SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08642  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA007950
Annotation
heat_shock_protein_70-3_[Bombyx_mori]
Location
Bomo_Chr15(-):1519699-1522872      View in EpiBrowser
Full name
Delta-aminolevulinic acid dehydratase      
Location in the cell
ER   Reliability : 4.419
 

Sequence

CDS
ATGCGGTGGAGTTTGTTCGCGCTAGTTTTGGTGGTCGCGGCCGTTTGTGCCGACGACAAGAAGGAGAAAGATAAGGACATCGGCACAGTAATCGGTATCGATTTGGGTACCACTTACTCATGTGTCGGTGTCTACAAAAATGGACGTGTAGAAATCATTGCCAATGACCAGGGAAACCGCATCACACCTTCATACGTGGCCTTCACTCAAGATGGTGAACGTTTAATTGGTGATGCTGCCAAAAACCAGCTTACTACCAACCCTGAAAACACTGTCTTTGATGCCAAGCGTCTGATTGGTCGTGAATGGAGTGACCAAACTGTACAACATGATGTTAAGTTCTTCCCCTTCAAGGTCGTTGAAAAGAACAGCAAACCTCATGTTCAAGTACAAACTTCACAAGGCGACAAAGTGTTTGCTCCTGAAGAAATCTCTGCTATGGTTCTGACTAAAATGAAGGAGACTGCTGAGGCTTACCTTGGAAAAAAGGTTACTCATGCTGTTGTTACTGTGCCTGCTTATTTCAATGATGCTCAACGTCAAGCAACCAAAGATGCTGGTACAATTTCTGGTCTTAATGTAATGAGAATCATTAATGAGCCTACTGCTGCAGCTATCGCCTATGGCCTTGACAAGAAGGAAGGAGAGAAGAATGTTCTAGTCTTTGATTTGGGTGGTGGAACCTTTGATGTCTCTCTGCTAACCATTGACAATGGTGTATTTGAAGTTGTTGCAACTAATGGGGATACCCACTTGGGAGGTGAAGACTTTGACCAGAGAGTCATGGAACACTTCATCAAGTTGTACAAGAAGAAGAAAGGCAAGGACATCAGAAAAGACAACCGTGCCGTGCAGAAGTTGCGTCGTGAGGTTGAAAAAGCAAAGAGAGCCCTGTCTTCCAGTCACCAGGTCAAGATCGAAATTGAATCATTCTTTGAAGGTGATGACTTCTCTGAAACACTCACCAGAGCTAAATTTGAAGAATTGAACATGGACCTCTTCAGATCCACTTTGAAACCTGTGCAGAAAGTATTAGAAGATGCTGACATGAACAAGAAAGATGTTGATGAAATTGTCTTAGTAGGAGGCTCTACCCGTATCCCTAAGGTTCAACAACTGGTCAAGGAATTCTTCAATGGCAAGGAGCCATCTCGTGGAATTAACCCTGATGAGGCTGTCGCATATGGTGCTGCTGTGCAGGCTGGTGTACTCAGTGGTGAACAAGATACTGATGCTATTGTCTTGCTTGATGTCAACCCTCTGACCATGGGTATTGAAACTGTCGGTGGAGTGATGACCAAACTCATTCCTCGTAACACTGTCATTCCAACTAAGAAATCTCAGATCTTCTCTACTGCCAGTGACAACCAACACACTGTCACTATCCAAGTGTACGAGGGTGAGCGACCAATGACCAAGGACAATCATTTACTTGGTAAATTTGACTTAACTGGGATCCCTCCTGCTCCTCGTGGTATTCCACAAATTGAAGTCACATTTGAAATTGATGCCAACGGTATTTTGCAAGTGTCTGCTGAAGATAAGGGAACAGGAAACAGGGAAAAGATTGTAATCACTAATGACCAGAACAGACTGACACCTGAAGATATTGAAAGAATGATTAAGGATGCTGAGAAGTTTGCCGATGATGACAAGAAGTTGAAGGAACGAGTAGAGTCAAGAAACGAGCTCGAAAGTTATGCTTACTCAATCAAAAACCAACTTCAGGATAAGGAAAAACTTGGTGCTAAGGTTACTGATGACGACAAGGCAAAGATGGAAGAAGCACTAGATGCAGCTATTAAGTGGTTAGAAGATAATCAAGATGCAGAATCTGAAGAATACAAGAAACAGAAGAAGACGCTTGAAGATGTGGTGCAGCCCATCATCGCCAAACTTTACCAAGGCCAGGGTGGAGTACCGCCCCCGGGGGCGCCGGAAGATGACGACTTCAAGGACGAGTTGTAA
Protein
MRWSLFALVLVVAAVCADDKKEKDKDIGTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTQDGERLIGDAAKNQLTTNPENTVFDAKRLIGREWSDQTVQHDVKFFPFKVVEKNSKPHVQVQTSQGDKVFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQRQATKDAGTISGLNVMRIINEPTAAAIAYGLDKKEGEKNVLVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKKGKDIRKDNRAVQKLRREVEKAKRALSSSHQVKIEIESFFEGDDFSETLTRAKFEELNMDLFRSTLKPVQKVLEDADMNKKDVDEIVLVGGSTRIPKVQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGEQDTDAIVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQIFSTASDNQHTVTIQVYEGERPMTKDNHLLGKFDLTGIPPAPRGIPQIEVTFEIDANGILQVSAEDKGTGNREKIVITNDQNRLTPEDIERMIKDAEKFADDDKKLKERVESRNELESYAYSIKNQLQDKEKLGAKVTDDDKAKMEEALDAAIKWLEDNQDAESEEYKKQKKTLEDVVQPIIAKLYQGQGGVPPPGAPEDDDFKDEL

