Gene

KWMTBOMO08631  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007629

Annotation

innexin_2_[Bombyx_mori]

Location

Bomo_Chr15(+):1417793-1418937      View in EpiBrowser

Full name

Innexin       + More
Innexin inx2      

Alternative Name

G-Inx2
Gap junction protein prp33
Pas-related protein 33

Location in the cell

PlasmaMembrane   Reliability : 4.329

CDS

ATGTTTGACGTTTTCGGCTCCGTAAAGGGGCTTCTCAAGCTCGACTCTGTGTGCATCGACAACAATGTGTTCCGCTTACATTACAAAGCCACCGTGATTATCTTGATCGCGTTCTCGCTTCTCGTCACGTCGCGACAGTACATCGGTGACCCGATTGACTGCATCGTTGATGAAATCCCGCTCGCCGTTATGGACACGTACTGCTGGATATACTCTACTTTCACCATCCCGAACAGACTTATCGGCCGCGTCGGAAAGGATTACGTGCAACCCGGCGTCGGCCCACATGTCGAAGGACAAGACGAAGTTAAATATCACAAATATTATCAGTGGGTTTGTTTTGTGTTATTCTTTCAAGCAATCCTGTTTTATGTTCCCCGCTACTTGTGGAAAACGTGGGAAGGAGGCCGCATCAAGATGTTGGTCCTGGATCTTAACTGTCCCATCGTTGAAGACGAGTGCAAGTCGGGTCGTAAAAAGCTACTTGTCGACTATTTCCACACGAACTTGCACACTCAAAACTTTTACGCTTTCCGATTCTTTATATGTGAAGTTCTCAACTTTATCAACGTAGTGGGTCAAATATTCTTCATGGACTTCTTTTTGGACGGAGAATTTTCAACTTATGGCAGTGACGTGGTCAGCTTCACAGAAATGGAGCCCGAGGAACGCGTGGACCCGATGGCCAGAGTGTTTCCTAAAGTAACTAAATGCACCTTCCATAAATACGGTCCATCCGGTACGGTGCAGAAATTCGATGGCTTGTGTGTTTTGCCATTGAATATCGTCAACGAGAAGATCTACGTGTTCCTCTGGTTTTGGTTTATGATACTATCTATCCTGAGTGGAATTTCTTTGTTATACCGCATGGCCGTTGTCGCTGGACCCCGCGTCCGTCTCTACTTGCTGCGCGCACGCAGTCGCCTTGCGCCACAAGAGCAAATCGAAGCCGTAGCCCGCAAGCTACAGATCGGCGACTGGTTCGTTTTGTACCAACTCGGGAAGAACATTGATCCACTGATTTATAAAGAACTGATGACCGAGCTAGCGGAGAAGTTTGAAGGAAACGACAAAGTATAG

Protein

MFDVFGSVKGLLKLDSVCIDNNVFRLHYKATVIILIAFSLLVTSRQYIGDPIDCIVDEIPLAVMDTYCWIYSTFTIPNRLIGRVGKDYVQPGVGPHVEGQDEVKYHKYYQWVCFVLFFQAILFYVPRYLWKTWEGGRIKMLVLDLNCPIVEDECKSGRKKLLVDYFHTNLHTQNFYAFRFFICEVLNFINVVGQIFFMDFFLDGEFSTYGSDVVSFTEMEPEERVDPMARVFPKVTKCTFHKYGPSGTVQKFDGLCVLPLNIVNEKIYVFLWFWFMILSILSGISLLYRMAVVAGPRVRLYLLRARSRLAPQEQIEAVARKLQIGDWFVLYQLGKNIDPLIYKELMTELAEKFEGNDKV

Description

Structural component of the gap junctions.
Structural components of the gap junctions. Involved in gap junctional communication between germline and somatic cells which is essential for normal oogenesis. In embryonic epidermis, required for epithelial morphogenesis. Required for keyhole formation during early stages of proventriculus development in response to wg signaling. In follicle cells, promotes the formation of egg chambers in part through regulation of shg and baz at the boundary between germ cells and follicle cells. In inner germarial sheath cells, required for survival of early germ cells and for cyst formation.

