Gene

KWMTBOMO08641

Pre Gene Modal

BGIBMGA007633

Annotation

PREDICTED:_adenylate_kinase_8-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr15(+):1511553-1519442      View in EpiBrowser

Full name

Adenylate kinase 8      

Alternative Name

ATP-AMP transphosphorylase 8

Location in the cell

Cytoplasmic   Reliability : 1.327 Nuclear   Reliability : 1.773

CDS

ATGGAAAAATATAGAGTATACCAAATATTTAAGGACATGTTGAAAGATCTACTAATCAACTTGCCCAAAGATCATTTGAAGCACATGAAAATATTCTTACATCGTTATTCGCAGAGCTGTAAAGATGCGGATAGGATCATCCTATTAGTATCACCAGAGCTCGAACATATCGATATCACAGCCATTCTAAAACAGTTGATAAAGGACTTGGGTTTGTTCGTGATCACACGCCGAGTCGTAATGGATCGATACGAGAAGCACGAAAATTACATGCCCGGATGCGTGTCTCCTGTTGTCTTATCGGAAATTACGAAAACTCTTACTATGAAAGATCAAATACTTCAAGCCGGCTGGTTGATGTTTGACCATCCCTGCACAGTGCGGGAGGCTCGTTGTCTGCAGCAGGACGGTGTGCTGCCAACCGTGACACTAGCCCTCATGCCAACCCCCCCTCAAGCTCCTCCGTCTGACAATCTACTCACATCAGCTAGATCGTTTTTTCAGCAGGATTTCGAAGGACTCAAGTTTGCATACAAGGCTACTCTAAAGGAGGTGTACATTGATTCCGAAGATGAAATAGAAAAAATATCAACAAAATGCTTTAATGCCATTCGGGCGTGTGCGGCCGGCGCTCAAGGACCATACCAGGGACACCACGTGGTCGGCGCTCCTGGAGTGTACAGAGTACTTGTTATTGGACCTCGTGGATCGGGCCGCAGGTCTCAGGCTTTGGCTCTGGCCAAACATTTCCGCTTAGTCTATTTACATTTCGACGATTTGTTAAGTGAAGCTAAAGCAAAGACCGACGAGTTTGGACAGAAACTACGTCAACATGAACCGAGCGTGCAAGTGAAAGCTGTCATAGTGAAGCGACGTATCTTGTTGAAGGACTGCATCGATAACGGTTGGGTTCTCGTTGGATTCCCGATGTCGGGAAAAGAATTCGAACTTTTAGACAATACACCGACCCCGCCAAATAGAATAATAATATTGAACGTGGATGCTTCAACGTGTAAGAGTCGTCGCTTGAGTCGAGGGGTGGACTGGTGCAGCGGTGATGAAGCACCCTTGGGTTCAGGGTCTCGTGTTATGCGGCATCCTAGAGATGACGAAGCTCAACTTGAAACCGAGTTAGACAACTATTTCTCCGAGGCATTAGCGGAGCTACGAGCGGCGGCCGGCATCACTGCGGTGGAATTCGACGCTAGTCAATCTTTTGACGGCGTGCAAGTGAAACTGCAGGCGGCCGTGATGGCGGCACCTAGTTTTGATATAGAGTGCGGGGCGCAACTCTGCCACGTCCGAGCAGACTGA

Protein

MEKYRVYQIFKDMLKDLLINLPKDHLKHMKIFLHRYSQSCKDADRIILLVSPELEHIDITAILKQLIKDLGLFVITRRVVMDRYEKHENYMPGCVSPVVLSEITKTLTMKDQILQAGWLMFDHPCTVREARCLQQDGVLPTVTLALMPTPPQAPPSDNLLTSARSFFQQDFEGLKFAYKATLKEVYIDSEDEIEKISTKCFNAIRACAAGAQGPYQGHHVVGAPGVYRVLVIGPRGSGRRSQALALAKHFRLVYLHFDDLLSEAKAKTDEFGQKLRQHEPSVQVKAVIVKRRILLKDCIDNGWVLVGFPMSGKEFELLDNTPTPPNRIIILNVDASTCKSRRLSRGVDWCSGDEAPLGSGSRVMRHPRDDEAQLETELDNYFSEALAELRAAAGITAVEFDASQSFDGVQVKLQAAVMAAPSFDIECGAQLCHVRAD

Description

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.

Catalytic Activity

AMP + ATP = 2 ADP
a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP
a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Biophysicochemical Properties

4.1 uM for AMP
630 uM for dAMP
1.4 uM for CMP

Similarity

Belongs to the adenylate kinase family.

Keywords

Alternative splicing   ATP-binding   Complete proteome   Cytoplasm   Kinase   Nucleotide-binding   Polymorphism   Reference proteome   Transferase  

Feature

chain  Adenylate kinase 8
splice variant  In isoform 2.
sequence variant  In dbSNP:rs2231400.

