Gene

KWMTBOMO08736

Pre Gene Modal

BGIBMGA007908

Annotation

PREDICTED:_stress-activated_map_kinase-interacting_protein_1_[Papilio_machaon]

Location

Bomo_Chr15(-):3833848-3838327      View in EpiBrowser

Full name

Stress-activated map kinase-interacting protein 1      

Location in the cell

Nuclear   Reliability : 3.775

CDS

ATGGCCACATACGACAACAAAATTTGGCTGTTGAAAAACATTAGAGATGCCTTCATAGCTACTGACGACACAGGCCTATGTGAAATTGTTATGGCAGGTGAAGATTTTTCTAAGATCTTCCAGATTAAGGGTTTAGAAGAAAAAAAAAGAATAAAAGAAGCTCGAGCGCTTCAGCCTGGAACTAGTAAAATAAGGGAAGGTGGAGACTCTTGTGAAGATTTCGAAAGAGAAATTATCACTCAATTTGAACCATATCCTGATATTGATGAAAGTGAAGATGAAGATCCCTTAGGTAGTAGCTATGTTCGATATGAAGAGTTTGGAGGTTACAGGCAGAGATCAAACACATCACAATGGTTAGACAAAAAGGAGCAGGCATTAAAAAAGGCAGCCAAAATTAAAGTAATTAAGTGGGAAGATTCATCACCACTGAGCAAGGAGCAATGTATGGAGTTATTCCCTACAGTCGAAGTTAAACCTCCAGAAAAACAAAAGTCATTATTGGCTCAGCAGCTAGAGAACTGCCCAGATCTACCTCATCGTCAGTATCTGGAGTATGGAAAGTTTGATGGCACAGCACAACTAGGATTACAAACAAAATGCTTTAAGATCTTTATGACGATGCTCTCGGAAAAACATCAAAATTATCCATTAGTTGTGTGTGTGATTGCTAGTGCCAAGATCAAAGATTTGATTGGTTTTACATGCTATAAATACAGCATTGAACATCCTGAAATTAGTCTTGGCTCTGTGCATGAATATGGACTTTGTATAGCGGAAGATGATGGAGAAGTTGACTGGGCGTTCCCATGCCTCGATGCCAACGAACCATGCTCAAAGTTTGGCTTCACATGTTTAGGACTTATTGAGTTAAAAAACAAGAAATCATTTAACAGTCCTCCAATCCCAATGCCCGATGACGGTCATGTGTTTCATTTATTTCCCAAAATGACCGACTCTGGACAAAGTCACAATAATCCATCTAGACACAATACAGGTGGAAGTCAAACTTCAGAAGCTGTTATAAGTGCATTAAGGGCTGTTAATGAAGAGAAAAAAAGCAGTGAAGATGCAAACCTAGAAAAGATTCAGTGTCATATAATGGCCACAGAAGCACCACAGTATAAATCATATAAAGTGCAATTATTAAGGAAAGTACGAACTAACACTTCTGTACAACTTGGCATCTCATTAGATAGAATAGAAATTGAACCTTTAGTTACTCATAAACATGTATTTTGGTCAAATTCTAGGTCAAAATATTTTTTACACAGCATAGAGTCTGTAGCTTGGTGTCAAATCCTTGAAACACGAGGATACAGGACTACGTTCAGAATAGTTTACTCGCCAAGTCAGAAAAATAATTCAGCCTTAGATAAAAACGCATCAGAACATGCAGGATACTCTCATTTGCACACAACCTACAAATATCATGATTTTGAAAGTGATCACGAAACAGCTAAGGAAATTGTTGAGAAAGTCAATACAATATTAGATTTACTAAACAGTTCTTGTAGACGTGAGTACAAAATATCTAAAGAAAAGAAATCGCAAACTCGAAGAAGCTTCCACACTAAACATCTTAGCTGA