Summary

Catalytic Activity
2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen
Subunit
Homooctamer.
Similarity
Belongs to the heat shock protein 70 family.
Uniprot
F8UN44   O76180   L0GD06   A0A437BXT3   T1SC36   A0A1L2EC15   + More
A0A0K0KIV3   A0A0N1IHN0   I4DIU0   A0A194PQY8   Q0MUU6   A2THY6   A0A2H1WX17   Q8I866   Q0MUU7   A0A212FBA7   A0A2A4K6P0   F5BYH9   S4PFA1   A0A1B6FP92   A0A023EUP2   K7ITP5   A0A232ETH5   U5EM92   A0A1B6M218   V5G2L7   A0A182QQ52   A0A0T6AXM8   A0A182NLE9   A0A386GY21   A0A182JM43   A0A151IKJ7   A0A158P200   B0W934   Q1HR69   A0A0E3J9X2   G8XSQ5   A0A0B4L0J4   F4W675   A0A195AVT6   A0A195FIF0   A0A158P201   A0A3G5BIM7   E9J3P4   A0A2J7QVA3   A0A195DNP5   W5J8P5   A0A084VNR9   D6WD04   A0A1Q3F6D4   A0A0C9RYT3   A0A067RKH3   A0A162ESE3   A0A182PKP4   E2AY69   A0A182TR51   A0A2M3ZYA4   A0A182VNH9   A0A182XJ64   Q7PQK5   A0A182I7P6   T1E8A2   E1AC53   A0A161MIJ3   A0A2M3ZDW3   A0A2M4BGP2   A0A182MA87   A0A023FAG0   A0A182W1F1   A0A0A9YH32   A0A1I8NNP7   A0A0L0C201   A0A182S044   A0A1L8DUA9   U6BMW7   A0A182FSB8   A0A2P0XJ04   A0A182YGQ9   R4FQG8   A0A1S5VZG3   A0A1I9WL38   E2BBQ5   A0A0J7L466   A0A1S5VZC5   A0A1Y1MTV0   V5TGF4   Q29HE5   A0A154PJN9   A0A026WBY7   A0A3B0KQK0   U5EZA5   A0A0M4EWI1   A0A0K8U1R7   M4XYZ9   A0A1J1HJV6   A0A1I8MSK2   B4L1X2   A0A2R7VR14   M4XXP6   R4WDB5  
EC Number
4.2.1.24
Pubmed
19121390    26354079    22651552    22118469    21452889    23622113    + More
24945155    26483478    20075255    28648823    30226893    21347285    17204158    17510324    25502019    21719571    30400621    21282665    20920257    23761445    24438588    18362917    19820115    24845553    20798317    12364791    14747013    17210077    25474469    25401762    26823975    26108605    25244985    27538518    28187833    28004739    15632085    17994087    23185243    24508170    30249741    25315136    18057021    23691247   
EMBL
BABH01003237    JF836796    AEI58998.1    FJ573458    FJ573459    AB016836    + More
ACL36369.1    BAA32395.1    JX948747    AGA84579.1    RSAL01000001    RVE55214.1    JX680678    JX680679    AGR84225.1    AGR84226.1    KT003963    ANJ86403.1    KM215268    AIJ00865.1    KQ460497    KPJ14331.1    AK401208    BAM17830.1    KQ459596    KPI95373.1    DQ845106    ABH09735.1    EF202591    ABM88156.1    ODYU01011696    SOQ57598.1    AY161271    AAN86047.1    DQ845105    ABH09734.1    AGBW02009363    OWR50998.1    NWSH01000087    PCG79739.1    JF417984    AEB26315.1    GAIX01004117    JAA88443.1    GECZ01017795    JAS51974.1    JXUM01110564    JXUM01110565    KU672623    GAPW01000453    ANO39920.1    JAC13145.1    NNAY01002271    OXU21665.1    GANO01001131    JAB58740.1    GEBQ01009996    JAT29981.1    GALX01004206    JAB64260.1    AXCN02000131    LJIG01022626    KRT79566.1    MH490977    AYD37990.1    KQ977199    KYN05002.1    ADTU01006919    ADTU01006920    ADTU01006921    DS231862    EDS39731.1    DQ440225    CH477376    ABF18258.1    EJY57621.1    KJ701755    AJO53611.1    FJ472843    ACS75353.1    KC620437    AHE77386.1    GL887707    EGI70210.1    KQ976731    KYM76291.1    KQ981523    KYN40445.1    MK075234    AYV99637.1    GL768069    EFZ12477.1    NEVH01010478    PNF32507.1    KQ980724    KYN14114.1    ADMH02001952    ETN60336.1    ATLV01014857    KE524991    KFB39613.1    KQ971311    EEZ98819.2    GFDL01011956    JAV23089.1    GBYB01014485    JAG84252.1    KK852460    KDR23518.1    KR349165    AKP54257.1    GL443762    EFN61604.1    GGFK01000131    MBW33452.1    AAAB01008880    EAA08691.4    APCN01002523    GAMD01002948    