Gene

KWMTBOMO08672  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007935

Annotation

phosphoribosylaminoimidazole_carboxylase?_phosphoribosylaminoimidazole_succinocarboxamide_synthetase_[Bombyx_mori]

Location

Bomo_Chr15(-):1902949-1909476      View in EpiBrowser

Full name

Multifunctional protein ADE2      

Alternative Name

Protein adenosine-5

Location in the cell

Cytoplasmic   Reliability : 2.894

CDS

ATGTCTCATCCTAAACAAGTTGGACAATATAAATTGGGCAAACTTCTCATTGAGGGTAAGACCAAACAGGTATTCGATGTTCCGGACCAACCTGGGTACTGCTTGCTTCTTAACAAGGACAGAATCACCGCAGGCGATGGTGTCAAAGCCCACGATTTGGAGGGAAAGGCGGCTATTTCCAATCAGACAAATGCAAAAGTGTTCGAAATCTTAAAGTCTGCAGGAATCAAAACTGCCTTCGTTAAGATTGCCTCTGAAACTGCGTTCTTATCCAAAAAATGTGAGATGATCCCCATTGAATGGGTTACCCGCCGCCTTGCAACTGGCTCTTTCCTAAAAAGAAATCCTGGTGTACCAGAAGGCTTCAGGTTCACTCCTCCAAAACAAGAGACGTTCTTCAAGGATGACGCAAACCACGATCCCCAATGGTCAGAGGAGCAAATCATTTCAGCCAAATTCAATTATAACGGTCTTCTAATCGGTCGCGACGAGGTCGACTACATGAGAAAAGCTACGATTCTAATATTTGAAATCTTGGAGAAAGCTTGGGCTCTGCGTGACTGCGCACTTATTGACATGAAAATAGAATTCGGAGTCGATACAGAAGGTAGCATTGTATTGGCGGATGTCATCGATTCTGACTCTTGGAGATTGTGGCCTTCCGGTGATAAAAGATTAATGGTTGACAAACAGGTGTACCGGAACCTCACAACGGTGACTGCAGCTGATCTAGACACAGTCAAACGCAACTTTGCTTGGGTGAAAGACCAGCTTGATTTCTTGAAGCCGACGATCCACCACAAAGTTGTCGTCTTTATGGGTTCACCAGCCGACCAAGAACATTGTCAGAAAATAGCTAAAGCTGCCCGTGAACTTGGACTGGATGTCGACCTTCGCGTGACATCAGCCCACAAGGCCACTGAAGAAACCCTTCGCATTATGCAGCAATATGAAGATACGCATGGTGCTCTCGTGTTCATTGCTGTAGCAGGACGATCGAACGGACTCGGGCCCGTTCTTTCTGGGAACACTTCCTACCCTGTCATCAACTGCCCACCTCCTTCCGATAAACTTGTACAGGACATCTGGTCGTCCCTCTCCGTACCGTCTGGATTAGGATGCGCTACAGTAATTTATCCTGACAGTGCTGCACTAATGGCTGCTCAAATAATCGGCCTTCAGGACTATTTAGTGTGGGGACGTCTTAGATCCAAACAACTTGACATGGCACATTCACTAAGACAAGCGGATAAGAAGCTCAGGAACCAAACAGCTTAA

Protein

MSHPKQVGQYKLGKLLIEGKTKQVFDVPDQPGYCLLLNKDRITAGDGVKAHDLEGKAAISNQTNAKVFEILKSAGIKTAFVKIASETAFLSKKCEMIPIEWVTRRLATGSFLKRNPGVPEGFRFTPPKQETFFKDDANHDPQWSEEQIISAKFNYNGLLIGRDEVDYMRKATILIFEILEKAWALRDCALIDMKIEFGVDTEGSIVLADVIDSDSWRLWPSGDKRLMVDKQVYRNLTTVTAADLDTVKRNFAWVKDQLDFLKPTIHHKVVVFMGSPADQEHCQKIAKAARELGLDVDLRVTSAHKATEETLRIMQQYEDTHGALVFIAVAGRSNGLGPVLSGNTSYPVINCPPPSDKLVQDIWSSLSVPSGLGCATVIYPDSAALMAAQIIGLQDYLVWGRLRSKQLDMAHSLRQADKKLRNQTA

Catalytic Activity

5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2

Similarity

In the N-terminal section; belongs to the SAICAR synthetase family.
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.

