SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08794
Pre Gene Modal
BGIBMGA007695
Annotation
PREDICTED:_ATP-dependent_helicase_brm_[Bombyx_mori]
Full name
Acyl carrier protein       + More
ATP-dependent helicase brm      
Alternative Name
Homeotic gene regulator
Protein brahma
Location in the cell
Nuclear   Reliability : 4.3
 

Sequence

CDS
ATGCCTCCTTCCGGAGCTATAGCAGCCAATGCTAATGGTCCACCGGGTGTTTCCCAACAACACCCAGGATTACCTAGTGGACATCAAATGCCACCGCATATGGTAGGACCACACATGTCAGGACCTCCAAGTCACCAGCCCCATCCACCAGGTCCCAACGGGCATCCAAATATGCCAGGAGGGCCACAGCATTCCAATATAGCAGCCCAAGGACCACCTCATGGATATTTACAACATCAAATGGGGCACATGCCACCTGGCCAGGGTCAACTGCCGATGGGTGGAGCACCGCCGTCCGGTAACGGTCCTCAAGGTCCTCTAGGCGGACCGATGCCAATGGGTGGACCTCCAACGCACGGTGTACATCCTGGACAGGGTATGCCACCCGGCGCTCCTGGACATATGCCATCTCATCACTCAATGATGCCGGGTCAAGGGCCTCCACCTCATGGTGCAAATACTGGGCCTTATGGCCATCCACCACAGGCTGGTTCTACGCCACCTGCCCAAAGTGGCGGTCAACCTACCTCAGGGGGCGCATCTACAACCGGGCCCATGCAGCACCCACCTTCAGCTCAGACGCCGCCTCATGGACAAGGCCCGCCGCAGTCGTCTTCTTCTAATGGAGCTCCACCATCCTCTTCACCCATGCAAGGGTCCCTTCCTGTTACTGGGCCCGACAATCTAAATGCTCTTCAACGTGCAATCGATTCCATGGAAGAAAAAGGTCTCCAAGAAGATCCCCGTTATTCACAGTTATTAGCTCTTAGAGCCCGCTCAAATCCACAAGATCCTAGTAAAGGACTTTTTTCAAATACGCAACTCTGTCAGTTGAAAGCACAGATTTCGGCGTATCGGAATCTCGCCAGAAATCAACCCTTGCCGCCGCAAGTGGCCGCCTTAGCTACGGGCAAACGTACCGGCGAGAGTCCTCCGGAGTGTCCGACCCCGCCCGCGAGCGGCGCGTACGGCGAGGCGCAGGGCGCGGCGGGCAAGCCTCCCGCTGCGCACGGCGGCGCGCCTCCCACCCCGCTGCCCATGACTGGACAAATGGCTCCACCTACACAGCACACGCCCCCCCTTGTTAATCCGCCGGTGGGTGGAGTGCCGCTTCGTGGCCCCGCGCCATTGCGTCCCTCGGCTCCTGGAGCTCCCGGGACTCCACAAACGCAGCAGCTACCTGGAGCCAAACAAAATCGTGTGACCACCATGCCCAAACCTGTCGGAATCGACCCCGTGCAGATATTGAACGAAAGAGAAAACAGGATTGCAGCACGAATAGCTCATCGTATAGAAATATTATCAAACCTACCCGCCAATATGCCTGACGACCTTCGGTTACAAGCTCAAATCGAGCTCAGAGCACTCCGAGTGATTAATTTCCAAAAGCAATTGCGTTCAGAGATATTAGGTCAAGTCCGCCGTGATACAACCCTAGAGACCGCTGTAAACATAAAGGCCTATAAGCGCACTAAACGACAAGGTTTGCGAGAGGCCCGAGCCACTGAGAAACTTGAGAAACAACAAAAACTGGAGGCCGAGAGGAAACGACGACAGAAGCACCAAGAATTCCTACAAACAGTTCTTCAGCACGTTAAGGATTTCAAGGAATATCACCGTAACAACCTAGCTAAAACAGCACGCATCAATAAATCAATCATGAACTATCACGCTAACGCCGAACGAGAACAGAAGAAAGAACAGGAACGCATAGAAAAAGAGCGCATGCGGCGGTTAATGGCAGAAGACGAAGAAGGTTACCGTAAACTGATCGATCAAAAGAAAGACAAAAGATTGGCGTTCTTATTGTCACAGACTGATGAGTATATAGCCAGCCTTACCGAGATGGTCAAGCAGCACAAGCAAGAGCAACGTAAAAAACAACAAGAAGAGGAACGGAGGAAGAGGAAATCAAGAAAGAAGAAGTTGCTGGAAGGTGGAGAGATTGACGCTTTGGATGACAGCTCCCAGACTTCAGACTCAAGAGTCAGCGTCGTGGATCCTAAGTCTGGCGAAATACTGAAGGGCGAAGATGCGCCGCTGCTGTCTCAATTAAAGGATTGGATGGAGACACACCCTGGATGGGAAGTAATGTCTGATTCCGATGATTCTGGTGACGACAGCCAAGACGATGATGAAAAGAGAAAAGACAGGCACAGAGACGACAGGGGCGATCGCGAGAAAACCGACGAAGAGAAAGCGCGAGATATGATTAAAAAGGCCAAAGTCGAGGACGATGAATATAAAACTGAGGAACAGACCTACTACAGCATTGCTCACACAGTTCACGAGTCCGTAACAGAACAAGCTAGTATTCTAGTGAACGGAAATCTCAAAGAATATCAAATAAAGGGCTTGGAATGGTTGGTGTCACTATTCAACAATAATCTTAATGGAATTTTGGCCGACGAGATGGGCCTGGGTAAGACCATTCAGACTATTGCACTGGTCACCTACCTCATGGAAAAGAAGAAAGTGAATGGACCTTATCTAATTATCGTACCGTTGAGTACTCTTTCAAACTGGGTATTGGAGTTCGAGAAGTGGGCTCCCACAGTTTCGGTCGTTTCCTACAAGGGCTCTCCGCAGTCGCGTCGCCTGGTGCAAGCTCAGATGCGATCCACCAAGTTCAATGTGCTGCTCACTACCTACGAGTACGTCATCAAGGATAAGGGAGTTCTCGCCAAGGTACAATGGAAGTACATGATAATTGACGAAGGTCATCGGATGAAAAATCATCACTGCAAACTAACACAAGTACTAAACACTCACTACATCGCGCCGCACCGTCTGCTCCTGACTGGTACGCCGCTGCAAAACAAACTACCAGAACTCTGGGCACTACTGAACTTCCTATTGCCATCTATATTTAAGAGCTGTTCTACTTTCGAACAATGGTTCAACGCTCCGTTTGCAACAACCGGTGAAAAGGTGGAATTAAATGAAGAAGAAACAATTTTAATTATTCGTCGTCTGCATAAAGTATTACGTCCGTTCTTGTTACGACGACTGAAAAAAGAAGTCGAGAGCCAACTACCTGACAAAGTCGAATACATCATCAAGTGCGACATGAGTGGGCTACAGAGAGTACTTTACAAACATATGCAGTCCAAGGGAGTTTTGCTGACGGATGGGTCTGAGAAAGGGAACAAAGGAAAGGGTGGCGCTAAAGCTTTGATGAACACGATCGTACAGCTCCGGAAGCTGTGTAATCATCCCTTCATGTTCCAGCACATAGAGGAAAAGTTCTGTGATCACCTCGGTACTGGTGGCACTGTTGTTTCCGGGCCAGATCTATACAGAGCTTCCGGCAAGTTCGAGTTGCTTGACCGGATATTGCCGAAGTTGAAAACAACTGGTCACAGGGTGCTTGTGTTCTGTCAGATGACGCAGTGCATGACCATCATCGAAGATTACCTTTCATGGAGAGCTTTCCAATATTTGAGATTGGACGGTATGACCAAGGCAGAGGATCGCGGAGAGCTACTGAAGAAATTTAACGACGCCAATTCTGAATATTTCATATTTTTACTGTCGACTCGCGCTGGAGGTCTCGGTCTCAACTTGCAGAGCGCTGATACTGTTATCATTTTCGATTCGGACTGGAATCCGCATCAGGATCTACAAGCTCAAGATCGTGCTCATCGTATCGGCCAACGGAATGAAGTACGTGTGCTCCGACTCATGACCGTCAACTCTGTAGAAGAGAGAATTTTAGCTGCTGCCAGATACAAATTAAACATGGACGAAAAAGTCATCCAAGCTGGTATGTTCGATCAGAAGTCTACTGGATCTGAGCGGCAACAGTTTCTGCAAAGTATTCTGCATCAAGACGGAGATGATGAAGAGGAAGAAAATGAAGTTCCCGATGACGATCTCATTAATGCAATGATAGCGCGTTCGGAAGAAGAGCTGGAGATATTCAAACAAATTGATTTGGAACGTAAAAAGACTGAGAAACATTCAAGGCTTATCGAGGAGTCAGAGCTGCCAGATTGGCTCGTGAAGGACGATGATGAAGTTGTCTGCAATAAGGGTCAAGGCTGGAATTATTTAGATGAAGACGAGACCCTCGGACGCGGGTCGAGACAACGCAAGGAAGTTGACTACACGGACTCGCTCACGGAGAAAGAGTGGCTGAAGGCTATCGATGAGGAGTTTGAGGAAGAAGAAGAAGAAGAAGACGACGAGGATGAAGTTCTCGATAAGAAGAAGAAGAAGGGACGTAAGCGACGACGAAATCAGGACGATTCTGACGAAGACGAAGTACCCACATCATCCAAGAAGAAAAGCAAAACAGAAATCAATCTTCTGAAGAAGAGACTGAAAAATATCATGAAGAAAATAATTGATTATGCAGATGAGAATGGACGAGTTTTGTCTGAACCATTCATGAAACTGCCGTCGAGACGTGAGTTACCTGACTACTATGATATTATCAAGAAACCACTGGACATCAAGAAAATCGTTAATAGGATTGAAGAGGGCAAGTACAACGATATATCTGATTTGGAGCGGGACTTTTTCACTTTATGCGCCAATGCGCAGACATACAACGAGGAGGCCTCACTTATATACGAAGATTCCGTAAGACTTCGGAATTTATTCATAGAACTACGACGAAGACACGAAAGTGGACAGAATTCTGATGATTCTGACGAAAATGAAAAAGATGAAGAAGATTCAGATGGTGAGTTTAATAGATCAGTCAAAATGAAAATTAAATTGAAAGGCAAAGGAAAAAATACCCCTTCCAGGAAAAGGAAACCACGGAAGCACATCTCGGATGACGAATATTACGAAGAAGATTGA
Protein
MPPSGAIAANANGPPGVSQQHPGLPSGHQMPPHMVGPHMSGPPSHQPHPPGPNGHPNMPGGPQHSNIAAQGPPHGYLQHQMGHMPPGQGQLPMGGAPPSGNGPQGPLGGPMPMGGPPTHGVHPGQGMPPGAPGHMPSHHSMMPGQGPPPHGANTGPYGHPPQAGSTPPAQSGGQPTSGGASTTGPMQHPPSAQTPPHGQGPPQSSSSNGAPPSSSPMQGSLPVTGPDNLNALQRAIDSMEEKGLQEDPRYSQLLALRARSNPQDPSKGLFSNTQLCQLKAQISAYRNLARNQPLPPQVAALATGKRTGESPPECPTPPASGAYGEAQGAAGKPPAAHGGAPPTPLPMTGQMAPPTQHTPPLVNPPVGGVPLRGPAPLRPSAPGAPGTPQTQQLPGAKQNRVTTMPKPVGIDPVQILNERENRIAARIAHRIEILSNLPANMPDDLRLQAQIELRALRVINFQKQLRSEILGQVRRDTTLETAVNIKAYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHQEFLQTVLQHVKDFKEYHRNNLAKTARINKSIMNYHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYIASLTEMVKQHKQEQRKKQQEEERRKRKSRKKKLLEGGEIDALDDSSQTSDSRVSVVDPKSGEILKGEDAPLLSQLKDWMETHPGWEVMSDSDDSGDDSQDDDEKRKDRHRDDRGDREKTDEEKARDMIKKAKVEDDEYKTEEQTYYSIAHTVHESVTEQASILVNGNLKEYQIKGLEWLVSLFNNNLNGILADEMGLGKTIQTIALVTYLMEKKKVNGPYLIIVPLSTLSNWVLEFEKWAPTVSVVSYKGSPQSRRLVQAQMRSTKFNVLLTTYEYVIKDKGVLAKVQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPHRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPDKVEYIIKCDMSGLQRVLYKHMQSKGVLLTDGSEKGNKGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKFCDHLGTGGTVVSGPDLYRASGKFELLDRILPKLKTTGHRVLVFCQMTQCMTIIEDYLSWRAFQYLRLDGMTKAEDRGELLKKFNDANSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQSILHQDGDDEEEENEVPDDDLINAMIARSEEELEIFKQIDLERKKTEKHSRLIEESELPDWLVKDDDEVVCNKGQGWNYLDEDETLGRGSRQRKEVDYTDSLTEKEWLKAIDEEFEEEEEEEDDEDEVLDKKKKKGRKRRRNQDDSDEDEVPTSSKKKSKTEINLLKKRLKNIMKKIIDYADENGRVLSEPFMKLPSRRELPDYYDIIKKPLDIKKIVNRIEEGKYNDISDLERDFFTLCANAQTYNEEASLIYEDSVRLRNLFIELRRRHESGQNSDDSDENEKDEEDSDGEFNRSVKMKIKLKGKGKNTPSRKRKPRKHISDDEYYEED