JAA98642.1    HM589531    ADM13382.1    GEMB01001687    JAS01476.1    GGFM01006006    MBW26757.1    GGFJ01003022    MBW52163.1    AXCM01001304    GBBI01000718    JAC17994.1    GBHO01011227    GBRD01008097    GDHC01014474    JAG32377.1    JAG57724.1    JAQ04155.1    JRES01000994    KNC26345.1    GFDF01004055    JAV10029.1    KC544269    AHA36969.1    KY661342    AVA17429.1    ACPB03005165    GAHY01000404    JAA77106.1    KX976472    AQP31362.1    KU932222    APA33858.1    GL447151    EFN86831.1    LBMM01000815    KMQ97426.1    KX695161    AQP31331.1    GEZM01024178    JAV87895.1    KF660252    AHB63835.1    CH379064    EAL31813.1    KRT06590.1    KRT06591.1    KQ434923    KZC11498.1    KK107293    QOIP01000005    EZA53141.1    RLU22375.1    OUUW01000016    SPP88899.1    GANO01001144    JAB58727.1    CP012528    ALC49822.1    GDHF01031858    JAI20456.1    KC430097    AGI37646.1    CVRI01000006    CRK88344.1    CH933810    EDW07693.1    KRF94144.1    KK854035    PTY09954.1    KC422577    AGI36553.1    AK417409    BAN20624.1   
Proteomes
UP000005204    UP000283053    UP000053240    UP000053268    UP000007151    UP000218220    + More
UP000069940    UP000002358    UP000215335    UP000075886    UP000075884    UP000075880    UP000078542    UP000005205    UP000002320    UP000008820    UP000007755    UP000078540    UP000078541    UP000235965    UP000078492    UP000000673    UP000030765    UP000007266    UP000027135    UP000075885    UP000000311    UP000075902    UP000075903    UP000076407    UP000007062    UP000075840    UP000075883    UP000075920    UP000095300    UP000037069    UP000075900    UP000069272    UP000076408    UP000015103    UP000008237    UP000036403    UP000001819    UP000076502    UP000053097    UP000279307    UP000268350    UP000092553    UP000183832    UP000095301    UP000009192   
PRIDE
F8UN44    O76180    L0GD06   
Pfam
PF00012   HSP70        + More
PF00490   ALAD
Interpro
IPR029048   HSP70_C_sf        + More
IPR018181   Heat_shock_70_CS       
IPR029047   HSP70_peptide-bd_sf       
IPR013126   Hsp_70_fam       
IPR042050   BIP_NBD       
IPR001731   ALAD       
IPR030656   ALAD_AS       
IPR013785   Aldolase_TIM       
SUPFAM
SSF100920   SSF100920        + More
SSF100934   SSF100934       
Gene 3D
1.20.1270.10     2.60.34.10     3.20.20.70    
CDD
cd10241  HSPA5-like_NBD
ProteinModelPortal
F8UN44   O76180   L0GD06   A0A437BXT3   T1SC36   A0A1L2EC15   + More
A0A0K0KIV3   A0A0N1IHN0   I4DIU0   A0A194PQY8   Q0MUU6   A2THY6   A0A2H1WX17   Q8I866   Q0MUU7   A0A212FBA7   A0A2A4K6P0   F5BYH9   S4PFA1   A0A1B6FP92   A0A023EUP2   K7ITP5   A0A232ETH5   U5EM92   A0A1B6M218   V5G2L7   A0A182QQ52   A0A0T6AXM8   A0A182NLE9   A0A386GY21   A0A182JM43   A0A151IKJ7   A0A158P200   B0W934   Q1HR69   A0A0E3J9X2   G8XSQ5   A0A0B4L0J4   F4W675   A0A195AVT6   A0A195FIF0   A0A158P201   A0A3G5BIM7   E9J3P4   A0A2J7QVA3   A0A195DNP5   W5J8P5   A0A084VNR9   D6WD04   A0A1Q3F6D4   A0A0C9RYT3   A0A067RKH3   A0A162ESE3   A0A182PKP4   E2AY69   A0A182TR51   A0A2M3ZYA4   A0A182VNH9   A0A182XJ64   Q7PQK5   A0A182I7P6   T1E8A2   E1AC53   A0A161MIJ3   A0A2M3ZDW3   A0A2M4BGP2   A0A182MA87   A0A023FAG0   A0A182W1F1   A0A0A9YH32   A0A1I8NNP7   A0A0L0C201   A0A182S044   A0A1L8DUA9   U6BMW7   A0A182FSB8   A0A2P0XJ04   A0A182YGQ9   R4FQG8   A0A1S5VZG3   A0A1I9WL38   E2BBQ5   A0A0J7L466   A0A1S5VZC5   A0A1Y1MTV0   V5TGF4   Q29HE5   A0A154PJN9   A0A026WBY7   A0A3B0KQK0   U5EZA5   A0A0M4EWI1   A0A0K8U1R7   M4XYZ9   A0A1J1HJV6   A0A1I8MSK2   B4L1X2   A0A2R7VR14   M4XXP6   R4WDB5  
PDB
6ASY     E-value=0,     Score=2315