Subunit

Monomer and heterooligomer with ogre or Inx3 (via cytoplasmic C-terminal region). Interacts (via cytoplasmic loop) with shg (via cytoplasmic region). Interacts with arm.

Similarity

Belongs to the pannexin family.

Keywords

Cell junction   Cell membrane   Gap junction   Ion channel   Ion transport   Membrane   Transmembrane   Transmembrane helix   Transport   Complete proteome   Cytoplasm   Developmental protein   Differentiation   Oogenesis   Reference proteome  

Feature

chain  Innexin inx2

Uniprot

A2TEZ0   Q6SA04   Q6PYX4   K9RY87   K9S0V4   Q6XZI1   + More
A0A2A4K0K9   A0A1E1WFT8   A0A0N0PCR1   A0A3S2LJH0   A0A194PPJ2   A0A0L7KXT9   A0A212EYK5   S4PA74   A0A2P8YZB7   A0A1W4WZU8   A0A1B6L2T6   A0A0C9PHI7   A0A1Y1NGD2   A0A067R1S3   A0A2J7PHC1   A0A1B6GUR0   Q9XYN1   A0A1B6IFW0   V5GVY7   C0KLS6   A0A2R7WYH0   A0A224XSQ0   A0A023F5Q4   A0A069DSD1   A0A154NW25   A0A0P4VS99   T1ICT1   A0A0N0U5Y4   A0A0V0GBJ4   N6T7Y7   J3JY90   F4WK98   E2BMI5   A0A195BSM6   A0A158NQK6   A0A1B6CKW9   A0A2H8TVN8   A0A088A2C9   A0A336LWA7   A0A0A9VUC1   A0A195DI29   A0A2S2PAU7   A0A026WXJ9   A0A2A3EBD4   V9IGC8   A0A2S2QZA9   J9K934   A0A151XB06   A0A195ERM9   D6X4J0   A0A0J7LA69   A0A0A1XMB6   A0A0K8VKP7   W8B342   W8AZ10   A0A1W4V8D0   A0A034VKH4   B3MQ11   E1ZXE9   T1DI93   A0A1I8P411   A0A1A9XRV8   T1E2R6   A0A1B0AP71   B4NEG0   E1JJF3   Q9V427   Q16FA2   Q29GY8   B4IHI6   B3NXY3   E0VLP5   A0A1B0G4W2   A0A1A9UUN2   A0A1A9ZE59   B4Q160   U5EUV3   A0A0P6IZ10   A0A0M5J2R8   T1PEY5   A0A182GB47   A0A1B0CVA1   E9J406   A0A1Q3FMF5   A0A3B0K691   A0A195D535   A0A1A9WPK2   A0A1L8E3F2   A0A0L7R3G0   A0A1B0DD12   A0A1B0CW54   B0X5H9   A0A1J1I1G9   B4M9W2  

Pubmed

17950307    19121390    28433752    26354079    26227816    22118469    + More
23622113    29403074    28004739    24845553    10079517    25474469    26334808    27129103    23537049    22516182    21719571    20798317    21347285    25401762    26823975    24508170    30249741    18362917    19820115    25830018    24495485    25348373    17994087    24330624    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    10352230    10888681    12537569    11956317    11960713    15047872    16436513    19038051    22001874    17510324    25585357    15632085    18057021    20566863    17550304    25315136    26483478    21282665   

