Gene

KWMTBOMO08688  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007928

Annotation

PREDICTED:_neuropathy_target_esterase_sws_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr15(-):2501931-2523551      View in EpiBrowser

Full name

Neuropathy target esterase sws      

Alternative Name

Swiss cheese

Location in the cell

Mitochondrial   Reliability : 1.467

CDS

ATGGTGACGCAGACTCGTCGGAGCACAACGGTGATGGCGGTGCGGGACTCGGAACTGGCGAAGCTGCCCGAAGGCCTCTTCAACGCCATCAAGCTGAGGTTCCCGGTCGTCGTGACTAGGCTGATCAACTTGCTGGGACATAGGATTCTAGGTTCCTGGCAGAAGCCGACGCGGAGTCTGGGCGGCGCGCCCGCGATCGACTCGAGGCCGTTGCAGCACAACTTCAGCACGGTGGCCGTGGTGCCCGTCAGCGACGACGTGCCCCTCACCGCCTTCACCTACGAGCTGTACCACTCGCTCTGCGCCATAGGTCCAACGGTCCGTCTCACTTCGGATGTCATAAGGAAACTGCTCGGTCTAACGATAATGGACCCGAATAACGAGTACAGACTAAGCTCTTGGCTGGCGCAACAAGAAGATAAACACAAGGTGGCGCTGTACCAGTGCGACCCGAGCCTCACGCAGTGGACGCAGCGCTGTATCCGGCAGGCCGACTGCATACTGATCGTGGCGCTCGGCGACAAGCAGCCCAGCATCGGGAAGATCGAGAAGGAAATCGAACGTCTAGCCATACGAACTCAGAAGGAGCTAGTTCTTCTGCACCGGGAGGGCGGACCGAACCCCTCCGGCACCGTGCACTGGCTCAACATGCGCACCTGGGTCAGCCAGCACCACCACGTGAGGTGTCCGCATCGAATGTTCACAAGGAAAAGCCAGTACCGGATTAGCGAGCTGTACAGCAAGGTGCTGATGTCTGAGGCCAACGTGCACTCGGACTTCAGTCGGCTGGCGCGCTGGCTCACCGCCACCGCCGTGGGGCTGGTGCTGGGGGGCGGAGGCGCGCGGGGGGCGGCGCACGTCGGCATGATCCGCGCCATACAGGAAGCAGGAATCCCAATAGATATGGTGGGGGGCGTCAGCATCGGCGCGTTTATGGGCGCCTTGTGGTGCATGGAGAGGAACATCACCACTGTCACGCAGAAGGCCAGGGAATGGTCCAAGAAAATGACGCAATGGGGTAGGCAGCTTCTAGACTTGACGTACCCAGCCACGTCGATGTTCTCCGGGCGACAGTTCAATGCCACCATCAGGGCGACGTTTGGCGAGGTTCACATCGAGGACCTGTGGCTGCCATACTTCACTGTCACCACTGACATTAGTTCCAGTTGCATGAGAATCCACAGGCACGGTTCGCTGTGGCGCTACATACGCGCTTCGATGTCGCTGAGCGGATACATGCCCCCGTTGTGCGACCCGGTAGACGGCCACCTCCTATTGGACGGCGGTTACGTCAACAACCTGCCAGCTGACGTTATGAGGTCTTTGGGAGCGAAACACATATTGGCCATCGACGTTGGATCTCAAGATGATACAGATCTAACGAACTACGGAGACGACTTGTCGGGCTGGTGGTTGCTCTGGAAAAGATGGAACCCGTTCACGACGCCGGTCAAAGTTCCCAATCTTCCCGACATACAGAGTCGATTGGCTTACGTGTCTTGCAACAGACAGTTGGAGGAAGTGAAGAAATCGGATTACTGCGAATACATCCGTCCCCCGATCGACGCGTACAAGACGCTGCAGTTCGGCTCGTTCGACGAGATACGCGAGGTCGGCTACCGGCACGGCGCCGCCTACTTCGAGGGGCAGCGGCGCGGCGGGGGCGGGGGGGTCAGCGGGGCCGCCGCCTCCGACCGCAAGGGACCCGAGCAGCAACCGGCGCTCACCGATTATACGTTCACGGACTTAGCTCAGATGGTGTGCTCGGTCCGCACCGGTCGCGACGCCGACAACGATTCCTCCTCGTCTTCAGACTACGAGGAGGATCAGAGGCACTTCGAGGGGTACGCCAGCGAGCCCAGCGCTGGGATACTGGAGGAGGGTATAAGGGCCCGACGCGTGGGAGGGTCCCTCTCGCTGTCGGAGGACGAGGTCGACTCGGAGGCGGAGGTGTACGATCCGCTGAACAAGCGCGGCTCGAGCAGATGA