Protein

MATYDNKIWLLKNIRDAFIATDDTGLCEIVMAGEDFSKIFQIKGLEEKKRIKEARALQPGTSKIREGGDSCEDFEREIITQFEPYPDIDESEDEDPLGSSYVRYEEFGGYRQRSNTSQWLDKKEQALKKAAKIKVIKWEDSSPLSKEQCMELFPTVEVKPPEKQKSLLAQQLENCPDLPHRQYLEYGKFDGTAQLGLQTKCFKIFMTMLSEKHQNYPLVVCVIASAKIKDLIGFTCYKYSIEHPEISLGSVHEYGLCIAEDDGEVDWAFPCLDANEPCSKFGFTCLGLIELKNKKSFNSPPIPMPDDGHVFHLFPKMTDSGQSHNNPSRHNTGGSQTSEAVISALRAVNEEKKSSEDANLEKIQCHIMATEAPQYKSYKVQLLRKVRTNTSVQLGISLDRIEIEPLVTHKHVFWSNSRSKYFLHSIESVAWCQILETRGYRTTFRIVYSPSQKNNSALDKNASEHAGYSHLHTTYKYHDFESDHETAKEIVEKVNTILDLLNSSCRREYKISKEKKSQTRRSFHTKHLS

Description

Component of a multiprotein complex that phosphorylates Akt1, a protein that regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.

Similarity

Belongs to the SIN1 family.

Keywords

Apoptosis   Complete proteome   Reference proteome   Phosphoprotein  

Feature

chain  Stress-activated map kinase-interacting protein 1

Uniprot

H9JEG1   A0A2A4JBN5   A0A2W1BC89   A0A2H1V063   A0A437BS25   A0A194QMA0   + More
A0A194PWE5   A0A212ERH0   A0A0L7L017   A0A195D2W1   E2B4M8   A0A151XDF6   E2AFW7   A0A026VYK2   A0A067R6T3   F4X091   A0A2A3EFP0   A0A195F6N9   A0A195AYZ3   A0A158NH39   A0A3L8DLM0   A0A154PN40   A0A232F2S9   A0A088AK07   A0A2J7Q9V4   A0A1Y1K0J9   A0A310SG33   K7IRD8   A0A0C9QPP2   A0A1Q3F155   B0W407   A0A182ISM3   A0A1B6BX00   A0A084VYE5   A0A182TN03   A0A182XDH3   Q0IG33   A0A1S4H033   A0A182UZV0   A0A2P8XXW0   A0A182KNF8   A0A2C9GS95   A0A182VU41   A0A0K8TMX3   A0A151JMQ5   A0A182G0J2   A0A182MC44   A0A182QCK7   Q7PWV9   A0A182P5W9   A0A182NUN0   A0A182K939   A0A1Y1K0I2   A0A182SD42   A0A2H8TJD3   E0W3T9   A0A1S3CUX7   A0A023F2U5   D6WD06   A0A1Y1K0I4   A0A1B6C8X3   A0A0M4M1C8   A0A2S2QP56   A0A0T6B765   T1I6Y7   A0A1B6HDH0   A0A1B6M5E6   A0A1B0AXD5   A0A1A9WMX0   A0A1A9XVH2   N6TTJ3   A0A1A9ZYC8   A0A034WFG4   A0A1A9V2E1   A0A1I8NYU0   A0A0K8W9R0   A0A1I8MIF4   Q291K8   B4GAK7   A0A1B0G3G6   B4P759   A0A224XS89   A0A3B0JUJ6   A0A0L7R550   A0A1S3J465   A0A1W4VZI1   A0A0L0BTT8   B3NR43   W8CAN7   A0A146KUD3   Q9V719   A0A1J1IRA6   B4QFH6   B4HRD1   B4MQ71   R7VC52   U4UB84   A0A0M3QVK1   J9K9Q9  

Pubmed

19121390    28756777    26354079    22118469    26227816    20798317    + More
24508170    24845553    21719571    21347285    30249741    28648823    28004739    20075255    24438588    17510324    12364791    29403074    20966253    26369729    26483478    20566863    25474469    18362917    19820115    23537049    25348373    25315136    15632085    17994087    17550304    26108605    24495485    26823975    10731132    12537572    12537569    16919458    18327897    22936249    23254933   

