Gene

KWMTBOMO08685

Pre Gene Modal

BGIBMGA007929

Annotation

Notch_homolog_[Bombyx_mori]

Location

Bomo_Chr15(-):2293278-2352911      View in EpiBrowser

Full name

Neurogenic locus Notch protein      

Location in the cell

Extracellular   Reliability : 3.102

CDS

ATGATTGTCTTTTGTTTCAGCTGCACCACAAGATACGCCGGTGAATTCTGCCAACACCTAAACCCTTGTCATAGCGAGTCGAGCTCGAGATGCCAGAATGGCGGTACTTGTCGCGTCAGACCCGGAGTCGGCGGCGGCCCCCCGTCTTTCGCCTGTGATTGTCCCTTGGGGTTCAGCGCTTCGTTATGCGAGATCAGAGTACCAGCAGCATGCGACTCTGCGCCTTGCCTTAATGGAGCCACGTGTCGGCTCACCTCTATTGAGACCTACGAGTGTGATTGCCCTCCTGGATACACAGGTGTCGAATGCTCGCACGAAGACCATTGTGCATCTCAGCCATGCCGTAACGGAGGACGTTGTGTAGCTGACAACACGACCGCGGCCGGCTACTCCTGCGTCTGTCCACCTGGCTTTACTGGCTCTCGATGCACGGAAGACGTTGTCGAATGCTCAAGCGGCTCTGGTCCATGTCACCACGGTAGATGCTTCAACACCCACGGCTCATATACGTGCGTTTGTGAACCTGGGTATACGGGAAGAGACTGTGATGCGGAGTATGTTCCTTGTGAGCCGTCTCCCTGTCTTCATGATGGAAGGTGCACGCCGTTGGATCAACTCCGATACGAATGTGATTGTCCGCCAGGATACCGCGGCCAGAACTGCGAGATTGACATCGACGATTGCCCCGGACATTTGTGCCAGAACGGAGCGAGCTGTATAGACGGTATTAACTCTTACACCTGCGAGTGTCCGCCCACCTTCACGGGGACCCTGTGCGAAACTGACGTCGATGAGTGCGCATTGAGGCCTCTGGTGTGCCAGAACGGTGCGACGTGTACCAACTCAGTGGGCGGATTCTCCTGCATTTGCGTCAATGGCTGGACCGGCCCCGAGTGTTCGGTCAATATAGATGATTGCGCCGGCGCTGCTTGCTTCAATGGAGCTACTTGTATCGACAGAGTGGGCGCATTCTACTGCAAATGTACTCCCGGGAAGACGGGTCTCCTGTGTCACTTGGACGACGCTTGCACTTCGAATCCTTGTCACGCGGACGCCATATGTGACACAAGCCCCATCAACGGCTCCTACACGTGCTCCTGCGCCTCCGGATACAAAGGTCTGGACTGCTCCGAGGACATCGACGAGTGCGAACAAGGTTCTCCCTGCGAGCACGACGGGATCTGCGTCAACACCCCGGGATCCTTCGCCTGTAACTGCTCGGTCGGTTTCACCGGACCCCGCTGCGAGACAAACGTCAATGAGTGCGAGAGTCACCCATGTCGGAACGACGGCTCCTGCCTGGACGACCCTGGCACGTTCAGATGCGTCTGCATGCCTGGTTTCACGGGAACTCAATGCGAGGTTGAAATCGACGAATGCGCTAACAACCCTTGTCTGAATGGAGGAGTTTGTCACGATATGATCAACGCCTTTCGATGTACCTGCGTTATTGGGTTCACGGGGGCTCGTTGTCAAGTCAACATCGACGACTGCGCGTCTAGTCCGTGCCGTAATGGCGGCACGTGCCACGACTCTATAGCTGGATACACATGCGAATGTCCCGCGGGCTATACAGGTATGTCGTGTGAGACGAACATCAATGACTGTTTGTCGGCGCCGTGTCACCGGGGCGAGTGCATCGACGGGGACAACAGCTTCACCTGCAACTGTCATCCGGGGTACACGGGCAGGGTCTGTCAGACCCAAATCAACGAGTGCGAGTCGAATCCCTGCCAGTTCGGAGGGCACTGCGAAGATTTGATCGGTGGATACCAGTGTCGCTGTAAGCCCGGTACTTCAGGGAGGAACTGTGAAATCAATGTGAACGAGTGCTACTCCAACCCTTGCAGGAACGGGGCTACGTGTATTGATGGCATCAACAGATATACCTGCGAATGTATTCCCGGTTTCACTGGACAACATTGCGAGACGAACATCAATGAATGTTTGTCAAATCCTTGCGCTAATGGCGGCAAATGTATCGATCGAATTAACGGATTCAGATGCGAATGTCCAAGAGGATACTACGATGCTAGATGCTTGTCCGATGTTAACGAGTGTGCGTCGAATCCGTGCACCAATGGCGGCTCCTGCGAGGATGGCGTCAACCAGTTCATATGCCACTGCCTTCCTGGTTACGGAGGACAACGTTGTGAACGCGATATAGATGAGTGCAGCTCGAACCCTTGTCAACACGGCGGCACTTGTCATGATCGACTGAACGCTTACAAATGCGACTGTATTCTTGGATTTACCGGCGTGAACTGCGAGACGAACATCGACGACTGCGCCGGCAACCCTTGTCTGCACGGCGGCTCGTGCATCGACCTGGTGAACGGGTACCGCTGCGTCTGCGCCCCCCCACACTCCGGACGAAACTGCGAAAACACCCTCGACCCTTGCATGCCGAACCAATGTCGTCACGGCGGGCGGTGCGTGGCGGAGGCGTCGTACGCGGAGTTCACGTGCCAGTGCCCGGTCGGGTGGACGGGCGCGCTGTGCGAGCGCGACGTGGACGAGTGCGCGGTGACGGCGCCCTGCCACAACGAGGCGACCTGCATCAACACGGAGGGCTCGTACGCGTGCCTCTGCGCCAGGGGATACGAGGGCAAGGACTGCGCCATCAACACGGACGACTGCGCATCGTTCCCGTGTCAGAACGGAGCGACATGTCTGGACAGCATCGGCGACTACAACTGTGTTTGCGCCAGCGGCTTCGCGGGCAAGCACTGCGAGGTGGACATCGACGAGTGCCAGTCGAGACCCTGCATGAACGGCGCCACTTGTAACCAGTATGTTGCGTCATACACGTGCACGTGCCCGCTTGGCTTCTCCGGCATCAACTGTCAGACCAACGACGAGGACTGCACCGAATCGAGCTGCATGAACGGAGGGACCTGTATCGACGGCATCAACTCTTACAACTGCTCCTGTCCGCCGGGGTACACCGGCTCCAATTGTCAGTTCCGCATCAACATGTGCGACAGTTCACCGTGCGACAACGGCGCGACATGTCACGATCACATCACCTACTACACATGTCACTGCCCGTATGGCTACACCGGAAAGCACTGCGAAGACTTTGTTGACTGGTGTGAGAACAATCCGTGCGAGAACGGAGCGACATGTTCGCAGAAAGGTCCCCAGTACACGTGCACCTGCGCCCCGGGATGGTCCGGGAAACTGTGCGACGTCGAAATGGTGTCTTGTAAAGATGCTTCCATCAGAAAAGGCGTAAAACTAAAGCAGCTCTGCAACAACGGCACCTGCGAAGACATCGGCAACTCTCATCGTTGTCACTGTCAGGACGGCTACACCGGCTCCTACTGCCAGAAGGATATTAACGAATGCGAATCCGCTCCTTGTCAGAACGGAGCTCTCTGCAAGGATCTCGTCGGAACTTACCAGTGTCAATGCGCCAAAGGTTTCCAAGGACAGAACTGCGAGCTCAACGTCAACGACTGCCTGCCGAACCCGTGCCAAAACGGAGGAACATGCCACGATCTCATCAACAACTTCTCATGCTCCTGCCCTTTCGGCACTTTGGGGAAGATATGCGAAATAAACGTTAACGATTGCAAACAAGATGCGTGTCATAACAACGGCACTTGCATCGACAGAGTCGGCGGCTTCGAGTGCAAGTGTCCGCCCGGCTTCGTCGGACCGAGGTGTGAAGGCGACATCAACGAGTGCCTCTCGAACCCTTGCTCGCTGCCCGGTACACAAGACTGCGTGCAACTCATCAATGACTATCACTGCAACTGCAAACCCGGGTACATGGGAAGGCACTGCGATGCCAAAGTCAACTTCTGCGCTAACTCGCCCTGTCAAAATGGCGGCATATGCACCGCTATACAGGGTGGCCACGAATGCTTGTGTAACGAAGGCTTTTACGGGAATAACTGCGAATATTCAGGCTACGCTTGCGATTCGAATCCGTGTCAAAACGGTGGATACTGCCACACTTCCCAAATAGGAGGATACGCGTGTGAATGTCCGTTGGGATTGTCCGGTGTCAGCTGCGAAATAGATTCAATGAACGAATGCTTGAGTAACCCGTGCAAGCATCCGGAGGCACGGTGCATAGACAAGCCCGGAGACTACATATGCTATTGTCCTAGACAATGGACAGGGAAGAACTGTGATATTCACGATCACAACGCCAAAGGCGGATACGGTAGTCCGATAACCGGCATTTTTAGCAACAAAAATCCGGGACTGACTCTAGAGGAACTTGATTTAGCCTTCCAAAGAGAGCAGTGCGTTAAAAAGGGCTGCAAAGAGAAACAGGGTGACCACCATTGCGACGAGGAATGCAACACGTACGCGTGTGAATTCGACGGCAACGATTGCTCGTTGGGCATCAATCCGTGGGCAAACTGTACGGCTCCGATCAACTGTTGGGAGGTGTTCATGAATGGTGAATGTAACGAGGTCTGCAACACCCAAGCTTGTCTGTTCGATGGAAGGGACTGTCAAAAGTCCCTACAGAGATGCAACCCTATATATGACGCGTACTGCCAGAAACATTACGCCAACGGTCATTGCGACTACGGCTGTAACAACGCCGAATGTAATTGGGACGGTCTTGACTGCGAAAACGAACCGCCTGATTTAGCCGAAGGAGTGATGTCCGTCATCCTGCTGATGGACATGAAGACCTTTAAGGAGAACTCGGTGGCCTTCCTCAGAGATCTCGGTCATCAGTTACGGACCACCGTTCTGATAAAGAAGGATCATTTAGGTAATGACATGGTGTTGCCTTGGAAGGGCTCCACTGACGTTGGACTGGAAGAGACCGAATTCGGAAAGAAACATCATATTGTTTACACGGAAAGAGGACAGTCCGGTGTGCAGGTGTACTTAGAACTTGACAACAGAAAATGCACTACAATGTTAAGTTCAGAGTGCTTCTTCTCAGCCAGAGAAGCCGCCGATTTTCTTGCAGCCACGGCCTCCAAACATTCGCTGTCACCGGACTTTCCGATTTACCAAGTCAAGGGCGTAAACCCTCCTATTACTGACGAAGTTCCTACAAACTCTAAATACGTCTTCATTGGAGTCATTTTGGTTCTGCTAGCCGGTCTCCTGATAGGAGTTTTAGTAACCGCTCAGAGGAAACGCGCCGCCGGCATAACATGGTTCCCAGAAGGATTTATCCGTTCGAACTCCTCGACACGGCGTCGGTCACGCCGCCGTGGACCAGACGGCCAGGAGATGCGGAATCTCAATAAAGGATCCATAGGCTGTATCGACGTCGATATCAATGGAGGCCACATGGGTCCACCGCACTCTTGGTCTGACGAAGACGACGATGGCTCGGCCCCTCCCAGAGCCAAGAGAGCCAGAGGACCAGGTGACGCGAATGGGGCTCCAGGAGGCTATGCCTCAGATCACACGGCCATCACTGATTATGAGGAAGCCGGCCATGAACCAAGAGTGTGGACTCAGCAACATTTGGATGCGGCAGATATCAGAGTACCGCCCAGTATGATGACCCCGCCTGCAATCCACGACAGTCACGTGGATGTTGACGTCCGTGGACCGCTGGGTATGACGCCGCTGATGGTAGCCGCAGTGAGGGGAGGAGGTCTGGACACCGGCTCCGACGTAGAAGATGAACAGACAGCCCACATTATATCCGAACTAGTCGCTCAGGGCGCTCAGCTCAACGCGGCCATGGATAAGACCGGGGAAACGAGTCTGCATTTAGCCGCGAGGTACGCCCGTGCGGACGCAGCCAAGCGCCTGCTGGACGCGGGCGCGGACGCCAACTCGCAGGACAACACCGGGCGGACCCCGCTGCACGCCGCCGTCGCCGCCGACGCGATGGGCGTCTTCCAGATCCTACTGCGGAATAGGGCCACCAACTTGAACGCTAGAATGCACGACGGAACCACGCCTCTGATTCTGGCAGCTCGGCTTGCCATCGAGGGCATGGTGGAAGATCTAATCAACGCCGACGCGGATATAAATGCAGCAGACAACAGCGGCAAGACAGCCCTGCACTGGGCGGCGGCTGTCAATAACGTTGACGCTGTCAATGTACTACTCGCACACGGCGCCAATAGGGATGCGCAAGATGACAAGGACGAGACTCCACTATTCCTGGGAGCGAGGGAGGGCTCGTACGGCGCCTGCAGGGCTCTCCTCGACGCGATGGCGAACAGGGAGATCACCGACCACATGGACCGGCTGCCGAGGGACGTGGCACAGGAGCGGATGCATGACGACATCGTGAGGCTCCTCGACGAACACTGTCCGAGGCCGCCTCCGCAGCATCCGCATCTCATGACCTCGCCGAACCCGCATCACCAGCTGATAAGTCAGCCGACAGTGATCGCGTCTGCGGCTAAAGGCAAGCCCAAGAAGCCCAGAGCGAAGGCCGGCCCAGACAGTCCTCAGGATCAAGTTTACGACAACAATAATCTACAACAGACACAGATAAGACGGAAACCAAGCGTAAAAAAGAGCAATAAAAAGATAGCGCAGGAAGTGCCGCAGAGCGTTGAGAGTCTCGGCTCCAGCCTCAGCCCAGTTGAATCGCCGCTCCAAAATTTACAGGACTTGCCGTCGCCATACGACGCAACGTCACTGTACTCGAACACGATGGCGCAGTTCGTCGGCATGGAGCAGCTACTGCACCACAAGCAGCCGCCAAGCTATGAGGATTGCGTCAAGACGGGTCAGACGCTGCAACAGTCGTACGGCGGCGGCGCGATGGGCGCGTCCTTGTCGCCGCCCTACTCCAACCACTCGCCCACACACAGCAACCAGACCACATCGCCGCACGCTTACATGGGCTCGCCGTCGCCAGGAAAGTCGCGACCGTCGCTGCCGACGTCACCGGCGCACATGGCGGCGTTACGTCACTCGCACCAGCACCAGCTGGACGCGTACTCAGCACTCGCACATCTGAGCGCGAGCAGTCAGCACAACGCGCAGCTGCAGGCGGTGATGACGCACGCGGCCGCACTGGGCCAGGTCCAAGGGGCGCAGCATCCGGCTCTCACCAATCTTATGTCGGGCTTGTACAGTTGGCACACCGGTATGGGTGACACGTTTCCGACGCCGTCTCCCGAGTCCCCGGACCACTGGTCGACCCCCTCCCCGCAGACACCCCTCACGCAGTCCCCGCACTCCGACTGGTCCGACCGCGCCGCCCTCTCGCCCAACGACATCCAACAAACGAACAAAGGCGCCGAAGGCATATACATTTAG