Summary

Description
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Transcriptional regulator (PubMed:1346755). Acts as a coactivator, assisting one or more dedicated transcriptional activators of ANTC and BXC homeotic gene clusters (PubMed:1346755). Can counteract the repressive effect of Polycomb protein (PubMed:1346755). ATPase subunit of the Brahma complex, a multiprotein complex which is the equivalent of the yeast SWI/SNF complex and acts by remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA (PubMed:1346755). This complex can both serve as a transcriptional coactivator or corepressor, depending on the context (PubMed:10809665). In type II neuroblast lineage, as part of the Brm remodeling complex, suppresses the formation of ectopic neuroblasts probably through interaction with erm and HDAC3 (PubMed:24618901).
Catalytic Activity
ATP + H2O = ADP + H(+) + phosphate
Subunit
Component of the Brahma complex, which is composed of brm, osa, mor, Snr1/Bap45, dalao/Bap111, Bap55, Bap60 and Act42A/Bap47 (PubMed:10601025, PubMed:10809665). Interacts with asf1 (PubMed:12381660). Associates with the brm-HDAC3-erm repressor complex, composed of brm, HDAC3 and erm (PubMed:24618901). Interacts with erm and HDAC3 (PubMed:24618901).
Miscellaneous
'Brahma' means 'fate' in India.
Keywords
Activator   Alternative splicing   ATP-binding   Bromodomain   Chromatin regulator   Complete proteome   Developmental protein   Helicase   Hydrolase   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Transcription   Transcription regulation  
Feature
chain  ATP-dependent helicase brm
splice variant  In isoform C.
EC Number
3.6.4.12
EMBL
ODYU01005599    SOQ46604.1    KQ461195    KPJ06699.1    RSAL01000266    RVE43252.1    + More
AGBW02011012    OWR47383.1    KQ971380    KYB25018.1    GECZ01020667    JAS49102.1    GECZ01009520    JAS60249.1    KT369801    AML25530.1    KYB25022.1    GECU01001588    JAT06119.1    KQ763450    OAD55062.1    EEZ97706.2    KYB25021.1    GDKW01003306    JAI53289.1    GFTR01008823    JAW07603.1    GBGD01000086    JAC88803.1    JXUM01109186    KQ565297    KXJ71118.1    CH477321    EAT43621.1    EAT43622.1    GFDF01008609    JAV05475.1    ACPB03005169    GEZM01034623    JAV83695.1    ATLV01016973    KE525139    KFB41670.1    AXCN02002120    GGFK01002782    MBW36103.1    AXCM01001215    AAAB01008849    AJWK01021204    AJWK01021205    AJWK01021206    AJWK01021207    EAA07201.4    APCN01005173    KQ982021    KYN30528.1    GGFJ01000268    MBW49409.1    GGFK01002191    MBW35512.1    GGFJ01000269    MBW49410.1    KQ434782    KZC04625.1    ADMH02001623    ETN61743.1    ADTU01023326    ADTU01023327    