Gene
KWMTBOMO08789
Pre Gene Modal
BGIBMGA007694
Annotation
surfeit_5_[Bombyx_mori]
Full name
Mediator of RNA polymerase II transcription subunit 22
Alternative Name
Mediator complex subunit 22
dMED24
dMED24
Location in the cell
Nuclear Reliability : 2.598
Sequence
CDS
ATGCAGCGGAGTCTACCTCAGAATAAAGAAGCACTTCTTAAATCGTACACTACAAGATTAAAAGAAGATGTCAAAAGCATGTTAGAGAATTTTGAAGAAATAATAAAATTGGCAAAAGTAGAGAATGAATCTCAATTAAACAGAATGACGCAAATAGAACAAGACACATTTGAAATGCAAGTCAGGGCTGCTAATATAGTCAGAGCTGGAGAATCACTTATGAAACTAGTATCAGATATTAAACAGTATTTAATTCTCAATGACTTTCCATCAGTCAATGAAGCCATTACCCAAAATTCAAAATTGTTTCGTACAAAACAACAAGAGTGTGACCAGAAATTAATGTCTTTACGGGATGATATTGCAGCAGATTTATATGATTTAGAAGATGAATATTTTACCAGTATTTATAAGTAA
Protein
MQRSLPQNKEALLKSYTTRLKEDVKSMLENFEEIIKLAKVENESQLNRMTQIEQDTFEMQVRAANIVRAGESLMKLVSDIKQYLILNDFPSVNEAITQNSKLFRTKQQECDQKLMSLRDDIAADLYDLEDEYFTSIYK
Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Subunit
Component of the Mediator complex.
Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
Component of the Mediator complex, which includes at least CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.
Similarity
Belongs to the Mediator complex subunit 22 family.
Keywords
Activator
Complete proteome
Nucleus
Reference proteome
Transcription
Transcription regulation
Coiled coil
Feature
chain Mediator of RNA polymerase II transcription subunit 22
Uniprot
Q1HQ73
A0A2A4K677
A0A2H1W0I3
A0A212FC24
A0A194QMC7
A0A194PQB2
+ More
S4NZ33 A0A437AYI7 A0A0M9ACH5 A0A067RUL8 A0A088ACB0 A0A310SUW6 A0A1B6G398 A0A154P8Q3 A0A0L7R5B1 A0A1B6KJG0 A0A195D4Z4 A0A2J7RM26 A0A1B6JNZ5 A0A195DJ64 F4WBW9 A0A195BDA1 A0A195FSR6 A0A158NQP0 A0A151XB03 A0A2A3EFM6 A0A026WLM8 A0A232F126 K7IRD2 A0A1Y1KK05 E1ZXC1 A0A0N7Z9B4 A0A023FB03 R4G519 A0A1W4XFW4 A0A0C9R7S3 A0A1B6CVC1 D6X4N7 A0A0A9Y8G6 E2BM98 N6TK11 E0VWE5 A0A0T6BG73 U5EXK4 A0A1B0CCT0 A0A1L8DHI3 A0A0K8VIX9 A0A034W3C0 W8BHE9 A0A212F0W1 A0A0K8TRK1 A0A1I8MZ77 T1J9Y9 A0A1I8QEP9 A0A1Q3FCZ7 A0A023EEL3 Q178E6 B0W307 A0A1A9W293 A0A182NLE8 A0A182M3S0 A0A182YGQ8 A0A182P6Q3 A0A182VJW5 A0A182K885 A0A182TGW1 A0A182XJ63 A0A182S045 A0A182I7P7 Q7QB45 A0A182W1F2 A0A1B0GAH8 A0A1A9ZLI7 A0A182Q9N2 A0A2M3ZCQ6 A0A2M4ARJ8 A0A2M4C317 W5JBZ1 A0A182FSB9 A0A084VNS0 A0A182ISM1 B4ND62 B4I976 B4PX53 B3P9B7 Q9V439 B4L3R1 B4MD40 B3MYC9 A0A3B0KYF1 A0A1W4VU02 B4JIZ8 B5DP00 B4GTU1 A0A1A9X800 A0A1B0ALU8 A0A1A9UU68 A0A3B0K2J3 A0A3B0K4H4 B4G3C9
