Gene

KWMTBOMO08684

Pre Gene Modal

BGIBMGA007930

Annotation

PREDICTED:_tyramine_receptor_Ser-2-like_[Amyelois_transitella]

Location

Bomo_Chr15(-):2277899-2287021      View in EpiBrowser

Full name

5-hydroxytryptamine receptor 1D       + More
Alpha-1A adrenergic receptor      

Alternative Name

Serotonin receptor 1D
Alpha-1A adrenoreceptor
MAR1

Location in the cell

PlasmaMembrane   Reliability : 4.64

CDS

ATGCAAAGTGTGTTGACGCTCCACCCTCGCGGTGACATGACGAGCTCGTGGTGGGCGGCTGCGGCAGCTATGGCCGCGGTGACTTTCTTCACGGTCGGTGGGAACGCTGCTGTGCTGGTGGCGCTGAAGAGAGTTAATCGCGCCCCAGCACACTATCCCTTGGCGAGCTTAGCGACCGCAGACTTGCTTCTCGGTCTACTAGTGCTGCCAATAGCAGCCGCCAGGGAATTGTTCGTCTTTCATTTGAACTGGGCAATATGTTCCTGTTGGAGCACCTTGGATGTCCTATGCTGCACCGCCTCTATCCTCTCCATCTGCACCCTAGGGTGGGAGAGATTCTGCGGCATCACCGCTCCGTTAGCTCGTGCACAGAGAGCAAAGACCGCTAGACTCTTGGCTGCACTGATCTGGCCCGTGGCGACAACAATCGCTATACCGACTGCCTTCATTCCTTCGCCGAAGCATTTTCTACCTGGAGAAATAGCTAAGGCTTGTACTGTTAACACTAATTCTAGTTACGTATTCGTCAGTATTTTCTTTTCGTTTTATCTTCCCGCAAGTGTGATGGTTGTTCTTTATGCCCGGATACTGCGAGCTCTGGCGGCACCGCCCTCAATCAGGTTCCATCGTGGCCAGGTCACAAACAATGTTGAAAAAGTCATCCCCGATGCTGTCGTGGTAAATGTGGACAGCGTTACTCCTGCAGATGAATCACAAGAGAATCATAAAGTACCCAAGAGCATAGTGGTACCACCTTCTCCAAAAACCGGCCATTTCATGATACCCTCGTCGGAAACGGTACGTGCCATAACTTCTCCTTTAAAGAGACTCAAATTTCCGGTCGCGGGTATAATATCGCGCCAACGTCGTGCCACCCGGACCATCGTGATGCTGATGTCACTGTTCCTACTGTGCTGGACGCCGTTCTTCGTGATGCTTCCCGTAGATTCTATATGCGAGTGCGTCAGAGATGCCGCGTGGTTGTGGTGCACTTGGCTTGGGTACACGAACTCGGCTCTCAATCCGCTGGTCTACGCGGCCTCCTCCCCGGCGGTCAGTCGGGCCCTCCACGCCTCCCTCACCACCACTACATGCACCAGAACTACGGATGTTACTCGTACTCCTTTACCGAGAAAATAG

Protein

MQSVLTLHPRGDMTSSWWAAAAAMAAVTFFTVGGNAAVLVALKRVNRAPAHYPLASLATADLLLGLLVLPIAAARELFVFHLNWAICSCWSTLDVLCCTASILSICTLGWERFCGITAPLARAQRAKTARLLAALIWPVATTIAIPTAFIPSPKHFLPGEIAKACTVNTNSSYVFVSIFFSFYLPASVMVVLYARILRALAAPPSIRFHRGQVTNNVEKVIPDAVVVNVDSVTPADESQENHKVPKSIVVPPSPKTGHFMIPSSETVRAITSPLKRLKFPVAGIISRQRRATRTIVMLMSLFLLCWTPFFVMLPVDSICECVRDAAWLWCTWLGYTNSALNPLVYAASSPAVSRALHASLTTTTCTRTTDVTRTPLPRK

Description

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction (By similarity).
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

Subunit

Homodimer. Heterodimer with HTR1B (By similarity).

Similarity

Belongs to the G-protein coupled receptor 1 family.
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.

Keywords

Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Receptor   Reference proteome   Transducer   Transmembrane   Transmembrane helix   Lipoprotein   Palmitate   Phosphoprotein  

Feature

chain  5-hydroxytryptamine receptor 1D

Uniprot

H9JEI3   A0A437BY54   A0A212EGU3   A0A2H1VAC3   A0A2W1BRP0   A0A194RF64   + More
A0A194PWA1   A0A091RZT6   U3I2H0   R0KN79   A0A182FPD0   A0A091I5X8   U3KIP3   A0A2K5XR79   A0A2K5HFW3   A0A2K6AWB4   A0A2K5UMI0   G7MHG5   A0A091EPK7   A0A2M3Z755   A0A2M3Z6T3   A0A096MXA4   C3Y3T3   F7FW05   A0A0D9S925   A0A2K5BZX2   A0A2K6S3B0   I3M8J5   A0A2K5PAY1   A0A2K5KLB4   G7NVU4   A0A218UXY1   H2ZTR3   P79400   H0YT67   I3L844   L5JV21   Q9N263   S7PXM8   A0A2D0QXV0   F6V9Y1   A0A2M4BJ57   A0A2M4BJY8   A0A2M4BJ77   A0A2M4BJ74   A0A383ZJX1   A0A2M4AM59   A0A1S3A3K6   A0A2M4CPW4   A0A060VTR1   G1Q9M2   Q2VA56   A0A3B1J4P6   W5QAN1   G1KD63   F7AXV1   A0A3Q3BZI2   A0A3B3DEV3   A0A3Q0QU85   A0A437D146   A0A3Q7MZ24   W5JAC2   A0A3P4S279   A0A2U3VIY5   A0A452E6Y0   Q91175   A0A383YYT4   G3TQH0   A0A3Q4N0A6   A0A0U2M149   A0A3B4BRC6   A0A1S3NJV2   A0A1U7TMX9   A0A341CF30   W5NP23   A0A2Y9PLB4   H2M9N5   A0A3Q2VFL3   A0A3P8PFR7   A0A2Y9DMB8   A0A3P9LSQ7   X2C6U2   A0A3P9BWW8   A0A3B4GKQ9   A0A1S3GJD4   A0A3P9JP07   H0ZQU1   A0A3M0KJA4   A0A2P4SMU4   A0A140TAV9   A0A2K5XHR2   A0A2K5KXA7   A0A2F0B829   X2CCR5   A0A093PMC8   Q60484  

Pubmed

19121390    22118469    28756777    26354079    23749191    22002653    + More
18563158    17431167    9215903    20360741    30723633    23258410    25243066    24755649    21993624    25329095    20809919    19892987    29451363    20920257    23761445    8654394    25186727    26580012    17554307    8978753    9225276    15189767   

EMBL

BABH01003169    BABH01003170    RSAL01000001    RVE55181.1    AGBW02015022    OWR40696.1    + More
ODYU01001500    SOQ37795.1    KZ150050    PZC74423.1    KQ460473    KPJ14566.1    KQ459596    KPI95410.1    KK938254    KFQ48619.1    ADON01133310    KB744656    EOA94663.1    KL218157    KFP02853.1    AGTO01000739    AQIA01005394    CM001253    EHH14435.1    KK718726    KFO58254.1    GGFM01003601    MBW24352.1    GGFM01003464    MBW24215.1    AHZZ02015472    GG666484    EEN64959.1    JSUE03000651    AQIB01141981    AGTP01007529    CM001276    EHH49638.1    MUZQ01000093    OWK58675.1    AFYH01257626    Y11868    ABQF01050233    AEMK02000045    DQIR01026014    DQIR01177805    HCZ81489.1    KB031148    ELK02158.1    AF117655    AAF61808.1    KE163683    EPQ13322.1    GAMT01007661    GAMS01008987    JAB04200.1    JAB14149.1    GGFJ01003965    MBW53106.1    GGFJ01003967    MBW53108.1    GGFJ01003966    MBW53107.1    GGFJ01003964    MBW53105.1    GGFK01008533    MBW41854.1    GGFL01002750    MBW66928.1    FR904262    CDQ56384.1    AAPE02027924    DQ278449    ABB83642.1    AMGL01057131    CM012445    RVE68482.1    ADMH02001946    ETN60373.1    CYRY02045770    VCX41304.1    LWLT01000002    D63859    KU052847    ALR88680.1    AHAT01009586    KC862488    KC862489    AGN73583.1    AGN73584.1    ABQF01000819    QRBI01000106    RMC13339.1    PPHD01034311    POI25433.1    AAGW02018996    NTJE010098057    MBV99163.1    KC862445    KC862446    KC862449    KC862450    KC862451    KC862454    AGN73540.1    AGN73541.1    AGN73544.1    AGN73545.1    AGN73546.1    AGN73549.1    KL670077    KFW77988.1    X94436    U82174   

Proteomes

UP000005204    UP000283053    UP000007151    UP000053240    UP000053268    UP000016666    + More
UP000069272    UP000054308    UP000016665    UP000233140    UP000233080    UP000233120    UP000233100    UP000052976    UP000028761    UP000001554    UP000006718    UP000029965    UP000233020    UP000233220    UP000005215    UP000233040    UP000233060    UP000009130    UP000197619    UP000008672    UP000008227    UP000007754    UP000010552    UP000221080    UP000008225    UP000261681    UP000079721    UP000193380    UP000001074    UP000018467    UP000002356    UP000001646    UP000002281    UP000264840    UP000261560    UP000261340    UP000286641    UP000000673    UP000245340    UP000291000    UP000001038    UP000265180    UP000265200    UP000007646    UP000261580    UP000261440    UP000087266    UP000189704    UP000252040    UP000018468    UP000248483    UP000265100    UP000248480    UP000265160    UP000261460    UP000081671    UP000269221    UP000001811    UP000053258    UP000005447   

