Silkworm Genome Informatics Database

Gene

KWMTBOMO08788

Annotation

PREDICTED:_argininosuccinate_synthase_[Papilio_xuthus]

Location

Bomo_Chr15(+):5378538-5385115 View in EpiBrowser

Full name

Argininosuccinate synthase

Alternative Name

Citrulline--aspartate ligase

Location in the cell

Cytoplasmic Reliability : 3.194

CDS

ATGGTTAAAGATCTTGTAATTCTTGCATACTCTGGTGGCTTAGACACTAGTTGTATATTAAAATGGCTAATACAAAAGAACTACGAAGTTGTCTGTTTCATGGCAGATGTCGGACAAAATGAGGACTTCGAAAAAGCTAAAAAGAAAGCTGTAGCAGTTGGTGCCAAAGATGTAGTCGTAGAAGATCTTCGTAAAGAGTTTGTATGTAATTATATGCTGCCTGCAGTACAAATGGGACTTGTCTACGAAAGTCGTTACTACTTGGGAACATCACTTGCCCGACCATGTATAACCGTCGGACTCGTAAACACTGCTAAAAATTTAGGCGCTAAATACATAGCCCACGGAGCCACTGGAAAGGGAAATGACCAAGTGCGGTTTGAATTAAGCATGTATTCGTTATGGCCAGAAGGAAAGATTATAGCACCGTGGCGCATCCCTGAATTCTTCCAAAGGTTTCAGGGAAGAACTGACTTGATTGAGTACGCTAAAAAAGAAAATATACCCGTTTCAGCTACGCCAAAAGAACCTTGGTCCACAGACGAAAATATTATGCATATTAGTTACGAATCTGGGGTATTGGAGGATCCCGCTGCCATTCCACCGGGGGGCATATTTAAAATGACACGAGACTTAGCAAAGGCTGATGATTATGCGAGCGTTTTGGATATACATTTTGAAAAAGGATTGCCTGTTTCTTTACGAATTCCAAGTGGTCACGAAATGGCTCTTCACGTAAACGATCCCCTTGTTATCGTAGAAACGTTAAACAAACTAGGCGGCCAGCATGGGATTGGCAGAATAGACATAGTTGAGAATCGTTTTCTTGGATTGAAGTCCAGAGGTTTGTATGAAACTCCAGCTGGCACCGTATTACATGTGGCGCACGTTGATTTGGAAGCATTCACCCTCGACAGAGAAGTACTGAGAGTGAAAAAATATCTACAAGATAAAATGGCTGATTTTGTATATAACGGATTTTGGTTTTCACCGGAAGCAGCTTTTACAAGGAAATGCCTGGAACTATCCCAGGAGTCTGTTACTGGAACTGTTACCGTTCAGTTATTCAAAGGAAACGTTACCGTTCTGGCAAGAAAAAGTCCAAACAGTTTATACAACAAGGACCTGGTGTCCATGGATATCGCCGGAGGCTTTTCTCCTGAAGATAGTACCGGTTTTATCAATATTAACGCAATTCGCTTGAAGGAATTCGCAAGATTATCCAATCTGAAATAA

Protein

MVKDLVILAYSGGLDTSCILKWLIQKNYEVVCFMADVGQNEDFEKAKKKAVAVGAKDVVVEDLRKEFVCNYMLPAVQMGLVYESRYYLGTSLARPCITVGLVNTAKNLGAKYIAHGATGKGNDQVRFELSMYSLWPEGKIIAPWRIPEFFQRFQGRTDLIEYAKKENIPVSATPKEPWSTDENIMHISYESGVLEDPAAIPPGGIFKMTRDLAKADDYASVLDIHFEKGLPVSLRIPSGHEMALHVNDPLVIVETLNKLGGQHGIGRIDIVENRFLGLKSRGLYETPAGTVLHVAHVDLEAFTLDREVLRVKKYLQDKMADFVYNGFWFSPEAAFTRKCLELSQESVTGTVTVQLFKGNVTVLARKSPNSLYNKDLVSMDIAGGFSPEDSTGFININAIRLKEFARLSNLK

Description

One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.

Catalytic Activity

ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)

Subunit

Homotetramer.

Similarity

Belongs to the argininosuccinate synthase family.
Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Keywords

Amino-acid biosynthesis Arginine biosynthesis ATP-binding Complete proteome Ligase Nucleotide-binding Reference proteome Urea cycle Cytoplasm Phosphoprotein