Protein

MIVFCFSCTTRYAGEFCQHLNPCHSESSSRCQNGGTCRVRPGVGGGPPSFACDCPLGFSASLCEIRVPAACDSAPCLNGATCRLTSIETYECDCPPGYTGVECSHEDHCASQPCRNGGRCVADNTTAAGYSCVCPPGFTGSRCTEDVVECSSGSGPCHHGRCFNTHGSYTCVCEPGYTGRDCDAEYVPCEPSPCLHDGRCTPLDQLRYECDCPPGYRGQNCEIDIDDCPGHLCQNGASCIDGINSYTCECPPTFTGTLCETDVDECALRPLVCQNGATCTNSVGGFSCICVNGWTGPECSVNIDDCAGAACFNGATCIDRVGAFYCKCTPGKTGLLCHLDDACTSNPCHADAICDTSPINGSYTCSCASGYKGLDCSEDIDECEQGSPCEHDGICVNTPGSFACNCSVGFTGPRCETNVNECESHPCRNDGSCLDDPGTFRCVCMPGFTGTQCEVEIDECANNPCLNGGVCHDMINAFRCTCVIGFTGARCQVNIDDCASSPCRNGGTCHDSIAGYTCECPAGYTGMSCETNINDCLSAPCHRGECIDGDNSFTCNCHPGYTGRVCQTQINECESNPCQFGGHCEDLIGGYQCRCKPGTSGRNCEINVNECYSNPCRNGATCIDGINRYTCECIPGFTGQHCETNINECLSNPCANGGKCIDRINGFRCECPRGYYDARCLSDVNECASNPCTNGGSCEDGVNQFICHCLPGYGGQRCERDIDECSSNPCQHGGTCHDRLNAYKCDCILGFTGVNCETNIDDCAGNPCLHGGSCIDLVNGYRCVCAPPHSGRNCENTLDPCMPNQCRHGGRCVAEASYAEFTCQCPVGWTGALCERDVDECAVTAPCHNEATCINTEGSYACLCARGYEGKDCAINTDDCASFPCQNGATCLDSIGDYNCVCASGFAGKHCEVDIDECQSRPCMNGATCNQYVASYTCTCPLGFSGINCQTNDEDCTESSCMNGGTCIDGINSYNCSCPPGYTGSNCQFRINMCDSSPCDNGATCHDHITYYTCHCPYGYTGKHCEDFVDWCENNPCENGATCSQKGPQYTCTCAPGWSGKLCDVEMVSCKDASIRKGVKLKQLCNNGTCEDIGNSHRCHCQDGYTGSYCQKDINECESAPCQNGALCKDLVGTYQCQCAKGFQGQNCELNVNDCLPNPCQNGGTCHDLINNFSCSCPFGTLGKICEINVNDCKQDACHNNGTCIDRVGGFECKCPPGFVGPRCEGDINECLSNPCSLPGTQDCVQLINDYHCNCKPGYMGRHCDAKVNFCANSPCQNGGICTAIQGGHECLCNEGFYGNNCEYSGYACDSNPCQNGGYCHTSQIGGYACECPLGLSGVSCEIDSMNECLSNPCKHPEARCIDKPGDYICYCPRQWTGKNCDIHDHNAKGGYGSPITGIFSNKNPGLTLEELDLAFQREQCVKKGCKEKQGDHHCDEECNTYACEFDGNDCSLGINPWANCTAPINCWEVFMNGECNEVCNTQACLFDGRDCQKSLQRCNPIYDAYCQKHYANGHCDYGCNNAECNWDGLDCENEPPDLAEGVMSVILLMDMKTFKENSVAFLRDLGHQLRTTVLIKKDHLGNDMVLPWKGSTDVGLEETEFGKKHHIVYTERGQSGVQVYLELDNRKCTTMLSSECFFSAREAADFLAATASKHSLSPDFPIYQVKGVNPPITDEVPTNSKYVFIGVILVLLAGLLIGVLVTAQRKRAAGITWFPEGFIRSNSSTRRRSRRRGPDGQEMRNLNKGSIGCIDVDINGGHMGPPHSWSDEDDDGSAPPRAKRARGPGDANGAPGGYASDHTAITDYEEAGHEPRVWTQQHLDAADIRVPPSMMTPPAIHDSHVDVDVRGPLGMTPLMVAAVRGGGLDTGSDVEDEQTAHIISELVAQGAQLNAAMDKTGETSLHLAARYARADAAKRLLDAGADANSQDNTGRTPLHAAVAADAMGVFQILLRNRATNLNARMHDGTTPLILAARLAIEGMVEDLINADADINAADNSGKTALHWAAAVNNVDAVNVLLAHGANRDAQDDKDETPLFLGAREGSYGACRALLDAMANREITDHMDRLPRDVAQERMHDDIVRLLDEHCPRPPPQHPHLMTSPNPHHQLISQPTVIASAAKGKPKKPRAKAGPDSPQDQVYDNNNLQQTQIRRKPSVKKSNKKIAQEVPQSVESLGSSLSPVESPLQNLQDLPSPYDATSLYSNTMAQFVGMEQLLHHKQPPSYEDCVKTGQTLQQSYGGGAMGASLSPPYSNHSPTHSNQTTSPHAYMGSPSPGKSRPSLPTSPAHMAALRHSHQHQLDAYSALAHLSASSQHNAQLQAVMTHAAALGQVQGAQHPALTNLMSGLYSWHTGMGDTFPTPSPESPDHWSTPSPQTPLTQSPHSDWSDRAALSPNDIQQTNKGAEGIYI

Description

Essential signaling protein which has a major role in many developmental processes (PubMed:3935325). Functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination (PubMed:10935637, PubMed:15620650, PubMed:12909620, PubMed:18243100). Upon ligand activation, and releasing from the cell membrane, the Notch intracellular domain (NICD) forms a transcriptional activator complex with Su(H) (Suppressor of hairless) and activates genes of the E(spl) complex (PubMed:7671825). Regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction (PubMed:11719214, PubMed:12369105, PubMed:3935325). Regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt; might also regulate dpn expression through the activation of the transcriptional regulator Su(H) (PubMed:27151950, PubMed:28899667, PubMed:20152183, PubMed:18342578, PubMed:23056424, PubMed:21262215).

Subunit

Homomer. Interacts with Su(H) when activated. Interacts with Dx via its ANK repeats. Interacts with Dl via the EGF repeats and the Dl EGF repeats. Interacts with Nedd4 and Su(dx). Interacts with O-fut1; the interaction glycosylates N and transports N to early endosomes. Interacts with Akap200; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degration of N/Notch (PubMed:29309414).

Similarity

Belongs to the NOTCH family.

