Gene

KWMTBOMO08775  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007690

Annotation

serine/threonine_protein_phosphatase_6_[Bombyx_mori]

Location

Bomo_Chr15(+):4992679-4996513      View in EpiBrowser

Full name

Serine/threonine-protein phosphatase       + More
Serine/threonine-protein phosphatase 6 catalytic subunit      

Alternative Name

Phosphatase V
Protein phosphatase V

Location in the cell

Cytoplasmic   Reliability : 2.732

CDS

ATGACGGATATAGATAAATGGATAGAAGTTGCAAAGAGATGCAAATACCTCCCGGAAGATGACCTACGGGAACTGTGCAATATAGTTTGTGATTTGTTACTTGAAGAACCTAATGTTCAGCCGGTACAGACACCTGTGACGGTTTGTGGTGATATTCATGGACAGTTCTATGATTTAGAGGAGCTTTTTCACATAGGTGGTCAAGTGCCATATACAAAATACATATTTATGGGAGATTATGTGGATCGAGGATATTATAGTTTAGAAACACTAACCTTGCTCATGGCCTTGAAAGCTAGATATCCAGATAGGATAATCTTATTAAGGGGTAATCATGAAACATGTCAAATAACTAAGGTTTATGGATTTTATGATGAATGTCTCAATAAATATGGAAATGCAAATGCATGGAAAGACTGTTGCAGAGTTTTTGATTTGCTCACTGTTGCTGCATTAATTGATGAAACCGTCCTATGTGTGCACGGTGGTCTATCACCAGAAATATCTATGATTGATCAAATAAGATGCATTGATAGAAATCAACAAATTCCACACAAAGGTGCATTCTGTGATTTGTTGTGGTCAGATCCTGCTGATGTGAAAATGTGGTCAGTAAGTCCTCGTGGAGCTGGATGGTTGTTTGGCTGTCAGGTTACAGAACTCTTCATGAATTACAATGATTTAACTCTTATATGCAGGGCACATCAATTAGTGAATGATGGTTATAAATACATGTTTGACAAAAGATTAGTAACAGTCTGGTCGGCGCCTAACTACTGTTACCGATGTGGTAATGTTGCCTCAATCTTGGAATTCAACACTGTTCATGATAGAACAGCAAGGTTATTCCAAGCAGTGCCTGACACCGAACGAGAAGTTCCTCCACAGCATACTACTCCATATTTCCTTTGA

Protein

MTDIDKWIEVAKRCKYLPEDDLRELCNIVCDLLLEEPNVQPVQTPVTVCGDIHGQFYDLEELFHIGGQVPYTKYIFMGDYVDRGYYSLETLTLLMALKARYPDRIILLRGNHETCQITKVYGFYDECLNKYGNANAWKDCCRVFDLLTVAALIDETVLCVHGGLSPEISMIDQIRCIDRNQQIPHKGAFCDLLWSDPADVKMWSVSPRGAGWLFGCQVTELFMNYNDLTLICRAHQLVNDGYKYMFDKRLVTVWSAPNYCYRCGNVASILEFNTVHDRTARLFQAVPDTEREVPPQHTTPYFL

Description

May be involved in controlling cellularization or in regulating transcription of the genes involved in this process.
Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation.

Catalytic Activity

H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate

Cofactor

Mn(2+)

Subunit

Protein phosphatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with subunits PPP6R1, PPP6R2 and PPP6R3. Interacts with subunit ANKRD28. Interacts with IGBP1. Interacts with MAP3K7. Interacts with NFKBIE. Interacts with TRIM14 and WRNIP1; these interactions positively regulate the RIG-I/DDX58 signaling pathway.

Similarity

Belongs to the PPP phosphatase family.
Belongs to the PPP phosphatase family. PP-6 (PP-V) subfamily.

Keywords

Complete proteome   Cytoplasm   Hydrolase   Manganese   Metal-binding   Protein phosphatase   Reference proteome   Acetylation   Cell cycle   Immunity   Innate immunity   Mitochondrion  