Uniprot

H9JDN6   A0A194PPY0   A0A437BXM4   A0A0N0PD18   A0A2A4K7V9   A0A0L7L2F2   + More
A0A139WMM8   E9J5Q4   A0A0L7R566   A0A2A3EFP1   A0A088AK29   A0A195CI11   A0A310SVP4   A0A195F0M6   A0A195E742   A0A151XBE6   A0A154PI47   A0A1B6CVM8   U4UKA9   N6TH76   A0A151I186   A0A1B6L896   A0A026VVQ7   J9LPR0   A0A1B6FAH0   A0A0A9Y5J0   A0A224XAJ8   A0A232EIA6   A0A2S2NR53   A0A452SIU4   A0A3Q7Y1A4   A0A2U3VDI1   H2PTS5   A0A3Q7TVT5   G1LBZ8   A0A3Q7RUD3   U6CW53   E2QSP0   A0A2Y9EH63   H0Y2C7   A0A2Y9H6C9   A0A3P4QBT3   A0A2J8UJ55   A0A2K6NBZ3   A0A2K6KU67   H2QY34   A0A2R9B4R4   A0A2J8NAJ2   Q96MA6   M3YM49   A0A2K6FVR1   A0A2K6TA67   U3CCA3   A0A2K6E6S5   A0A2K5JYB2   H9EWJ8   A0A096P0D8   A0A2K5M076   G7PRA1   F6YCP3   A0A0D9RR30   F6PLL4   A0A2Y9J8U8   Q4R3W4   A0A1S3A1N3   A0A2I2V3K2   Q502L7   L5K726   U3I3A1   A0A2Y9DJY9   A2BFD3   A0A1A8FDG0   U3JFI3   I3M2A2   A0A2R8Q451   A0A3M7QQ56   A0A2K5D2I4   A0A3B3RYF1   A0A0B8RRT5   Q68FP8   E1BLG0   A0A452UP54   A0A401PII7   Q32M07   A0A1Y1XJS7   A0A1D5PVQ4  

EC Number

2.7.4.3
2.7.4.6

Pubmed

19121390    26354079    26227816    18362917    19820115    21282665    + More
23537049    24508170    25401762    28648823    20010809    16341006    25362486    16136131    22722832    14702039    15164053    15489334    21080915    23416111    25243066    25319552    22002653    17431167    17495919    17975172    23258410    23749191    23594743    30375419    29240929    25476704    19393038    24813606    30297745    19468303    21183079    15592404   

EMBL

BABH01003237    KQ459596    KPI95372.1    RSAL01000001    RVE55215.1    KQ460497    + More
KPJ14330.1    NWSH01000087    PCG79740.1    JTDY01003375    KOB69653.1    KQ971312    KYB29097.1    GL768174    EFZ11860.1    KQ414654    KOC65988.1    KZ288256    PBC30575.1    KQ977721    KYN00371.1    KQ759867    OAD62463.1    KQ981864    KYN34135.1    KQ979568    KYN21008.1    KQ982335    KYQ57664.1    KQ434923    KZC11525.1    GEDC01020025    JAS17273.1    KB632338    ERL92898.1    APGK01038386    KB740954    ENN77093.1    KQ976580    KYM79962.1    GEBQ01020057    JAT19920.1    KK107766    EZA47873.1    ABLF02028091    GECZ01022624    JAS47145.1    GBHO01015277    GBRD01002305    JAG28327.1    JAG63516.1    GFTR01007020    JAW09406.1    NNAY01004284    OXU18107.1    GGMR01006988    MBY19607.1    ABGA01088221    ABGA01088222    ABGA01088223    ABGA01088224    ABGA01088225    ABGA01088226    ABGA01088227    ABGA01088228    ABGA01088229    ABGA01088230    ACTA01018302    ACTA01026302    ACTA01034302    ACTA01042301    HAAF01002713    CCP74539.1    AAEX03006812    AAEX03006813    AAQR03116685    AAQR03116686    AAQR03116687    AAQR03116688    AAQR03116689    AAQR03116690    CYRY02036932    VCX20087.1    NDHI03003456    PNJ45289.1    AACZ04069149    AJFE02078021    AJFE02078022    AJFE02078023    AJFE02078024    AJFE02078025    AJFE02078026    AJFE02078027    AJFE02078028    AJFE02078029    NBAG03000232    PNI68780.1    AK057266    AK093446    AK292186    AL160165    AL445645    CH471090    BC034776    BC050576    AEYP01042405    AEYP01042406    AEYP01042407    AEYP01042408    AEYP01042409    AEYP01042410    AEYP01042411    GAMS01006604    GAMP01003350    JAB16532.1    JAB49405.1    JU323001    AFE66757.1    AHZZ02007974    AQIA01023155    AQIA01023156    AQIA01023157    AQIA01023158    AQIA01023159    CM001290    EHH57017.1    JSUE03013934    CM001267    EHH23721.1    AQIB01140538    AQIB01140539    AQIB01140540    AQIB01140541    AQIB01140542    AQIB01140543    AQIB01140544    AQIB01140545    AB179151    AANG04002451    BC095649    KB030979    ELK07315.1    ADON01031071    ADON01031072    ADON01031073    BX276128    HAEB01010306    SBQ56833.1    AGTO01010822    AGTP01020290    AGTP01020291    AGTP01020292    BX510918    REGN01005372    RNA13587.1    GBSH01000210    JAG68814.1    BC079446    BFAA01000555    GCB72946.1    AL731851    AL732526    BC100481    BC109352    MCFG01000027    ORX85975.1    AADN05000150   

