Gene
KWMTBOMO08759
Pre Gene Modal
BGIBMGA007895
Annotation
will_die_slowly_[Danaus_plexippus]
Full name
Protein will die slowly
Location in the cell
Extracellular Reliability : 1.874
Sequence
CDS
ATGGTGCCGCTAGGTCCCGTGCCAGGCCACCCTGCTGCACATCAAACTCACGGTGGCCCTTCAGCCAGCTTATCCGGTCCAAATTCATTATCACAATCTGCTCCACAGTCAAACAAGTCTTCAGTGGCGAAGCCGAACTATACCCTCAAATTCACTCTCGCTGGTCATACAAAGGCTGTGTCATCGGTAAAATTCAGTCCAAATGGAGAATGGCTGGCTAGCTCTTCTGCTGACAAACTTATTAAGATTTGGGGTGCATATGATGGTAAATTTGAAAAGACAATATCTGGCCACAAAATGGGGATCAGTGATGTGGCATGGTCCTCTGACAGCAGGTTGATTGTCAGTGCTAGTGACGATAAAACTTTAAAAGTTTGGGAACTTAGTTCAGGAAAATGTTTAAAAACGCTTAAAGGTCACAGTAATTATGTTTTTTGCTGTAACTTCAATCCACAAAGTAATCTAATTGTATCAGGCAGTTTCGATGAGAGTGTTCGGATATGGGATGTGAGAACAGGGAAATGTCTAAAACCATTACCGGCGCATTCAGATCCAGTTTCAGCTGTTCATTTCAACAGAGACGGGAGCCTAATCGTTTCTTCAAGTTATGATGGTTTATGTCGAATTTGGGATACAGCTTCAGGACAATGTCTTAAAACTCTAATAGACGATGACAACCCTCCTGTTTCGTTTGTTAAATTCTCACCGAATGGAAAATATATATTGGCGGCGACGTTAGACAACACACTCAAATTATGGGACTATAGCAGAGGAAAATGTTTGAAGACATATACGGGACACAAGAACGAAAAATATTGTATCTTTGCCAACTTTAGTGTCACTGGCGGGAAGTGGATAGTATCGGGATCAGAAGACAACTTGGTGTACATATGGAACCTTCAATCAAAGGAGATTGTACAGAGGTTGTCTGGACACACGGATACAGTTCTCTGCACGGCCTGCCACCCCACCGAAAACATTATCGCTTCGGCTGCCCTTGAAAACGACAAGACAATCAAACTATGGAAGAGTGATACTTAA
Protein
MVPLGPVPGHPAAHQTHGGPSASLSGPNSLSQSAPQSNKSSVAKPNYTLKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKMGISDVAWSSDSRLIVSASDDKTLKVWELSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKPLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSRGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQSKEIVQRLSGHTDTVLCTACHPTENIIASAALENDKTIKLWKSDT
Summary
Description
Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'.
Subunit
Core component of several methyltransferase-containing complexes. Component of the SET1 complex, composed at least of the catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf and Dpy-30L1 (PubMed:21694722). Interacts with Set1 (PubMed:21694722, PubMed:21875999, PubMed:22048023). Component of the MLL3/4 complex composed at least of the catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx, Lpt and Ncoa6 (PubMed:21875999). Interacts with Nup98 (PubMed:25310983).
Similarity
Belongs to the WD repeat WDR5/wds family.
