AHC00665.1    NEVH01027067    PNF13920.1    KQ434845    KZC08226.1    KQ971312    EEZ98297.1    KK853205    KDR09853.1    PYGN01001658    PSN33521.1    GL769168    EFZ10703.1    NNAY01004144    OXU18306.1    GL438870    EFN68118.1    KQ435702    KOX80344.1    ADTU01026381    KQ976417    KYM89924.1    KZ288256    PBC30588.1    KQ981193    KYN45165.1    KQ980575    KYN15513.1    GBYB01010937    JAG80704.1    LJIG01022444    KRT80576.1    KQ759886    OAD62137.1    GL888900    EGI57478.1    KQ983203    KYQ46734.1    KK107256    EZA54304.1    KQ414654    KOC66004.1    GL450786    EFN80469.1    GANO01000986    JAB58885.1    QOIP01000006    RLU22119.1    APGK01017814    KB740053    KB632093    ENN81800.1    ERL88692.1    KY053222    ATX63057.1    GGFJ01008419    MBW57560.1    GEBQ01006695    JAT33282.1    GGFK01011729    MBW45050.1    GGFL01004489    MBW68667.1    GECU01007211    JAT00496.1    GBHO01001557    GBHO01001556    GBRD01017344    JAG42047.1    JAG42048.1    JAG48483.1    AJWK01010762    GECZ01031859    JAS37910.1    GFDF01003756    JAV10328.1    GGLE01003594    MBY07720.1    GFDF01003757    JAV10327.1    GEFM01005988    GEGO01000875    JAP69808.1    JAR94529.1    GECL01001703    JAP04421.1    GBBI01000888    JAC17824.1    GFTR01004351    JAW12075.1    GEDC01016803    GEDC01013349    JAS20495.1    JAS23949.1    GFWV01019602    MAA44330.1    GBGD01002534    JAC86355.1    DS235824    EEB17845.1    GFAC01005435    JAT93753.1    GDKW01000859    JAI55736.1    ACPB03003540    GAHY01001154    JAA76356.1    KK856454    PTY25799.1    GACK01005709    JAA59325.1    GEFH01005239    JAP63342.1    GEDV01009457    JAP79100.1    JO843507    AEO35124.1    GDAI01000432    JAI17171.1    GDHF01019287    JAI33027.1    AM087006    CM000162    CAJ31275.1    EDX02385.1    AM086999    CH954180    CAJ31268.1    EDV47459.1    AE014298    AY069596    AM086998    CH902622    CAJ31267.1    EDV34123.1    CH480839    EDW49361.1    AM087004    CM000366    CAJ31273.1    EDX17324.1    OUUW01000003    SPP78383.1    CH963925    EDW78515.1    QCYY01001084    ROT80704.1    GDRN01068599    JAI64176.1    CH479193    EDW26743.1    AM087003    CH379064    CAJ31272.1    EAL32202.1    AM087001    CH933810    CAJ31270.1    EDW07787.1   

Proteomes

UP000283053    UP000053240    UP000218220    UP000053268    UP000007151    UP000005204    + More
UP000037510    UP000030765    UP000008820    UP000075920    UP000075882    UP000007062    UP000235965    UP000076502    UP000007266    UP000027135    UP000245037    UP000215335    UP000000311    UP000053105    UP000005205    UP000078540    UP000002358    UP000242457    UP000005203    UP000078541    UP000078492    UP000007755    UP000075809    UP000053097    UP000192223    UP000053825    UP000008237    UP000279307    UP000019118    UP000030742    UP000069272    UP000092461    UP000009046    UP000015103    UP000095301    UP000002282    UP000008711    UP000000803    UP000007801    UP000001292    UP000000304    UP000095300    UP000192221    UP000268350    UP000007798    UP000283509    UP000008744    UP000001819    UP000009192    UP000076420    UP000092443    UP000078200   

PRIDE

B7TZ42    H9JED1    Q9W3R7   

Pfam

PF04106   APG5

Interpro

IPR007239   Atg5       

ProteinModelPortal

B7TZ42   A0A3S2NSB0   S4NY94   A0A1E1WSD6   A0A194QME3   A0A142FH18   + More
A0A2H1W0G2   A0A2A4K4V0   A0A194PPY9   A0A212F101   H9JED1   A0A0L7LGC0   A0A1E1WPQ9   A0A1E1WJ12   A0A084WQA8   Q17IN4   A0A1Y1MN24   A0A182WFW0   A0A182KKC5   Q7QGY1   A0A1Q3G268   A0A0A7A838   A0A2J7PC63   A0A154P8G5   D6W8J7   A0A067QVF6   A0A2P8XND1   E9J914   A0A232EIX1   E2AEP3   A0A0N0U7D4   A0A158NUG6   A0A195BU31   K7IRC9   A0A2A3EFU4   A0A088ACH4   A0A195FWY4   A0A151J127   A0A0C9RCT0   A0A0T6AZE4   A0A310SHI4   F4X811   A0A151WFW6   A0A026WGU7   A0A1W4XBE2   A0A0L7R5A5   E2BV18   U5EVK4   A0A3L8DQD0   N6UJ75   A0A3Q8C034   A0A2M4BWV6   A0A1B6MBH7   A0A2M4AWA5   A0A2M4CTK6   A0A1B6JMT8   A0A182FKD5   A0A0A9Z9U2   A0A1B0CG54   A0A1B6EIZ2   A0A1L8DV62   A0A2R5LDV6   A0A1L8DV69   A0A131XU97   A0A0V0GAY1   A0A023F9Z9   A0A224XHW2   A0A1B6DE50   A0A293MYB1   A0A069DR74   E0VWT9   A0A1E1X3C7   A0A0N7Z9D4   R4FNU1   A0A2R7X1W2   L7M5J6   A0A131XAE9   A0A131YKY0   G3MNQ6   A0A0K8TSS0   A0A0K8V270   A0A1I8N7E4   Q3MQ12   Q3MQ19   Q9W3R7   Q3MQ20   B4IHL0   Q3MQ14   A0A1I8PKD9   A0A1W4V6X8   A0A3B0JCS4   B4N2C6   A0A423TW72   A0A0N7ZCD9   B4GVP8   Q3MQ15   Q3MQ17   A0A2C9JR67   A0A1A9XYE1   A0A1A9UUY2  

PDB

5NPW     E-value=3.77322e-78,     Score=740

KEGG

100216348    K08339 autophagy-related protein 5 | (RefSeq) Atg5; autophagy 5-like

PATHWAY

04136    Autophagy - other - Bombyx mori (domestic silkworm)
04137    Mitophagy - animal - Bombyx mori (domestic silkworm)
04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0006914   GO:0034045   GO:0000045   GO:0006501   GO:0006995   GO:0000422   GO:0034274   GO:0035096   GO:0061723   GO:0009267   GO:0005776   GO:0016236   GO:0005737   GO:0015031   GO:0005840   GO:0006412   GO:0008097   GO:0016817   GO:0008270   GO:0043565   GO:0016876   GO:0043039  

PANTHER

PTHR13040  

Subcellular location

Preautophagosomal structure membrane  
Cytoplasm  

Length:

264

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00514

Exp number, first 60 AAs:

0.0047

Total prob of N-in:

0.07785

outside

1  -  264

 

 

Pi

123.905945

Theta

150.044935

Tajima's D

-0.482278

CLR

10.842794

CSRT

0.245737713114344

Interpretation

Possibly Positive selection