Keywords

3D-structure   Activator   ANK repeat   Cell membrane   Complete proteome   Developmental protein   Differentiation   Disulfide bond   EGF-like domain   Endosome   Glycoprotein   Membrane   Neurogenesis   Notch signaling pathway   Nucleus   Oogenesis   Phosphoprotein   Polymorphism   Receptor   Reference proteome   Repeat   Signal   Transcription   Transcription regulation   Transmembrane   Transmembrane helix   Ubl conjugation  

Feature

chain  Neurogenic locus Notch protein

Uniprot

H9JEI2   C5NS64   A0A2W1BLA6   A0A437BXR5   A0A2A4IXY6   A0A2H1VAB7   + More
A0A2A4IZB7   A0A1Y1N5H2   A0A1W4XG35   A0A139WAL3   Q16TK9   A0A0N0U3F0   A0A2J7PJ04   D6X555   A0A2P8YLM3   A0A088ACI3   K7IZP0   Q25253   A0A1I8QB81   A0A182FK74   E0VHU5   A0A182QJJ7   A0A0C9RJQ9   A0A151IBA4   A0A195DWW8   A0A195BZE4   A0A3F2YXN4   A0A158NP33   A0A1S4GB93   A0A182Y4Z3   A0A084WQ00   A0A151X8F5   A0A0A1XFK0   W8ASE1   A0A2Z2RBZ8   A0A2Z2R333   A0A2Z2R601   A0A2R7WAC9   A0A3L8DHI8   A0A453YJE9   A0A0P6IP86   A0A026WQY1   A0A1I8NFC3   A0A182V6K7   A0A0C9R6K5   A0A0M5J369   Q7PSV8   A0A182PDM5   A0A1B0A8H5   B4IA25   A0A1A9V0J7   A0A1B0B3W0   A0A1B0BQ12   B4L8A9   A0A1A9XVJ0   B4Q0L7   A0A1A9W977   M9NE67   B3NTZ8   P07207   A0A1B0FLR2   A0A182LU30   A0A1B0CIH7   A0A3B0K5G0   A0A182XLU4   A0A182W4X7   A0A182J2C4   B4JJG8   B4MCT2   B3N1W3   B4NQ59   B5DM97   B4GYL6   A0A0P5KD33   A0A385JGB0   A0A1W4VRN7   A0A0P6C283   A0A0N8CZS2   A0A0P4X1W3   A0A0P4WTR0   A0A0N8EJC5   A0A0P5BBV9   A0A0P4ZRR2   A0A0P5YMH6   A0A0P5UUP8   A0A0P5AIU4   A0A0N8DGS7   A0A0P5XGR2   A0A0P5ZT83   A0A0N8CGA4   A0A0P5D0N6   A0A0P5CV60   A0A0P4ZJ10   A0A0N8CSW0   A0A090BZQ7   A0A0N8B4C9   A0A0P5L772   A0A0P5NA73   A0A0P6EXF3  

Pubmed

19121390    28756777    28004739    18362917    19820115    17510324    + More
29403074    20075255    8807304    9753770    20566863    21347285    12364791    25244985    24438588    25830018    24495485    30249741    24508170    25315136    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    3935325    3097517    10731137    3037327    2981631    2780284    8162848    7671825    10206646    10206647    10935637    11719214    11799064    12369105    12909620    15620649    15620650    17329366    18243100    18342578    18327897    20152183    21262215    23056424    27268051    27151950    28899667    29309414    14573873    15632085   