Feature

chain  Serine/threonine-protein phosphatase 6 catalytic subunit

Uniprot

Q1HPV3   I6LWZ6   A0A2H1X0P5   A0A3S2TDY9   S4PIT6   A0A194PWI0   + More
W0FXW4   A0A1L8DM96   E2B693   A0A023GL49   G3MNN8   A0A0C9RUU7   A0A131XL30   A0A1E1X4M3   A0A131YIP6   L7M6Y3   A0A151IL65   A0A067RDI9   A0A151IYY2   F4W3W8   A0A195FY99   A0A158NUW3   A0A151XFZ4   A0A0A9Y4D3   A0A293LI51   A0A224YZ55   A0A023FJX2   A0A0J7L2N5   E2AA60   A0A2R5LIQ6   A0A1B6DZA0   A0A3L8DHW2   A0A023FV98   A0A154PL02   A0A194QMW1   A0A2S2NMM7   A0A0L7QPJ6   A0A2H8TCL1   C4WVH6   A0A0B6ZVP9   V5HV40   T1I943   A0A1L8DKD4   A0A0N0BCL0   A0A310SEM2   A0A151I2I4   A0A0V0GBS1   A0A069DR82   A0A2A3EAW9   A0A088A6S1   A0A023F5P2   A0A076FFM7   A0A2S2R1N2   B4N2L1   V9KQQ6   M9PGI3   Q27884   A0A401PA56   A0A401SBA3   B4L2G5   A0A3B4DJV5   H3BFY5   A0A3B4H9U1   A0A3Q3CKX9   T1JA19   B3MXY0   Q52L13   B4M7X9   A0A1W4W2P9   A0A3P8PKI0   A0A1S3M4T1   A0A060XDV4   A0A3B1IPY2   B3NXS4   A0A1A8GC15   A0A1A8AT17   A0A1S3KYE4   Q7ZUS7   Q28GT8   A0A3L7HC66   A0A3Q0DA58   Q64620   Q9CQR6   A0A232EWF6   K7IZQ1   A0A1A8KM57   A0A1A8UAN6   A0A1A8RBS7   A0A1A8M844   A0A1A8CY77   A0A1A8FTU2   A0A1A8SEX8   A0A0P7WS88   A0A3B3I5J2   A0A3S2PFM8   A0A3P9JSI5   A0A3P8YZ84   A0A3Q3NCS7   A0A3Q4GW39   I3JZ68  

EC Number

3.1.3.16

Pubmed

19121390    23622113    26354079    20798317    22216098    28049606    + More
28503490    26830274    25576852    24845553    21719571    21347285    25401762    26823975    28797301    30249741    25765539    26334808    25474469    17994087    24402279    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    8223492    12537569    30297745    9215903    27762356    24755649    25329095    23594743    20431018    29704459    26319212    8077208    15489334    16141072    19468303    16769727    21183079    28648823    20075255    17554307    25069045    25186727   

EMBL

BABH01002941    DQ443299    ABF51388.1    JF704119    AEG64801.1    ODYU01012545    + More
SOQ58930.1    RSAL01000268    RVE43220.1    GAIX01000074    JAA92486.1    KQ459596    KPI95490.1    KF255602    AHF45929.1    GFDF01006589    JAV07495.1    GL445930    EFN88786.1    GBBM01001878    JAC33540.1    JO843489    AEO35106.1    GBYB01011425    GBYB01011426    JAG81192.1    JAG81193.1    GEFH01002195    JAP66386.1    GFAC01005212    JAT93976.1    GEDV01009384    JAP79173.1    GACK01005432    JAA59602.1    KQ977133    KYN05492.1    KK852705    KDR18025.1    KQ980744    KYN13708.1    GL887490    EGI71103.1    KQ981161    KYN45413.1    ADTU01026743    KQ982174    KYQ59309.1    GBHO01017631    GBRD01006034    GDHC01015246    JAG25973.1    JAG59787.1    JAQ03383.1    GFWV01002799    MAA27529.1    GFPF01011721    MAA22867.1    GBBK01003097    JAC21385.1    LBMM01001030    KMQ97047.1    GL438029    EFN69698.1    GGLE01005286    MBY09412.1    GEDC01011771    GEDC01008432    GEDC01006290    JAS25527.1    JAS28866.1    JAS31008.1    QOIP01000008    RLU19509.1    GBBL01001534    JAC25786.1    KQ434936    KZC11968.1    KQ461195    KPJ06679.1    GGMR01005821    MBY18440.1    KQ414819    KOC60479.1    GFXV01000024    MBW11829.1    ABLF02030852    AK341520    BAH71896.1    HACG01024985    CEK71850.1    GANP01002079    JAB82389.1    ACPB03003492    GFDF01007165    JAV06919.1    KQ435899    KOX69134.1    KQ760631    OAD59710.1    KQ976534    KYM81474.1    GECL01000784    JAP05340.1    GBGD01002306    JAC86583.1    KZ288312    PBC28442.1    GBBI01002225    JAC16487.1    KF516596    AII16500.1    GGMS01014477    MBY83680.1    CH963925    EDW78600.1    JW868154    AFP00672.1    AE014298    AGB95118.1    X75980    BT021230    AY119179    BFAA01006078    GCB70031.1    BEZZ01000173    GCC27666.1    CH933810    EDW06841.1    AFYH01007584    AFYH01007585    JH431980    CH902630    EDV38595.1    BC094109    CM004481    AAH94109.1    OCT65562.1    OCT65563.1    CH940653    EDW62896.1    FR904844    FR905261    CDQ72595.1    CDQ77783.1    CH954180    EDV47375.1    HAEC01001203    SBQ69280.1    HADY01019131    SBP57616.1    CR925807    CU468955    BC047847    BC075751    AAH47847.1    AAH75751.1    AAMC01117200    BC123920    CR761231    AAI23921.1    CAJ81892.1    RAZU01000237    RLQ63534.1    X77236    BC078747    AK002764    AK009104    AL928639    BC002223    NNAY01001870    OXU22679.1    HAEE01013308    SBR33358.1    HAEJ01003935    SBS44392.1    HAEH01015428    SBS02724.1    HAEF01011824    HAEG01011067    SBR52983.1    HADZ01020821    HAEA01001556    SBP84762.1    HAEB01015751    SBQ62278.1    HAEI01013646    SBS16115.1    JARO02006823    KPP64726.1    CM012448    RVE65573.1    AERX01003745   

