Gene

KWMTBOMO08765  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007893

Annotation

PREDICTED:_probable_E3_ubiquitin-protein_ligase_HERC2_[Amyelois_transitella]

Location

Bomo_Chr15(-):4712325-4731238      View in EpiBrowser

Full name

E3 ubiquitin-protein ligase HERC2      

Alternative Name

HECT domain and RCC1-like domain-containing protein 2
HECT-type E3 ubiquitin transferase HERC2

Location in the cell

Extracellular   Reliability : 1.139 PlasmaMembrane   Reliability : 1.439

CDS

ATGTCAAGCCATGACGAGCACGAACAGTTCATTTTTCGTCCACAACAACATTTGGATGCTAAATGGCTCAATCCTGACTTACAGGAGGCCTTACACAATCCAGATTCCCTTTCTGCTTTATTTAATATTCTTTTACAAGACAGAGAAATATATTTCAATGCCGGAAGCGGCCTCGTAAACGGTGCTGGTATTACTGCTAAACTTGGGGATAGTGGAAAATACTACTGCGGCCTAAGGATATTAACCTGTACTTGTTGTGATGGTCTTTGTGGTCCCCACTCTGGATGTGCTTGTGTTCCATGCACTGCACTATCTGTTGAAGAAGAGCATAGAATATCTATCCTGACAAAATATGTGAATCCGCCAACATCACTTCAAATAATAGATGATCTCAAATGGAAACAAGATCCAGGACCAGAATGCCTTCTAAGTTTAATGGAGTCATTGATTTTTGAGCAAAGATTTAGAGCCATCAACACTGCTGTCAGCTGTCCATTAGTTTCAGAAATCCGTCATCTCATCGTCTTGTGCAACAGACATCTTGTGGCAGTTATAAGGGATCAAAGTCACAGAAAAGAAGTTAAAAAAGCGAATTTAGAGAAGAAACCTCCACATGGTGTAAGCAATAGAGCACTAAGCAATGTTGTAAATGCACTTAACAACCCCATAGATGCAAGCGCAGAAAGTCAAGAAGAAATTGAGGAGCCCACTGATGATTCAGAAAGTACTCTCGGCTTGGCACGGGTTGGTGCTCGTGCAGCGTTACGCTTAGCTTTGTCGCTGGTACGTCGTGCGTGGCGCTGTGGAGAAGATGCAGATGTTTGCTCAGCTTTGCTGAAAGATGCGTTGGATGCAGTGCGGGCTTTACCTGATGCTGCGCTATATGCCGGTACAGGGACCCCACAGCAAGCGCCAAGATCGCAGAAAATATGGGCGGAAGTTGTAGATAGCGCTGCTCAGTTCCTACATCAGGTTGTGACAGGTGAAGTGGGTTGTAATGTACCTGTTGGTGATTGGCGTATATCATTATGTGTGTGGGTTGAGTTGTGTGCGAGACGTGCCGAACTGCCAGCACTACTGAAAGCAGCTGATGTTCTAGTCACTTTACCTCCTAAGCAAAAACGACAGCCTGCCAATCACAGAATTACTCTAGAAGAATGTACAGCGCCCTTGGGGCCTTTTCTCAGACGTATGGCAAAAGTCGCAGCGCCTAACCCCATGGTCAACAATGAACCTTCAACAGAAACAAATCCCACTGAAGTATTTTTAAAAGAGCTGAATATTCCAAGCGGCGATGGTTTGATGAGTGTAAGAAAAGCGGGTATTGCGTTACTGTGTCATTTAGATAGACTCGGGGCACCCCTACTACCACCATTAAAAGGATTCGTAACGTGTACAGAATCCGCCCAAGAAGTGATCTCAGTAGGATTAGGCCCTATACAACTAGGTTCACTTAGAATACAGCAAATATCCTGTGCAGAAAAATTAGCATTACTTTTGACTCAAGACGGAGTTGTATACACACTGCCCTATGATACTATGACACCACAGTTGGTTCCAGGTTTGGAAAATAAGAGTATATGTCAAGTGGCATGTCACTCCGCCGGACGACACTTCTTGTGCTGCTCGTCGTGCGGCGGCGTGTGGTCCTGGGGTGTCGGCGAGGACGGCCGGCTCGGACACGGCGATACCGCTAATAGGGATGCGCCCTCTGCAATACATCACCTCGCACATCACGAAGTGACGCGCGTCACTGCCGGTGTGGCCTGCAGCGCTGTTATAACATCGCGTGGCGCTTTGTATACGTGGGGTCGTGGACCTCACGGCCGTCTCGGTCACGGCACTATTGAAAATTGTCTCACTCCACAACCCGTGTCCTTTAACGCGCATAACATTGAACGCATTATAGACGTGTCTTTAGGTTGGGGTGACAGCCTCACATTGTGTTGTACATGGGAGGGGGCAGTGCAAGGATTTGGCGACAATGAAGGCGGTGCTCCTAGAACCATAGCATCACTTTCGGTATTAAGGATCACAAGGGTATATACTGGAGAGCATTTCCACGCTGTTCTGACTGACAATGGTCAAGTTTATACATGGGGAAAAGGCGATAATTACCGTCTAGGACACGGCAACCTGGAAAACGTTAAGCTCCCAAAAGTAATGGAAGCTTTTCAAGGTATACGTATAATAGACGTGTCATTGGGATTATGTCACGGAGTAGCTCTGACGTCAGAGGGCGCCGTGTACGCTTGGGGCACGCACGAACGAGCGCAAATCGTGCGACCTGTACCGCAATTACTACAAGTACTCAGTCCTTCGTTTAAAGCGAATGGAATTAGCGGTGGTCCAAATCATATATTCGTATGGAGTGAAGAAAATCCCAGAGACTTACCATCGTCTATGCCTTTCGTGATAGATTTGTCAGATGGGACCTTTAAATTTTTAGAAAGACTTCTAAGATTAGTTGTGGAACAAAGTACATCAGGTGATCCAAAAGAGAATGAATGCTTAGCGGTAGCGTGTTTGAATCTACTGAGGTTGCAGGTTCATGCGTGGCAATACTCCCGAGGTATAGATTCGGTGGAGAGCGAGACAGAGAGTAGATCGTGGTGCGGCGGCGTGCACAGCGCACTGGTGTCGCTGGCGGAGGGGCGCGCGGGTCCTGTAGCCGCGGTGGCGGCGCGGCGCGCGCTGGCCGCGTCGTGGCCGCTGCTGCTGCCCACGCCTCAAGTTCGGGCACATCATCTCATTTCCTTATTGCCTCAAGGTTCAATGCCCGCTAGTGCAGGCGCACGTTTCATGACAGAGCTCCTGGTGTGGTCTCTGCTGGGGGGAGGAGGTCTACGTGACGCCGTACGGAATGCTTTGCAAATTCATTCAGCCGAGATGTATAACCATTTGCAGCTTGATAACGAATATGACCAGGTGGATATAATAACAGGACAACGTGGTCCTCCCGTATCGAAAACCGGCGACGATCCTGATCAGGTCACCGGGTTCTCTGAAGAATATCATCTGAGCAACACTGCAACATCGGACAAGTGCGCCTCCGTACCGCTCATGCACTTGGTGAAACATTTGATACGAAATACAAGCTGTCAGACACAAACGTCCATAAACGCAATAATTAATGGTGATCCCAGCAAGGTGGATGAGCCCAAGGGCCAAGACGCCGTCAGCCCCAGCTGTGATCTACTCATACGATTTCAAAGGTTATTGTTCTGTGAGGCGATGTGGTGTCGCGGCGGCCGCAGCTCGCGCGGCGGAGTCCGCTCGCTCCTGAACCAATACACGGTTCTACTGTCCGAGCACGTACAGTCGACGCTGAGCTCGTTCTCGCGAGCCGTGCACGGCGCCGACAATACCCAGCTCGTGGCTCTGTGTGATCTGCTAGCTTCTGACATTGTCGGTCGCGTTGTGACGGAGTTGAGCGCATGGATATGTGCTTGTTCGGCGCGGTCCGCACACGCGCTGTCCGACTGCGCGGGCTCGCTCGTGAGGATAGCGCGCGCGTGCGACGAGGCGGCCCGCGCGTTACCCTCGTCCGCGAAGCTAGACGCGGACCTGCTGGGCTGGCCCGGCCTCGTTTCGAAGAAACACCAGCTGAACAGTAGCGTTATACGCAAATGCGACTTACAGAATCATATAAAAGACGGCGGTTCGTGGATAATAGTGGCCGGTCACGTTTTCGACGTTGAGAATTTCGATTGCGAGAACGCGAGCACGGTGGAGTTGGTCCGCAAGTTGCGGGGCGGCGACGCGACCGCGGCCCTGAGCGTGGAGCCGCACGCCGCATTCCTAGCGCGGATCACTGAGAAGTGCGTCGGCCTCTATGCAGATCAGATTTATAGTCACAAATGTCATGAGAGTACGTCCAGTCTTCGTGCCCATCACATCCTGTCGTCTGTCGCGTTCCACGTCGCGGTGGGGCTGGCGCAGTGCGGCTCGAGGCTGGCGCGGTCGCTGCCCGTGCAGCAGGCGGAGCTCGACGCCGCGCCGTATGCAGCGGCTGTATTCCTGCGCGGGGGAATGCAGGCATATAGTGCGCGACGCGTCAATCCGAAACCGAGACCGTAA