Feature

chain Argininosuccinate synthase

Uniprot

A0A2A4K5L2 A0A2H1WPY3 A0A212FC20 A0A194QMD4 A0A3S2NBM0 A0A194PPX9 + More
D6X477 A0A336M4E0 A0A336MHX5 A0A2P8XPL1 A0A2J7QV22 A0A2J7QV24 U5EV09 J3JX12 A0A182SAU0 A0A182K946 A0A067QUJ2 W5J7W2 A0A182N639 A0A182Y4A8 A0A084VRC0 A0A2M4AI34 T1PCL4 A0A1B0CVH8 A0A182P5T4 A0A182RNR2 A0A1I8N6S5 A0A182Q4G0 A0A182VJI6 A0A182WRJ6 A0A182HU80 Q7PR38 A0A182TG76 A0A1I8PQ65 A0A182W065 A0A182M9E8 A0A182LFT6 A0A182FNH6 A0A0L0BSH4 B0X0Q1 A0A2K7P6A0 A0A182HB60 A0A1Q3FPP3 Q0IFL5 K7IZP3 A0A232FI12 T1J5A1 A0A1Y1L1P6 B4M578 W8CDU4 E9G328 E2AA51 Q5M8Z6 B4PSK4 A0A034VEK6 A0A0M5IZK8 E9IB02 A0A0A1X0R6 B3P2N5 B4QYD4 A0A0J7NMR8 B3M0W9 A0A0K8W8U8 A0A182IMR5 O97069 E2B6A2 A0A0P5IAU0 F7CD55 A0A0P5K2I4 Q7ZWM4 A0A452HV90 A0A1J1HXG2 A0A401SZR3 S4V5K7 A0A1W4V572 F6WVH7 A0A3Q2XDJ5 A0A2R5LK45 Q66I24 A0A293LYB3 A0A162P1R3 A0A1U7S2F0 G3SMU8 A0A341CVL9 A0A2Y9NJB3 A0A3Q2D7Y0 A0A131XZF6 A0A384B4K0 A0A2I0M414 A0A3Q7WYC8 A0A384CQ01 A0A088ACI2 G3PWQ7 A0A3Q4GPG8 U5YQ50 L8Y5S8 A0A060WCU7 G3PWR1 G1MCK8 B4JUJ3

EC Number

6.3.4.5

Pubmed

22118469 26354079 18362917 19820115 29403074 22516182 + More
24845553 20920257 23761445 25244985 24438588 25315136 12364791 20966253 26108605 26483478 17510324 20075255 28648823 28004739 17994087 24495485 21292972 20798317 17550304 25348373 21282665 25830018 10731132 12537572 20431018 28562605 30297745 23371554 24813606 25186727 23385571 24755649 20010809

EMBL

NWSH01000105 PCG79517.1 ODYU01010139 SOQ55036.1 AGBW02009246 OWR51268.1 + More
KQ461195 KPJ06692.1 RSAL01000268 RVE43214.1 KQ459596 KPI95501.1 KQ971410 EEZ97516.1 UFQT01000546 SSX25142.1 UFQT01001289 SSX29856.1 PYGN01001576 PSN33936.1 NEVH01010479 PNF32432.1 PNF32433.1 GANO01002084 JAB57787.1 BT127780 AEE62742.1 KK853400 KDR07860.1 ADMH02002109 ETN58945.1 ATLV01015601 KE525023 KFB40514.1 GGFK01007113 MBW40434.1 KA646429 AFP61058.1 AJWK01030592 AXCN02000193 APCN01000612 AAAB01008859 AXCM01000884 JRES01001422 KNC23030.1 DS232243 EDS38293.1 JXUM01031743 KQ560934 KXJ80285.1 GFDL01005464 JAV29581.1 CH477312 NNAY01000215 OXU29967.1 JH431855 GEZM01066974 JAV67609.1 CH940652 EDW59789.1 GAMC01001341 JAC05215.1 GL732530 EFX86402.1 GL438029 EFN69689.1 BC087767 CM000160 EDW96464.1 GAKP01018405 JAC40547.1 CP012526 ALC45768.1 GL762091 EFZ22280.1 GBXI01010064 JAD04228.1 CH954181 EDV48057.1 CM000364 EDX11891.1 LBMM01003212 KMQ93800.1 CH902617 EDV43198.2 GDHF01027485 GDHF01027252 GDHF01011616 GDHF01004855 JAI24829.1 JAI25062.1 JAI40698.1 JAI47459.1 AE001572 AE014297 BT060440 GL445930 EFN88795.1 GDIQ01220512 GDIQ01220511 GDIQ01220510 GDIQ01173620 GDIP01135803 JAK31215.1 JAL67911.1 AAMC01054407 AAMC01054408 AAMC01054409 AAMC01054410 AAMC01054411 AAMC01054412 AAMC01054413 GDIQ01242853 GDIQ01241406 GDIQ01238263 GDIQ01238262 GDIQ01207117 GDIQ01207116 GDIQ01207115 GDIQ01190570 GDIQ01190569 GDIQ01190568 GDIQ01099905 GDIQ01052873 GDIQ01033680 JAK61156.1 BC046941 CVRI01000020 CRK91214.1 BEZZ01000757 GCC35889.1 KC513735 AGO20698.1 GGLE01005760 MBY09886.1 BC081578 BC154282 AAH81578.1 GFWV01008933 MAA33662.1 LRGB01000512 KZS18447.1 GEFM01004276 JAP71520.1 AKCR02000043 PKK24425.1 KF444054 AGZ94902.2 KB364971 ELV11783.1 FR904427 CDQ63059.1 ACTA01001207 ACTA01177198 ACTA01185196 ACTA01193194 CH916374 EDV91163.1