Keywords
3D-structure
Complete proteome
Nucleus
Reference proteome
Repeat
WD repeat
Feature
chain Protein will die slowly
Uniprot
A0A2H1VC02
A0A2A4K8L8
A0A212ER47
A0A194QT01
S4P951
E3SRH1
+ More
A0A194PRU8 Q6SA00 D3TRP5 A0A1A9XLP7 A0A1A9VUG0 A0A1B0B6C7 A0A1B0AC46 A0A1A9W6A9 A0A0K8TMA9 A0A0A1XJ75 A0A034WX03 A0A0K8WK50 A0A1B0D8Q7 A0A1L8DH23 A0A067QUB7 A0A2J7PIW3 W8BHV0 T1PH81 A0A0L0CN91 A0A1I8P2X3 A0A2P8YLL1 A0A310SFZ6 A0A1J1I5E3 A0A347ZJ84 A0A0L7R4W3 A0A154PN95 B3MYW7 A0A0T6AVT7 E2BGW5 A0A0M3QYY6 E2A016 A0A1B6HNC5 A0A3B0J7S4 B4GV46 Q29IF8 A0A182FKR8 A0A1B6KKN2 B4JNZ8 A0A0A9YBQ7 W5JAH1 Q17GJ0 A0A182G529 A0A182XBA2 A0A182UNE3 A0A182LH35 D6W9F7 A0A084VHB4 V5GQH4 A0A2C9GRK6 A0A182T1G7 A0A151XIT6 Q7PCU7 A0A182VZ26 A0A1W4V9W6 A0A0V0GA59 A0A182PRJ6 B3P930 A0A182QPS3 A0A195FLH6 A0A195DZJ9 E9IDG7 A0A182NCG3 F4WRP3 A0A195BWG4 A0A182XVY5 A0A182K8M1 A0A158NEQ1 B4MSL6 B4Q0Z2 A0A336LJS1 A0A2M4BUD7 A0A224XRL4 A0A069DT50 A0A1B0GB34 M9NDM4 B2ZIA8 B0FE79 B4L5Q4 B2ZID2 Q9V3J8 A0A182J7U2 A0A2R7X2H6 A0A158NEQ2 B4M792 A0A1Q3EZW2 A0A026WDK9 A0A232EUR5 K7JA87 A0A1Y1JRA1 A0A2R5L4T2 A0A1B6FHA2 A0A1B6CWV9 T1IR12 A0A1I8JUD6
A0A194PRU8 Q6SA00 D3TRP5 A0A1A9XLP7 A0A1A9VUG0 A0A1B0B6C7 A0A1B0AC46 A0A1A9W6A9 A0A0K8TMA9 A0A0A1XJ75 A0A034WX03 A0A0K8WK50 A0A1B0D8Q7 A0A1L8DH23 A0A067QUB7 A0A2J7PIW3 W8BHV0 T1PH81 A0A0L0CN91 A0A1I8P2X3 A0A2P8YLL1 A0A310SFZ6 A0A1J1I5E3 A0A347ZJ84 A0A0L7R4W3 A0A154PN95 B3MYW7 A0A0T6AVT7 E2BGW5 A0A0M3QYY6 E2A016 A0A1B6HNC5 A0A3B0J7S4 B4GV46 Q29IF8 A0A182FKR8 A0A1B6KKN2 B4JNZ8 A0A0A9YBQ7 W5JAH1 Q17GJ0 A0A182G529 A0A182XBA2 A0A182UNE3 A0A182LH35 D6W9F7 A0A084VHB4 V5GQH4 A0A2C9GRK6 A0A182T1G7 A0A151XIT6 Q7PCU7 A0A182VZ26 A0A1W4V9W6 A0A0V0GA59 A0A182PRJ6 B3P930 A0A182QPS3 A0A195FLH6 A0A195DZJ9 E9IDG7 A0A182NCG3 F4WRP3 A0A195BWG4 A0A182XVY5 A0A182K8M1 A0A158NEQ1 B4MSL6 B4Q0Z2 A0A336LJS1 A0A2M4BUD7 A0A224XRL4 A0A069DT50 A0A1B0GB34 M9NDM4 B2ZIA8 B0FE79 B4L5Q4 B2ZID2 Q9V3J8 A0A182J7U2 A0A2R7X2H6 A0A158NEQ2 B4M792 A0A1Q3EZW2 A0A026WDK9 A0A232EUR5 K7JA87 A0A1Y1JRA1 A0A2R5L4T2 A0A1B6FHA2 A0A1B6CWV9 T1IR12 A0A1I8JUD6
Pubmed
22118469
26354079
23622113
21104437
20353571
26369729
+ More
