Gene

KWMTBOMO08643  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007949

Annotation

PREDICTED:_heat_shock_70_kD_protein_cognate_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr15(-):1524634-1531332      View in EpiBrowser

Full name

Delta-aminolevulinic acid dehydratase      

Location in the cell

Cytoplasmic   Reliability : 1.412 Mitochondrial   Reliability : 1.406

CDS

ATGAGTAATTTGTATTTAACACCTGAACATGTGCTGCAAGGCGGATACCATCATGCTGCCTTGAGAAAGTTACAGGAACCGAACACAAGCATCGAACCGCACAATATTATGTATCCTGTGTTTTTAGTAGAAAAAGATAATGCTATCGAACCGGTTCATAGTATGCCGAATGTAAACAGATATGGTGTTGACCAACTCATACCCCTTTTAGCAGAACTTGTGGAAAAAGGACTCAAATCTATACTCATTTTTGGGATTGTGGAGACACTGCCTAAGGACCCAACAGGTACTAGTGCAGATTCAGTAGACAATCCAGTAATAAAAGCATTGCCGAAATTGCGTGCTGCCTTTCCTGATTTGTTAATAGCATGTGATGTATGTTTATGTCCGTACACATCACACGGACATTGTGGCTTACTGAAGAGTGGAGGAGGTATCGACCATGAAGCATCAGTAAAGAGGATAGCTGAAGTCGCATTGGCTTATGCAAAAGCTGGTGCTCATGTGGTGGCTCCTTCAGACATGATGGACAATAGGATTAAAGCAATCAAAGAGGAGCTGGTCAGAAATAAATTGCAAAACCAAGTGTCGATACTGTCTTACTCGTGTAAGTTCGCGTCGTCGATGTACGGACCCTTCCGTGACACTATGAAGAGCTCTCCGATGGAAGGCGACCGGAAATGCTATCAGCTTCCGCCGGGCAGCGCCGCTTTAGCCGCCAGGGCCGCAGCGCGTGACGTTGCTGAAGGCGCAGACTTCCTGATGGTGAAACCGGGGCTGCCCTACCTGGACATTGTGCGGCAGACCAAGGACCGCTTCCCGCACCACCCCTTGTTCATATACCAGGTATCCGGCGAGTACGAGTTGATATCTAGGAGCGGTGACCGCGCGAGCATGCAGACCAACCTGATGGAGATCCTCACGTGCATGAGGAGGGCGGGCGCTGATTGCATCATAACGTATTTCGCTCCTCTCATTTTAAGCATAATATCAGAAAAGAAGTAA

Protein

MSNLYLTPEHVLQGGYHHAALRKLQEPNTSIEPHNIMYPVFLVEKDNAIEPVHSMPNVNRYGVDQLIPLLAELVEKGLKSILIFGIVETLPKDPTGTSADSVDNPVIKALPKLRAAFPDLLIACDVCLCPYTSHGHCGLLKSGGGIDHEASVKRIAEVALAYAKAGAHVVAPSDMMDNRIKAIKEELVRNKLQNQVSILSYSCKFASSMYGPFRDTMKSSPMEGDRKCYQLPPGSAALAARAAARDVAEGADFLMVKPGLPYLDIVRQTKDRFPHHPLFIYQVSGEYELISRSGDRASMQTNLMEILTCMRRAGADCIITYFAPLILSIISEKK

Catalytic Activity

2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen

Subunit

Homooctamer.

Similarity

Belongs to the ALAD family.

Uniprot

S4PGN8   A0A2A4K674   A0A3S2TU09   A0A212FBA0   A0A2H1WWZ8   H9JEK2   + More
A0A0K8TSS3   A0A182V005   B0WF62   Q1HQH0   A0A1Q3FC04   A0A182KKC0   A0A182LZ53   A0A1B0CG52   A0A182WUN9   Q7QGX8   A0A182IZU1   A0A182RYW3   A0A182HVT6   A0A182QJH4   A0A182PJA3   A0A182UIS9   A0A182GZ32   A0A182K5A2   A0A2M4BSG8   A0A182FKD1   A0A182GYT3   A0A2M3ZGX4   A0A2M4ASP0   W5JNK1   A0A2M4CG71   A0A182WFW4   A0A182YKM8   T1E9Y9   A0A182SJR4   A0A195DMQ8   A0A0N7ZCW9   K7ITP7   A0A0L0BWK3   T1PIQ7   A0A151IKJ1   U5EKG4   A0A195FJL2   F4W674   R4G3N4   A0A0C9RCB1   A0A034WPC6   A0A310SGR9   A0A423SST2   A0A1W4WIU1   A0A195AW61   A0A0K8VLB7   A0A1I8P405   W8CCQ8   A0A336LML7   J3JVW8   A0A0A9XHP9   A0A0K8VZ16   A0A0A9XN56   A0A154PI30   A0A0A9XJW8   A0A0B7ANN1   A0A026VU46   A0A0L7R5D2   A0A1A9WCZ5   A0A0A1XEV8   A0A0J7L3H2   V5GG21   A0A067RKI6   E0VHL1   A0A194PW64   A0A069DYN0   B4HFK9   A0A088ACF3   B3NH88   B4QR82   A0A084VSI6   B4PGB6   A0A2A3EH53   Q2M0R1   A0A224XJP0   B4GR82   B4MLG5   Q9VTV9   R7TCP0   B3M7U1   D0QWS1   A0A1B0C5L0   A0A1Y1JY47   A0A0V0G5V8   B4LFF2   A0A1S3K0K7   A0A1A9XPZ7   N6TWI0   A0A444TBC1   B4KZZ5   A0A3B0J4A6   A0A210Q6E1   H2TPX9   A0A0M5J151  