Protein

MSSHDEHEQFIFRPQQHLDAKWLNPDLQEALHNPDSLSALFNILLQDREIYFNAGSGLVNGAGITAKLGDSGKYYCGLRILTCTCCDGLCGPHSGCACVPCTALSVEEEHRISILTKYVNPPTSLQIIDDLKWKQDPGPECLLSLMESLIFEQRFRAINTAVSCPLVSEIRHLIVLCNRHLVAVIRDQSHRKEVKKANLEKKPPHGVSNRALSNVVNALNNPIDASAESQEEIEEPTDDSESTLGLARVGARAALRLALSLVRRAWRCGEDADVCSALLKDALDAVRALPDAALYAGTGTPQQAPRSQKIWAEVVDSAAQFLHQVVTGEVGCNVPVGDWRISLCVWVELCARRAELPALLKAADVLVTLPPKQKRQPANHRITLEECTAPLGPFLRRMAKVAAPNPMVNNEPSTETNPTEVFLKELNIPSGDGLMSVRKAGIALLCHLDRLGAPLLPPLKGFVTCTESAQEVISVGLGPIQLGSLRIQQISCAEKLALLLTQDGVVYTLPYDTMTPQLVPGLENKSICQVACHSAGRHFLCCSSCGGVWSWGVGEDGRLGHGDTANRDAPSAIHHLAHHEVTRVTAGVACSAVITSRGALYTWGRGPHGRLGHGTIENCLTPQPVSFNAHNIERIIDVSLGWGDSLTLCCTWEGAVQGFGDNEGGAPRTIASLSVLRITRVYTGEHFHAVLTDNGQVYTWGKGDNYRLGHGNLENVKLPKVMEAFQGIRIIDVSLGLCHGVALTSEGAVYAWGTHERAQIVRPVPQLLQVLSPSFKANGISGGPNHIFVWSEENPRDLPSSMPFVIDLSDGTFKFLERLLRLVVEQSTSGDPKENECLAVACLNLLRLQVHAWQYSRGIDSVESETESRSWCGGVHSALVSLAEGRAGPVAAVAARRALAASWPLLLPTPQVRAHHLISLLPQGSMPASAGARFMTELLVWSLLGGGGLRDAVRNALQIHSAEMYNHLQLDNEYDQVDIITGQRGPPVSKTGDDPDQVTGFSEEYHLSNTATSDKCASVPLMHLVKHLIRNTSCQTQTSINAIINGDPSKVDEPKGQDAVSPSCDLLIRFQRLLFCEAMWCRGGRSSRGGVRSLLNQYTVLLSEHVQSTLSSFSRAVHGADNTQLVALCDLLASDIVGRVVTELSAWICACSARSAHALSDCAGSLVRIARACDEAARALPSSAKLDADLLGWPGLVSKKHQLNSSVIRKCDLQNHIKDGGSWIIVAGHVFDVENFDCENASTVELVRKLRGGDATAALSVEPHAAFLARITEKCVGLYADQIYSHKCHESTSSLRAHHILSSVAFHVAVGLAQCGSRLARSLPVQQAELDAAPYAAAVFLRGGMQAYSARRVNPKPRP

Description

E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Interacts (when phosphorylated at Thr-4827 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionizing radiation (IR) treatment. Interacts with XPA. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.

Miscellaneous

A regulatory element withinin an intron of the HERC2 gene inhibits OCA2 promoter. There are several single nucleotide polymorphisms within the OCA2 gene and within the HERC2 gene that have a statistical association with human eye color.