Ontologies

KEGG
692373    K09490 heat shock 70kDa protein 5 | (RefSeq) HSP70, grp78; heat shock 70 kD protein cognate
PATHWAY
03060    Protein export - Bombyx mori (domestic silkworm)
04141    Protein processing in endoplasmic reticulum - Bombyx mori (domestic silkworm)
GO
GO:0005524   GO:0004655   GO:0006779   GO:0046872   GO:0030968   GO:0051085   GO:0016887   GO:0042623   GO:0051787   GO:0034620   GO:0044183   GO:0005634   GO:0005737   GO:0042026   GO:0005788   GO:0034605   GO:0016020   GO:0030433   GO:0034663   GO:0031072   GO:0006986   GO:0051082   GO:0036335   GO:0005615   GO:0005783   GO:0034976   GO:0016246  
PANTHER
PTHR19375  

Topology

SignalP
Position:   1 - 17,         Likelihood:  0.999234
 
 
Length:
655
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.00752999999999998
Exp number, first 60 AAs:
0.00642
Total prob of N-in:
0.00045
outside
1  -  655
 
 

Population Genetic Test Statistics

Pi
237.148655
Theta
208.642887
Tajima's D
0.061514
CLR
0.693735
CSRT
0.381880905954702
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
26280517 NPGVPEGFR 96.55 4e-13
26822097 VIEDADMNKK 100.00 1e-12
26280517 QSEEEVYFSASVIR 100.00 1e-12
28467696 SQIEGFNTSCIR 100.00 1e-12
28556443 VVEKNSKPHVQVQTSQGDK 100.00 1e-12
26280517 ITPFTIGAIIAMYEHK 95.24 1e-07
27102218 NEIESYAYSIKNQIQDKEK 95.24 1e-07
20518026 ITPSYVAFTADGER 95.24 6e-07
26280517 EWINSYVNYNVK 100.00 3e-06
26280517 VVEEFIDVAAPIR 100.00 4e-06
28556443 VTHAVVTVPAYFNDAQR 100.00 4e-06
28556443 VFAPEEISAM 100.00 4e-06
20518026 ETAEAYLGKK 100.00 5e-06
26822097 ETAEAYIGKK 100.00 5e-06
26280517 IYQGQGGVPPPGAPEDDDFKDEI 100.00 5e-06
25044914 KVTDPSKR 100.00 5e-06
28467696 KVSSNVQETNEK 100.00 5e-06
26822097 IVITNDQNR 100.00 1e-05
26280517 VGYEEFPNEFTSADGKPAHK 100.00 1e-05
25044914 VTGVVETAPR 100.00 1e-05
24093152 VTGPVASVR 100.00 1e-05
24402669 VTGIDPAGPR 100.00 1e-05
27102218 NQITTNPENTVFDAK 100.00 1e-05
28467696 VTHASMYPDPDIGEYDIGGER 100.00 1e-05
28556443 VTHAVVTVPAYFNDAQR 100.00 1e-05
