Gene

KWMTBOMO08640

Pre Gene Modal

BGIBMGA007951

Annotation

Folylpolyglutamate_synthase?_mitochondrial_[Papilio_machaon]

Location

Bomo_Chr15(-):1502122-1509712      View in EpiBrowser

Full name

Folylpolyglutamate synthase      

Alternative Name

Folylpoly-gamma-glutamate synthetase
Tetrahydrofolylpolyglutamate synthase

Location in the cell

Mitochondrial   Reliability : 2.127

CDS

ATGTGTTCCTATTACGAAGATGCAGTTCGTAAATTAAACAAATTGCAATCAAACAAATCTACAATAGAACAAATCAGAAAGGATATCAGAACAGGACAAAAATGTACAAATTTAGAAGATATGGAGAATTATTTGTCAAGAACAGGTGTGACCATGTCAAAGTTGGACGAGCTATCTGTGGTTCATGTTGCTGGAACCAAAGGCAAGGGTTCAACGAGTGCGATGTGCGAATCAATACTTCGTCACCACGGCTTCCGCACAGGGTTCTATTCGTCACCGCATCTAGTGGCTGTTCGAGAACGGGTACGCTTAGACGGACGGGTCATCTCCGAAGATATGTTCGCGAAGTATTTTCATGATGTTCACCAGCGACTTGAAAATACAAAGAAATTTGAAGGCGACATGCCGAAATACTTCGCGTTTTTGACTGTGATGGCTTACAATATATTCCTCAAGGAGAAGGTGGATGTGGCCATCGTGGAAGTCGGTATAGGCGGCTTAGTCGACTATACAAATATTTTGAGGAAAGTTCCCGTTGTCGGCATAACGGCATTAGGATTGGATCACACTTCGATATTAGGGAACACGATACAGGAAATAGCGGCGTCCAAAGCGGGCATCATGAAGCGAGGCTGCGAAGCTTACACTGTGCGACAACCTAACGAAGCTATGGATGTACTCATACAATATGCTGATAGTTTAAAGTGTCCCCTAACTGTCGTTCCCGATTACGACTTGTACTCGTTCGAAACATCACAAAAAACCCGTTTACCTGTCGAATTAACGGCATATCGGACCAACGCGTCTCTAGCAATACAACTGGCGCACGCTTGGATGCGAAAAAAACACGAAAACAAAATAAACTTCCCGAAAAACACCGTGAATGGAGTTCTCAACGGACTGATCACCAGTAAAATGGTGTTAGAATTGCCGCCATCGACGTGCCAAGTGGTTCAGCGATAA

Protein

MCSYYEDAVRKLNKLQSNKSTIEQIRKDIRTGQKCTNLEDMENYLSRTGVTMSKLDELSVVHVAGTKGKGSTSAMCESILRHHGFRTGFYSSPHLVAVRERVRLDGRVISEDMFAKYFHDVHQRLENTKKFEGDMPKYFAFLTVMAYNIFLKEKVDVAIVEVGIGGLVDYTNILRKVPVVGITALGLDHTSILGNTIQEIAASKAGIMKRGCEAYTVRQPNEAMDVLIQYADSLKCPLTVVPDYDLYSFETSQKTRLPVELTAYRTNASLAIQLAHAWMRKKHENKINFPKNTVNGVLNGLITSKMVLELPPSTCQVVQR

Description

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

Catalytic Activity

(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate

Cofactor

a monovalent cation

Similarity

Belongs to the folylpolyglutamate synthase family.