25830018 25348373 24845553 24495485 25315136 26108605 29403074 17994087 20798317 15632085 23185243 25401762 26823975 20920257 23761445 17510324 26483478 20966253 18362917 19820115 24438588 9087549 12364791 14747013 17210077 21282665 21719571 25244985 21347285 17550304 26334808 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 18560591 18288436 18057021 12471440 10731137 12537569 21694722 21875999 22048023 25310983 24508170 30249741 28648823 20075255 28004739
25830018 25348373 24845553 24495485 25315136 26108605 29403074 17994087 20798317 15632085 23185243 25401762 26823975 20920257 23761445 17510324 26483478 20966253 18362917 19820115 24438588 9087549 12364791 14747013 17210077 21282665 21719571 25244985 21347285 17550304 26334808 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 18560591 18288436 18057021 12471440 10731137 12537569 21694722 21875999 22048023 25310983 24508170 30249741 28648823 20075255 28004739
EMBL
ODYU01001750
SOQ38378.1
NWSH01000054
PCG80153.1
AGBW02013164
OWR43924.1
+ More
KQ461195 KPJ06666.1 GAIX01003884 JAA88676.1 GU073311 ADE75588.1 KQ459596 KPI95474.1 AY461709 AAR97571.1 EZ424097 ADD20373.1 JXJN01009055 GDAI01002320 JAI15283.1 GBXI01002898 JAD11394.1 GAKP01000232 JAC58720.1 GDHF01027392 GDHF01009464 GDHF01009086 GDHF01001099 JAI24922.1 JAI42850.1 JAI43228.1 JAI51215.1 AJVK01027661 GFDF01008338 JAV05746.1 KK852930 KDR13642.1 NEVH01024952 PNF16280.1 GAMC01013734 JAB92821.1 KA648182 AFP62811.1 JRES01000262 KNC32884.1 PYGN01000508 PSN45145.1 KQ761783 OAD57064.1 CVRI01000042 CRK95559.1 FX985652 BBA84390.1 KQ414654 KOC65883.1 KQ434998 KZC13345.1 CH902632 EDV32811.1 LJIG01022751 KRT78910.1 GL448228 EFN85097.1 CP012528 ALC48493.1 GL435537 EFN73227.1 GECU01031530 GECU01020966 JAS76176.1 JAS86740.1 OUUW01000003 SPP77875.1 CH479192 EDW26583.1 CH379063 EAL32695.1 KRT06251.1 GEBQ01027977 JAT12000.1 CH916371 EDV92441.1 GBHO01013087 GBRD01010598 GDHC01018362 JAG30517.1 JAG55226.1 JAQ00267.1 ADMH02002044 ETN59784.1 CH477259 EAT45735.1 JXUM01145008 KQ569902 KXJ68490.1 KQ971312 EEZ98489.1 ATLV01013150 KE524842 KFB37358.1 GALX01002072 JAB66394.1 APCN01002042 KQ982080 KYQ60251.1 AAAB01008987 AAAB01007362 EAA01221.5 EAA02931.4 GECL01001837 JAP04287.1 CH954183 EDV45635.1 AXCN02000017 KQ981490 KYN41268.1 KQ979999 KYN18298.1 GL762454 EFZ21306.1 GL888292 EGI63050.1 KQ976401 KYM92306.1 ADTU01013602 ADTU01013603 CH963851 EDW75105.1 CM000162 EDX01359.1 UFQT01000038 SSX18434.1 GGFJ01007555 MBW56696.1 GFTR01005244 JAW11182.1 GBGD01002052 JAC86837.1 CCAG010006531 AE014298 AFH07217.1 