28556443 VTHAVVTVPAYFNDAQR 100.00 1e-05
28556443 VTHAVVTVPAYFNDAQR 100.00 1e-05
28556443 VTHAVVTVPAYFNDAQR 100.00 1e-05
28556443 VFAPEEISAMVLTK 100.00 1e-05
28556443 VFAPEEISAMVLTK 100.00 1e-05
28556443 IINEPTAAAIAYGLDKK 100.00 1e-04
28556443 IINEPTAAAIAYGLDKK 100.00 1e-04
31223520 TTPSYVAFTDTER 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDKK 100.00 2e-04
28556443 IINEPTAAAIAYGLDK 100.00 2e-04
28556443 IINEPTAAAIAYGLDK 100.00 2e-04
20518026 DAGAIAGLNVLR 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAY 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 IINEPTAAAIAYGLDK 100.00 4e-04
28556443 HWPFEVVSDGGKPK 100.00 4e-04
28556443 HWPFEVVSDGGKPK 100.00 4e-04
28556443 VVEKNSKPHVQVQTSQGDK 100.00 9e-04
28556443 VTHAVVTVPAYFNDAQR 100.00 9e-04
26822097 NQITTNPENTVFDAKR 100.00 0.001
26280517 NSDEFIECIAR 100.00 0.001
25044914 NSIPENVK 100.00 0.001
24402669 NSIMGIDIGSVSEIPGITVIK 100.00 0.001
28556443 NQLTTNPENTVFDAK 100.00 0.001
28556443 NQLTTNPENTVFDAK 100.00 0.001
28556443 NELESYAYSIK 100.00 0.001
28556443 NELESYAYSIK 100.00 0.001
26822097 IEIESFFEGDDFSETITR 100.00 0.002
26280517 IQAAVQNTVQESQK 100.00 0.002
25044914 ITPSIVNVK 100.00 0.002
24093152 ITNNMIMGITGMATAECMNMGIK 100.00 0.002
24402669 ITPMFPEDPR 100.00 0.002
27102218 AVAHVWDHDQVVSGIR 100.00 0.002
28467696 ITPQAIAMYK 100.00 0.002
29197581 VEIIANDQGNR 100.00 0.002
28556443 ITPSYVAFTQDGER 100.00 0.002
28556443 ITPSYVAFTQDGER 100.00 0.002
28556443 IINEPTAAAIAYGLDKK 100.00 0.002
28556443 FEELNMDLFR 100.00 0.002
28556443 AKFEELNMDLFR 100.00 0.003
28556443 AKFEELNMDLFR 100.00 0.003
26280517 NGPAIIQDVNFIDEMSSFDRER 100.00 0.019
28556443 VFAPEEISAMVLTK 100.00 0.030
28556443 VFAPEEISAMVLTK 100.00 0.030
28556443 VFAPEEISAMVLTK 100.00 0.030
28556443 VFAPEEISAMVLTK 100.00 0.030
28556443 VEIIANDQGNR 100.00 0.030
28556443 TLEDVVQPIIAK 100.00 0.030
Copyright@ 2018-2023    Any Comments and suggestions mail to:zhuzl@cqu.edu.cn   渝ICP备19006517号

渝公网安备 50010602502065号