Protein

MVTQTRRSTTVMAVRDSELAKLPEGLFNAIKLRFPVVVTRLINLLGHRILGSWQKPTRSLGGAPAIDSRPLQHNFSTVAVVPVSDDVPLTAFTYELYHSLCAIGPTVRLTSDVIRKLLGLTIMDPNNEYRLSSWLAQQEDKHKVALYQCDPSLTQWTQRCIRQADCILIVALGDKQPSIGKIEKEIERLAIRTQKELVLLHREGGPNPSGTVHWLNMRTWVSQHHHVRCPHRMFTRKSQYRISELYSKVLMSEANVHSDFSRLARWLTATAVGLVLGGGGARGAAHVGMIRAIQEAGIPIDMVGGVSIGAFMGALWCMERNITTVTQKAREWSKKMTQWGRQLLDLTYPATSMFSGRQFNATIRATFGEVHIEDLWLPYFTVTTDISSSCMRIHRHGSLWRYIRASMSLSGYMPPLCDPVDGHLLLDGGYVNNLPADVMRSLGAKHILAIDVGSQDDTDLTNYGDDLSGWWLLWKRWNPFTTPVKVPNLPDIQSRLAYVSCNRQLEEVKKSDYCEYIRPPIDAYKTLQFGSFDEIREVGYRHGAAYFEGQRRGGGGGVSGAAASDRKGPEQQPALTDYTFTDLAQMVCSVRTGRDADNDSSSSSDYEEDQRHFEGYASEPSAGILEEGIRARRVGGSLSLSEDEVDSEAEVYDPLNKRGSSR

Description

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain.

Catalytic Activity

a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H(+) + sn-glycerol 3-phosphocholine

Subunit

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.

Similarity

Belongs to the NTE family.

Keywords

Alternative splicing   Complete proteome   Developmental protein   Endoplasmic reticulum   Hydrolase   Lipid degradation   Lipid metabolism   Membrane   Neurogenesis   Phosphoprotein   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Neuropathy target esterase sws
splice variant  In isoform B.

Uniprot

H9JEI1   A0A3S2MAJ0   D6W9Q7   A0A026WPN4   A0A3L8DN19   E2BKL4   + More
K7IQ10   A0A2J7QV86   A0A2J7QV89   A0A1B6CYY3   E2A0X2   A0A154PJP7   A0A067RS17   A0A158NV62   A0A0L7R5B4   A0A088ACE8   A0A195BQH0   A0A310SL74   A0A195CH99   A0A1Y1MJ22   A0A1Y1MMU8   A0A0C9RHG8   A0A1Y1MJ32   A0A151JN95   A0A1Y1MJA9   A0A1Y1MPB8   A0A151XE85   F4W4X6   A0A232F867   A0A2H1W600   A0A1B6F290   Q16I35   B0W7V2   A0A1Q3FE81   A0A023F3T3   A0A0V0G706   A0A0A9XBN8   A0A0A9XIY4   A0A224XEX9   A0A069DWW5   A0A0A1XGU3   A0A1I8M443   A0A0K8V7Q6   T1HIF7   A0A034V8P2   T1PMW0   A0A0N7Z8B7   A0A1I8P2Y4   A0A084VLT2   A0A1J1IYU6   A0A182MPR2   A0A1L8DZF0   A0A336MD57   A0A182PFX8   Q9U969   A0A0R3P339   A0A0R1EJ12   A0A0R3NY08   A0A0R3NYB8   A0A0Q5TGH0   A0A182XDV8   A0A1S4G951   A0A0Q5TKA4   A0A1W4VIK0   Q7PRV7   A0A1I8M435   A0A0Q9WTH0   A0A182U619   A0A1J1IVY4   A0A0P8XK54   A0A1I8P2X7   W8APK1   A0A182W5J3   Q9U969-3   A0A0R1EB53   E1JJF4   E0VWM1   A0A0Q9W766   A0A1W4VWL3   A0A3B0JY38   A0A0Q9XNK5   I6TQD9   A0A0P8XJV1   A0A2S2NHV6   A0A182FJG4   W5JW82   A0A2M3ZG82   A0A2M4AA44   A0A2M4A6K6   A0A2M4AIR1   A0A0P6D011   A0A0N8E5X3   A0A0P6EES6   A0A087T7D2   A0A0P5TJ89   A0A0P5VMZ6   A0A0P5I455   A0A0N8BYJ2   A0A0P4XIS7   A0A0P6BYK3  