EMBL

BABH01003166    BABH01003167    BABH01003168    BABH01003169    AB474575    BAH83638.1    + More
KZ150050    PZC74424.1    RSAL01000001    RVE55180.1    NWSH01004646    PCG64827.1    ODYU01001500    SOQ37793.1    PCG64826.1    GEZM01015499    JAV91596.1    KQ971382    KYB24943.1    CH477646    EAT37841.1    KQ435899    KOX69108.1    NEVH01024952    PNF16320.1    EEZ97204.1    PYGN01000508    PSN45155.1    U58977    AAC36151.1    DS235171    EEB12868.1    AXCN02002558    GBYB01008435    JAG78202.1    KQ978112    KYM96932.1    KQ980167    KYN17390.1    KQ976394    KYM93296.1    ADTU01021961    ADTU01021962    ADTU01021963    ADTU01021964    ADTU01021965    ADTU01021966    ADTU01021967    ADTU01021968    ADTU01021969    ADTU01021970    AAAB01008811    ATLV01025145    KE525369    KFB52294.1    KQ982422    KYQ56600.1    GBXI01004555    JAD09737.1    GAMC01019062    JAB87493.1    KX429606    ASU52605.1    KX429602    KX429604    KX429605    ASU52601.1    ASU52603.1    ASU52604.1    KX429603    ASU52602.1    KK854455    PTY15990.1    QOIP01000008    RLU19915.1    APCN01004792    APCN01004793    GDIQ01002122    JAN92615.1    KK107126    EZA58452.1    GBYB01008437    JAG78204.1    CP012528    ALC48824.1    EAA04964.6    CH480825    EDW44056.1    JXJN01008088    JXJN01018334    CH933814    EDW05684.2    CM000162    EDX01301.2    AE014298    AFH07224.1    CH954180    EDV45706.2    M16152    M16153    M16149    M16150    M16151    K03508    M13689    K03507    AL035436    AL035395    M16025    M12175    CCAG010014983    AXCM01006039    AJWK01013364    AJWK01013365    OUUW01000015    SPP88533.1    CH916370    EDV99720.1    CH940660    EDW58004.2    CH902663    EDV30004.2    CH964291    EDW86284.2    CH379064    EDY72615.1    CH479197    EDW27872.1    GDIQ01211728    JAK39997.1    MG213851    AXY96273.1    GDIP01006717    JAM96998.1    GDIP01082871    JAM20844.1    GDIP01251652    JAI71749.1    GDIP01251702    JAI71699.1    GDIQ01021068    JAN73669.1    GDIP01191958    JAJ31444.1    GDIP01213307    JAJ10095.1    GDIP01069824    LRGB01002193    JAM33891.1    KZS08456.1    GDIP01109867    JAL93847.1    GDIP01198210    JAJ25192.1    GDIP01035231    JAM68484.1    GDIP01084672    JAM19043.1    GDIP01039581    JAM64134.1    GDIP01134615    JAL69099.1    GDIP01168110    JAJ55292.1    GDIP01207507    GDIP01205607    GDIP01165109    JAJ58293.1    GDIP01216406    JAJ06996.1    GDIP01102167    JAM01548.1    AB851454    BAP63963.1    GDIQ01214027    JAK37698.1    GDIQ01173788    JAK77937.1    GDIQ01157745    GDIQ01152002    JAK99723.1    GDIQ01056336    JAN38401.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000192223    UP000007266    UP000008820    + More
UP000053105    UP000235965    UP000245037    UP000005203    UP000002358    UP000095300    UP000069272    UP000009046    UP000075886    UP000078542    UP000078492    UP000078540    UP000075900    UP000005205    UP000076408    UP000030765    UP000075809    UP000279307    UP000075840    UP000053097    UP000095301    UP000075903    UP000092553    UP000007062    UP000075885    UP000092445    UP000001292    UP000078200    UP000092460    UP000009192    UP000092443    UP000002282    UP000091820    UP000000803    UP000008711    UP000092444    UP000075883    UP000092461    UP000268350    UP000076407    UP000075920    UP000075880    UP000001070    UP000008792    UP000007801    UP000007798    UP000001819    UP000008744    UP000192221    UP000076858   

PRIDE

H9JEI2    C5NS64    M9NE67    P07207   

Pfam

PF07684   NODP        + More
PF12796   Ank_2
PF00008   EGF
PF00066   Notch
PF07645   EGF_CA
PF12661   hEGF
PF00023   Ank
PF06816   NOD
PF11936   DUF3454
PF13606   Ank_3
PF02891   zf-MIZ

Interpro

IPR002110   Ankyrin_rpt        + More
IPR000800   Notch_dom       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR001881   EGF-like_Ca-bd_dom       
IPR008297   Notch       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR020683   Ankyrin_rpt-contain_dom       
IPR011656   Notch_NODP_dom       
IPR035993   Notch-like_dom_sf       
IPR010660   Notch_NOD_dom       
IPR000742   EGF-like_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR018097   EGF_Ca-bd_CS       
IPR013032   EGF-like_CS       
IPR024600   DUF3454_notch       
IPR001190   SRCR       
IPR013083   Znf_RING/FYVE/PHD       
IPR004181   Znf_MIZ       