EMBL

EF197891    ABM88790.1    BABH01003247    AY461704    AAR97567.2    AY570724    + More
AAS77384.1    KC018471    AFY62975.1    KC018473    AFY62977.1    AY196138    ODYU01003264    AAP40732.1    SOQ41789.1    NWSH01000281    PCG77801.1    GDQN01005226    JAT85828.1    KQ460497    KPJ14319.1    RSAL01000001    RVE55224.1    KQ459596    KPI95361.1    JTDY01004529    KOB68042.1    AGBW02011483    OWR46576.1    GAIX01003374    JAA89186.1    PYGN01000272    PSN49595.1    GEBQ01022017    JAT17960.1    GBYB01000293    JAG70060.1    GEZM01005729    JAV95960.1    KK853092    KDR11527.1    NEVH01025142    PNF15718.1    GECZ01003608    JAS66161.1    AF115854    GECU01021896    JAS85810.1    GALX01004058    JAB64408.1    FJ619503    ACN41954.1    KK855997    PTY24583.1    GFTR01005427    JAW10999.1    GBBI01002208    JAC16504.1    GBGD01001916    JAC86973.1    KQ434769    KZC03793.1    GDKW01000604    JAI55991.1    ACPB03013214    KQ435762    KOX75478.1    GECL01001431    JAP04693.1    APGK01048500    KB741112    KB632184    ENN73823.1    ERL89627.1    BT128214    AEE63175.1    GL888199    EGI65322.1    GL449233    EFN83094.1    KQ976419    KYM89300.1    ADTU01023369    GEDC01023218    GEDC01018802    JAS14080.1    JAS18496.1    GFXV01006530    MBW18335.1    UFQS01000021    UFQT01000021    SSW97532.1    SSX17918.1    GBHO01044300    GBHO01030105    GBRD01012033    GDHC01002278    JAF99303.1    JAG13499.1    JAG53791.1    JAQ16351.1    KQ980824    KYN12492.1    GGMR01013437    MBY26056.1    KK107087    QOIP01000001    EZA59869.1    RLU27633.1    KZ288311    PBC28519.1    JR046173    AEY60148.1    GGMS01013904    MBY83107.1    ABLF02022825    KQ982335    KYQ57519.1    KQ982021    KYN30557.1    KQ971380    EEZ97563.1    LBMM01000146    KMR04738.1    GBXI01002190    JAD12102.1    GDHF01015923    GDHF01012857    JAI36391.1    JAI39457.1    GAMC01015097    JAB91458.1    GAMC01015098    JAB91457.1    GAKP01016340    JAC42612.1    CH902621    EDV44437.1    GL435038    EFN74126.1    GALA01001056    JAA93796.1    GALA01001055    JAA93797.1    JXJN01001234    CH964239    EDW82129.1    AE014298    ACZ95220.1    AF137269    AF172257    AY060368    KJ736824    CH478475    AIF75096.1    EAT32915.1    CH379064    EAL31971.1    CH480839    EDW49337.1    CH954180    EDV47434.1    AAZO01003379    DS235277    EEB14301.1    CCAG010000780    CM000162    EDX02415.1    GANO01001288    JAB58583.1    GDIQ01002289    JAN92448.1    CP012528    ALC48311.1    KA646715    AFP61344.1    JXUM01157673    KQ572819    KXJ67988.1    AJWK01030336    GL768069    EFZ12445.1    GFDL01006362    JAV28683.1    OUUW01000016    SPP88803.1    KQ976885    KYN07539.1    GFDF01000920    JAV13164.1    KQ414663    KOC65363.1    AJVK01014295    AJWK01031780    AJWK01031781    DS232380    EDS40864.1    CVRI01000024    CRK92217.1    CH940655    EDW66021.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000283053    UP000053268    UP000037510    + More
UP000007151    UP000245037    UP000192223    UP000027135    UP000235965    UP000076502    UP000015103    UP000053105    UP000019118    UP000030742    UP000007755    UP000008237    UP000078540    UP000005205    UP000005203    UP000078492    UP000053097    UP000279307    UP000242457    UP000007819    UP000075809    UP000078541    UP000007266    UP000036403    UP000192221    UP000007801    UP000000311    UP000095300    UP000092443    UP000092460    UP000007798    UP000000803    UP000008820    UP000001819    UP000001292    UP000008711    UP000009046    UP000092444    UP000078200    UP000092445    UP000002282    UP000092553    UP000095301    UP000069940    UP000249989    UP000092461    UP000268350    UP000078542    UP000091820    UP000053825    UP000092462    UP000002320    UP000183832    UP000008792   