Keywords

3D-structure   Coiled coil   Complete proteome   Cytoplasm   Cytoskeleton   Disease mutation   DNA damage   DNA repair   Mental retardation   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   Transferase   Ubl conjugation   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  E3 ubiquitin-protein ligase HERC2
sequence variant  In MRT38; less stable than wild-type; diffuse cytosolic localization with the formation of abnormal aggregates; dbSNP:rs397518474.

Uniprot

H9JEE6   A0A2A4K8M6   A0A3S2PJI5   A0A2H1WXV6   A0A194PPV9   A0A026WJZ9   + More
A0A3L8DD68   E2BM75   E2AK78   A0A0J7L4R0   A0A139WAN5   K7IQ42   A0A067R2N5   A0A158NCL1   F4WFF7   A0A151X600   A0A2A3E3G7   A0A195F9S1   A0A195ELX0   A0A195CR34   A0A088AL05   A0A139WAP8   A0A139WAR9   A0A154P7I9   A0A195BYI1   A0A146M433   V3ZE73   A0A1V4JBE1   H0ZJQ4   A0A2I0MLM1   E1BW48   G1KDV1   U3I746   U3JN73   A0A2T7PNV3   A0A091JXI0   A0A093HB52   A0A2I0MLL8   A0A091MCL6   A0A3M0K0M4   A0A3Q2UE20   R0L7U7   A0A091S499   A0A091JP83   A0A286XAB6   H0VHC2   A0A091EHF1   A0A091I9P4   A0A091LFD1   A0A093FPE5   I3M8T9   A0A287CWT3   A0A091VSZ3   A0A093CBX9   A0A0B8RTL9   F7A4S9   A0A384DC01   A0A091HM07   A0A061IGX1   A0A3Q0DBS9   A0A3Q7XI86   A0A094KRD9   A0A3Q2HE57   A0A3Q2IC42   F7AM44   A0A0Q3TAC1   A0A3Q2IA83   G3STX9   G5AZH7   A0A0P6J146   A0A2Y9QW94   E1B782   F7EP78   A0A0A0A8M2   F1RX57   A0A093BN38   A0A091TBI0   H9G1F0   A0A452GTE7   A0A452GSK3   A0A1U7UNG5   O95714   A0A250Y8J0   A0A151NXF6   A0A2K5K3Q5   A0A1U7RFM8   A0A287B1U2   A0A452GSM4   A0A3L8SV73   U3EA95   A0A2K5K3S5   A0A0G2JUC9   A0A452GSJ6   A0A2U4B2F2   A0A3Q7S9L4   A0A0D9R2F7   W5Q2G3  

EC Number

2.3.2.26

Pubmed

19121390    26354079    24508170    30249741    20798317    18362917    + More
19820115    20075255    24845553    21347285    21719571    26823975    23254933    20360741    23371554    15592404    23749191    21993624    20431018    23929341    26319212    19892987    21993625    19393038    17495919    30723633    25319552    28562605    9949213    16572171    10720573    17081983    18252221    18252222    18172690    18669648    19413330    19690332    20457063    20023648    20304803    20068231    21269460    21406692    22508508    22261722    23186163    26692333    23065719    28087693    22293439    30282656    25243066    15057822    22673903    20809919   

