Gene

KWMTBOMO08763  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007893

Annotation

PREDICTED:_probable_E3_ubiquitin-protein_ligase_HERC2_[Amyelois_transitella]

Location

Bomo_Chr15(-):4661643-4708918      View in EpiBrowser

Full name

Probable E3 ubiquitin-protein ligase HERC2       + More
E3 ubiquitin-protein ligase HERC2      
Putative HERC2-like protein 3      

Alternative Name

HECT domain and RCC1-like domain-containing protein 2
HECT-type E3 ubiquitin transferase HERC2

Location in the cell

Mitochondrial   Reliability : 1.176 Nuclear   Reliability : 1.534

CDS

ATGTTCCAGGTATCGCAACTGACAAATCCATTTGAAGAGGAGAAAGCAGAAGCTCGCAGTGGATCATCGACAGGCGGCAACAGTCCCGCCAGCGAGACTCCGGCGACGACCCGGATATCTCGGCCGCTACCTCGCGTTAACGTGGCTTCGTCTCCGGCCAGAGCTGAATCTCTATTGTTTGCACTTGCTGAGCCGAAGCTACACGATCCGTTAGCACTTCATCTGTGGTGGGCGTGTGAACGTCACGAAGGCTGTGCACCACATTTCCCTCCGGAGCATCCACTGGAAGAACTGCGTCGCGCTTTACTCGCTGTGTTATTATACCATGCTGGATTAAAGGAACACGCCTTAGCCACTGCGAAAGCCGAAATGGAGAAAGGTGAGGTGAAACTTTCGCCGGCTATGTTGGAGATCGTTAAAGCTGTGCAACAAAGTAAATGGACATTGATGAGGACTAGGCAGCAGCTGTCCAGGGGCTATAAGGAGGTTTGTGCAGCTCCGCTTGAACGCGCTCGATTTCTTCTCCACGAAATTCGTCCCGCCATGTCTCCGGCCGTTAATGCATTACGTAATCGGCCGCCGTCGCATCGACCTCCTACGGCCAAAAGAATATTCCAGAAGGTCATGCGCGTAGCTAAAACACCTAGTTTCAACAAATGTTTTGAAACCACCAAGGACCTGCGAAACCGACAAAACAGTCTAAGTAAGAGCATGTTCAAAGCTACCGGAAGTCTCTTACAAGGAGACGCGCTGCTTATAAAATCGTCGATAGCCAACGCCACGAGTAAAACTCCTGAAGACATCACCCCAAGCATCGTGATTGAACCATTTAAACCCAGCGAAGGCGCTAGTGACGTAAGGGAACCTAAACTAAGAGTTAAAACCAAAGATAAACTATTAGAGAAAGATCTGAAGAATGCCTGCAATTATGATGACATGAGAAACGAAAGTCATCGCGCGGCAGATAGAGATGACATACTTGACCGGGACGATGATAAAACTCCAACCAACGAGATATCTTTCAGTTCAATAAACGATATGACTGATAATTCGGTGTTCAAAGACTCTATAGAAAGCGAGAAACAAGTGATACTGCTCGCTGACGATCTCAAGAATGACTTGATTATGGCTGACGAAGAAAAAGACGACGATACTTCAGAAAGAAATAAGTTTGTGAATGCGTGGGTGTCTAGGCTAGCTGGTGAAGAGAAAGATTTGCACTGGCTGTTAGAGTCGGTCACTCCCGAACAACAGAGTTTAACGATAGCTATTATAGACTTCGTAATGACTGAAGAAACCTGTGATATAGATATATTAAGACGAGCCCTGTATTGTCAGGTACAGCGTGCCGAAATAAGAAGAACTGGCTACAGTATTATAAACAGCATACTACATTCCTCACAAACGATGTCGGAAAGTGTCAAATACGGAGCTCTTGTTGGATTGCTGGGTGCTTCGATGGCCGAATCAGTATCTGGTGTTCCGCTAAAACCTACCATACCGTTAACACCTCCGTTGGACTCTATAGAATCTGTGATACCGTATTCCAAGTATATGGTGCTTCTAGAACGATCGAAGCTGATGGATTTCGTTTTGATTGAATTGAAAGCGAGGGTTATGGAAGGGGAGCAGCATCAGACGCTACCGACGAAAATGAGTGCTAATTACGGTGCACATGCATTATTGAATCGACCTTCTAGAGCAAGGTTTCTGATAACTTTACTATCGCTTCTCACCGAAGGCTGTCAAGGGCCGGAATTAGAACAGCTGATAAATGGCGGCGCACTAAGTTCCTGTCTGACGTTACTGAAACAAATCGGCGGTGATACATCTCAATATTCATCCCTTATTACTAACGGACTGAAAAGTAAACCGGAATGTCTCATTATTTATGAGGATGAAAGATTGGGAGCCAGGGCTCGTGGCGCGTCATTATCAGGACCGGAATTGGCTTCTTTGATGAAAATTGGAACGAGGGTAGTAAGAGGAAAAGACTGGAAATGGGGTGACCAGGATGGCGTACCCGGCGGCGAAGGTCGAGTAATTGGTGAGCTGGGTGAAGATGGATGGGTTCGTGTAGCGTGGGATGCGGGCGGCACAAACTCTTACCGAATGGGGAAGGAAGGCAAATATGATTTAAAACTCGCACGTTCACCATCTCCACCGCCCTCTATTGACGAGACTGTGCATGGAACAGTGGAAAACAACATAGAGTGGTGGCCCGTGAGCGAGGTCCGTTCGGCGTGTACGGGTGCTATCCGCGCGCTGTGTGCGGGCGCGGGCCGCCAGCTGTGCGCGCTGGGCAGCGTGGCCCGCAGGAACGTGACCGCTCTACAACGGCGGCTGCTCACGTTAGCGCATGCGCACGCCACTCCGCCGCCTACTGCCTTCGCCGCTAACTACCACACCGCTCTGGCTTTACTTAGAGCAAGTGCTCAAAGTCCAGAGATGAGGATATCTCTATGTACAGACTCATGGTTTGAACTATGCTACAGTATCATATCAACTTCGGATAAACCTATCACTTTAGATCACATCTATTTACAAATACAATCCCTCTGGCTTCTGCGCCGAGTATTAGTTGAGCACAGTGGGTCTCCCGAATGGCGTCGAACTGTAGCAGCGCAGTTACTTGCGCTCATCGGCCGGCTGTGGCTAGAGACACATTCTTGGGATCCTGCTCTAAGATTAAACCAACAAGCGTTCGCAGCCCATAATGATGAAGAGGAAATAGACAATAGATGGCGCGCCCCGGCTACGGCTAGCTACACAGGGGGTACGTGCGCCGCCCTCGTGCAGCTCGTGCGGCAGCTACACACGGCAACACAGTGGCACGCCCCAATCACAGCTTTATTACTAGAGAAACTACAGTTGGCAGCTCAAATGGTAACAAGCGACTGGCATTGGTGGCCACATGCAAGTCAAGAAATTACTCAAACTGTTAAGCCCACTCCGCCTAGTCTCGAGACTTGTCTCATTGCTGGTGCTTTGGGAGTGATTGGGGGAGTGGAATGGAGAATTCGGATTGGTCAGCGTGTGTCCGCCGGTACACCTCCTCGTAACGGAATAGTGATACAACTGTCGTCGCGAGCAAAAATCTCCTTGATGCACGACGATAACACTATTGTGAAGACTGAATTAAACAGCATTCAGAATTCGGAATGTGAGCGTTTGGCTCAGCCGCTCGGAGGAGGCGAGAGCGCTCTGCGGGTTTGCGCGGCTTTACTGGGAGCCGGACCTCAGGCCTCGCCGCTGCATCCGCATCACTTACCCGCTGAAATTGACGTTTATGGTCTAAGAAAACAACAAATAGAATTATTGACGCTGTGTGCGGTACGAGGTTTACTCACAACACGAACGCGACTCCGGAAAGTTCTGATGCAACCACCGGATAATTCAGGTACATCAGAGAGAGCATCTACTTGCTTGGGTACAGAAGGTACATTACTCCGGCGACTGTTGGCGCTAGCGACACGGCCCAGTCCGTTATCCGCGTCGTACACTCCGAAGGAACTAGCCGCGGCCGCCCTCACCATAGTGCAGCAGCTAGCTGCTCATGTCAATGGTGACGAAAAGGATCACGAAAGCTCACCGGACATGCCAATTATTGATAAAAGTAACGTAATGCATGTATCGGTGGGACCATCTACCAGTACTGCCTCTCTGTCAAGAAAAGATCTTAATACATGGGCTAACTCATCTCAGGTGCAACAGGTTATTGAGATGGGATTTTCAAGACACGCTGTCTATGGAGCTATACAAGCTTTAGGTGGAACGAGTCTCCCGTCAGTCGAAGCTCTCGTAGCATATCTATTAGAACTATCGCAACAAGGTATGGACGATTCCGTTTTTGAAGTGAAACCACAGCCAGCTAAACAAGATAAGAAACAAACGCCGTATAGATGGCGCAGTTGTTTCGCATCCGAAGACGAATACTCGCAGTACTTATCGGATGTGATAACACCGGGCATGACTGTACGCTGCTGTAAGGCGTTTGAAAGTGTGGCACTTGGTGATGTTGGGCAAGTGCAGAAAATTGAACGGGATATCAAACAGAACGTTTTTCTTCACGTCGAGTGGCGTGGTCTGGGGCGCGTGGCCGGCGTGCGAGCCGTGCACGCCGAAGTAGTATCGGGGGCGCCGCCATTCGCGGTCGGCGACAGAGTAAGGGTGCGAGCTGCAGTCACCCAGCCCCGGTACAAATGGGGTTGCATCGATCACACGAGCGTTGGTACTGTTACAGCGGTATCAACGAACGGCCGCGATTTGACTGTCGACTTCCCTCAACAACCTGGATGGACCGGACAAGTGAGCGAAATGGAACTAGTCACCGATCAGTCGGAATGGAGCGAAAGTTCTGGAGGAATGACGGTCGGCTGGCGGGGAACCATTCGTGCCGTGAGAGTATCGTCATGCAGGCTCGGTGCTGGAGCAAGGAGACTGCTTGACTCACAACCCCACACTTACTGGCAAAGTTCTAGTGGGACCGGACAGCACTGGATTCGTATAGAGATGCGCTGCGGCGTGCGCGTCCGTCGACTCGGCCTAGGGGTGGGCGGCGGCGTACACGGTCCCGCGGCGCTGGCCGTGCGGGCGGGGAACAGCTTCGACGACAGCGCACTGGCGCCCGTGGCAGCCCTGGTGTGCGCGCCCTCGCCGCCCAGGGACAGACCGTCAGCGCATCTGGCGCAGATACAGCTTGTAGCTGACTGCAAACAGTACTATCCATGCATTGAGATCGGTATTAAGCAGAATAGAAATATTAACGCAGATTGTCGTGTGCACGGACTGTACATAACCGGCTTCAGACCAAACCCACTATACACTGAAATATTGCAGAACATGAATTTTGTAGCTGAAGATTGGATGGAAAAGGATTGTCCATCAAGTGCAATTTCCGTAGATAATAATCCTCCAATTTTGCCAAACGATTGTCCTAAGGTATACGTCTGGGGATTGAATGATAAAGATCAACTGGGAGGCGTGAAAGGTTCCAAAGTAAAAGTGCCTGTTTTCTCACCTGTGCTAAGCGCCTTGCGTCCCGTGCATATCGCGGGTGGATCTAAAACGCTCTTCATTGTATCTCACGATGGAAAGCTCTACGCGTGCGGTGAAGGCACGAACGGGCGCTTAGGCCTAGGGCACAGCAACAACGTGTCGACGCCGCGAGCTAACCCGTACTTATCACATGTGCTCGTGCGGAAAGTAGCCGTACATTCTGGAGGGAAACACGCCTTAGCTCTGACTGCAGACGGAAAGGTTTACTCGTGGGGTGAAGGCGAAGACGGTAAACTAGGTCACGGAAACCGTTTGACTTTAGAAGTGCCGCGTCTCATAGACGCGTTGTCCGGAGAGCGCGTGGTCAGCGTGGCGTGTGGATCTGCTCACAGCGCCTGCGTCACGGCCCGAGGACATCTCTACACCTGGGGCCTCGGAGAGTATGGGAGGCTGGGACATCGTGATAATATTACCCAGTTGGTACCTAAGATGGTGGAAGCCTTAGCTAATTTTAGGGTGATACAAGTAGCTTGTGGATCGCGGGATGCGCAAACGTTGGCATTGACGGCTTGCGGGAAAGTCTTCTCGTGGGGCGATGGTGATTTTGGAAAATTAGGTCGAGGTGGGTCTGACGGGTGTGCAGTACCAATGAACATAGAAAGATTGAATTCCCTTGGAGTTGTTCAAGTCGAATGCGGTGCTCAATTCAGTTTGGCTCTGACAAGAGACGGCGAGGTGTGGACGTGGGGCAAGGGAGATTATTTTCGGCTCGGTCATGGCTGCGACGCTCACGTGCGTCGCCCGACACTCGTCGAAGCGTTGCGCGGCCGGAGAGTCGTTCACGTCGCTGTGGGAGCCTTACACTGTCTGGCTGTAACTAGCGATCATCAGGTGTGGGCGTGGGGCGACAACGATCACGGTCAGCAGGGTAACGGCACGACGTACGTGAACCGTCGGCCGGCGGCCGTGGCGGGCGTGGAGGGCGTGCAGCGAGCGGCGGCGGGCTCGTCGCACTCGGCGGCGTGGTCGCTGCGGCCGCCGGACGCGCACGCGCCGCACGTCGCGCCCCTCCCCTTCCCCACGCTCAAGGACCCGCTCGGCGTGCAAAGTCTCGGTTTATATGCAGAGGAATCCACAGTTGAAGAACCGCAAGGGCCTCGTGCGTCTTTGGCAGCAGCTGCACTCGCTCTAGAACCACCGGTGGCTGTTCAACACGCGTTGTCTTTGATTTTGTTATCCCTGCACATTTGTCAAGCACGCAATCTACTGGTAGAAGCATTGCGGGCGCACGAAGCTACTTCGACTGCGGCTCCTGTGTCGGCGGCCATTGACACTGAAGACGAAGATGCCGATGGAGACGCACGCACTGGTGGCGGAGAAGCTCCGGCCGACAGAGCTACATTGCCAAGCGGTGCGAGCAGCCCTCTCAGTGGTTCTATGTCTTCTCGACACTCGGCCGTAATGTCTTCGAGTGCTGTATCCGTCGCAGCCGCCACCATGACTGTGCAACAATCCGAAGCTCCAAAGATGGAGTTAGATGACTTCACGTCGCAGCTTGGTGAATCTGATGCGAGAGCACTCGTGGATTTGTTAAAACTGGCAGCGGCGGGTCGAATACCCGATGCTAATAATGCGGTCAAAATTATTAAGGATGTTCTCATGTCTCTATGCGCCAGCAAGCCTGCCGTAGCGGATATGGTGGTGGAGGTGTGCGTTTGCGAACTAGAAGAGGCCGCTGCGGGGGGAGGGCGTGCCCCCCCGCAACCTGTAACAGTGGACAGTCCGCACCCTTACGCCGACGATACGGATATTTCGGGTGTTGTCAAAATTCCGGGAGCATCGTCGTTGCGCGTGGTCTTTGAGCAGGGATGTTCGACGGAGAGGAGAAACGATCCTTTGACGATATCAGACAGCACTGGCCGCGTGCTCGCCACGCGCTCGGGCCGGGAACCGTCTGATTGGGCGCAGGAAATTATTGTTAATGGTGATGAACTTCGCTGGAGATTCACAAGCGACGGCTCGGTAAACGGATGGGGTTGGAGATTTACCGCTCATCCCATATTACAAACACACGCTATAGCGGAAAGCGGATCAGACCGCTATGTTTTGTCTTGTCCCTCAGTTGAACTTGCGTGGAGATTGTTGGATGGGCCATTACTGACGGCCATATCTAATGACCACCAGCTCGCACCGCGGCTGGCTCAGGCATTAGCAATCTGTGCTCAGATGCCAACATTATCGTGGCGGGCGCGCGTGTGGTGCGTGCGTCGGCTGCGCGGCGTCGTGTGCGGCTCCGGCGACGGAGAGCCGACCACCGGCATCCCGCCCGCGCTGGCGCACCTGCCGCAGCTGCTCCAAGCTCAGTACGAAAACGAAGAGCCGGCTCTCAGGACCGGCTCGCATCTCATGCACACTCATTATATGAAGGAATTAGCGTGGTTAGCTTGCGGCCTACGTATCGACTCGCGTGTGTGCAACGGGCCGGACTCGTCCCGCTGGGCCTGGTTCAAGCGGTACTGTCTGTGCATACGCACGGCGGACGCGCTCATCCGCCGTAGACAGATGCCGTCGCCATTCTTGGGCGACGTCAGGAAACGACTTGCCGACCTCGGCGTCTACAGCGAGGAGTCGACCAGCGAGGCGCCCTACGCCTGGGAGGACAACACGAAGTTCACAAAGCAGCATGACGAACAGTTGCTGCACTGGGTCAATAAACGTCCAGAGGACTGGACTGGTTGGTGGGGCAGTAGTTCTCGTGGCTGTGCCGTATACGGCTGGGGACACAATCATCGCGGGCAATTAGGTGGAGTTGAAGGGGCTAAAGTGCGAACGCCTACTCCCTGCCACGCCCTCGCGGCTCTGAACCCCGTGCAACTAGTGGGCGGTGAACAGACACTCTTCGCGGTCACCCCAGATGGGAAAGTCTATGCAACAGGTTATGGAGCGGGAGGACGATTGGGCATTGGTGGAATAGATTCGGTCTCGCAACCATCGCTGTTAGCATCGATACAACATGTGTTCATCACTAAGGTCGCATGCAATTCCGGTGGAAAACATTGTTTAGCCCTCTCTGCCGAAGGAGAAGTTTATAGTTGGGGCGAAGGTGAAGACGGAAAACTCGGTCATGGAAACAGAGTGAGCTACGATCGTCCTAAGCTAATAACGGCCCTGTCCGGACTAGAAGTGGTAGCCATTGCGTGCGGAGGCGCTCACTCGGCGTGCCTAACTGCTCGAGGACGCATCTACACCTGGGGCAAGGGGAGGTATGGACGACTCGGACATGGAGATTCTGAAGATCAACTCGTGCCTAAATTGGTTGAAGCGCTGGCAACCCAACGCGTAATTGATGTCGCATGCGGATCCGGTGACGCGCAAACCCTTTGTATCACCGACGATGACAACGTGTGGTCTTGGGGCGACGGCGACTATGGAAAATTAGGTCGTGGCGGCTCAGACGGATGCAAGCTACCGATGCGGATAGATTGCTTGAAGGGATTGCGTGTTATCAAAGTAGAATGCGGCTCGCAGTTCTCAGTGGCGCTATGTCAATGCGGTAGCGTTTACACTTGGGGCAAAGGGGACTACCACAGACTCGGGCACGGCAGCTACGAACACGTACGACGCCCGATGCGAGTAACAGGAATGCAAGGGAAAATGATCGTGTCCATAGCAACAGGTAGTCTTCATTGCGTAGCGTGTACGGACACGGGCGAGGTCTATACATGGGGTGACAACGACGAAGGGCAACTGGGAGACGGGACCACGCTCGCTGCTCAAAGACCGAGACTCCTCATGGCTCTGCAGGGTAAAAGAGTGACGAAAGTGGCATGCGGTAGTGCTCACACCGTGGCACTCTGCGTAGAAGCGCCTCGGGCTCCCAGAGCCCCGCCCCCGCCGCCGCTCGAGTGTCACCTGCTCAGAGATCTATCGACGCAACTCATATGCAATCGACTGGTTTTATTGCATCAGTTTTCTGAGCTGATATGCCCGAACCTGTCGTTATTGATCTTGGAAGGACCTCTGGATGCTCTCAGGAATTTGCTGTTCCACAGCGTCAAAGAAGCTGCATTTAGAAAGGCGATAATGGCTACAATGCTACGCGAGCGGCAGCACGGGCCCGTGGTGGAGCTGTCCCGCGTGGCGGCGCGGCGCTCCCGCAAGGGCGGCGCGGGGCTGGCGGGCGCGGCCGGCATGCGCTCCGTGTTCGGGCAGATGGTGGCGCGCCTGCCCACCTTCCCGCACGACGCGCTCACCCTCCCGCACCGCGTCTGGAAGGTCAAGTTTGTAGGGGAAAGTGTTGATGACTGTGGTGGAGGGTACAGCGAGAGCATTGCCGAGATGTGCGAAGAACTTCAGAACGGTTCGCTGCCGCTGTTAATGGCGACGCCGAATGGACGCGGAGACGCCGGCGCCTCCAGGGATGCCTTCTTACTGAACCCAACTGCCAATACGCCTCTTCACCTGCACTGCTTTAGGTTCCTGGGTCTTCTGATGGGCATCGCCATAAGAACTGGTTCGCCGTTGTCATTGTCTCTGGCGGAGGGCGTCTGGCGCCAGTTGGCAGGACAACCGCTGCGTCCACAAGATCTCGCCGAAGTCGACAAAGATTTCCTGCCAGCTCTACTGTGCATCCGAGATATGACTCCGCAAAATAAGGAGCTGCAGAACCTGGAGTTGCCGTTCTCGATACCATCGGCGGCTGGGCATGAAGTACCCCTGTCTACTCGACATAAGAGGGTCACCCCTGACAATAAAGAGGAATATGTGCAGTTAGCATTGCATTACAGGCTCCATGAATTCGACGAGCAAGTCCGTGCGGTCCGGGACGGCATGTCCCGCGTGATCCCGGCGCCGCTCGTCGCGCTCTTCAACGCGTCCGAACTCGAGACTCTGGTCTGCGGCTCGCCCGATATACCGGTCAACGCGTTACGCGCTTCCGCCACTTACAAAGGTGTCGAACCAAATGCGCCCCTAGTTCAATGGTTTTGGGAAGTAATGGAAGAGCTGTCGGGAAGCGAGCGCGCTTTGTTCCTTCGATTCGTATGGGGCCGGACACGTTTGCCGAGAGCGCCGCAAGATCCAAGACAAAGGGATTTCGTCTTACAGGTACTCGATAAATACCAACCACCGGATCACTTTTTACCGGAGAGTTACACGTGTTTCTTTCTCCTCAAGATGCCAAGATATTCGTGTAAATCTGTTTTACGGGAAAAACTAAGATACGCGATCCATTTCTGCAAAAGTATCGACACTGATGAGTACGCTAGAGTGGCACTAAGCGCGGCCGAACGTGTTTCGTCCGAAGAATCGGATTCCGATGGGGATGCACCGCACCCCTCGCACCCGCCCCCGCTGTACTCCTTGACCAGAGCACCGACCTGGCTCTAA

