SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08649
Pre Gene Modal
BGIBMGA007636
Annotation
PREDICTED:_protein_vav_isoform_X1_[Bombyx_mori]
Full name
Protein vav      
Location in the cell
Nuclear   Reliability : 2.167
 

Sequence

CDS
ATGGCTTCGGGCGGTGAGGAACTGTGGCGCGATTGCGCGTCTTGGCTTACAAGATGTGGGTTGCTGCGTCCCGACCATAAGGCAAATTGGGAAACTAGCACCATTCACGACTTGGCGTATACATTACGCGACGGTGTGCTTCTTTGCAATCTCTTGAACGTACTACATCCGGGATGCATCGACATGAAGGACGTCAATCAGAGACCTCAAATGGCGCAGTTCTTGTGTCTTCGCAACATCAAAGTCTTCTTAAGGACATGCCATGAAGTATTTGAACTACGAGAAACTGATCTTTTTGATCCATCAATGCTGTTTGAACTGTCAAATTTTCATCGAGTTTTATGTACACTTGCTAAGCTTAGCCAGTGTCCTAAAGTTCTCGCTAACAGTATTACGCCCTTCTCAGCACATAGAACTCAATCTGAGGAGGATATATATAAAGATCTGCAGTCTGTCGGCGAGGCGTGTGCCCCGCTGGGAGCCGACGTCGGTGAGTACTCCAGCTACTGCGCTCGCATACACGACGAGGAGATCTACCACGACCTCTGCGCGGTCAAGAACAACAGGGAATTCACTACGCCGACGCGCACTTTGCACACACTAGCAACATCTTCACACAGCTTGGAGAAGAGGGACTATGTTATTAGGGAACTTGTGGACACTGAAAGTAATTACGTGGATGTTTTGAGCAAAATAATACAACATTTTATGAGGCCGCTTATGCCGTATTTGAAGCCGCAGGACCTACAAGGAATATTCTTTGGGATTAAGGAGCTGTACGAGATCCACTCCGGACTGCTGCGCCAGTTGAAGCTGGCGACGGAAGCGTGCGTGCCCGGCAGCGGCGCCCCGCGGCTCGCGGACGTGTTCCTGGCGTGGCGGGAGAAGCTCCTGCTGTACGGGGACTACTGCTCGAACCTCACGCACGCCCAGGACACACTCAAGCTGCTCGATGCCAAGGATAACACATTCAATAAGCAATTAGCGAAATGTCAGAAAGAGCACAGCGACGGTCGGATACAGCTGAGAGACATACTGTCCGTGCCGATGCAGAGGGTGCTCAAATATCATTTGCTGCTAGACAAACTTGTGCATGAAACGCAACCGAATCATGAAGAGTTCCGAGGACTGGAGCGAGCGAAGGAAGCCATGGTCGACGTCGCGCAGTACATCAACGAGGTGAAACGAGACAGCGAGGTGCTGACGCTGTTGGCCAACGTGCAGGACAGTATTATAAACTGGGAGGGCGCAGCCCTAGGTGCCGGGGGCGCAGGGCTGGCGGCATACGGCCGTCTGTTACTGGACGGAGAACTGAAGGTGAAAGCGCACGAAGATCAGAAGCTGAGGACCCGTTACGTTTTTGTCTTTGATAAACTTATGCTGCTTTGTAAACCCGTTAAGGAGAACCAGTACCTGTACCGCGTGGGCGTGCGGCTGGCCGAGTTCCGCGTGGAGGAGGGCAGCAGCCGGCGCGCGCTGCGCACGGACGCGCGCTGGGCGGCGCACTTCTACCTCGTGCGCCGCACCAAGGACTCCACCTACACGCTGTACGCGCGCACCGACGACTGCAAGCGGAAGTGGGTCAAGGCCATCAAGGACGCCATTGATAATCTGGAGCCGGCGGGCTGTCGGAGTACGAACCACAAGTTCGTGCTGCACACGTTCGAGAAGGCCGCCACGTGCCACCACTGCTCCAAGTTCCTCAAAGGCAGAATATTCCAGGGCTACCTGTGCTCGGTGTGCAACGCGTGCGCCCACAAGGAGTGCATCGCTCTGTCGGGGCGCTGCGGAGGGGGGCTCGCCCCCGCGCCGCCCCTGCCGCCCCACCACCACCAGCCTGACAACGCGCTGCACTACTACATGTGGTATGTGGGTGAGATGGGACGAGAGACGGCGACCGCCCGCCTGGAGCGGCGCGTGGACGGCACGTTCCTGCTGCGCGTGCGACCGCATCACGCCGCGCATCCCGCGCTGCATCCCGCCAACGACACGCACTACGCTCTCTCGCTCAAGACTGACAACACCGTGAAACACATGCGAGTGTGCCGCAAACCGATCGATCAGATCCCTCACTACTTCCTGTCGGAGTCGCGCTTCTTCCGGAGCGTCGTGGAACTGGTCTCTTACTACGAGAAGACGAGCCTGTCGGAGAACTTCGAAGGCTTAAACTCAAATCTTCGATGGCCGTTCCGTCGCGTGGTGGCGACCGTCATCCACGACTTCCGCCCGCTGGAGAGCTCCCAGCTGGCGCTCCGGCCCGGCTCCAAGGTGCTGGTGCTCAGTAAGGAGGGAGACTCCCAGGGCTGGTGGAAGGGACGAACGCTAGATAAGGGTGACAATAGATCCGGGTACTTCCCCAAGGAGTGCGTGCGGGAGGAGCCGGAGTGCATCGGGGCGCTGGACTGA
Protein
MASGGEELWRDCASWLTRCGLLRPDHKANWETSTIHDLAYTLRDGVLLCNLLNVLHPGCIDMKDVNQRPQMAQFLCLRNIKVFLRTCHEVFELRETDLFDPSMLFELSNFHRVLCTLAKLSQCPKVLANSITPFSAHRTQSEEDIYKDLQSVGEACAPLGADVGEYSSYCARIHDEEIYHDLCAVKNNREFTTPTRTLHTLATSSHSLEKRDYVIRELVDTESNYVDVLSKIIQHFMRPLMPYLKPQDLQGIFFGIKELYEIHSGLLRQLKLATEACVPGSGAPRLADVFLAWREKLLLYGDYCSNLTHAQDTLKLLDAKDNTFNKQLAKCQKEHSDGRIQLRDILSVPMQRVLKYHLLLDKLVHETQPNHEEFRGLERAKEAMVDVAQYINEVKRDSEVLTLLANVQDSIINWEGAALGAGGAGLAAYGRLLLDGELKVKAHEDQKLRTRYVFVFDKLMLLCKPVKENQYLYRVGVRLAEFRVEEGSSRRALRTDARWAAHFYLVRRTKDSTYTLYARTDDCKRKWVKAIKDAIDNLEPAGCRSTNHKFVLHTFEKAATCHHCSKFLKGRIFQGYLCSVCNACAHKECIALSGRCGGGLAPAPPLPPHHHQPDNALHYYMWYVGEMGRETATARLERRVDGTFLLRVRPHHAAHPALHPANDTHYALSLKTDNTVKHMRVCRKPIDQIPHYFLSESRFFRSVVELVSYYEKTSLSENFEGLNSNLRWPFRRVVATVIHDFRPLESSQLALRPGSKVLVLSKEGDSQGWWKGRTLDKGDNRSGYFPKECVREEPECIGALD