EMBL

BABH01003043    BABH01003044    NWSH01002176    PCG68964.1    KZ150318    PZC71434.1    + More
ODYU01000077    SOQ34227.1    RSAL01000014    RVE53244.1    KQ461195    KPJ06647.1    KQ459596    KPI95455.1    AGBW02013012    OWR44096.1    JTDY01004087    KOB68619.1    KQ976973    KYN06699.1    GL445574    EFN89381.1    KQ982294    KYQ58379.1    GL439166    EFN67674.1    KK107566    EZA48883.1    KK852703    KDR18087.1    GL888493    EGI60156.1    KZ288256    PBC30557.1    KQ981768    KYN35857.1    KQ976698    KYM77463.1    ADTU01015556    QOIP01000006    RLU21324.1    KQ434998    KZC13286.1    NNAY01001120    OXU25064.1    NEVH01016343    PNF25370.1    GEZM01096230    JAV55024.1    KQ760357    OAD60750.1    GBYB01005594    JAG75361.1    GFDL01013758    JAV21287.1    DS231834    EDS32600.1    GEDC01031759    GEDC01029770    GEDC01029188    GEDC01021837    GEDC01008051    JAS05539.1    JAS07528.1    JAS08110.1    JAS15461.1    JAS29247.1    ATLV01018363    KE525231    KFB42989.1    CH477274    EAT45179.1    AAAB01008984    PYGN01001182    PSN36837.1    APCN01003342    GDAI01001891    JAI15712.1    KQ978899    KYN27601.1    JXUM01000171    KQ560102    KXJ84552.1    AXCM01000044    AXCM01000045    AXCN02000732    AXCN02000733    EAA14845.5    GEZM01096233    JAV55019.1    GFXV01002420    MBW14225.1    DS235883    EEB20295.1    GBBI01003194    JAC15518.1    KQ971311    EEZ99088.1    GEZM01096231    JAV55022.1    GEDC01027424    GEDC01020860    JAS09874.1    JAS16438.1    KR075856    ALE20575.1    GGMS01010325    MBY79528.1    LJIG01009381    KRT83193.1    ACPB03007038    GECU01034912    JAS72794.1    GEBQ01008849    JAT31128.1    JXJN01005228    APGK01055062    KB741259    ENN71696.1    GAKP01004661    JAC54291.1    GDHF01004418    JAI47896.1    CM000071    CH479181    EDW31959.1    CCAG010013345    CM000158    EDW91024.1    GFTR01005565    JAW10861.1    OUUW01000001    SPP74748.1    KQ414654    KOC65973.1    JRES01001351    KNC23421.1    CH954179    EDV56032.1    GAMC01005586    JAC00970.1    GDHC01019100    JAP99528.1    AE013599    BT003261    CVRI01000055    CRL01041.1    CM000362    CM002911    EDX07086.1    KMY93772.1    CH480816    EDW47860.1    CH963849    EDW74260.1    AMQN01000624    KB293180    ELU16433.1    KB631924    ERL87225.1    CP012524    ALC42533.1    ABLF02030203   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000007151    + More
UP000037510    UP000078542    UP000008237    UP000075809    UP000000311    UP000053097    UP000027135    UP000007755    UP000242457    UP000078541    UP000078540    UP000005205    UP000279307    UP000076502    UP000215335    UP000005203    UP000235965    UP000002358    UP000002320    UP000075880    UP000030765    UP000075902    UP000076407    UP000008820    UP000075903    UP000245037    UP000075882    UP000075840    UP000075920    UP000078492    UP000069940    UP000249989    UP000075883    UP000075886    UP000007062    UP000075885    UP000075884    UP000075881    UP000075901    UP000009046    UP000079169    UP000007266    UP000015103    UP000092460    UP000091820    UP000092443    UP000019118    UP000092445    UP000078200    UP000095300    UP000095301    UP000001819    UP000008744    UP000092444    UP000002282    UP000268350    UP000053825    UP000085678    UP000192221    UP000037069    UP000008711    UP000000803    UP000183832    UP000000304    UP000001292    UP000007798    UP000014760    UP000030742    UP000092553    UP000007819   