Pubmed

19121390    18362917    19820115    24508170    30249741    20798317    + More
20075255    24845553    21347285    28004739    21719571    28648823    17510324    25474469    25401762    26823975    26334808    25830018    25315136    25348373    27129103    24438588    9295388    10731132    12537572    12537569    15772346    18945896    18327897    15632085    17994087    17550304    23185243    12364791    24495485    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20566863    20920257    23761445   

EMBL

BABH01003155    RSAL01000001    RVE55177.1    KQ971312    EEZ98531.2    KK107135    + More
EZA58017.1    QOIP01000006    RLU21676.1    GL448819    EFN83712.1    NEVH01010478    PNF32498.1    PNF32499.1    GEDC01018845    GEDC01013659    JAS18453.1    JAS23639.1    GL435626    EFN73025.1    KQ434923    KZC11508.1    KK852460    KDR23520.1    ADTU01026908    ADTU01026909    ADTU01026910    KQ414654    KOC66038.1    KQ976424    KYM88209.1    KQ760132    OAD61817.1    KQ977827    KYM99458.1    GEZM01030135    GEZM01030129    JAV85792.1    GEZM01030133    JAV85795.1    GBYB01006371    JAG76138.1    GEZM01030128    JAV85802.1    KQ978850    KYN27955.1    GEZM01030136    JAV85791.1    GEZM01030138    GEZM01030132    JAV85796.1    KQ982254    KYQ58682.1    GL887596    EGI70672.1    NNAY01000723    OXU26792.1    ODYU01006561    SOQ48510.1    GECZ01025400    JAS44369.1    CH478114    EAT33921.1    DS231855    EDS38246.1    GFDL01009172    JAV25873.1    GBBI01002661    JAC16051.1    GECL01002914    JAP03210.1    GBHO01026548    GBRD01007579    JAG17056.1    JAG58242.1    GBHO01026549    GBRD01007580    GDHC01009539    JAG17055.1    JAG58241.1    JAQ09090.1    GFTR01008088    JAW08338.1    GBGD01000534    JAC88355.1    GBXI01004115    JAD10177.1    GDHF01017352    JAI34962.1    ACPB03001249    GAKP01021029    JAC37923.1    KA650107    AFP64736.1    GDKW01003795    JAI52800.1    ATLV01014551    KE524974    KFB38926.1    CVRI01000063    CRL04334.1    AXCM01003763    GFDF01002287    JAV11797.1    UFQT01000668    SSX26327.1    Z97187    AE014298    BT030819    AY061431    CH379063    KRT05973.1    CM000162    KRK06711.1    KRT05974.1    KRT05975.1    KRT05972.1    CH954180    KQS30549.1    AAAB01008846    KQS30548.1    EAA06510.6    CH963925    KRF98861.1    CRL04335.1    CH902622    KPU75112.1    GAMC01018608    JAB87947.1    KRK06712.1    BT133162    AAN09222.2    AEZ02855.1    DS235822    EEB17777.1    CH940653    KRF80723.1    OUUW01000003    SPP78276.1    CH933811    KRG06868.1    JN989963    AFM78641.1    KPU75113.1    GGMR01004120    MBY16739.1    ADMH02000256    ETN67229.1    GGFM01006826    MBW27577.1    GGFK01004291    MBW37612.1    GGFK01003106    MBW36427.1    GGFK01007342    MBW40663.1    GDIP01007524    JAM96191.1    GDIQ01058684    JAN36053.1    GDIQ01064339    JAN30398.1    KK113780    KFM61021.1    GDIP01125524    JAL78190.1    GDIP01097833    JAM05882.1    GDIQ01220540    JAK31185.1    GDIQ01132323    JAL19403.1    GDIP01240620    JAI82781.1    GDIP01007525    JAM96190.1   

Proteomes

UP000005204    UP000283053    UP000007266    UP000053097    UP000279307    UP000008237    + More
UP000002358    UP000235965    UP000000311    UP000076502    UP000027135    UP000005205    UP000053825    UP000005203    UP000078540    UP000078542    UP000078492    UP000075809    UP000007755    UP000215335    UP000008820    UP000002320    UP000095301    UP000015103    UP000095300    UP000030765    UP000183832    UP000075883    UP000075885    UP000000803    UP000001819    UP000002282    UP000008711    UP000076407    UP000192221    UP000007062    UP000007798    UP000075902    UP000007801    UP000075920    UP000009046    UP000008792    UP000268350    UP000009192    UP000069272    UP000000673    UP000054359   