SUPFAM

SSF57184   SSF57184        + More
SSF90193   SSF90193       
SSF48403   SSF48403       

Gene 3D

1.25.40.20     3.30.40.10    

CDD

cd00204  ANK

ProteinModelPortal

H9JEI2   C5NS64   A0A2W1BLA6   A0A437BXR5   A0A2A4IXY6   A0A2H1VAB7   + More
A0A2A4IZB7   A0A1Y1N5H2   A0A1W4XG35   A0A139WAL3   Q16TK9   A0A0N0U3F0   A0A2J7PJ04   D6X555   A0A2P8YLM3   A0A088ACI3   K7IZP0   Q25253   A0A1I8QB81   A0A182FK74   E0VHU5   A0A182QJJ7   A0A0C9RJQ9   A0A151IBA4   A0A195DWW8   A0A195BZE4   A0A3F2YXN4   A0A158NP33   A0A1S4GB93   A0A182Y4Z3   A0A084WQ00   A0A151X8F5   A0A0A1XFK0   W8ASE1   A0A2Z2RBZ8   A0A2Z2R333   A0A2Z2R601   A0A2R7WAC9   A0A3L8DHI8   A0A453YJE9   A0A0P6IP86   A0A026WQY1   A0A1I8NFC3   A0A182V6K7   A0A0C9R6K5   A0A0M5J369   Q7PSV8   A0A182PDM5   A0A1B0A8H5   B4IA25   A0A1A9V0J7   A0A1B0B3W0   A0A1B0BQ12   B4L8A9   A0A1A9XVJ0   B4Q0L7   A0A1A9W977   M9NE67   B3NTZ8   P07207   A0A1B0FLR2   A0A182LU30   A0A1B0CIH7   A0A3B0K5G0   A0A182XLU4   A0A182W4X7   A0A182J2C4   B4JJG8   B4MCT2   B3N1W3   B4NQ59   B5DM97   B4GYL6   A0A0P5KD33   A0A385JGB0   A0A1W4VRN7   A0A0P6C283   A0A0N8CZS2   A0A0P4X1W3   A0A0P4WTR0   A0A0N8EJC5   A0A0P5BBV9   A0A0P4ZRR2   A0A0P5YMH6   A0A0P5UUP8   A0A0P5AIU4   A0A0N8DGS7   A0A0P5XGR2   A0A0P5ZT83   A0A0N8CGA4   A0A0P5D0N6   A0A0P5CV60   A0A0P4ZJ10   A0A0N8CSW0   A0A090BZQ7   A0A0N8B4C9   A0A0P5L772   A0A0P5NA73   A0A0P6EXF3  

PDB

1OT8     E-value=1.4063e-91,     Score=865

KEGG

692561    K02599 Notch 1 | (RefSeq) Notch; Notch homolog

PATHWAY

04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)
04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0007275   GO:0030154   GO:0050793   GO:0007219   GO:0005509   GO:0004714   GO:0016787   GO:0032440   GO:0046872   GO:0005044   GO:0043235   GO:0005886   GO:0009986   GO:0008407   GO:0042688   GO:0048803   GO:0048190   GO:0007498   GO:0014019   GO:1990433   GO:0002213   GO:0060289   GO:0016348   GO:0048664   GO:0060288   GO:0007440   GO:0040008   GO:0035171   GO:0045316   GO:0046716   GO:0036335   GO:0003682   GO:0051489   GO:0005770   GO:0008340   GO:0007403   GO:0009950   GO:0061331   GO:0007521   GO:0045944   GO:0042686   GO:0009608   GO:0007400   GO:0016330   GO:0043697   GO:0046843   GO:0007616   GO:0010629   GO:0007455   GO:0006110   GO:0005887   GO:0036099   GO:0045466   GO:0002052   GO:0016360   GO:1900087   GO:0035204   GO:0030713   GO:0097150   GO:0035003   GO:0043525   GO:0008347   GO:0060250   GO:0030720   GO:0007519   GO:0035172   GO:0030139   GO:0042691   GO:0007474   GO:0005764   GO:0004888   GO:0008045   GO:0008587   GO:0007405   GO:2000035   GO:0060571   GO:0007015   GO:0035162   GO:0007422   GO:0048052   GO:0005915   GO:0007298   GO:0005769   GO:2000048   GO:0048665   GO:0061382   GO:0035153   GO:0042689   GO:0035214   GO:0046666   GO:0048863   GO:0032991   GO:0009952   GO:0007451   GO:0005796   GO:0005768   GO:0007346   GO:0007450   GO:0010628   GO:0045893   GO:0050877   GO:0007473   GO:0005634   GO:0007314   GO:0007398   GO:0022416   GO:0005829   GO:0048749   GO:0010001   GO:0005737   GO:0005654   GO:0008284   GO:0008356   GO:0007478   GO:0048477   GO:0007293   GO:0045595   GO:0005788   GO:0046331   GO:0005912   GO:0007447   GO:0030707   GO:0007391   GO:0042067   GO:0030718   GO:0007423   GO:0007411   GO:0035167   GO:0048542   GO:0007476   GO:0007419   GO:0050767   GO:0016333   GO:0007446   GO:1902692   GO:0030708   GO:0007297   GO:0036011   GO:0007464   GO:0050768   GO:0035165   GO:0001745   GO:0035222   GO:0001708   GO:0042676   GO:0046329   GO:0046667   GO:0008270   GO:0005515   GO:0003676   GO:0016876   GO:0043039  

Subcellular location

Cell membrane  
Endosome  
Nucleus  

Length:

2406

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

12.25871

Exp number, first 60 AAs:

0.00019

Total prob of N-in:

0.00001

outside

1  -  2406

 

 

Pi

224.090043

Theta

169.19032

Tajima's D

1.118725

CLR

0.121339

CSRT

0.698015099245038

Interpretation

Uncertain