Proteomes

UP000005204    UP000053268    UP000283053    UP000053240    UP000218220    UP000037510    + More
UP000007266    UP000053825    UP000242457    UP000005203    UP000078542    UP000078541    UP000078492    UP000075809    UP000076502    UP000030742    UP000019118    UP000078540    UP000053097    UP000007819    UP000215335    UP000291022    UP000286642    UP000245340    UP000001595    UP000286640    UP000008912    UP000286641    UP000002254    UP000248484    UP000005225    UP000248481    UP000233200    UP000233180    UP000002277    UP000240080    UP000005640    UP000000715    UP000233160    UP000233220    UP000008225    UP000233120    UP000233080    UP000028761    UP000233060    UP000009130    UP000233100    UP000006718    UP000029965    UP000002280    UP000248482    UP000079721    UP000011712    UP000000437    UP000010552    UP000016666    UP000248480    UP000016665    UP000005215    UP000276133    UP000233020    UP000261540    UP000002494    UP000009136    UP000291021    UP000288216    UP000000589    UP000193944    UP000000539   

PRIDE

H9JDN6    Q96MA6    Q68FP8    Q32M07   

Pfam

PF00089   Trypsin        + More
PF18701   DUF5641

Interpro

IPR027417   P-loop_NTPase        + More
IPR000850   Adenylat/UMP-CMP_kin       
IPR009003   Peptidase_S1_PA       
IPR001314   Peptidase_S1A       
IPR001254   Trypsin_dom       
IPR022700   CLIP       
IPR040676   DUF5641       
IPR036193   ADK_active_lid_dom_sf       

SUPFAM

SSF52540   SSF52540        + More
SSF50494   SSF50494       
SSF57774   SSF57774       

CDD

cd01428  ADK
cd00190  Tryp_SPc

ProteinModelPortal

H9JDN6   A0A194PPY0   A0A437BXM4   A0A0N0PD18   A0A2A4K7V9   A0A0L7L2F2   + More
A0A139WMM8   E9J5Q4   A0A0L7R566   A0A2A3EFP1   A0A088AK29   A0A195CI11   A0A310SVP4   A0A195F0M6   A0A195E742   A0A151XBE6   A0A154PI47   A0A1B6CVM8   U4UKA9   N6TH76   A0A151I186   A0A1B6L896   A0A026VVQ7   J9LPR0   A0A1B6FAH0   A0A0A9Y5J0   A0A224XAJ8   A0A232EIA6   A0A2S2NR53   A0A452SIU4   A0A3Q7Y1A4   A0A2U3VDI1   H2PTS5   A0A3Q7TVT5   G1LBZ8   A0A3Q7RUD3   U6CW53   E2QSP0   A0A2Y9EH63   H0Y2C7   A0A2Y9H6C9   A0A3P4QBT3   A0A2J8UJ55   A0A2K6NBZ3   A0A2K6KU67   H2QY34   A0A2R9B4R4   A0A2J8NAJ2   Q96MA6   M3YM49   A0A2K6FVR1   A0A2K6TA67   U3CCA3   A0A2K6E6S5   A0A2K5JYB2   H9EWJ8   A0A096P0D8   A0A2K5M076   G7PRA1   F6YCP3   A0A0D9RR30   F6PLL4   A0A2Y9J8U8   Q4R3W4   A0A1S3A1N3   A0A2I2V3K2   Q502L7   L5K726   U3I3A1   A0A2Y9DJY9   A2BFD3   A0A1A8FDG0   U3JFI3   I3M2A2   A0A2R8Q451   A0A3M7QQ56   A0A2K5D2I4   A0A3B3RYF1   A0A0B8RRT5   Q68FP8   E1BLG0   A0A452UP54   A0A401PII7   Q32M07   A0A1Y1XJS7   A0A1D5PVQ4  

PDB

2AK2     E-value=3.47334e-07,     Score=130

KEGG

101735797    K00939 adenylate kinase [EC:2.7.4.3] | (RefSeq) adenylate kinase 2, mitochondrial-like

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
00730    Thiamine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0006139   GO:0019205   GO:0004252   GO:0016301   GO:0004017   GO:0004550   GO:0021591   GO:0036126   GO:0009142   GO:0004127   GO:0005930   GO:0006165   GO:0015949   GO:0005829   GO:0016787  

PANTHER

PTHR23359  

Subcellular location

  

Length:

437

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00751999999999998

Exp number, first 60 AAs:

0.00218

Total prob of N-in:

0.01336

outside

1  -  437

 

 

Pi

158.581716

Theta

159.124672

Tajima's D

0.946339

CLR

0.747713

CSRT

0.644117794110294

Interpretation

Uncertain