Protein

MFQVSQLTNPFEEEKAEARSGSSTGGNSPASETPATTRISRPLPRVNVASSPARAESLLFALAEPKLHDPLALHLWWACERHEGCAPHFPPEHPLEELRRALLAVLLYHAGLKEHALATAKAEMEKGEVKLSPAMLEIVKAVQQSKWTLMRTRQQLSRGYKEVCAAPLERARFLLHEIRPAMSPAVNALRNRPPSHRPPTAKRIFQKVMRVAKTPSFNKCFETTKDLRNRQNSLSKSMFKATGSLLQGDALLIKSSIANATSKTPEDITPSIVIEPFKPSEGASDVREPKLRVKTKDKLLEKDLKNACNYDDMRNESHRAADRDDILDRDDDKTPTNEISFSSINDMTDNSVFKDSIESEKQVILLADDLKNDLIMADEEKDDDTSERNKFVNAWVSRLAGEEKDLHWLLESVTPEQQSLTIAIIDFVMTEETCDIDILRRALYCQVQRAEIRRTGYSIINSILHSSQTMSESVKYGALVGLLGASMAESVSGVPLKPTIPLTPPLDSIESVIPYSKYMVLLERSKLMDFVLIELKARVMEGEQHQTLPTKMSANYGAHALLNRPSRARFLITLLSLLTEGCQGPELEQLINGGALSSCLTLLKQIGGDTSQYSSLITNGLKSKPECLIIYEDERLGARARGASLSGPELASLMKIGTRVVRGKDWKWGDQDGVPGGEGRVIGELGEDGWVRVAWDAGGTNSYRMGKEGKYDLKLARSPSPPPSIDETVHGTVENNIEWWPVSEVRSACTGAIRALCAGAGRQLCALGSVARRNVTALQRRLLTLAHAHATPPPTAFAANYHTALALLRASAQSPEMRISLCTDSWFELCYSIISTSDKPITLDHIYLQIQSLWLLRRVLVEHSGSPEWRRTVAAQLLALIGRLWLETHSWDPALRLNQQAFAAHNDEEEIDNRWRAPATASYTGGTCAALVQLVRQLHTATQWHAPITALLLEKLQLAAQMVTSDWHWWPHASQEITQTVKPTPPSLETCLIAGALGVIGGVEWRIRIGQRVSAGTPPRNGIVIQLSSRAKISLMHDDNTIVKTELNSIQNSECERLAQPLGGGESALRVCAALLGAGPQASPLHPHHLPAEIDVYGLRKQQIELLTLCAVRGLLTTRTRLRKVLMQPPDNSGTSERASTCLGTEGTLLRRLLALATRPSPLSASYTPKELAAAALTIVQQLAAHVNGDEKDHESSPDMPIIDKSNVMHVSVGPSTSTASLSRKDLNTWANSSQVQQVIEMGFSRHAVYGAIQALGGTSLPSVEALVAYLLELSQQGMDDSVFEVKPQPAKQDKKQTPYRWRSCFASEDEYSQYLSDVITPGMTVRCCKAFESVALGDVGQVQKIERDIKQNVFLHVEWRGLGRVAGVRAVHAEVVSGAPPFAVGDRVRVRAAVTQPRYKWGCIDHTSVGTVTAVSTNGRDLTVDFPQQPGWTGQVSEMELVTDQSEWSESSGGMTVGWRGTIRAVRVSSCRLGAGARRLLDSQPHTYWQSSSGTGQHWIRIEMRCGVRVRRLGLGVGGGVHGPAALAVRAGNSFDDSALAPVAALVCAPSPPRDRPSAHLAQIQLVADCKQYYPCIEIGIKQNRNINADCRVHGLYITGFRPNPLYTEILQNMNFVAEDWMEKDCPSSAISVDNNPPILPNDCPKVYVWGLNDKDQLGGVKGSKVKVPVFSPVLSALRPVHIAGGSKTLFIVSHDGKLYACGEGTNGRLGLGHSNNVSTPRANPYLSHVLVRKVAVHSGGKHALALTADGKVYSWGEGEDGKLGHGNRLTLEVPRLIDALSGERVVSVACGSAHSACVTARGHLYTWGLGEYGRLGHRDNITQLVPKMVEALANFRVIQVACGSRDAQTLALTACGKVFSWGDGDFGKLGRGGSDGCAVPMNIERLNSLGVVQVECGAQFSLALTRDGEVWTWGKGDYFRLGHGCDAHVRRPTLVEALRGRRVVHVAVGALHCLAVTSDHQVWAWGDNDHGQQGNGTTYVNRRPAAVAGVEGVQRAAAGSSHSAAWSLRPPDAHAPHVAPLPFPTLKDPLGVQSLGLYAEESTVEEPQGPRASLAAAALALEPPVAVQHALSLILLSLHICQARNLLVEALRAHEATSTAAPVSAAIDTEDEDADGDARTGGGEAPADRATLPSGASSPLSGSMSSRHSAVMSSSAVSVAAATMTVQQSEAPKMELDDFTSQLGESDARALVDLLKLAAAGRIPDANNAVKIIKDVLMSLCASKPAVADMVVEVCVCELEEAAAGGGRAPPQPVTVDSPHPYADDTDISGVVKIPGASSLRVVFEQGCSTERRNDPLTISDSTGRVLATRSGREPSDWAQEIIVNGDELRWRFTSDGSVNGWGWRFTAHPILQTHAIAESGSDRYVLSCPSVELAWRLLDGPLLTAISNDHQLAPRLAQALAICAQMPTLSWRARVWCVRRLRGVVCGSGDGEPTTGIPPALAHLPQLLQAQYENEEPALRTGSHLMHTHYMKELAWLACGLRIDSRVCNGPDSSRWAWFKRYCLCIRTADALIRRRQMPSPFLGDVRKRLADLGVYSEESTSEAPYAWEDNTKFTKQHDEQLLHWVNKRPEDWTGWWGSSSRGCAVYGWGHNHRGQLGGVEGAKVRTPTPCHALAALNPVQLVGGEQTLFAVTPDGKVYATGYGAGGRLGIGGIDSVSQPSLLASIQHVFITKVACNSGGKHCLALSAEGEVYSWGEGEDGKLGHGNRVSYDRPKLITALSGLEVVAIACGGAHSACLTARGRIYTWGKGRYGRLGHGDSEDQLVPKLVEALATQRVIDVACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPMRIDCLKGLRVIKVECGSQFSVALCQCGSVYTWGKGDYHRLGHGSYEHVRRPMRVTGMQGKMIVSIATGSLHCVACTDTGEVYTWGDNDEGQLGDGTTLAAQRPRLLMALQGKRVTKVACGSAHTVALCVEAPRAPRAPPPPPLECHLLRDLSTQLICNRLVLLHQFSELICPNLSLLILEGPLDALRNLLFHSVKEAAFRKAIMATMLRERQHGPVVELSRVAARRSRKGGAGLAGAAGMRSVFGQMVARLPTFPHDALTLPHRVWKVKFVGESVDDCGGGYSESIAEMCEELQNGSLPLLMATPNGRGDAGASRDAFLLNPTANTPLHLHCFRFLGLLMGIAIRTGSPLSLSLAEGVWRQLAGQPLRPQDLAEVDKDFLPALLCIRDMTPQNKELQNLELPFSIPSAAGHEVPLSTRHKRVTPDNKEEYVQLALHYRLHEFDEQVRAVRDGMSRVIPAPLVALFNASELETLVCGSPDIPVNALRASATYKGVEPNAPLVQWFWEVMEELSGSERALFLRFVWGRTRLPRAPQDPRQRDFVLQVLDKYQPPDHFLPESYTCFFLLKMPRYSCKSVLREKLRYAIHFCKSIDTDEYARVALSAAERVSSEESDSDGDAPHPSHPPPLYSLTRAPTWL

Description

Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.
E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333).

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Interacts (when phosphorylated at Thr-4829 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionising radiation (IR) treatment. Interacts with XPA. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.
Interacts (when phosphorylated at Thr-4827 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionizing radiation (IR) treatment. Interacts with XPA. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.

Miscellaneous

A regulatory element withinin an intron of the HERC2 gene inhibits OCA2 promoter. There are several single nucleotide polymorphisms within the OCA2 gene and within the HERC2 gene that have a statistical association with human eye color.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Cytoskeleton   Phosphoprotein   Reference proteome   Repeat   Transferase   Ubl conjugation pathway   Coiled coil   DNA damage   DNA repair   Metal-binding   Nucleus   Ubl conjugation   Zinc   Zinc-finger   3D-structure   Disease mutation   Mental retardation   Polymorphism  

Feature

chain  Probable E3 ubiquitin-protein ligase HERC2
splice variant  In isoform A.
sequence variant  In MRT38; less stable than wild-type; diffuse cytosolic localization with the formation of abnormal aggregates; dbSNP:rs397518474.

Uniprot

Q9VR91.3   Q4U2R1.3   O95714.2   Q9BVR0.2  

EC Number

2.3.2.26

Pubmed

10731132    12537572    12537569    10720573    18327897    9689098    + More
9949213    19468303    16141072    15489334    10441737    17242355    21183079    16572171    17081983    18252221    18252222    18172690    18669648    19413330    19690332    20457063    20023648    20304803    20068231    21269460    21406692    22508508    22261722    23186163    26692333    23065719   

EMBL

AE014298    AY113293    AF189221    AAF61856.1    AAM29298.1    AF061529    + More
AF071173    AC102121    AC102150    AK141515    AK148361    AK161826    AK162270    AK162708    AK220338    BC044667    BC054829    AAC31431.1    AAD08658.1    AAH44667.1    AAH54829.1    BAD90404.1    BAE24711.1    BAE36593.1    BAE37031.1    AF071172    AC091304    AC126332    AC135329    AF224243    AF224242    AF224245    AF224244    AF224249    AF224246    AF224247    AF224248    AF224251    AF224250    AF224255    AF224254    AF224252    AF224253    AF224257    AF224256    AF225401    AF225400    AF225404    AF225402    AF225403    AF225407    AF225405    AF225406    AF225409    AF225408    AAD08657.1    AAO27483.1    AC026495    BC000975    BC070076   

Proteomes

UP000000803    UP000000589    UP000005640   

PRIDE

Q9VR91    Q4U2R1    O95714    Q9BVR0   

Pfam

PF00632   HECT        + More
PF00415   RCC1
PF11515   Cul7
PF00173   Cyt-b5
PF06701   MIB_HERC2
PF00569   ZZ
PF03256   ANAPC10

Interpro

IPR037252   Mib_Herc2_sf        + More
IPR009091   RCC1/BLIP-II       
IPR010606   Mib_Herc2       
IPR001199   Cyt_B5-like_heme/steroid-bd       
IPR015940   UBA       
IPR004939   APC_su10/DOC_dom       
IPR035983   Hect_E3_ubiquitin_ligase       
IPR000408   Reg_chr_condens       
IPR008979   Galactose-bd-like_sf       
IPR021097   CPH_domain       
IPR009060   UBA-like_sf       
IPR000569   HECT_dom       
IPR037976   HERC2_APC10       
IPR014722   Rib_L2_dom2       
IPR000433   Znf_ZZ       
IPR041987   ZZ_HERC2       
IPR006624   Beta-propeller_rpt_TECPR       
IPR036400   Cyt_B5-like_heme/steroid_sf       

SUPFAM

SSF159034   SSF159034        + More
SSF56204   SSF56204       
SSF46934   SSF46934       
SSF50985   SSF50985       
SSF49785   SSF49785       
SSF55856   SSF55856       

Gene 3D

2.130.10.30     2.30.30.30     2.30.30.920     2.60.120.260     3.10.120.10    

CDD

cd00078  HECTc
cd08664  APC10-HERC2
cd02344  ZZ_HERC2

ProteinModelPortal

Q9VR91.3   Q4U2R1.3   O95714.2   Q9BVR0.2  

PDB

3KCI     E-value=4.00119e-156,     Score=1423

KEGG

101738581    K10595 E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] | (RefSeq) probable E3 ubiquitin-protein liga

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)

GO

GO:0016567   GO:0004842   GO:0005737   GO:0046872   GO:0005634   GO:0005814   GO:0006281   GO:0032183   GO:0008270   GO:0007283   GO:0006974   GO:0031625   GO:0043161   GO:0005743   GO:0006886   GO:0016020   GO:0006303   GO:0005085   GO:0005654   GO:0006811   GO:0005509   GO:0050793   GO:0003676   GO:0016876   GO:0043039  

Subcellular location

  
Cytoplasm   Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.   With evidence from 3 publications.
Cytoskeleton   Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.   With evidence from 3 publications.
Microtubule organizing center   Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.   With evidence from 3 publications.
Centrosome   Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.   With evidence from 3 publications.
Centriole   Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.   With evidence from 3 publications.
Nucleus   Recruited to sites of DNA damage in response to ionising radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mitosis.   With evidence from 3 publications.

Length:

3461

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01599

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00002

outside

1  -  3461

 

 

Pi

287.839959

Theta

188.719894

Tajima's D

1.78834

CLR

0.224846

CSRT

0.844257787110644

Interpretation

Uncertain