Proteomes

UP000218220 UP000007151 UP000053240 UP000283053 UP000053268 UP000007266 + More
UP000245037 UP000235965 UP000075901 UP000075881 UP000027135 UP000000673 UP000075884 UP000076408 UP000030765 UP000092461 UP000075885 UP000075900 UP000095301 UP000075886 UP000075903 UP000076407 UP000075840 UP000007062 UP000075902 UP000095300 UP000075920 UP000075883 UP000075882 UP000069272 UP000037069 UP000002320 UP000069940 UP000249989 UP000008820 UP000002358 UP000215335 UP000008792 UP000000305 UP000000311 UP000008143 UP000002282 UP000092553 UP000008711 UP000000304 UP000036403 UP000007801 UP000075880 UP000000803 UP000008237 UP000291020 UP000183832 UP000287033 UP000192221 UP000264820 UP000000437 UP000076858 UP000189705 UP000007646 UP000252040 UP000248483 UP000265020 UP000261681 UP000053872 UP000286642 UP000261680 UP000291021 UP000005203 UP000007635 UP000261580 UP000011518 UP000193380 UP000008912 UP000001070

PRIDE

Q7PR38 Q0IFL5 Q5M8Z6 O97069 Q7ZWM4 Q66I24 + More

Pfam

PF00764 Arginosuc_synth

Interpro

IPR024074   AS_cat/multimer_dom_body        + More
IPR023434   Arginosuc_synth_type_1_subfam
IPR014729   Rossmann-like_a/b/a_fold
IPR001518   Arginosuc_synth
IPR018223   Arginosuc_synth_CS

Gene 3D

3.40.50.620 3.90.1260.10

CDD

cd01999 Argininosuccinate_Synthase

ProteinModelPortal

A0A2A4K5L2 A0A2H1WPY3 A0A212FC20 A0A194QMD4 A0A3S2NBM0 A0A194PPX9 + More
D6X477 A0A336M4E0 A0A336MHX5 A0A2P8XPL1 A0A2J7QV22 A0A2J7QV24 U5EV09 J3JX12 A0A182SAU0 A0A182K946 A0A067QUJ2 W5J7W2 A0A182N639 A0A182Y4A8 A0A084VRC0 A0A2M4AI34 T1PCL4 A0A1B0CVH8 A0A182P5T4 A0A182RNR2 A0A1I8N6S5 A0A182Q4G0 A0A182VJI6 A0A182WRJ6 A0A182HU80 Q7PR38 A0A182TG76 A0A1I8PQ65 A0A182W065 A0A182M9E8 A0A182LFT6 A0A182FNH6 A0A0L0BSH4 B0X0Q1 A0A2K7P6A0 A0A182HB60 A0A1Q3FPP3 Q0IFL5 K7IZP3 A0A232FI12 T1J5A1 A0A1Y1L1P6 B4M578 W8CDU4 E9G328 E2AA51 Q5M8Z6 B4PSK4 A0A034VEK6 A0A0M5IZK8 E9IB02 A0A0A1X0R6 B3P2N5 B4QYD4 A0A0J7NMR8 B3M0W9 A0A0K8W8U8 A0A182IMR5 O97069 E2B6A2 A0A0P5IAU0 F7CD55 A0A0P5K2I4 Q7ZWM4 A0A452HV90 A0A1J1HXG2 A0A401SZR3 S4V5K7 A0A1W4V572 F6WVH7 A0A3Q2XDJ5 A0A2R5LK45 Q66I24 A0A293LYB3 A0A162P1R3 A0A1U7S2F0 G3SMU8 A0A341CVL9 A0A2Y9NJB3 A0A3Q2D7Y0 A0A131XZF6 A0A384B4K0 A0A2I0M414 A0A3Q7WYC8 A0A384CQ01 A0A088ACI2 G3PWQ7 A0A3Q4GPG8 U5YQ50 L8Y5S8 A0A060WCU7 G3PWR1 G1MCK8 B4JUJ3

PDB

2NZ2 E-value=1.83652e-134, Score=1228

KEGG

101737917 K01940 argininosuccinate synthase [EC:6.3.4.5] | (RefSeq) argininosuccinate synthase

PATHWAY

00220    Arginine biosynthesis - Bombyx mori (domestic silkworm)
00250    Alanine, aspartate and glutamate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01230    Biosynthesis of amino acids - Bombyx mori (domestic silkworm)

GO

GO:0004055 GO:0006526 GO:0005524 GO:0000050 GO:0005737 GO:0000053 GO:0005829 GO:0000052 GO:0071499 GO:0045429 GO:0016597 GO:1903038 GO:0006531 GO:0042802 GO:0007623 GO:0005739 GO:0003707 GO:0005634 GO:0003700 GO:0008270 GO:0043565 GO:0016876 GO:0043039

PANTHER

PTHR11587

Subcellular location

Length:

411

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32641

Exp number, first 60 AAs:

0.30359

Total prob of N-in:

0.01890

outside

1 - 411

Pi

199.931688

Theta

148.831617

Tajima's D

1.030207

CLR

0

CSRT

0.665566721663917

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics