Gene

KWMTBOMO08773  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007689

Annotation

putative_ribonucleoprotein_[Danaus_plexippus]

Location

Bomo_Chr15(+):4973519-4981937      View in EpiBrowser

Full name

60 kDa SS-A/Ro ribonucleoprotein      

Alternative Name

TROVE domain family member 2
Ro 60 kDa autoantigen
Sjoegren syndrome antigen A2
Sjoegren syndrome type A antigen

Location in the cell

Mitochondrial   Reliability : 2.328

CDS

ATGACTGAAAAAAAAAATTCACTAGATCCAGCATTGCGCTGTAGAATTCTACGATACCTGTATACTGGAAATGAGGTTCCCAAGTACTACCCTGGTTGCTGGGAAGCCCATAATTATTTTAAAATCGATAAACTAACTGCACTTAATGAAGCATTGACAAATGATCCAAACAATACTGAAGTCATAAACCTTATTGTAAAGGTTGCTAAAGATGGCATGTACACTCGTTTCGAACCAATTGCATTTGCTTTGGCCAAATGTCTCCTATTGGGAACTCCAACAATAAAGGAGGCTACATACAATGCTGCTGCAGAAATATGTGTTACCTCAGAACAGATGTTGTTATTCCAAAAATTCAGCAGGCTATTTAAAACAGGTAATGGCCGTGGATGGTGTAAGAATGTAATCCAATGGTACACAAATAAAAAACCAATGGATCTCATTAAAGAAATTACTAGAGTCAGAGGACGCTATGGACGTACTCATAAGACATTGCTGCGTAAATCACACATCAAAGTTCCGGAAAATGACTTTTTGCGTGACGCCATTGTGAAGTATGCTATATTTGGTCTGAAACGTGCCAAGCAATTGATGGGCGACAAGCCAGGGACCAGTGAAATATTTGAATACATTCAAAAAGTAGAAGACCTACGCCACTGTGAAGATCCTCCAGCCGCTGCAGAGATGATTGTGAGGAATAAATTCGTCCTTGACCATATTCCTGGACATTTGCTGACAACTCAAGAGGTATGGGAAGCTCTTTTACCTCACTTCACTCTACCGCAACTACTGCACCACCTCCAGCGTATGCACAATATGGCCTTCTTGAGCGGAACATCTACTTTGATTCCAAAATTGTTGACCCTACTGAACAACCAGGATTACATTCAGAGTTCTGATGTTACTCCGCTGCATGTGTACATCGCGAAATGTGACTACAGACTAAAAACTAGACCAATGAGACACGAAAAAGCAAAAGTAGCCGCTGAAAAAGAGCAACGCCGTCGCAGTCGGCAAATATATGACAGCAAAACTGGACTGTGGGAGTGGACAACAACTCGAAGACATCCCAAAGAACTAAAAAATTGGGGCATTGACAAGCCACCCAATCCGCTCGTGCTTGCATCGTTGAGTAAGCTTGTTGACCAAACCTGGTGTTTAACTCCACCTACAAAAAAGCGTTACTTGATCACTATGGATATGAGACACCATATGTTTAAAGGTCGTCATTTCTGCAAGAGTTACACAGTGCCAAAGAAGGGTAAATTGGCAGCTAATAAAGCCACTGCTCTGGGATCTGGTGACACCGACACAGAGAAAAAAAGCAAAAAGCATCTTCTTGCTGAATGCTTCTACAATAAGCATATAACTCCAGGACATGCAGCAATTGTCATGGCTCTGCAATTGTTAAAACGCGAGAAAGATGTAAAACTAGCCGTATTTTCAGAGGAAGGTATCGAATTTGTTTCAATCGAACGGAACTTTACGAACATGGAGGAAGCTGAATTCGTTCTCAGAAAAGCGAATCTCGGACGCGTCCAGCTAGACGCTCCTATTGAATGGGCCGCGAAGTCCAACGTTAAGTTCGACGTGTTCATCAACATGGTAGACCGCGTTACTCGGTACATGGAGCTGGACCAAAAGGACCGCGGCGGCCGGGGTCCGGGAGGACGGTTCGGGCCTCCGCCGTCGCCGGAGAAGAACCTCGTCGATCATTGCCCCGTGCGAGCGCTCCAACGCTACAGGAAGACCAGCGGCGTCAAGGATGCTAAATTGATCGTGATGAACTTGGCATCTCACCGCGTGTCCACGACTGACGGCAGCCACGAAGGAGTGCTCGACGTTGTCGGCGTCGACAAACACGTGCCCCAACTAATCGACGCATTCGCGTTGGGACACTTCTACTGA

Protein

MTEKKNSLDPALRCRILRYLYTGNEVPKYYPGCWEAHNYFKIDKLTALNEALTNDPNNTEVINLIVKVAKDGMYTRFEPIAFALAKCLLLGTPTIKEATYNAAAEICVTSEQMLLFQKFSRLFKTGNGRGWCKNVIQWYTNKKPMDLIKEITRVRGRYGRTHKTLLRKSHIKVPENDFLRDAIVKYAIFGLKRAKQLMGDKPGTSEIFEYIQKVEDLRHCEDPPAAAEMIVRNKFVLDHIPGHLLTTQEVWEALLPHFTLPQLLHHLQRMHNMAFLSGTSTLIPKLLTLLNNQDYIQSSDVTPLHVYIAKCDYRLKTRPMRHEKAKVAAEKEQRRRSRQIYDSKTGLWEWTTTRRHPKELKNWGIDKPPNPLVLASLSKLVDQTWCLTPPTKKRYLITMDMRHHMFKGRHFCKSYTVPKKGKLAANKATALGSGDTDTEKKSKKHLLAECFYNKHITPGHAAIVMALQLLKREKDVKLAVFSEEGIEFVSIERNFTNMEEAEFVLRKANLGRVQLDAPIEWAAKSNVKFDVFINMVDRVTRYMELDQKDRGGRGPGGRFGPPPSPEKNLVDHCPVRALQRYRKTSGVKDAKLIVMNLASHRVSTTDGSHEGVLDVVGVDKHVPQLIDAFALGHFY

Description

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.
May play roles in cilia formation and/or maintenance.
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).

Subunit

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.

Miscellaneous

Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).

Similarity

Belongs to the Ro 60 kDa family.

Keywords

3D-structure   Cytoplasm   Metal-binding   Ribonucleoprotein   RNA-binding   Acetylation   Alternative splicing   Complete proteome   Direct protein sequencing   Phosphoprotein   Reference proteome   Repeat  

Feature

chain  60 kDa SS-A/Ro ribonucleoprotein
splice variant  In isoform Short.

Uniprot

H9JDU2   A0A437AYF8   A0A212EIK8   A0A2A4K5K4   A0A194PRW3   A0A1E1WHJ4   + More
S4P6B2   A0A194QMB7   A0A0L7LK66   A0A067QSE1   A0A2J7PZX2   A0A310SUI5   A0A2A3EFV9   A0A088ACC0   A0A0L7R5I9   A0A195AWE7   A0A158P203   E2BBQ4   K7ITP3   F4W676   A0A195DMQ5   E2AY68   A0A151IKJ8   A0A195FJ59   A0A154PI63   A0A0N0BJR8   A0A026WDP8   E0VGE6   A0A1Y1MIU8   A0A0T6AZP3   A0A1X7UUZ1   A0A1B6ILM2   A0A293L8S1   A0A401SNU3   A0A210PMQ7   A0A2R5LHC8   H9GDQ6   G3WJ90   F7E322   B7ZQ38   P42700   A0A1L8GNJ3   A0A402EUC2   M3XKV2   F7CE78   A7RN19   A0A3L5TT78   A0A091Q496   K9IU86   F7AA69   A0A2I0ME10   A0A2Y9DWX7   A0A091CU70   G3TDW4   M7BXL8   A0A091NKS7   K7FSJ4   A0A2Y9GSS5   A0A091HEA8   A0A384BMS8   G1MBQ7   A0A3Q7Y690   A0A2K6T4Y2   A0A1S3HVE9   A0A3Q7RNI6   A0A1A6HQM9   A0A1U7TYK1   A0A3P4MV10   A0A452I9C9   R7THM6   A0A2K5K2C4   L8II60   A0A087RDT3   A0A452RDL0   A0A3Q7QNT0   R0LQU1   A0A2I2ULJ2   A0A2U3ZRS0   F1PUR1   S7Q379   A0A452F4E3   A0A091IHM3   A0A287B742   W5PI89   A0A0B8RVE7   A0A2I3RSL6   A0A3L7HK29   M3XZU5   A0A2J8UY06   A0A2K6PWV9   A0A2I3HJ18   A0A2I2Y4R5   A0A024R983   P10155  

Pubmed

19121390    22118469    26354079    23622113    26227816    24845553    + More
21347285    20798317    20075255    21719571    24508170    20566863    28004739    30297745    28812685    21881562    21709235    20431018    7688474    15907467    17041599    27762356    9215903    17495919    17615350    26977809    19892987    23371554    23624526    17381049    24813606    20010809    28562605    23254933    22751099    17975172    16341006    20809919    16136131    29704459    25362486    22398555    11181995    3200833    2649513    14702039    16710414    15489334    10545525    10668799    18056422    17289661    17525332    18691976    18669648    19413330    19608861    20068231    21269460    22223895    23186163    26382853   

EMBL

BABH01002945    BABH01002946    RSAL01000268    RVE43221.1    AGBW02014626    OWR41314.1    + More
NWSH01000105    PCG79507.1    KQ459596    KPI95489.1    GDQN01004602    JAT86452.1    GAIX01005129    JAA87431.1    KQ461195    KPJ06678.1    JTDY01000831    KOB75744.1    KK852991    KDR12777.1    NEVH01020330    PNF21884.1    KQ760132    OAD61808.1    KZ288256    PBC30610.1    KQ414654    KOC66026.1    KQ976731    KYM76289.1    ADTU01006921    GL447151    EFN86830.1    GL887707    EGI70211.1    KQ980724    KYN14112.1    GL443762    EFN61603.1    KQ977199    KYN05003.1    KQ981523    KYN40443.1    KQ434923    KZC11497.1    KQ435712    KOX79364.1    KK107293    EZA53139.1    DS235138    EEB12452.1    GEZM01030292    JAV85644.1    LJIG01022528    KRT80103.1    GECU01019879    GECU01003713    JAS87827.1    JAT03994.1    GFWV01000022    MAA24752.1    BEZZ01000410    GCC32064.1    NEDP02005581    OWF37761.1    GGLE01004763    MBY08889.1    AAWZ02022652    AEFK01157121    AAMC01088296    BC169669    BC169699    AAI69669.1    L15430    CM004472    OCT85415.1    BDOT01000044    GCF47792.1    AFYH01219007    AFYH01219008    AFYH01219009    AFYH01219010    AFYH01219011    AFYH01219012    DS469521    EDO47247.1    KV584749    OPL33119.1    KK686292    KFQ14705.1    GABZ01001338    JAA52187.1    AKCR02000018    PKK27917.1    KN124374    KFO21538.1    KB538685    EMP32827.1    KL387380    KFP90378.1    AGCU01128075    AGCU01128076    AGCU01128077    KL532124    KFO93152.1    ACTA01034000    ACTA01041999    LZPO01017545    OBS80027.1    CYRY02014773    VCW84644.1    AMQN01002711    KB309928    ELT92967.1    JH881289    ELR55214.1    KL226315    KFM11637.1    KB742477    EOB08094.1    AANG04002036    AAEX03018287    KE164406    EPQ17778.1    LWLT01000016    KL218774    KFP08119.1    AEMK02000071    AMGL01020377    AMGL01020378    AMGL01020379    GBZA01000687    JAG69081.1    AACZ04056118    GABC01004407    GABF01006637    GABD01003376    GABD01003375    GABE01006808    NBAG03000235    JAA06931.1    JAA15508.1    JAA29724.1    JAA37931.1    PNI67274.1    PNI67275.1    PNI67276.1    RAZU01000200    RLQ66213.1    AEYP01029094    ABGA01201760    ABGA01201761    ABGA01201762    ABGA01201763    NDHI03003439    PNJ50151.1    PNJ50152.1    PNJ50153.1    ADFV01022860    ADFV01022861    ADFV01022862    ADFV01022863    CABD030008017    CABD030008018    CABD030008019    CABD030008020    CH471067    EAW91244.1    J04137    M25077    U44388    AY205314    AY205315    AK314594    AL136370    BC036658   