PRIDE

H9JEI3    P79400    I3L844    Q91175   

Pfam

PF00001   7tm_1

Interpro

IPR000276   GPCR_Rhodpsn        + More
IPR017452   GPCR_Rhodpsn_7TM       
IPR000505   5HT1D_rcpt       
IPR002231   5HT_rcpt       
IPR001115   ADRA1B_rcpt       
IPR002233   ADR_fam       
IPR002147   5HT1B_rcpt       

ProteinModelPortal

H9JEI3   A0A437BY54   A0A212EGU3   A0A2H1VAC3   A0A2W1BRP0   A0A194RF64   + More
A0A194PWA1   A0A091RZT6   U3I2H0   R0KN79   A0A182FPD0   A0A091I5X8   U3KIP3   A0A2K5XR79   A0A2K5HFW3   A0A2K6AWB4   A0A2K5UMI0   G7MHG5   A0A091EPK7   A0A2M3Z755   A0A2M3Z6T3   A0A096MXA4   C3Y3T3   F7FW05   A0A0D9S925   A0A2K5BZX2   A0A2K6S3B0   I3M8J5   A0A2K5PAY1   A0A2K5KLB4   G7NVU4   A0A218UXY1   H2ZTR3   P79400   H0YT67   I3L844   L5JV21   Q9N263   S7PXM8   A0A2D0QXV0   F6V9Y1   A0A2M4BJ57   A0A2M4BJY8   A0A2M4BJ77   A0A2M4BJ74   A0A383ZJX1   A0A2M4AM59   A0A1S3A3K6   A0A2M4CPW4   A0A060VTR1   G1Q9M2   Q2VA56   A0A3B1J4P6   W5QAN1   G1KD63   F7AXV1   A0A3Q3BZI2   A0A3B3DEV3   A0A3Q0QU85   A0A437D146   A0A3Q7MZ24   W5JAC2   A0A3P4S279   A0A2U3VIY5   A0A452E6Y0   Q91175   A0A383YYT4   G3TQH0   A0A3Q4N0A6   A0A0U2M149   A0A3B4BRC6   A0A1S3NJV2   A0A1U7TMX9   A0A341CF30   W5NP23   A0A2Y9PLB4   H2M9N5   A0A3Q2VFL3   A0A3P8PFR7   A0A2Y9DMB8   A0A3P9LSQ7   X2C6U2   A0A3P9BWW8   A0A3B4GKQ9   A0A1S3GJD4   A0A3P9JP07   H0ZQU1   A0A3M0KJA4   A0A2P4SMU4   A0A140TAV9   A0A2K5XHR2   A0A2K5KXA7   A0A2F0B829   X2CCR5   A0A093PMC8   Q60484  

PDB

6G79     E-value=5.0294e-20,     Score=240

KEGG

101744471    no KO assigned | (RefSeq) octopamine receptor 2-like

GO

GO:0004930   GO:0016021   GO:0006939   GO:0007268   GO:0040012   GO:0042310   GO:0005887   GO:0004993   GO:0050795   GO:0051378   GO:0009636   GO:0007193   GO:0014827   GO:0007204   GO:0007188   GO:0045987   GO:0004935   GO:0001994   GO:0045907   GO:0007200   GO:0004937   GO:0071880   GO:0030425   GO:0030594   GO:0007187   GO:0005886   GO:0046849   GO:0035690   GO:0005737   GO:0071312   GO:0099154   GO:1904707   GO:0007205   GO:0099056   GO:0014063   GO:0008144   GO:0002031   GO:0007198   GO:0071502   GO:0007186   GO:0006189   GO:0005840   GO:0006426   GO:0003676   GO:0016876   GO:0043039  

PANTHER

PTHR24247:SF17   PTHR24248:SF17   PTHR24247:SF16  

Subcellular location

Cell membrane  

Length:

379

Number of predicted TMHs:

7

Exp number of AAs in TMHs:

145.65134

Exp number, first 60 AAs:

30.40836

Total prob of N-in:

0.00926

POSSIBLE N-term signal

sequence

outside

1  -  19

TMhelix

20  -  42

inside

43  -  53

TMhelix

54  -  73

outside

74  -  87

TMhelix

88  -  110

inside

111  -  130

TMhelix

131  -  150

outside

151  -  174

TMhelix

175  -  197

inside

198  -  295

TMhelix

296  -  315

outside

316  -  324

TMhelix

325  -  347

inside

348  -  379

 

 

Pi

184.769254

Theta

167.921564

Tajima's D

-1.94458

CLR

139.803212

CSRT

0.0172991350432478

Interpretation

Possibly Positive selection