Summary

Subunit
Interacts (via SH2 domain) with Egfr (when phosphorylated on tyrosine residues).
Keywords
Alternative splicing   Complete proteome   Guanine-nucleotide releasing factor   Metal-binding   Phosphoprotein   Reference proteome   Repeat   SH2 domain   SH3 domain   Zinc   Zinc-finger  
Feature
chain  Protein vav
splice variant  In isoform B.
EMBL
NWSH01000087    PCG79726.1    PCG79728.1    ODYU01001486    SOQ37755.1    AGBW02009363    + More
OWR50992.1    KQ459596    KPI95380.1    KQ459781    KPJ19989.1    PCG79727.1    GEDC01002438    JAS34860.1    NEVH01010478    PNF32490.1    GDHC01013005    GDHC01003954    GDHC01000198    JAQ05624.1    JAQ14675.1    JAQ18431.1    GBBI01002835    JAC15877.1    ACPB03012381    GDKW01001955    JAI54640.1    GL437652    EFN70226.1    GL765940    EFZ15824.1    AGBW02009681    OWR50144.1    ADTU01015035    KQ414654    KOC65970.1    GEBQ01021654    JAT18323.1    KQ977721    KYN00384.1    PNF32491.1    GEBQ01013682    JAT26295.1    KZ288256    PBC30554.1    KQ761783    OAD56983.1    GBYB01001447    JAG71214.1    ABLF02034141    ABLF02034150    GEZM01062436    JAV69723.1    GECZ01015145    JAS54624.1    GDHF01008463    GDHF01004786    JAI43851.1    JAI47528.1    AXCN02001876    GAKP01015362    JAC43590.1    ATLV01020681    KE525304    KFB45541.1    GBXI01011264    JAD03028.1    CVRI01000045    CRK96932.1    AXCM01002077    GFDL01000510    JAV34535.1    GGFK01004536    MBW37857.1    GAMC01004922    JAC01634.1    GGFL01004545    MBW68723.1    CH477886    EAT35348.1    GGFL01004087    MBW68265.1    AJWK01022411    AAAB01008980    EAA14588.5    GGFK01008367    MBW41688.1    CH940651    EDW65275.1    CH902650    EDV30071.2    CH954180    EDV46687.1    KQ971382    EEZ97169.2    GBHO01029968    GBHO01029963    GBHO01020587    JAG13636.1    JAG13641.1    JAG23017.1    OUUW01000015    SPP88665.1    CH964291    EDW86355.1    CH379064    EAL32068.2    CM000162    EDX02153.1    GGMR01007084    MBY19703.1    AF218780    AE014298    AY069536    AY095173    BT029984    CH933810    EDW06943.1    DS235803    EEB17268.1    CH916376    EDV95174.1    CH479192    EDW26422.1    KYB24949.1    JRES01000424    KNC31399.1    KQ982339    KYQ57402.1    NNAY01002290    OXU21609.1    UFQS01000021    UFQT01000021    SSW97536.1    SSX17922.1    GBYB01001446    JAG71213.1    GBYB01001445    JAG71212.1    CH480823    EDW56135.1    KQ981625    KYN38999.1    KQ976574    KYM80363.1    LBMM01002207    KMQ95143.1    KQ979568    KYN21024.1    KQ435715    KOX79097.1    GBYB01001449    JAG71216.1    GBYB01008620    JAG78387.1    GL888236    EGI64311.1    QOIP01000006    RLU21663.1    KQ434998    KZC13283.1    CRK96931.1    EAT35349.1    GDHF01006452    GDHF01005789    JAI45862.1    JAI46525.1    GBXI01004617    JAD09675.1    GFDL01000512    JAV34533.1    GGFK01005649    MBW38970.1    JXJN01001873    KK107487    EZA50030.1   
Pfam
PF00621   RhoGEF        + More
PF00307   CH
PF00018   SH3_1
PF00017   SH2
PF00169   PH
PF00130   C1_1
PF07653   SH3_2
PF14604   SH3_9
Interpro
IPR000219   DH-domain        + More
IPR001849   PH_domain       
IPR036028   SH3-like_dom_sf       
IPR002219   PE/DAG-bd       
IPR011993   PH-like_dom_sf       
IPR035899   DBL_dom_sf       
IPR036860   SH2_dom_sf       
IPR000980   SH2       
IPR036872   CH_dom_sf       
IPR001715   CH-domain       
IPR001452   SH3_domain       
IPR037832   PH_Vav       
IPR035031   Vav_SH2_invertebrate       
IPR003096   SM22_calponin       
SUPFAM
SSF55550   SSF55550        + More
SSF50044   SSF50044       
SSF48065   SSF48065       
SSF47576   SSF47576       
PDB
3KY9     E-value=2.31763e-97,     Score=911

Ontologies

Topology

Length:
801
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00846
Exp number, first 60 AAs:
0.00056
Total prob of N-in:
0.00015
outside
1  -  801
 
 

Population Genetic Test Statistics

Pi
20.848741
Theta
36.184673
Tajima's D
-2.398089
CLR
1.397132
CSRT
0.000849957502124894
Interpretation
Possibly Positive selection
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