EMBL

BABH01002966    BABH01002967    BABH01002968    BABH01002969    BABH01002970    BABH01002971    + More
BABH01002972    NWSH01000054    PCG80163.1    RSAL01000014    RVE53266.1    ODYU01011831    SOQ57796.1    KQ459596    KPI95481.1    KK107167    EZA56377.1    QOIP01000010    RLU17868.1    GL449158    EFN83201.1    GL440194    EFN66182.1    LBMM01000739    KMQ97601.1    KQ971380    KYB24996.1    KK852747    KDR17278.1    ADTU01011956    ADTU01011957    GL888115    EGI67208.1    KQ982490    KYQ55797.1    KZ288445    PBC25641.1    KQ981727    KYN36962.1    KQ978691    KYN29213.1    KQ977408    KYN02952.1    KYB24998.1    KYB24997.1    KQ434831    KZC07832.1    KQ976396    KYM92996.1    GDHC01005102    JAQ13527.1    KB202591    ESO89418.1    LSYS01008075    OPJ69496.1    ABQF01013058    AKCR02000007    PKK30566.1    AADN05000806    ADON01107485    AGTO01010249    PZQS01000003    PVD35047.1    KK533157    KFP28643.1    KL205917    KFV76655.1    PKK30567.1    KK526502    KFP68314.1    QRBI01000120    RMC06696.1    KB743662    EOA97514.1    KK810732    KFQ35330.1    KK502211    KFP21555.1    AAKN02056864    AAKN02056865    AAKN02056866    AAKN02056867    KK718333    KFO55839.1    KL218306    KFP04203.1    KK750440    KFP41621.1    KK631876    KFV56169.1    AGTP01003739    AGTP01003740    AGTP01003741    AGTP01003742    AGTP01003743    AGTP01003744    KL411326    KFR05628.1    KL456900    KFV09832.1    GBZA01000283    JAG69485.1    AAMC01064616    AAMC01064617    AAMC01064618    AAMC01064619    AAMC01064620    AAMC01064621    AAMC01064622    KL517030    KFO88368.1    KE671461    ERE80238.1    KL355465    KFZ61813.1    LMAW01002756    KQK77446.1    JH167620    EHB02438.1    GEBF01005829    JAN97803.1    KL871155    KGL90914.1    AEMK02000100    DQIR01037948    DQIR01068330    DQIR01073830    DQIR01075520    DQIR01081569    DQIR01088855    DQIR01133935    DQIR01204555    HCZ93423.1    HDA89411.1    KN126200    KFU87496.1    KK444263    KFQ71182.1    JU336956    AFE80709.1    AF071172    AC091304    AC126332    AC135329    AF224243    AF224242    AF224245    AF224244    AF224249    AF224246    AF224247    AF224248    AF224251    AF224250    AF224255    AF224254    AF224252    AF224253    AF224257    AF224256    AF225401    AF225400    AF225404    AF225402    AF225403    AF225407    AF225405    AF225406    AF225409    AF225408    AAD08657.1    AAO27483.1    GFFV01000008    JAV39937.1    AKHW03001628    KYO41478.1    DQIR01081570    DQIR01088852    DQIR01187019    DQIR01311487    HDA37046.1    HDB42496.1    QUSF01000007    RLW07720.1    GAMT01008985    GAMR01001332    GAMQ01000671    GAMP01004912    JAB02876.1    JAB32600.1    JAB41180.1    JAB47843.1    AABR07003539    AABR07003540    AQIB01148333    AQIB01148334    AQIB01148335    AQIB01148336    AQIB01148337    AQIB01148338    AQIB01148339    AQIB01148340    AQIB01148341    AQIB01148342    AMGL01051687    AMGL01051688    AMGL01051689    AMGL01051690    AMGL01051691    AMGL01051692   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000053097    UP000279307    + More
UP000008237    UP000000311    UP000036403    UP000007266    UP000002358    UP000027135    UP000005205    UP000007755    UP000075809    UP000242457    UP000078541    UP000078492    UP000078542    UP000005203    UP000076502    UP000078540    UP000030746    UP000190648    UP000007754    UP000053872    UP000000539    UP000001646    UP000016666    UP000016665    UP000245119    UP000053584    UP000269221    UP000053119    UP000005447    UP000052976    UP000054308    UP000005215    UP000053283    UP000008143    UP000261680    UP000030759    UP000189706    UP000286642    UP000002281    UP000051836    UP000007646    UP000006813    UP000248480    UP000009136    UP000002280    UP000053858    UP000008227    UP000291020    UP000189704    UP000005640    UP000050525    UP000233080    UP000189705    UP000276834    UP000002494    UP000245320    UP000286640    UP000029965    UP000002356   

PRIDE

H9JEE6    O95714   

Pfam

PF00415   RCC1        + More
PF06701   MIB_HERC2
PF11515   Cul7
PF03256   ANAPC10
PF00173   Cyt-b5
PF00632   HECT
PF00569   ZZ
PF18346   SH3_15
PF01266   DAO
PF08669   GCV_T_C
PF16350   FAO_M
PF01571   GCV_T