S4NZ33 A0A437AYI7 A0A0M9ACH5 A0A067RUL8 A0A088ACB0 A0A310SUW6 A0A1B6G398 A0A154P8Q3 A0A0L7R5B1 A0A1B6KJG0 A0A195D4Z4 A0A2J7RM26 A0A1B6JNZ5 A0A195DJ64 F4WBW9 A0A195BDA1 A0A195FSR6 A0A158NQP0 A0A151XB03 A0A2A3EFM6 A0A026WLM8 A0A232F126 K7IRD2 A0A1Y1KK05 E1ZXC1 A0A0N7Z9B4 A0A023FB03 R4G519 A0A1W4XFW4 A0A0C9R7S3 A0A1B6CVC1 D6X4N7 A0A0A9Y8G6 E2BM98 N6TK11 E0VWE5 A0A0T6BG73 U5EXK4 A0A1B0CCT0 A0A1L8DHI3 A0A0K8VIX9 A0A034W3C0 W8BHE9 A0A212F0W1 A0A0K8TRK1 A0A1I8MZ77 T1J9Y9 A0A1I8QEP9 A0A1Q3FCZ7 A0A023EEL3 Q178E6 B0W307 A0A1A9W293 A0A182NLE8 A0A182M3S0 A0A182YGQ8 A0A182P6Q3 A0A182VJW5 A0A182K885 A0A182TGW1 A0A182XJ63 A0A182S045 A0A182I7P7 Q7QB45 A0A182W1F2 A0A1B0GAH8 A0A1A9ZLI7 A0A182Q9N2 A0A2M3ZCQ6 A0A2M4ARJ8 A0A2M4C317 W5JBZ1 A0A182FSB9 A0A084VNS0 A0A182ISM1 B4ND62 B4I976 B4PX53 B3P9B7 Q9V439 B4L3R1 B4MD40 B3MYC9 A0A3B0KYF1 A0A1W4VU02 B4JIZ8 B5DP00 B4GTU1 A0A1A9X800 A0A1B0ALU8 A0A1A9UU68 A0A3B0K2J3 A0A3B0K4H4 B4G3C9
Pubmed
22118469
26354079
23622113
24845553
21719571
21347285
+ More
24508170 30249741 28648823 20075255 28004739 20798317 27129103 25474469 18362917 19820115 25401762 26823975 23537049 20566863 25348373 24495485 26369729 25315136 24945155 17510324 25244985 12364791 20920257 23761445 24438588 17994087 17550304 10731132 12537572 10731137 12537569 12021283 15632085
24508170 30249741 28648823 20075255 28004739 20798317 27129103 25474469 18362917 19820115 25401762 26823975 23537049 20566863 25348373 24495485 26369729 25315136 24945155 17510324 25244985 12364791 20920257 23761445 24438588 17994087 17550304 10731132 12537572 10731137 12537569 12021283 15632085
EMBL
DQ443179
ABF51268.1
NWSH01000105
PCG79516.1
ODYU01005599
SOQ46609.1
+ More
AGBW02009246 OWR51267.1 KQ461195 KPJ06693.1 KQ459596 KPI95502.1 GAIX01011512 JAA81048.1 RSAL01000266 RVE43250.1 KQ435702 KOX80339.1 KK852460 KDR23534.1 KQ759886 OAD62142.1 GECZ01012862 JAS56907.1 KQ434845 KZC08221.1 KQ414654 KOC66009.1 GEBQ01028389 JAT11588.1 KQ976885 KYN07499.1 NEVH01002577 PNF41893.1 GECU01006742 JAT00965.1 KQ980824 KYN12539.1 GL888066 EGI68397.1 KQ976511 KYM82551.1 KQ981280 KYN43486.1 ADTU01023454 KQ982335 KYQ57563.1 KZ288256 PBC30593.1 KK107154 QOIP01000001 EZA56858.1 RLU26537.1 NNAY01001402 OXU24098.1 GEZM01086153 GEZM01086152 JAV59736.1 GL435030 EFN74211.1 GDKW01001019 JAI55576.1 