Keywords

ATP-binding   Complete proteome   Decarboxylase   Ligase   Lyase   Multifunctional enzyme   Nucleotide-binding   Purine biosynthesis   Reference proteome  

Feature

chain  Multifunctional protein ADE2

Uniprot

Q1HQ66   A0A437BXM1   A0A2H1WCU2   A0A2W1BMY5   A0A2A4IU77   S4PGW8   + More
A0A212F8T0   A0A194PPN0   A1YM13   A0A1W4WUJ5   A0A1B0AP01   A0A1B0A4R8   A0A1Q3F2R0   D6X4R1   A0A1A9WEQ1   A0A034WLN4   Q17F22   A0A023ES15   A0A0A1WGL3   D3TM11   A0A1A9V290   A0A182GWZ0   A0A0C9RA29   T1E2N3   A0A182W508   B0WPD0   B3MS12   A0A0L0BSM2   A0A182R1A7   A0A1A9W5D7   W8BH16   A0A182SP00   A0A182LRQ2   A0A182P2A0   A0A0K8UGK4   A0A182YQ72   A0A336KFW7   A0A084VIX2   A0A182NAB1   A0A2M4A043   A0A2M4BP29   A0A182R7J1   A0A2M4BNQ5   T1DPD5   U5EW89   A0A2M3YXP0   B4L213   Q29GZ6   A0A2M3ZYZ5   A0A182FID9   A0A2M4BNI4   A0A0M4F9P8   A0A0A1WMV3   A0A2M3ZYG7   B4H0P3   A0A182JGL4   B4M6N9   W5JMN1   B4N1Z1   A0A1W4V7Q0   B4IGJ0   B4R3Z3   A0A182KCQ7   B3NXA0   A0A3B0K3H1   Q9I7S8   F0JAN1   A0A1J1HQD6   K7IQ46   U4UIX1   A0A1I8PRB4   T1P8U6   N6UJX4   A0A182X7Z1   A0A182UP35   A0A182KY39   A0A182UKZ6   A0A182HIC5   B4Q1Q3   A0A232FBA9   V5GWK5   A0A1I8NGM8   J3JUG4   Q7PRW1   A0A1B0DP59   E0VTD3   A0A067QNC4   A0A1Y1JZP7   B4JK15   A0A1B6EQT7   A0A0T6B715   A0A1L8DXY3   A0A1B0GK94   A0A1B6MDC7   A0A1B6C5I8   A0A161MQN1   A0A0A9WZ50   A0A2J7PC66   R4FNG8   A0A226DKZ0  

Pubmed

19121390    23553965    28756777    23622113    22118469    26354079    + More
18362917    19820115    25348373    17510324    24945155    25830018    20353571    26483478    24330624    17994087    26108605    24495485    25244985    24438588    15632085    20920257    23761445    10757766    10731132    12537572    12537569    12537568    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20075255    23537049    20966253    17550304    28648823    25315136    22516182    12364791    14747013    17210077    20566863    24845553    28004739    25401762   

EMBL

BABH01003213    DQ443186    ABF51275.1    RSAL01000001    RVE55188.1    ODYU01007812    + More
SOQ50895.1    KZ150060    PZC74236.1    NWSH01006302    PCG63527.1    GAIX01003472    JAA89088.1    AGBW02009681    OWR50123.1    KQ459596    KPI95401.1    EF105371    ABM05496.1    JXJN01001088    JXJN01001089    JXJN01001090    GFDL01013226    JAV21819.1    KQ971380    EEZ97680.1    GAKP01003383    JAC55569.1    CH477277    EAT45109.1    GAPW01001580    JAC12018.1    GBXI01016652    GBXI01011738    JAC97639.1    JAD02554.1    CCAG010023143    EZ422463    ADD18739.1    JXUM01094256    KQ564116    KXJ72751.1    GBYB01005095    JAG74862.1    GALA01001125    JAA93727.1    DS232022    EDS32305.1    CH902622    EDV34567.1    JRES01001419    KNC23080.1    AXCN02001415    GAMC01005990    JAC00566.1    AXCM01007375    GDHF01026517    GDHF01018197    GDHF01001433    JAI25797.1    JAI34117.1    JAI50881.1    UFQS01000116    UFQT01000116    SSW99960.1    SSX20340.1    ATLV01013412    KE524855    KFB37916.1    GGFK01000800    MBW34121.1    GGFJ01005560    MBW54701.1    GGFJ01005501    MBW54642.1    GAMD01003434    JAA98156.1    GANO01001535    JAB58336.1    GGFM01000257    MBW21008.1    CH933810    EDW07734.1    CH379064    EAL31963.1    GGFK01000371    MBW33692.1    GGFJ01005505    MBW54646.1    CP012528    ALC48995.1    GBXI01014492    JAC99799.1    GGFK01000282    MBW33603.1    CH479200    EDW29838.1    CH940653    EDW62456.1    ADMH02000959    ETN64568.1    CH963925    EDW78380.1    CH480836    EDW48940.1    CM000366    EDX17760.1    CH954180    EDV47272.1    OUUW01000016    SPP88775.1    AF102579    AF102580    AE014298    AY095520    AAF06356.1    AAG22346.2    AAM12252.1    BT126073    ADY17772.1    AGB95335.1    CVRI01000013    CRK89596.1    KB632192    ERL89880.1    KA645107    AFP59736.1    APGK01017070    APGK01017071    KB739995    ENN82030.1    APCN01003927    CM000162    EDX01494.1    NNAY01000571    OXU27617.1    GALX01002379    JAB66087.1    BT126877    AEE61839.1    AAAB01008846    EAA06482.5    AJVK01007915    DS235762    EEB16639.1    KK853205    KDR09851.1    GEZM01099550    JAV53280.1    CH916370    EDV99917.1    GECZ01029501    JAS40268.1    LJIG01009441    KRT83073.1    GFDF01002810    JAV11274.1    AJWK01028576    GEBQ01006088    JAT33889.1    GEDC01028551    JAS08747.1    GEMB01002231    JAS00949.1    GBHO01030913    GBRD01001436    JAG12691.1    JAG64385.1    NEVH01027067    PNF13929.1    ACPB03003540    GAHY01001299    JAA76211.1    LNIX01000017    OXA45658.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000007151    UP000053268    UP000192223    + More
UP000092460    UP000092445    UP000007266    UP000091820    UP000008820    UP000092444    UP000078200    UP000069940    UP000249989    UP000075920    UP000002320    UP000007801    UP000037069    UP000075886    UP000075901    UP000075883    UP000075885    UP000076408    UP000030765    UP000075884    UP000075900    UP000009192    UP000001819    UP000069272    UP000092553    UP000008744    UP000075880    UP000008792    UP000000673    UP000007798    UP000192221    UP000001292    UP000000304    UP000075881    UP000008711    UP000268350    UP000000803    UP000183832    UP000002358    UP000030742    UP000095300    UP000019118    UP000076407    UP000075903    UP000075882    UP000075902    UP000075840    UP000002282    UP000215335    UP000095301    UP000007062    UP000092462    UP000009046    UP000027135    UP000001070    UP000092461    UP000235965    UP000015103    UP000198287   