Interpro

IPR036400   Cyt_B5-like_heme/steroid_sf        + More
IPR010606   Mib_Herc2       
IPR037252   Mib_Herc2_sf       
IPR009091   RCC1/BLIP-II       
IPR015940   UBA       
IPR004939   APC_su10/DOC_dom       
IPR001199   Cyt_B5-like_heme/steroid-bd       
IPR008979   Galactose-bd-like_sf       
IPR000408   Reg_chr_condens       
IPR014722   Rib_L2_dom2       
IPR021097   CPH_domain       
IPR000569   HECT_dom       
IPR035983   Hect_E3_ubiquitin_ligase       
IPR006624   Beta-propeller_rpt_TECPR       
IPR000433   Znf_ZZ       
IPR040847   SH3_15       
IPR037976   HERC2_APC10       
IPR041987   ZZ_HERC2       
IPR016024   ARM-type_fold       
IPR013977   GCV_T_C       
IPR006076   FAD-dep_OxRdtase       
IPR032503   FAO_M       
IPR006222   GCV_T_N       
IPR027266   TrmE/GcvT_dom1       
IPR036188   FAD/NAD-bd_sf       
IPR029043   GcvT/YgfZ_C       
IPR009060   UBA-like_sf       

SUPFAM

SSF50985   SSF50985        + More
SSF55856   SSF55856       
SSF49785   SSF49785       
SSF159034   SSF159034       
SSF56204   SSF56204       
SSF48371   SSF48371       
SSF51905   SSF51905       
SSF46934   SSF46934       
SSF101790   SSF101790       

Gene 3D

2.130.10.30     2.30.30.30     2.30.30.920     2.60.120.260     3.10.120.10     3.30.1360.120     3.50.50.60    

CDD

cd00078  HECTc
cd08664  APC10-HERC2
cd02344  ZZ_HERC2

ProteinModelPortal

H9JEE6   A0A2A4K8M6   A0A3S2PJI5   A0A2H1WXV6   A0A194PPV9   A0A026WJZ9   + More
A0A3L8DD68   E2BM75   E2AK78   A0A0J7L4R0   A0A139WAN5   K7IQ42   A0A067R2N5   A0A158NCL1   F4WFF7   A0A151X600   A0A2A3E3G7   A0A195F9S1   A0A195ELX0   A0A195CR34   A0A088AL05   A0A139WAP8   A0A139WAR9   A0A154P7I9   A0A195BYI1   A0A146M433   V3ZE73   A0A1V4JBE1   H0ZJQ4   A0A2I0MLM1   E1BW48   G1KDV1   U3I746   U3JN73   A0A2T7PNV3   A0A091JXI0   A0A093HB52   A0A2I0MLL8   A0A091MCL6   A0A3M0K0M4   A0A3Q2UE20   R0L7U7   A0A091S499   A0A091JP83   A0A286XAB6   H0VHC2   A0A091EHF1   A0A091I9P4   A0A091LFD1   A0A093FPE5   I3M8T9   A0A287CWT3   A0A091VSZ3   A0A093CBX9   A0A0B8RTL9   F7A4S9   A0A384DC01   A0A091HM07   A0A061IGX1   A0A3Q0DBS9   A0A3Q7XI86   A0A094KRD9   A0A3Q2HE57   A0A3Q2IC42   F7AM44   A0A0Q3TAC1   A0A3Q2IA83   G3STX9   G5AZH7   A0A0P6J146   A0A2Y9QW94   E1B782   F7EP78   A0A0A0A8M2   F1RX57   A0A093BN38   A0A091TBI0   H9G1F0   A0A452GTE7   A0A452GSK3   A0A1U7UNG5   O95714   A0A250Y8J0   A0A151NXF6   A0A2K5K3Q5   A0A1U7RFM8   A0A287B1U2   A0A452GSM4   A0A3L8SV73   U3EA95   A0A2K5K3S5   A0A0G2JUC9   A0A452GSJ6   A0A2U4B2F2   A0A3Q7S9L4   A0A0D9R2F7   W5Q2G3  

PDB

4L1M     E-value=9.30907e-62,     Score=606

KEGG

NA   

GO

GO:0046872   GO:0004842   GO:0016740   GO:0016874   GO:0008270   GO:0016491   GO:0005737   GO:0005634   GO:0006974   GO:0007283   GO:0032183   GO:0031625   GO:0043161   GO:0016020   GO:0006886   GO:0005085   GO:0006303   GO:0016567   GO:0005654   GO:0005814  

Subcellular location

Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  
Centriole  
Nucleus  

Length:

1359

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03242

Exp number, first 60 AAs:

0.00628

Total prob of N-in:

0.00060

outside

1  -  1359

 

 

Pi

212.086645

Theta

193.255961

Tajima's D

0.873891

CLR

0.419599

CSRT

0.620268986550672

Interpretation

Uncertain