GBBI01000508 JAC18204.1 ACPB03016454 GAHY01000875 JAA76635.1 GBYB01008892 JAG78659.1 GEDC01019866 JAS17432.1 KQ971380 EEZ97247.1 GBHO01017769 GBRD01012642 GDHC01012544 JAG25835.1 JAG53182.1 JAQ06085.1 GL449158 EFN83224.1 APGK01021776 KB740363 KB631964 ENN80804.1 ERL87505.1 DS235819 EEB17696.1 LJIG01000769 KRT86171.1 GANO01000909 JAB58962.1 AJWK01007070 GFDF01008178 JAV05906.1 GDHF01013470 JAI38844.1 GAKP01010699 GAKP01010696 JAC48253.1 GAMC01017471 GAMC01017468 GAMC01017465 GAMC01017461 JAB89084.1 AGBW02011012 OWR47389.1 GDAI01000835 JAI16768.1 JH431980 GFDL01009574 JAV25471.1 GAPW01005786 GAPW01005784 JAC07812.1 CH477365 DS231830 EDS30715.1 AXCM01001304 APCN01002523 AAAB01008880 CCAG010017803 AXCN02000131 GGFM01005524 MBW26275.1 GGFK01010073 MBW43394.1 GGFJ01010524 MBW59665.1 ADMH02001952 ETN60339.1 ATLV01014857 KE524991 KFB39614.1 CH964239 EDW82771.1 CH480825 EDW43757.1 CM000162 EDX00839.1 CH954183 EDV45413.1 AE014298 AL109630 AY071113 CH933810 EDW07189.1 CH940660 EDW58112.1 CH902632 EDV32623.1 OUUW01000018 SPP89128.1 CH916370 EDV99562.1 CH379065 EDY73252.1 CH479190 EDW25961.1 JXJN01000159 OUUW01000005 SPP80179.1 SPP89127.1 CH479179 EDW24311.1
AGBW02009246 OWR51267.1 KQ461195 KPJ06693.1 KQ459596 KPI95502.1 GAIX01011512 JAA81048.1 RSAL01000266 RVE43250.1 KQ435702 KOX80339.1 KK852460 KDR23534.1 KQ759886 OAD62142.1 GECZ01012862 JAS56907.1 KQ434845 KZC08221.1 KQ414654 KOC66009.1 GEBQ01028389 JAT11588.1 KQ976885 KYN07499.1 NEVH01002577 PNF41893.1 GECU01006742 JAT00965.1 KQ980824 KYN12539.1 GL888066 EGI68397.1 KQ976511 KYM82551.1 KQ981280 KYN43486.1 ADTU01023454 KQ982335 KYQ57563.1 KZ288256 PBC30593.1 KK107154 QOIP01000001 EZA56858.1 RLU26537.1 NNAY01001402 OXU24098.1 GEZM01086153 GEZM01086152 JAV59736.1 GL435030 EFN74211.1 GDKW01001019 JAI55576.1 GBBI01000508 JAC18204.1 ACPB03016454 GAHY01000875 JAA76635.1 GBYB01008892 JAG78659.1 GEDC01019866 JAS17432.1 KQ971380 EEZ97247.1 GBHO01017769 GBRD01012642 GDHC01012544 JAG25835.1 JAG53182.1 JAQ06085.1 GL449158 EFN83224.1 APGK01021776 KB740363 KB631964 ENN80804.1 ERL87505.1 DS235819 EEB17696.1 LJIG01000769 KRT86171.1 GANO01000909 JAB58962.1 AJWK01007070 GFDF01008178 JAV05906.1 GDHF01013470 JAI38844.1 GAKP01010699 GAKP01010696 JAC48253.1 GAMC01017471 GAMC01017468 GAMC01017465 GAMC01017461 JAB89084.1 AGBW02011012 OWR47389.1 