EU670499 EU670500 EU670501 EU670502 CM000366 ACD56175.1 ACD56176.1 ACD56177.1 ACD56178.1 EDX16944.1 EU310367 EU310368 EU310369 EU310370 EU310371 ABY55475.1 ABY55476.1 ABY55477.1 ABY55478.1 ABY55479.1 CH933811 EDW06513.1 KRG07005.1 KRG07006.1 EU670523 EU670524 CH480825 ACD56179.1 ACD56180.1 EDW43997.1 AF233288 AL138972 AY118386 KK856547 PTY25998.1 CH940653 EDW62659.1 KRF80754.1 KRF80755.1 GFDL01014211 JAV20834.1 KK107260 QOIP01000001 EZA54175.1 RLU27624.1 NNAY01002098 OXU22091.1 AAZX01006344 GEZM01102903 JAV51734.1 GGLE01000359 MBY04485.1 GECZ01020209 JAS49560.1 GEDC01019332 JAS17966.1 JH431327
KQ461195 KPJ06666.1 GAIX01003884 JAA88676.1 GU073311 ADE75588.1 KQ459596 KPI95474.1 AY461709 AAR97571.1 EZ424097 ADD20373.1 JXJN01009055 GDAI01002320 JAI15283.1 GBXI01002898 JAD11394.1 GAKP01000232 JAC58720.1 GDHF01027392 GDHF01009464 GDHF01009086 GDHF01001099 JAI24922.1 JAI42850.1 JAI43228.1 JAI51215.1 AJVK01027661 GFDF01008338 JAV05746.1 KK852930 KDR13642.1 NEVH01024952 PNF16280.1 GAMC01013734 JAB92821.1 KA648182 AFP62811.1 JRES01000262 KNC32884.1 PYGN01000508 PSN45145.1 KQ761783 OAD57064.1 CVRI01000042 CRK95559.1 FX985652 BBA84390.1 KQ414654 KOC65883.1 KQ434998 KZC13345.1 CH902632 EDV32811.1 LJIG01022751 KRT78910.1 GL448228 EFN85097.1 CP012528 ALC48493.1 GL435537 EFN73227.1 GECU01031530 GECU01020966 JAS76176.1 JAS86740.1 OUUW01000003 SPP77875.1 CH479192 EDW26583.1 CH379063 EAL32695.1 KRT06251.1 GEBQ01027977 JAT12000.1 CH916371 EDV92441.1 GBHO01013087 GBRD01010598 GDHC01018362 JAG30517.1 JAG55226.1 JAQ00267.1 ADMH02002044 ETN59784.1 CH477259 EAT45735.1 JXUM01145008 KQ569902 KXJ68490.1 KQ971312 EEZ98489.1 ATLV01013150 KE524842 KFB37358.1 GALX01002072 JAB66394.1 APCN01002042 KQ982080 KYQ60251.1 AAAB01008987 AAAB01007362 EAA01221.5 EAA02931.4 GECL01001837 JAP04287.1 CH954183 EDV45635.1 AXCN02000017 KQ981490 KYN41268.1 KQ979999 KYN18298.1 GL762454 EFZ21306.1 GL888292 EGI63050.1 KQ976401 KYM92306.1 ADTU01013602 ADTU01013603 CH963851 EDW75105.1 CM000162 EDX01359.1 UFQT01000038 SSX18434.1 GGFJ01007555 MBW56696.1 GFTR01005244 JAW11182.1 GBGD01002052 JAC86837.1 CCAG010006531 AE014298 AFH07217.1 EU670499 EU670500 EU670501 EU670502 CM000366 ACD56175.1 ACD56176.1 ACD56177.1 ACD56178.1 EDX16944.1 EU310367 EU310368 EU310369 EU310370 EU310371 ABY55475.1 ABY55476.1 ABY55477.1 ABY55478.1 ABY55479.1 CH933811 