PRIDE

H9JEI1    Q9U969    E1JJF4   

Pfam

PF01734   Patatin        + More
PF00027   cNMP_binding
PF00651   BTB

Interpro

IPR001423   LysoPLipase_patatin_CS        + More
IPR002641   PNPLA_dom       
IPR016035   Acyl_Trfase/lysoPLipase       
IPR014710   RmlC-like_jellyroll       
IPR018490   cNMP-bd-like       
IPR000595   cNMP-bd_dom       
IPR000210   BTB/POZ_dom       
IPR011333   SKP1/BTB/POZ_sf       

SUPFAM

SSF52151   SSF52151        + More
SSF51206   SSF51206       
SSF54695   SSF54695       

Gene 3D

2.60.120.10    

CDD

cd00038  CAP_ED

ProteinModelPortal

H9JEI1   A0A3S2MAJ0   D6W9Q7   A0A026WPN4   A0A3L8DN19   E2BKL4   + More
K7IQ10   A0A2J7QV86   A0A2J7QV89   A0A1B6CYY3   E2A0X2   A0A154PJP7   A0A067RS17   A0A158NV62   A0A0L7R5B4   A0A088ACE8   A0A195BQH0   A0A310SL74   A0A195CH99   A0A1Y1MJ22   A0A1Y1MMU8   A0A0C9RHG8   A0A1Y1MJ32   A0A151JN95   A0A1Y1MJA9   A0A1Y1MPB8   A0A151XE85   F4W4X6   A0A232F867   A0A2H1W600   A0A1B6F290   Q16I35   B0W7V2   A0A1Q3FE81   A0A023F3T3   A0A0V0G706   A0A0A9XBN8   A0A0A9XIY4   A0A224XEX9   A0A069DWW5   A0A0A1XGU3   A0A1I8M443   A0A0K8V7Q6   T1HIF7   A0A034V8P2   T1PMW0   A0A0N7Z8B7   A0A1I8P2Y4   A0A084VLT2   A0A1J1IYU6   A0A182MPR2   A0A1L8DZF0   A0A336MD57   A0A182PFX8   Q9U969   A0A0R3P339   A0A0R1EJ12   A0A0R3NY08   A0A0R3NYB8   A0A0Q5TGH0   A0A182XDV8   A0A1S4G951   A0A0Q5TKA4   A0A1W4VIK0   Q7PRV7   A0A1I8M435   A0A0Q9WTH0   A0A182U619   A0A1J1IVY4   A0A0P8XK54   A0A1I8P2X7   W8APK1   A0A182W5J3   Q9U969-3   A0A0R1EB53   E1JJF4   E0VWM1   A0A0Q9W766   A0A1W4VWL3   A0A3B0JY38   A0A0Q9XNK5   I6TQD9   A0A0P8XJV1   A0A2S2NHV6   A0A182FJG4   W5JW82   A0A2M3ZG82   A0A2M4AA44   A0A2M4A6K6   A0A2M4AIR1   A0A0P6D011   A0A0N8E5X3   A0A0P6EES6   A0A087T7D2   A0A0P5TJ89   A0A0P5VMZ6   A0A0P5I455   A0A0N8BYJ2   A0A0P4XIS7   A0A0P6BYK3  

PDB

5FYA     E-value=4.29152e-13,     Score=183

KEGG

101741635    K14676 lysophospholipid hydrolase [EC:3.1.1.5] | (RefSeq) neuropathy target esterase sws

GO

GO:0016042   GO:0004622   GO:0046470   GO:0016021   GO:0016787   GO:0005789   GO:0034236   GO:0061024   GO:0005737   GO:0034349   GO:0072657   GO:0006643   GO:0006644   GO:2000480   GO:0051402   GO:0007272   GO:0007608   GO:0045494   GO:0005886   GO:0005783   GO:0008152   GO:0006629   GO:0007219   GO:0007275   GO:0050793   GO:0003676   GO:0016876   GO:0043039  

Subcellular location

Endoplasmic reticulum membrane  

Length:

662

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

11.2222

Exp number, first 60 AAs:

0.08085

Total prob of N-in:

0.27593

outside

1  -  662

 

 

Pi

279.626998

Theta

176.966218

Tajima's D

1.821376

CLR

0.562272

CSRT

0.850157492125394

Interpretation

Uncertain