EC Number

4.2.1.24

Pubmed

23622113    22118469    19121390    26369729    17204158    17510324    + More
20966253    12364791    14747013    17210077    26483478    20920257    23761445    25244985    20075255    26108605    25315136    21719571    25348373    24495485    22516182    25401762    26823975    24508170    30249741    25830018    24845553    20566863    26354079    26334808    17994087    22936249    24438588    17550304    15632085    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    23254933    19859648    28004739    23537049    28812685    21551351   

EMBL

GAIX01003577    JAA88983.1    NWSH01000087    PCG79737.1    RSAL01000001    RVE55213.1    + More
AGBW02009363    OWR50997.1    ODYU01011696    SOQ57599.1    BABH01003235    BABH01003236    BABH01003237    GDAI01000191    JAI17412.1    DS231915    EDS26038.1    DQ440474    CH477238    ABF18507.1    EAT46522.1    GFDL01010003    JAV25042.1    AXCM01007054    AJWK01010758    AAAB01008823    EAA05538.4    AXCP01008426    APCN01001416    AXCN02001762    JXUM01021456    KQ560601    KXJ81683.1    GGFJ01006793    MBW55934.1    JXUM01098060    KQ564391    KXJ72354.1    GGFM01006974    MBW27725.1    GGFK01010495    MBW43816.1    ADMH02001012    ETN64460.1    GGFL01000136    MBW64314.1    GAMD01000877    JAB00714.1    KQ980724    KYN14116.1    GDRN01058260    JAI65616.1    JRES01001238    KNC24408.1    KA647985    AFP62614.1    KQ977199    KYN05001.1    GANO01001822    JAB58049.1    KQ981523    KYN40447.1    GL887707    EGI70209.1    GAHY01001511    JAA75999.1    GBYB01014214    JAG83981.1    GAKP01001516    GAKP01001515    JAC57436.1    KQ760132    OAD61810.1    QCYY01002829    ROT67257.1    KQ976731    KYM76292.1    GDHF01012645    JAI39669.1    GAMC01003271    JAC03285.1    UFQT01000011    SSX17597.1    BT127386    AEE62348.1    GBHO01023347    JAG20257.1    GDHF01008156    JAI44158.1    GBHO01023349    GBHO01023346    GBRD01007230    JAG20255.1    JAG20258.1    JAG58591.1    KQ434923    KZC11499.1    GBHO01023345    GDHC01012839    JAG20259.1    JAQ05790.1    HACG01034640    CEK81505.1    KK111518    QOIP01000005    EZA46379.1    RLU23142.1    KQ414654    KOC66029.1    GBXI01004795    JAD09497.1    LBMM01000815    KMQ97427.1    GALX01005552    JAB62914.1    KK852460    KDR23528.1    DS235171    EEB12897.1    KQ459596    KPI95375.1    GBGD01002105    JAC86784.1    CH480815    EDW41240.1    CH954178    EDV51545.1    CM000363    CM002912    EDX10212.1    KMY99204.1    ATLV01016038    KE525054    KFB40930.1    CM000159    EDW94280.1    KZ288256    PBC30612.1    CH379069    EAL30869.2    GFTR01005162    JAW11264.1    CH479188    EDW40267.1    CH963847    EDW72821.1    AE014296    AY071047    AAF49936.1    AAL48669.1    AGB94445.1    AMQN01002930    KB310466    ELT91513.1    CH902618    EDV38814.1    FJ821035    ACN94783.1    JXJN01026061    GEZM01097362    JAV54252.1    GECL01002739    JAP03385.1    CH940647    EDW69250.1    APGK01049750    KB741156    KB631941    ENN73615.1    ERL87379.1    SAUD01005232    RXG67273.1    CH933809    EDW18007.1    OUUW01000002    SPP76285.1    NEDP02004840    OWF44259.1    CP012525    ALC45061.1   