Feature

chain  Folylpolyglutamate synthase

Uniprot

H9JEK4   A0A2H1WWM0   A0A2A4K675   A0A0N1PI32   A0A3S2MB48   A0A212FB94   + More
A0A194PPK1   A0A2J7RM51   A0A2J7RM46   A0A146YA35   A0A3Q3G8U0   A0A3B3QSZ5   A0A146YBN1   A0A3B3XR46   A0A3B3VXX5   A0A3P9NNJ7   A0A3Q2NVZ9   A0A147ATP8   A0A087XIT6   A0A1A8HA83   A0A2I4CSR9   A0A1A7YA13   C3ZPE3   A0A3Q2YKM2   A0A3B5Q0E6   A0A1A8J4T3   A0A1A7ZQS2   A0A1A8DHT5   A0A1A8EZ40   A0A1A8MJQ1   A0A1A8CAA6   A0A3Q3GAE9   A0A3Q1B4S8   A0A3P8SUN6   A0A3Q1B4V4   A0A1A8RRI3   A0A401PER2   A0A3B5KJC1   A0A3B3QQQ2   A0A3B5A4Z6   A0A3Q3MUF1   A0A067RKH8   A0A3B4F553   A0A1B0CTM4   A0A1S3NKR7   A0A1S3M4Z6   A0A0P5LNP8   A0A3Q1GW75   A0A2R8RY36   A0A3P9ATQ5   F1Q7N0   A0A1S3NKQ5   A0A3Q3CRR6   W5UDI5   A0A437CS76   A0A3Q2ZUG8   A0A0P5JS26   A0A0N8EDU9   A0A3B3D466   A0A3B1KCV2   A0A3P8NSV6   A0A060XF08   A0A0P5X5C7   A0A0N8BVD5   A0A1S3M4B8   A0A0P5IHH1   A0A0P5KXQ1   A0A0P4Y6A2   H2TAJ2   A0A0P5M2S7   A0A0P5NWC8   A0A0N8BMN6   A0A2D4JBU1   A0A0P5W7E4   Q6PE17   A0A0P5R522   A0A1S3M463   A0A0P6FH55   A0A3Q2WR06   A0A0P5RVE3   H2TAJ3   A0A0P5V652   A0A1W4Y9N9   A0A1W4YIV9   A0A162RQH2   A0A401SJE3   A0A0P6DQ62   A0A1W5AK33   A0A0P6EC87   A0A0P5UHW2   A0A0N8D2D7   A0A0P5YNW9   A0A0P5MZT9   A0A0P5SZ33   A0A0P5LTZ4   A0A3N0XSR8   A0A3B3QEZ6   A0A232F8J1   A0A0P4Y274   A0A0P5WYS2  

EC Number

6.3.2.17

Pubmed

19121390    26354079    22118469    29240929    18563158    23542700    + More
30297745    24845553    23594743    25186727    23127152    29451363    25329095    24755649    21551351    28648823   

EMBL

BABH01003237    ODYU01011611    SOQ57460.1    NWSH01000087    PCG79741.1    KQ460497    + More
KPJ14327.1    RSAL01000001    RVE55216.1    AGBW02009363    OWR51000.1    KQ459596    KPI95371.1    NEVH01002577    PNF41912.1    PNF41914.1    GCES01035329    JAR50994.1    GCES01035328    JAR50995.1    GCES01004379    JAR81944.1    AYCK01016465    HAEC01012065    SBQ80282.1    HADX01004881    SBP27113.1    GG666656    EEN45640.1    HAED01017268    SBR03713.1    HADY01006624    HAEJ01002568    SBP45109.1    HAEA01004558    SBQ33038.1    HAEB01005848    SBQ52375.1    HAEF01015818    HAEG01002974    SBR56977.1    HADZ01012871    SBP76812.1    HAEI01009768    SBS08710.1    BFAA01003500    GCB71613.1    KK852460    KDR23523.1    AJWK01027780    GDIQ01175856    JAK75869.1    BX530036    JT412641    AHH39935.1    CM012448    RVE65477.1    GDIQ01194802    JAK56923.1    GDIQ01036476    JAN58261.1    FR905261    CDQ77792.1    GDIP01077237    JAM26478.1    GDIQ01141179    JAL10547.1    GDIQ01214255    JAK37470.1    GDIQ01177660    JAK74065.1    GDIP01235734    JAI87667.1    GDIQ01161421    JAK90304.1    GDIQ01136777    JAL14949.1    GDIQ01162771    JAK88954.1    IACK01163117    LAA93961.1    GDIP01090390    JAM13325.1    BC058343    AAH58343.1    GDIQ01114943    JAL36783.1    GDIQ01047863    JAN46874.1    GDIQ01101004    JAL50722.1    GDIP01119780    JAL83934.1    LRGB01000124    KZS20702.1    BEZZ01000303    GCC30450.1    GDIQ01088835    JAN05902.1    GDIQ01066153    JAN28584.1    GDIP01112653    JAL91061.1    GDIP01075551    JAM28164.1    GDIP01055206    JAM48509.1    GDIQ01193013    GDIQ01153312    JAK98413.1    GDIP01135940    JAL67774.1    GDIQ01165624    JAK86101.1    RJVU01061862    ROJ30623.1    NNAY01000723    OXU26788.1    GDIP01237380    JAI86021.1    GDIP01080142    JAM23573.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000283053    UP000007151    UP000053268    + More
UP000235965    UP000261660    UP000261540    UP000261480    UP000261500    UP000242638    UP000265000    UP000028760    UP000192220    UP000001554    UP000264820    UP000002852    UP000257160    UP000265080    UP000288216    UP000261380    UP000261400    UP000261640    UP000027135    UP000261460    UP000092461    UP000087266    UP000257200    UP000000437    UP000265160    UP000264840    UP000221080    UP000264800    UP000261560    UP000018467    UP000265100    UP000193380    UP000005226    UP000192224    UP000076858    UP000287033    UP000215335   