Proteomes

UP000005204    UP000283053    UP000007151    UP000218220    UP000053268    UP000053240    + More
UP000037510    UP000027135    UP000235965    UP000242457    UP000005203    UP000053825    UP000078540    UP000005205    UP000008237    UP000002358    UP000007755    UP000078492    UP000000311    UP000078542    UP000078541    UP000076502    UP000053105    UP000053097    UP000009046    UP000007879    UP000287033    UP000242188    UP000001646    UP000007648    UP000008143    UP000186698    UP000288954    UP000008672    UP000002280    UP000001593    UP000002281    UP000053872    UP000248480    UP000028990    UP000007646    UP000031443    UP000007267    UP000248481    UP000261680    UP000291021    UP000008912    UP000286642    UP000233220    UP000085678    UP000286640    UP000092124    UP000189704    UP000291020    UP000014760    UP000233080    UP000053286    UP000291022    UP000286641    UP000011712    UP000245340    UP000002254    UP000291000    UP000054308    UP000008227    UP000002356    UP000002277    UP000273346    UP000000715    UP000001595    UP000233200    UP000001073    UP000001519    UP000005640   

PRIDE

H9JDU2    P42700    P10155   

Pfam

PF05731   TROVE

Interpro

IPR037214   TROVE_dom_sf        + More
IPR008858   TROVE_dom       
IPR036465   vWFA_dom_sf       
IPR040322   TROVE2       

SUPFAM

SSF140864   SSF140864        + More
SSF53300   SSF53300       

Gene 3D

3.40.50.410    

ProteinModelPortal

H9JDU2   A0A437AYF8   A0A212EIK8   A0A2A4K5K4   A0A194PRW3   A0A1E1WHJ4   + More
S4P6B2   A0A194QMB7   A0A0L7LK66   A0A067QSE1   A0A2J7PZX2   A0A310SUI5   A0A2A3EFV9   A0A088ACC0   A0A0L7R5I9   A0A195AWE7   A0A158P203   E2BBQ4   K7ITP3   F4W676   A0A195DMQ5   E2AY68   A0A151IKJ8   A0A195FJ59   A0A154PI63   A0A0N0BJR8   A0A026WDP8   E0VGE6   A0A1Y1MIU8   A0A0T6AZP3   A0A1X7UUZ1   A0A1B6ILM2   A0A293L8S1   A0A401SNU3   A0A210PMQ7   A0A2R5LHC8   H9GDQ6   G3WJ90   F7E322   B7ZQ38   P42700   A0A1L8GNJ3   A0A402EUC2   M3XKV2   F7CE78   A7RN19   A0A3L5TT78   A0A091Q496   K9IU86   F7AA69   A0A2I0ME10   A0A2Y9DWX7   A0A091CU70   G3TDW4   M7BXL8   A0A091NKS7   K7FSJ4   A0A2Y9GSS5   A0A091HEA8   A0A384BMS8   G1MBQ7   A0A3Q7Y690   A0A2K6T4Y2   A0A1S3HVE9   A0A3Q7RNI6   A0A1A6HQM9   A0A1U7TYK1   A0A3P4MV10   A0A452I9C9   R7THM6   A0A2K5K2C4   L8II60   A0A087RDT3   A0A452RDL0   A0A3Q7QNT0   R0LQU1   A0A2I2ULJ2   A0A2U3ZRS0   F1PUR1   S7Q379   A0A452F4E3   A0A091IHM3   A0A287B742   W5PI89   A0A0B8RVE7   A0A2I3RSL6   A0A3L7HK29   M3XZU5   A0A2J8UY06   A0A2K6PWV9   A0A2I3HJ18   A0A2I2Y4R5   A0A024R983   P10155  

PDB

2I91     E-value=8.45768e-34,     Score=362

KEGG

101738580    K11089 60 kDa SS-A/Ro ribonucleoprotein | (RefSeq) 60 kDa SS-A/Ro ribonucleoprotein

GO

GO:0003723   GO:0030620   GO:0010468   GO:0035457   GO:0060271   GO:0005654   GO:0007224   GO:1990904   GO:0002520   GO:0009411   GO:0005829   GO:0030030   GO:0005737   GO:0046872   GO:0034336   GO:0006383   GO:0051056   GO:0043565   GO:0006811   GO:0016020   GO:0005509   GO:0050793   GO:0003676   GO:0016876   GO:0043039  

PANTHER

PTHR14202  

Subcellular location

Cytoplasm  

Length:

635

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03135

Exp number, first 60 AAs:

0.00022

Total prob of N-in:

0.00207

outside

1  -  635

 

 

Pi

197.090952

Theta

185.004446

Tajima's D

-0.638735

CLR

1.535412

CSRT

0.205539723013849

Interpretation

Uncertain