EDW06513.1 KRG07005.1 KRG07006.1 EU670523 EU670524 CH480825 ACD56179.1 ACD56180.1 EDW43997.1 AF233288 AL138972 AY118386 KK856547 PTY25998.1 CH940653 EDW62659.1 KRF80754.1 KRF80755.1 GFDL01014211 JAV20834.1 KK107260 QOIP01000001 EZA54175.1 RLU27624.1 NNAY01002098 OXU22091.1 AAZX01006344 GEZM01102903 JAV51734.1 GGLE01000359 MBY04485.1 GECZ01020209 JAS49560.1 GEDC01019332 JAS17966.1 JH431327
Proteomes
UP000218220
UP000007151
UP000053240
UP000053268
UP000092443
UP000078200
+ More
UP000092460 UP000092445 UP000091820 UP000092462 UP000027135 UP000235965 UP000095301 UP000037069 UP000095300 UP000245037 UP000183832 UP000053825 UP000076502 UP000007801 UP000008237 UP000092553 UP000000311 UP000268350 UP000008744 UP000001819 UP000069272 UP000001070 UP000000673 UP000008820 UP000069940 UP000249989 UP000076407 UP000075903 UP000075882 UP000007266 UP000030765 UP000075840 UP000075901 UP000075809 UP000007062 UP000075920 UP000192221 UP000075885 UP000008711 UP000075886 UP000078541 UP000078492 UP000075884 UP000007755 UP000078540 UP000076408 UP000075881 UP000005205 UP000007798 UP000002282 UP000092444 UP000000803 UP000000304 UP000009192 UP000001292 UP000075880 UP000008792 UP000053097 UP000279307 UP000215335 UP000002358 UP000075900
UP000092460 UP000092445 UP000091820 UP000092462 UP000027135 UP000235965 UP000095301 UP000037069 UP000095300 UP000245037 UP000183832 UP000053825 UP000076502 UP000007801 UP000008237 UP000092553 UP000000311 UP000268350 UP000008744 UP000001819 UP000069272 UP000001070 UP000000673 UP000008820 UP000069940 UP000249989 UP000076407 UP000075903 UP000075882 UP000007266 UP000030765 UP000075840 UP000075901 UP000075809 UP000007062 UP000075920 UP000192221 UP000075885 UP000008711 UP000075886 UP000078541 UP000078492 UP000075884 UP000007755 UP000078540 UP000076408 UP000075881 UP000005205 UP000007798 UP000002282 UP000092444 UP000000803 UP000000304 UP000009192 UP000001292 UP000075880 UP000008792 UP000053097 UP000279307 UP000215335 UP000002358 UP000075900
Interpro
SUPFAM
SSF50978
SSF50978
Gene 3D
ProteinModelPortal
A0A2H1VC02
A0A2A4K8L8
A0A212ER47
A0A194QT01
S4P951
E3SRH1
+ More