PRIDE

Q1HQ66    A1YM13    Q9I7S8   

Pfam

PF01259   SAICAR_synt        + More
PF00731   AIRC
PF00485   PRK
PF10148   SCHIP-1
PF10171   Tim29

Interpro

IPR028923   SAICAR_synt/ADE2_N        + More
IPR000031   PurE_dom       
IPR035893   PurE_sf       
IPR033626   PurE_classII       
IPR018236   SAICAR_synthetase_CS       
IPR000764   Uridine_kinase-like       
IPR006083   PRK/URK       
IPR027417   P-loop_NTPase       
IPR015649   SCHIP_1_C       
IPR019322   TIMM29       

SUPFAM

SSF52255   SSF52255        + More
SSF52540   SSF52540       

Gene 3D

3.40.50.7700    

CDD

cd02023  UMPK

ProteinModelPortal

Q1HQ66   A0A437BXM1   A0A2H1WCU2   A0A2W1BMY5   A0A2A4IU77   S4PGW8   + More
A0A212F8T0   A0A194PPN0   A1YM13   A0A1W4WUJ5   A0A1B0AP01   A0A1B0A4R8   A0A1Q3F2R0   D6X4R1   A0A1A9WEQ1   A0A034WLN4   Q17F22   A0A023ES15   A0A0A1WGL3   D3TM11   A0A1A9V290   A0A182GWZ0   A0A0C9RA29   T1E2N3   A0A182W508   B0WPD0   B3MS12   A0A0L0BSM2   A0A182R1A7   A0A1A9W5D7   W8BH16   A0A182SP00   A0A182LRQ2   A0A182P2A0   A0A0K8UGK4   A0A182YQ72   A0A336KFW7   A0A084VIX2   A0A182NAB1   A0A2M4A043   A0A2M4BP29   A0A182R7J1   A0A2M4BNQ5   T1DPD5   U5EW89   A0A2M3YXP0   B4L213   Q29GZ6   A0A2M3ZYZ5   A0A182FID9   A0A2M4BNI4   A0A0M4F9P8   A0A0A1WMV3   A0A2M3ZYG7   B4H0P3   A0A182JGL4   B4M6N9   W5JMN1   B4N1Z1   A0A1W4V7Q0   B4IGJ0   B4R3Z3   A0A182KCQ7   B3NXA0   A0A3B0K3H1   Q9I7S8   F0JAN1   A0A1J1HQD6   K7IQ46   U4UIX1   A0A1I8PRB4   T1P8U6   N6UJX4   A0A182X7Z1   A0A182UP35   A0A182KY39   A0A182UKZ6   A0A182HIC5   B4Q1Q3   A0A232FBA9   V5GWK5   A0A1I8NGM8   J3JUG4   Q7PRW1   A0A1B0DP59   E0VTD3   A0A067QNC4   A0A1Y1JZP7   B4JK15   A0A1B6EQT7   A0A0T6B715   A0A1L8DXY3   A0A1B0GK94   A0A1B6MDC7   A0A1B6C5I8   A0A161MQN1   A0A0A9WZ50   A0A2J7PC66   R4FNG8   A0A226DKZ0  

PDB

4JA0     E-value=0,     Score=2269

KEGG

732910    K01587 phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide sy

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006189   GO:0004639   GO:0005524   GO:0016301   GO:0005829   GO:0005737   GO:0004638   GO:0043727   GO:0042721   GO:0006164   GO:0005840   GO:0006426   GO:0003676   GO:0016876   GO:0043039  

Length:

425

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.1767

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01235

outside

1  -  425

 

 

Pi

255.863641

Theta

185.958823

Tajima's D

0.959667

CLR

12.090716

CSRT

0.645767711614419

Interpretation

Uncertain