PRIDE

H9JEG1    Q291K8    Q9V719   

Pfam

PF16979   SIN1_PH        + More
PF05422   SIN1
PF16978   CRIM
PF12872   OST-HTH
PF00567   TUDOR
PF12215   Glyco_hydr_116N

Interpro

IPR031313   Sin1_PH_dom        + More
IPR011993   PH-like_dom_sf       
IPR032679   Sin1_N       
IPR031567   CRIM_dom       
IPR002999   Tudor       
IPR041966   LOTUS-like       
IPR025605   OST-HTH/LOTUS_dom       
IPR035437   SNase_OB-fold_sf       
IPR024462   GH116_N       

Gene 3D

2.30.29.30     1.10.10.1880     2.40.50.90    

ProteinModelPortal

H9JEG1   A0A2A4JBN5   A0A2W1BC89   A0A2H1V063   A0A437BS25   A0A194QMA0   + More
A0A194PWE5   A0A212ERH0   A0A0L7L017   A0A195D2W1   E2B4M8   A0A151XDF6   E2AFW7   A0A026VYK2   A0A067R6T3   F4X091   A0A2A3EFP0   A0A195F6N9   A0A195AYZ3   A0A158NH39   A0A3L8DLM0   A0A154PN40   A0A232F2S9   A0A088AK07   A0A2J7Q9V4   A0A1Y1K0J9   A0A310SG33   K7IRD8   A0A0C9QPP2   A0A1Q3F155   B0W407   A0A182ISM3   A0A1B6BX00   A0A084VYE5   A0A182TN03   A0A182XDH3   Q0IG33   A0A1S4H033   A0A182UZV0   A0A2P8XXW0   A0A182KNF8   A0A2C9GS95   A0A182VU41   A0A0K8TMX3   A0A151JMQ5   A0A182G0J2   A0A182MC44   A0A182QCK7   Q7PWV9   A0A182P5W9   A0A182NUN0   A0A182K939   A0A1Y1K0I2   A0A182SD42   A0A2H8TJD3   E0W3T9   A0A1S3CUX7   A0A023F2U5   D6WD06   A0A1Y1K0I4   A0A1B6C8X3   A0A0M4M1C8   A0A2S2QP56   A0A0T6B765   T1I6Y7   A0A1B6HDH0   A0A1B6M5E6   A0A1B0AXD5   A0A1A9WMX0   A0A1A9XVH2   N6TTJ3   A0A1A9ZYC8   A0A034WFG4   A0A1A9V2E1   A0A1I8NYU0   A0A0K8W9R0   A0A1I8MIF4   Q291K8   B4GAK7   A0A1B0G3G6   B4P759   A0A224XS89   A0A3B0JUJ6   A0A0L7R550   A0A1S3J465   A0A1W4VZI1   A0A0L0BTT8   B3NR43   W8CAN7   A0A146KUD3   Q9V719   A0A1J1IRA6   B4QFH6   B4HRD1   B4MQ71   R7VC52   U4UB84   A0A0M3QVK1   J9K9Q9  

PDB

5ZCS     E-value=1.33752e-32,     Score=350

KEGG

101741071    K20410 target of rapamycin complex 2 subunit MAPKAP1 | (RefSeq) stress-activated map kinase-interact

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016301   GO:0038203   GO:0005737   GO:0005546   GO:0031932   GO:0005886   GO:0030950   GO:0046628   GO:0006915   GO:0034063   GO:0071902   GO:0048813   GO:0051897   GO:0045887   GO:0032869   GO:0019901   GO:0001932   GO:0001934   GO:0004168   GO:0016021   GO:0043048  

Length:

529

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00677999999999999

Exp number, first 60 AAs:

0.00098

Total prob of N-in:

0.00425

outside

1  -  529

 

 

Pi

261.121926

Theta

180.744735

Tajima's D

1.38859

CLR

1.577154

CSRT

0.76161191940403

Interpretation

Uncertain