Proteomes

UP000218220    UP000283053    UP000007151    UP000005204    UP000075903    UP000002320    + More
UP000008820    UP000075882    UP000075883    UP000092461    UP000076407    UP000007062    UP000075880    UP000075900    UP000075840    UP000075886    UP000075885    UP000075902    UP000069940    UP000249989    UP000075881    UP000069272    UP000000673    UP000075920    UP000076408    UP000075901    UP000078492    UP000002358    UP000037069    UP000095301    UP000078542    UP000078541    UP000007755    UP000283509    UP000192223    UP000078540    UP000095300    UP000076502    UP000053097    UP000279307    UP000053825    UP000091820    UP000036403    UP000027135    UP000009046    UP000053268    UP000001292    UP000005203    UP000008711    UP000000304    UP000030765    UP000002282    UP000242457    UP000001819    UP000008744    UP000007798    UP000000803    UP000014760    UP000007801    UP000092460    UP000008792    UP000085678    UP000092443    UP000019118    UP000030742    UP000288706    UP000009192    UP000268350    UP000242188    UP000005226    UP000092553   

PRIDE

H9JEK2    Q9VTV9   

Pfam

PF00490   ALAD        + More
PF05033   Pre-SET
PF12796   Ank_2
PF00856   SET
PF04145   Ctr

Interpro

IPR001731   ALAD        + More
IPR030656   ALAD_AS       
IPR013785   Aldolase_TIM       
IPR002110   Ankyrin_rpt       
IPR001214   SET_dom       
IPR007728   Pre-SET_dom       
IPR020683   Ankyrin_rpt-contain_dom       
IPR036770   Ankyrin_rpt-contain_sf       
IPR007274   Cop_transporter       

SUPFAM

SSF48403   SSF48403       

Gene 3D

3.20.20.70     1.25.40.20    

CDD

cd00204  ANK

ProteinModelPortal

S4PGN8   A0A2A4K674   A0A3S2TU09   A0A212FBA0   A0A2H1WWZ8   H9JEK2   + More
A0A0K8TSS3   A0A182V005   B0WF62   Q1HQH0   A0A1Q3FC04   A0A182KKC0   A0A182LZ53   A0A1B0CG52   A0A182WUN9   Q7QGX8   A0A182IZU1   A0A182RYW3   A0A182HVT6   A0A182QJH4   A0A182PJA3   A0A182UIS9   A0A182GZ32   A0A182K5A2   A0A2M4BSG8   A0A182FKD1   A0A182GYT3   A0A2M3ZGX4   A0A2M4ASP0   W5JNK1   A0A2M4CG71   A0A182WFW4   A0A182YKM8   T1E9Y9   A0A182SJR4   A0A195DMQ8   A0A0N7ZCW9   K7ITP7   A0A0L0BWK3   T1PIQ7   A0A151IKJ1   U5EKG4   A0A195FJL2   F4W674   R4G3N4   A0A0C9RCB1   A0A034WPC6   A0A310SGR9   A0A423SST2   A0A1W4WIU1   A0A195AW61   A0A0K8VLB7   A0A1I8P405   W8CCQ8   A0A336LML7   J3JVW8   A0A0A9XHP9   A0A0K8VZ16   A0A0A9XN56   A0A154PI30   A0A0A9XJW8   A0A0B7ANN1   A0A026VU46   A0A0L7R5D2   A0A1A9WCZ5   A0A0A1XEV8   A0A0J7L3H2   V5GG21   A0A067RKI6   E0VHL1   A0A194PW64   A0A069DYN0   B4HFK9   A0A088ACF3   B3NH88   B4QR82   A0A084VSI6   B4PGB6   A0A2A3EH53   Q2M0R1   A0A224XJP0   B4GR82   B4MLG5   Q9VTV9   R7TCP0   B3M7U1   D0QWS1   A0A1B0C5L0   A0A1Y1JY47   A0A0V0G5V8   B4LFF2   A0A1S3K0K7   A0A1A9XPZ7   N6TWI0   A0A444TBC1   B4KZZ5   A0A3B0J4A6   A0A210Q6E1   H2TPX9   A0A0M5J151  

PDB

2Z1B     E-value=2.79901e-97,     Score=906

KEGG

NA   

GO

GO:0004655   GO:0006779   GO:0046872   GO:0018024   GO:0005634   GO:0005694   GO:0008270   GO:0005829   GO:0006783   GO:0005375   GO:0016021   GO:0033014   GO:0003824   GO:0007165   GO:0016620   GO:0006418   GO:0003676   GO:0016876   GO:0043039  

PANTHER

PTHR11458  

Subcellular location

Chromosome  
Nucleus  

Length:

334

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.31926

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01405

outside

1  -  334

 

 

Pi

328.578181

Theta

179.0156

Tajima's D

-1.980895

CLR

1552.611032

CSRT

0.0144992750362482

Interpretation

Uncertain