PRIDE

H9JEK4   

Pfam

PF08245   Mur_ligase_M        + More
PF04145   Ctr

Interpro

IPR013221   Mur_ligase_cen        + More
IPR036615   Mur_ligase_C_dom_sf       
IPR018109   Folylpolyglutamate_synth_CS       
IPR023600   Folylpolyglutamate_synth_euk       
IPR001645   Folylpolyglutamate_synth       
IPR036565   Mur-like_cat_sf       
IPR007274   Cop_transporter       

SUPFAM

SSF53623   SSF53623        + More
SSF53244   SSF53244       

Gene 3D

3.40.1190.10     3.90.190.20    

ProteinModelPortal

H9JEK4   A0A2H1WWM0   A0A2A4K675   A0A0N1PI32   A0A3S2MB48   A0A212FB94   + More
A0A194PPK1   A0A2J7RM51   A0A2J7RM46   A0A146YA35   A0A3Q3G8U0   A0A3B3QSZ5   A0A146YBN1   A0A3B3XR46   A0A3B3VXX5   A0A3P9NNJ7   A0A3Q2NVZ9   A0A147ATP8   A0A087XIT6   A0A1A8HA83   A0A2I4CSR9   A0A1A7YA13   C3ZPE3   A0A3Q2YKM2   A0A3B5Q0E6   A0A1A8J4T3   A0A1A7ZQS2   A0A1A8DHT5   A0A1A8EZ40   A0A1A8MJQ1   A0A1A8CAA6   A0A3Q3GAE9   A0A3Q1B4S8   A0A3P8SUN6   A0A3Q1B4V4   A0A1A8RRI3   A0A401PER2   A0A3B5KJC1   A0A3B3QQQ2   A0A3B5A4Z6   A0A3Q3MUF1   A0A067RKH8   A0A3B4F553   A0A1B0CTM4   A0A1S3NKR7   A0A1S3M4Z6   A0A0P5LNP8   A0A3Q1GW75   A0A2R8RY36   A0A3P9ATQ5   F1Q7N0   A0A1S3NKQ5   A0A3Q3CRR6   W5UDI5   A0A437CS76   A0A3Q2ZUG8   A0A0P5JS26   A0A0N8EDU9   A0A3B3D466   A0A3B1KCV2   A0A3P8NSV6   A0A060XF08   A0A0P5X5C7   A0A0N8BVD5   A0A1S3M4B8   A0A0P5IHH1   A0A0P5KXQ1   A0A0P4Y6A2   H2TAJ2   A0A0P5M2S7   A0A0P5NWC8   A0A0N8BMN6   A0A2D4JBU1   A0A0P5W7E4   Q6PE17   A0A0P5R522   A0A1S3M463   A0A0P6FH55   A0A3Q2WR06   A0A0P5RVE3   H2TAJ3   A0A0P5V652   A0A1W4Y9N9   A0A1W4YIV9   A0A162RQH2   A0A401SJE3   A0A0P6DQ62   A0A1W5AK33   A0A0P6EC87   A0A0P5UHW2   A0A0N8D2D7   A0A0P5YNW9   A0A0P5MZT9   A0A0P5SZ33   A0A0P5LTZ4   A0A3N0XSR8   A0A3B3QEZ6   A0A232F8J1   A0A0P4Y274   A0A0P5WYS2  

PDB

1O5Z     E-value=2.04085e-27,     Score=303

KEGG

101735925    K01930 folylpolyglutamate synthase [EC:6.3.2.17] | (RefSeq) folylpolyglutamate synthase, mitochondri

PATHWAY

00790    Folate biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004326   GO:0005524   GO:0046872   GO:0006730   GO:0016021   GO:0005375   GO:0005829   GO:0005739   GO:0009396   GO:0005737   GO:0046901   GO:0009058   GO:0007165   GO:0016620   GO:0006418   GO:0003676   GO:0016876   GO:0043039  

PANTHER

PTHR11136:SF5   PTHR11136  

Length:

320

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.13848

Exp number, first 60 AAs:

0.00021

Total prob of N-in:

0.07546

outside

1  -  320

 

 

Pi

286.052688

Theta

185.300651

Tajima's D

1.21737

CLR

0.730134

CSRT

0.71786410679466

Interpretation

Uncertain