KQ982335    KYQ57487.1    KQ976419    KYM89324.1    KQ980824    KYN12466.1    GL439108    EFN67856.1    KQ977595    KYN01585.1    GL888199    EGI65350.1    GBYB01007997    JAG77764.1    QOIP01000008    RLU19639.1    KK107274    EZA53694.1    AJVK01017052    AJVK01017053    AJVK01017054    AJVK01017055    GDHF01024089    GDHF01022255    JAI28225.1    JAI30059.1    GECZ01008659    JAS61110.1    GL445320    EFN89841.1    GBXI01013845    JAD00447.1    GECZ01016225    JAS53544.1    KZ288402    PBC26249.1    GAMC01007370    JAB99185.1    DS235869    EEB19434.1    JXJN01010041    GANO01002316    JAB57555.1    GECL01002435    JAP03689.1    CCAG010020780    ABLF02026084    NEVH01024425    PNF17191.1    KK852482    KDR22877.1    DS235072    EEB11322.1    PNF17190.1    PNF17193.1    NEVH01004959    PNF39264.1    CH940647    EDW70034.2    GL768069    EFZ12469.1    CH933809    EDW18792.2    CH902618    EDV40133.1    KA648250    AFP62879.1    KR152260    AKJ26287.1    CP012525    ALC44792.1    KK852661    KDR19105.1    CH964168    EDW80159.2    AE014296    AGB94600.1    M85049    AY095048    BT009972    APGK01021802    KB740364    KB632275    ENN80792.1    ERL91162.1   
Pfam
PF08880   QLQ        + More
PF07529   HSA
PF07533   BRK
PF00176   SNF2_N
PF00271   Helicase_C
PF14619   SnAC
PF00439   Bromodomain
PF00622   SPRY
PF00550   PP-binding
Interpro
IPR014001   Helicase_ATP-bd        + More
IPR037259   BRK_sf       
IPR018359   Bromodomain_CS       
IPR001650   Helicase_C       
IPR014012   HSA_dom       
IPR001487   Bromodomain       
IPR014978   Gln-Leu-Gln_QLQ       
IPR000330   SNF2_N       
IPR036427   Bromodomain-like_sf       
IPR029295   SnAC       
IPR006576   BRK_domain       
IPR038718   SNF2-like_sf       
IPR027417   P-loop_NTPase       
IPR030088   SMARCA2       
IPR030100   BRG1       
IPR009081   PP-bd_ACP       
IPR036736   ACP-like_sf       
IPR003877   SPRY_dom       
IPR013320   ConA-like_dom_sf       
IPR003231   Acyl_carrier       
IPR001870   B30.2/SPRY       
IPR000637   HMGI/Y_DNA-bd_CS       
SUPFAM
SSF52540   SSF52540        + More
SSF47370   SSF47370       
SSF160481   SSF160481       
SSF47336   SSF47336       
SSF49899   SSF49899       
PDB
5HZR     E-value=0,     Score=1833

Ontologies

Topology

Subcellular location
Nucleus  
Length:
1603
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.000820000000000001
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00000
outside
1  -  1603
 
 

Population Genetic Test Statistics

Pi
198.263189
Theta
184.821735
Tajima's D
0.157356
CLR
0.580991
CSRT
0.415329233538323
Interpretation
Uncertain
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