PRIDE

Q6SA04    Q6PYX4    E1JJF3    Q9V427   

Pfam

PF00876   Innexin

Interpro

IPR000990   Innexin       

ProteinModelPortal

A2TEZ0   Q6SA04   Q6PYX4   K9RY87   K9S0V4   Q6XZI1   + More
A0A2A4K0K9   A0A1E1WFT8   A0A0N0PCR1   A0A3S2LJH0   A0A194PPJ2   A0A0L7KXT9   A0A212EYK5   S4PA74   A0A2P8YZB7   A0A1W4WZU8   A0A1B6L2T6   A0A0C9PHI7   A0A1Y1NGD2   A0A067R1S3   A0A2J7PHC1   A0A1B6GUR0   Q9XYN1   A0A1B6IFW0   V5GVY7   C0KLS6   A0A2R7WYH0   A0A224XSQ0   A0A023F5Q4   A0A069DSD1   A0A154NW25   A0A0P4VS99   T1ICT1   A0A0N0U5Y4   A0A0V0GBJ4   N6T7Y7   J3JY90   F4WK98   E2BMI5   A0A195BSM6   A0A158NQK6   A0A1B6CKW9   A0A2H8TVN8   A0A088A2C9   A0A336LWA7   A0A0A9VUC1   A0A195DI29   A0A2S2PAU7   A0A026WXJ9   A0A2A3EBD4   V9IGC8   A0A2S2QZA9   J9K934   A0A151XB06   A0A195ERM9   D6X4J0   A0A0J7LA69   A0A0A1XMB6   A0A0K8VKP7   W8B342   W8AZ10   A0A1W4V8D0   A0A034VKH4   B3MQ11   E1ZXE9   T1DI93   A0A1I8P411   A0A1A9XRV8   T1E2R6   A0A1B0AP71   B4NEG0   E1JJF3   Q9V427   Q16FA2   Q29GY8   B4IHI6   B3NXY3   E0VLP5   A0A1B0G4W2   A0A1A9UUN2   A0A1A9ZE59   B4Q160   U5EUV3   A0A0P6IZ10   A0A0M5J2R8   T1PEY5   A0A182GB47   A0A1B0CVA1   E9J406   A0A1Q3FMF5   A0A3B0K691   A0A195D535   A0A1A9WPK2   A0A1L8E3F2   A0A0L7R3G0   A0A1B0DD12   A0A1B0CW54   B0X5H9   A0A1J1I1G9   B4M9W2  

PDB

5H1R     E-value=2.09787e-16,     Score=209

KEGG

692687    K22037 innexin | (RefSeq) Inx2; innexin 2

GO

GO:0005921   GO:0006811   GO:0016021   GO:0005886   GO:0005243   GO:0030727   GO:0016331   GO:0007154   GO:0007440   GO:0007283   GO:0036098   GO:0016327   GO:0010496   GO:0016324   GO:0005737   GO:0007293   GO:0016328   GO:0016323   GO:0006355   GO:0043565   GO:0005057   GO:0007165   GO:0016620   GO:0006418   GO:0003676   GO:0016876   GO:0043039  

PANTHER

PTHR11893  

Subcellular location

Cell membrane  
Cell junction  
Gap junction  
Cytoplasm  
Apical cell membrane  
Apicolateral cell membrane  
Basolateral cell membrane  
Lateral cell membrane  

Length:

359

Number of predicted TMHs:

4

Exp number of AAs in TMHs:

88.18775

Exp number, first 60 AAs:

18.87395

Total prob of N-in:

0.77265

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  107

TMhelix

108  -  130

inside

131  -  174

TMhelix

175  -  197

outside

198  -  266

TMhelix

267  -  289

inside

290  -  359

 

 

Pi

314.971061

Theta

243.923125

Tajima's D

0.917477

CLR

1.101862

CSRT

0.634668266586671

Interpretation

Uncertain