GDAI01000835 JAI16768.1 JH431980 GFDL01009574 JAV25471.1 GAPW01005786 GAPW01005784 JAC07812.1 CH477365 DS231830 EDS30715.1 AXCM01001304 APCN01002523 AAAB01008880 CCAG010017803 AXCN02000131 GGFM01005524 MBW26275.1 GGFK01010073 MBW43394.1 GGFJ01010524 MBW59665.1 ADMH02001952 ETN60339.1 ATLV01014857 KE524991 KFB39614.1 CH964239 EDW82771.1 CH480825 EDW43757.1 CM000162 EDX00839.1 CH954183 EDV45413.1 AE014298 AL109630 AY071113 CH933810 EDW07189.1 CH940660 EDW58112.1 CH902632 EDV32623.1 OUUW01000018 SPP89128.1 CH916370 EDV99562.1 CH379065 EDY73252.1 CH479190 EDW25961.1 JXJN01000159 OUUW01000005 SPP80179.1 SPP89127.1 CH479179 EDW24311.1
Proteomes
UP000218220
UP000007151
UP000053240
UP000053268
UP000283053
UP000053105
+ More
UP000027135 UP000005203 UP000076502 UP000053825 UP000078542 UP000235965 UP000078492 UP000007755 UP000078540 UP000078541 UP000005205 UP000075809 UP000242457 UP000053097 UP000279307 UP000215335 UP000002358 UP000000311 UP000015103 UP000192223 UP000007266 UP000008237 UP000019118 UP000030742 UP000009046 UP000092461 UP000095301 UP000095300 UP000008820 UP000002320 UP000091820 UP000075884 UP000075883 UP000076408 UP000075885 UP000075903 UP000075881 UP000075902 UP000076407 UP000075900 UP000075840 UP000007062 UP000075920 UP000092444 UP000092445 UP000075886 UP000000673 UP000069272 UP000030765 UP000075880 UP000007798 UP000001292 UP000002282 UP000008711 UP000000803 UP000009192 UP000008792 UP000007801 UP000268350 UP000192221 UP000001070 UP000001819 UP000008744 UP000092443 UP000092460 UP000078200
UP000027135 UP000005203 UP000076502 UP000053825 UP000078542 UP000235965 UP000078492 UP000007755 UP000078540 UP000078541 UP000005205 UP000075809 UP000242457 UP000053097 UP000279307 UP000215335 UP000002358 UP000000311 UP000015103 UP000192223 UP000007266 UP000008237 UP000019118 UP000030742 UP000009046 UP000092461 UP000095301 UP000095300 UP000008820 UP000002320 UP000091820 UP000075884 UP000075883 UP000076408 UP000075885 UP000075903 UP000075881 UP000075902 UP000076407 UP000075900 UP000075840 UP000007062 UP000075920 UP000092444 UP000092445 UP000075886 UP000000673 UP000069272 UP000030765 UP000075880 UP000007798 UP000001292 UP000002282 UP000008711 UP000000803 UP000009192 UP000008792 UP000007801 UP000268350 UP000192221 UP000001070 UP000001819 UP000008744 UP000092443 UP000092460 UP000078200