Proteomes

UP000005204    UP000283053    UP000053268    UP000008237    UP000078542    UP000027135    + More
UP000078492    UP000007755    UP000078541    UP000005205    UP000075809    UP000036403    UP000000311    UP000279307    UP000076502    UP000053240    UP000053825    UP000007819    UP000015103    UP000053105    UP000078540    UP000242457    UP000005203    UP000007798    UP000000803    UP000288216    UP000287033    UP000009192    UP000261440    UP000008672    UP000261460    UP000264840    UP000007801    UP000186698    UP000008792    UP000192223    UP000265100    UP000087266    UP000193380    UP000018467    UP000008711    UP000000437    UP000008143    UP000273346    UP000189706    UP000002494    UP000000589    UP000215335    UP000002358    UP000034805    UP000192224    UP000001038    UP000265180    UP000265200    UP000265140    UP000261640    UP000261580    UP000005207   

PRIDE

Q1HPV3    M9PGI3    Q27884    Q64620    Q9CQR6   

Pfam

PF00149   Metallophos        + More
PF07707   BACK

Interpro

IPR029052   Metallo-depent_PP-like        + More
IPR006186   Ser/Thr-sp_prot-phosphatase       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR011705   BACK       

Gene 3D

3.60.21.10    

ProteinModelPortal

Q1HPV3   I6LWZ6   A0A2H1X0P5   A0A3S2TDY9   S4PIT6   A0A194PWI0   + More
W0FXW4   A0A1L8DM96   E2B693   A0A023GL49   G3MNN8   A0A0C9RUU7   A0A131XL30   A0A1E1X4M3   A0A131YIP6   L7M6Y3   A0A151IL65   A0A067RDI9   A0A151IYY2   F4W3W8   A0A195FY99   A0A158NUW3   A0A151XFZ4   A0A0A9Y4D3   A0A293LI51   A0A224YZ55   A0A023FJX2   A0A0J7L2N5   E2AA60   A0A2R5LIQ6   A0A1B6DZA0   A0A3L8DHW2   A0A023FV98   A0A154PL02   A0A194QMW1   A0A2S2NMM7   A0A0L7QPJ6   A0A2H8TCL1   C4WVH6   A0A0B6ZVP9   V5HV40   T1I943   A0A1L8DKD4   A0A0N0BCL0   A0A310SEM2   A0A151I2I4   A0A0V0GBS1   A0A069DR82   A0A2A3EAW9   A0A088A6S1   A0A023F5P2   A0A076FFM7   A0A2S2R1N2   B4N2L1   V9KQQ6   M9PGI3   Q27884   A0A401PA56   A0A401SBA3   B4L2G5   A0A3B4DJV5   H3BFY5   A0A3B4H9U1   A0A3Q3CKX9   T1JA19   B3MXY0   Q52L13   B4M7X9   A0A1W4W2P9   A0A3P8PKI0   A0A1S3M4T1   A0A060XDV4   A0A3B1IPY2   B3NXS4   A0A1A8GC15   A0A1A8AT17   A0A1S3KYE4   Q7ZUS7   Q28GT8   A0A3L7HC66   A0A3Q0DA58   Q64620   Q9CQR6   A0A232EWF6   K7IZQ1   A0A1A8KM57   A0A1A8UAN6   A0A1A8RBS7   A0A1A8M844   A0A1A8CY77   A0A1A8FTU2   A0A1A8SEX8   A0A0P7WS88   A0A3B3I5J2   A0A3S2PFM8   A0A3P9JSI5   A0A3P8YZ84   A0A3Q3NCS7   A0A3Q4GW39   I3JZ68  

PDB

3P71     E-value=1.01811e-94,     Score=883

KEGG

732977    K15498 serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] | (RefSeq) serine/thre

GO

GO:0004721   GO:0016787   GO:0005737   GO:0000082   GO:0046329   GO:0000278   GO:0006470   GO:0046872   GO:0004722   GO:0001878   GO:0005829   GO:0005739   GO:0045087   GO:0007049   GO:0051056   GO:0043565   GO:0006811   GO:0016020   GO:0005509   GO:0050793   GO:0003676   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  
Mitochondrion  

Length:

303

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0764

Exp number, first 60 AAs:

0

Total prob of N-in:

0.05008

outside

1  -  303

 

 

Pi

121.894227

Theta

185.378363

Tajima's D

-1.101782

CLR

123.006367

CSRT

0.121893905304735

Interpretation

Uncertain