A0A194PRU8 Q6SA00 D3TRP5 A0A1A9XLP7 A0A1A9VUG0 A0A1B0B6C7 A0A1B0AC46 A0A1A9W6A9 A0A0K8TMA9 A0A0A1XJ75 A0A034WX03 A0A0K8WK50 A0A1B0D8Q7 A0A1L8DH23 A0A067QUB7 A0A2J7PIW3 W8BHV0 T1PH81 A0A0L0CN91 A0A1I8P2X3 A0A2P8YLL1 A0A310SFZ6 A0A1J1I5E3 A0A347ZJ84 A0A0L7R4W3 A0A154PN95 B3MYW7 A0A0T6AVT7 E2BGW5 A0A0M3QYY6 E2A016 A0A1B6HNC5 A0A3B0J7S4 B4GV46 Q29IF8 A0A182FKR8 A0A1B6KKN2 B4JNZ8 A0A0A9YBQ7 W5JAH1 Q17GJ0 A0A182G529 A0A182XBA2 A0A182UNE3 A0A182LH35 D6W9F7 A0A084VHB4 V5GQH4 A0A2C9GRK6 A0A182T1G7 A0A151XIT6 Q7PCU7 A0A182VZ26 A0A1W4V9W6 A0A0V0GA59 A0A182PRJ6 B3P930 A0A182QPS3 A0A195FLH6 A0A195DZJ9 E9IDG7 A0A182NCG3 F4WRP3 A0A195BWG4 A0A182XVY5 A0A182K8M1 A0A158NEQ1 B4MSL6 B4Q0Z2 A0A336LJS1 A0A2M4BUD7 A0A224XRL4 A0A069DT50 A0A1B0GB34 M9NDM4 B2ZIA8 B0FE79 B4L5Q4 B2ZID2 Q9V3J8 A0A182J7U2 A0A2R7X2H6 A0A158NEQ2 B4M792 A0A1Q3EZW2 A0A026WDK9 A0A232EUR5 K7JA87 A0A1Y1JRA1 A0A2R5L4T2 A0A1B6FHA2 A0A1B6CWV9 T1IR12 A0A1I8JUD6
A0A194PRU8 Q6SA00 D3TRP5 A0A1A9XLP7 A0A1A9VUG0 A0A1B0B6C7 A0A1B0AC46 A0A1A9W6A9 A0A0K8TMA9 A0A0A1XJ75 A0A034WX03 A0A0K8WK50 A0A1B0D8Q7 A0A1L8DH23 A0A067QUB7 A0A2J7PIW3 W8BHV0 T1PH81 A0A0L0CN91 A0A1I8P2X3 A0A2P8YLL1 A0A310SFZ6 A0A1J1I5E3 A0A347ZJ84 A0A0L7R4W3 A0A154PN95 B3MYW7 A0A0T6AVT7 E2BGW5 A0A0M3QYY6 E2A016 A0A1B6HNC5 A0A3B0J7S4 B4GV46 Q29IF8 A0A182FKR8 A0A1B6KKN2 B4JNZ8 A0A0A9YBQ7 W5JAH1 Q17GJ0 A0A182G529 A0A182XBA2 A0A182UNE3 A0A182LH35 D6W9F7 A0A084VHB4 V5GQH4 A0A2C9GRK6 A0A182T1G7 A0A151XIT6 Q7PCU7 A0A182VZ26 A0A1W4V9W6 A0A0V0GA59 A0A182PRJ6 B3P930 A0A182QPS3 A0A195FLH6 A0A195DZJ9 E9IDG7 A0A182NCG3 F4WRP3 A0A195BWG4 A0A182XVY5 A0A182K8M1 A0A158NEQ1 B4MSL6 B4Q0Z2 A0A336LJS1 A0A2M4BUD7 A0A224XRL4 A0A069DT50 A0A1B0GB34 M9NDM4 B2ZIA8 B0FE79 B4L5Q4 B2ZID2 Q9V3J8 A0A182J7U2 A0A2R7X2H6 A0A158NEQ2 B4M792 A0A1Q3EZW2 A0A026WDK9 A0A232EUR5 K7JA87 A0A1Y1JRA1 A0A2R5L4T2 A0A1B6FHA2 A0A1B6CWV9 T1IR12 A0A1I8JUD6
PDB
5M25
E-value=3.21913e-168,
Score=1518
Ontologies
GO
GO:0003743
GO:0008137
GO:0016021
GO:0005739
GO:0042393
GO:0005634
GO:0051568
GO:0048188
GO:0001654
GO:0005671
GO:0007482
GO:0004402
GO:0044666
GO:0032436
GO:0006338
GO:0044545
GO:0016573
GO:0044665
GO:0005515
GO:0005891
GO:0005216
GO:0006811
GO:0016020
GO:0005509
GO:0050793
GO:0003676
GO:0016876
GO:0043039
PANTHER
Topology
Subcellular location
Nucleus
Length:
346
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.001
Exp number, first 60 AAs:
0
Total prob of N-in:
0.00122
outside
1 - 346
Population Genetic Test Statistics
Pi
223.878201
Theta
186.451316
Tajima's D
0.606989
CLR
152.928306
CSRT
0.546322683865807
Interpretation
Uncertain