Pfam
PF06179 Med22
Gene 3D
ProteinModelPortal
Q1HQ73
A0A2A4K677
A0A2H1W0I3
A0A212FC24
A0A194QMC7
A0A194PQB2
+ More
S4NZ33 A0A437AYI7 A0A0M9ACH5 A0A067RUL8 A0A088ACB0 A0A310SUW6 A0A1B6G398 A0A154P8Q3 A0A0L7R5B1 A0A1B6KJG0 A0A195D4Z4 A0A2J7RM26 A0A1B6JNZ5 A0A195DJ64 F4WBW9 A0A195BDA1 A0A195FSR6 A0A158NQP0 A0A151XB03 A0A2A3EFM6 A0A026WLM8 A0A232F126 K7IRD2 A0A1Y1KK05 E1ZXC1 A0A0N7Z9B4 A0A023FB03 R4G519 A0A1W4XFW4 A0A0C9R7S3 A0A1B6CVC1 D6X4N7 A0A0A9Y8G6 E2BM98 N6TK11 E0VWE5 A0A0T6BG73 U5EXK4 A0A1B0CCT0 A0A1L8DHI3 A0A0K8VIX9 A0A034W3C0 W8BHE9 A0A212F0W1 A0A0K8TRK1 A0A1I8MZ77 T1J9Y9 A0A1I8QEP9 A0A1Q3FCZ7 A0A023EEL3 Q178E6 B0W307 A0A1A9W293 A0A182NLE8 A0A182M3S0 A0A182YGQ8 A0A182P6Q3 A0A182VJW5 A0A182K885 A0A182TGW1 A0A182XJ63 A0A182S045 A0A182I7P7 Q7QB45 A0A182W1F2 A0A1B0GAH8 A0A1A9ZLI7 A0A182Q9N2 A0A2M3ZCQ6 A0A2M4ARJ8 A0A2M4C317 W5JBZ1 A0A182FSB9 A0A084VNS0 A0A182ISM1 B4ND62 B4I976 B4PX53 B3P9B7 Q9V439 B4L3R1 B4MD40 B3MYC9 A0A3B0KYF1 A0A1W4VU02 B4JIZ8 B5DP00 B4GTU1 A0A1A9X800 A0A1B0ALU8 A0A1A9UU68 A0A3B0K2J3 A0A3B0K4H4 B4G3C9
S4NZ33 A0A437AYI7 A0A0M9ACH5 A0A067RUL8 A0A088ACB0 A0A310SUW6 A0A1B6G398 A0A154P8Q3 A0A0L7R5B1 A0A1B6KJG0 A0A195D4Z4 A0A2J7RM26 A0A1B6JNZ5 A0A195DJ64 F4WBW9 A0A195BDA1 A0A195FSR6 A0A158NQP0 A0A151XB03 A0A2A3EFM6 A0A026WLM8 A0A232F126 K7IRD2 A0A1Y1KK05 E1ZXC1 A0A0N7Z9B4 A0A023FB03 R4G519 A0A1W4XFW4 A0A0C9R7S3 A0A1B6CVC1 D6X4N7 A0A0A9Y8G6 E2BM98 N6TK11 E0VWE5 A0A0T6BG73 U5EXK4 A0A1B0CCT0 A0A1L8DHI3 A0A0K8VIX9 A0A034W3C0 W8BHE9 A0A212F0W1 A0A0K8TRK1 A0A1I8MZ77 T1J9Y9 A0A1I8QEP9 A0A1Q3FCZ7 A0A023EEL3 Q178E6 B0W307 A0A1A9W293 A0A182NLE8 A0A182M3S0 A0A182YGQ8 A0A182P6Q3 A0A182VJW5 A0A182K885 A0A182TGW1 A0A182XJ63 A0A182S045 A0A182I7P7 Q7QB45 A0A182W1F2 A0A1B0GAH8 A0A1A9ZLI7 A0A182Q9N2 A0A2M3ZCQ6 A0A2M4ARJ8 A0A2M4C317 W5JBZ1 A0A182FSB9 A0A084VNS0 A0A182ISM1 B4ND62 B4I976 B4PX53 B3P9B7 Q9V439 B4L3R1 B4MD40 B3MYC9 A0A3B0KYF1 A0A1W4VU02 B4JIZ8 B5DP00 B4GTU1 A0A1A9X800 A0A1B0ALU8 A0A1A9UU68 A0A3B0K2J3 A0A3B0K4H4 B4G3C9
Ontologies
GO
PANTHER
Topology
Subcellular location
Nucleus
Length:
138
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00023
Exp number, first 60 AAs:
0
Total prob of N-in:
0.31194
outside
1 - 138
Population Genetic Test Statistics
Pi
175.565113
Theta
138.903875
Tajima's D
-0.955033
CLR
0.410793
CSRT
0.147792610369482
Interpretation
Uncertain
