Gene

KWMTBOMO08617

Pre Gene Modal

BGIBMGA007621

Annotation

PREDICTED:_cap-specific_mRNA_(nucleoside-2'-O-)-methyltransferase_2_[Papilio_xuthus]

Location

Bomo_Chr15(+):980433-984267      View in EpiBrowser

Full name

Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2      

Alternative Name

Cap methyltransferase 2 homolog
Cap2 2'O-ribose methyltransferase 2 homolog
FtsJ methyltransferase domain-containing protein 1 homolog
Protein Adrift

Location in the cell

Nuclear   Reliability : 1.704 PlasmaMembrane   Reliability : 1.563

CDS

ATGGACGGATCAATAAAAAAAGATGATGTAAAATCTGAGCGTAAGATGGTATCATTGCACTTGTGTGAGGCACCGGGAGCATTCATCACATCTTTGAACCACTATTTGAAGTTAAATCATCCTGGGATACAGTGGACCTGGGTTGCTAACACACTAAATCCATACTATGAGGGTAATTCCCCATCGAGCATGATCAGTGATGACAGGTTCATGTTTCACACCCTAGATAACTGGCATTTTGGGGTAGACAATACTGGTAACTTAATGGATTGGGAAAATTCACAAGCCATCATTAGAAAAGCGAAATCCCTTGGAAAGGTTATGTTAGTGACGGCAGATGGCTCCATTGATTGTCTACAGGCACCTGATGCACAGGAAGAGGCAACATCTCTATTACATTACTGTGAAATCACTACTGCCCTGCAAGCATTAAGCCAGGGTGGAACTTTAATATTCAAGCTTTTTACTATCTTCGAACATAGCACTGTGAGTCTGCTTTACCTAATTAATCATTTGTTCTCTGAAGTTAACATCTACAAACCGGTCACCTCGAGACAGGGCAACTCTGAAGTGTATGCAGTGTGCTTAAATTATAAAGGAATGTCTATACTGGAGAAGTTTACGCCGGTACTCATGTCAGCATATGGAACGGAACTATATGGAAATTTATCATTATTCCGACTTGATGACATCCCAGATACATTTTTGAAGCAAATCCAAGAGTGCGCATGTTACTTTTGTTCAATACAATGTCAAGTTATCAATAATAACCTGCAGGCATACTTAATGCAGAATAATATCGCTCTACACCGAAATATAAAGAAAATAAGGGCTGTTGTTGCTGACGAATTTATTTGGCATTATGACTTGAAACCCTTAAATTCTCATGAGGAGATACTCAAAGGTATTCTACATGAGGAGAACAAAATCAATATGAATCCCAGATACCACCGAGGATCTTACACTGAACGACAGCTCTATTCAAAGATGTCTTTACGAGAGAAATTGCACAATTTGAACTCATATCTGCATGCTGAAGTCCTAACGAATCCTACAGTGTTGATAAATGAACCGGTCAAATGGAAGAGATTTTATGATGCTCCTAAAGAAATAGAATTAACATTTACTTTTGGACGACCTTTACAAAAAATTAATAGCTCAAAATTTATATTCGTGCCAATATTTAAGCTATATCAAAAGATTTTAGAAGAGAAAGAATTTAAACACATTGCAGTATGTACAGATAGTAATCGTGATGTCAATTTAACGGCACTAGATTATGAAGTGGACAAAGTGCTCTGCGTACAGGAGTACCGTTGCAGTGAAAGTTTTTATAAATATGAGAAAAACTGTTTTAGATCTATAATGAAATATTTGAGAAATTTATCTTCAAACGAGACTCTTGTAATACAGAATATGAATGCTTTAACCCATTTTATCGTGAGCATTCTATATATTCTCTCTGTTAAATGTTTCGAGAAAATTGGGTTTACATCAACCAATGGTATAGTTTTAAGAAATCTTAAGGATCCATCTGGACTGAAATACTTAGAAAGTATTGAAACTGAATGTGATAATGTATTAGATGATGACAAAAAGGATTTGTTGAATTCGTTGAATGTACAAACAACGAATGCCGGAGATTTTTACTATAGCATCGTGTTCTACAATAACACCTTTTACAGGAATAAGTGTATTGAGTATTTGTCAAAAATAGAGAAATTAATATAA

Protein

MDGSIKKDDVKSERKMVSLHLCEAPGAFITSLNHYLKLNHPGIQWTWVANTLNPYYEGNSPSSMISDDRFMFHTLDNWHFGVDNTGNLMDWENSQAIIRKAKSLGKVMLVTADGSIDCLQAPDAQEEATSLLHYCEITTALQALSQGGTLIFKLFTIFEHSTVSLLYLINHLFSEVNIYKPVTSRQGNSEVYAVCLNYKGMSILEKFTPVLMSAYGTELYGNLSLFRLDDIPDTFLKQIQECACYFCSIQCQVINNNLQAYLMQNNIALHRNIKKIRAVVADEFIWHYDLKPLNSHEEILKGILHEENKINMNPRYHRGSYTERQLYSKMSLREKLHNLNSYLHAEVLTNPTVLINEPVKWKRFYDAPKEIELTFTFGRPLQKINSSKFIFVPIFKLYQKILEEKEFKHIAVCTDSNRDVNLTALDYEVDKVLCVQEYRCSESFYKYEKNCFRSIMKYLRNLSSNETLVIQNMNALTHFIVSILYILSVKCFEKIGFTSTNGIVLRNLKDPSGLKYLESIETECDNVLDDDKKDLLNSLNVQTTNAGDFYYSIVFYNNTFYRNKCIEYLSKIEKLI

Description

Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap2 2'-O-ribose methylation to the 5'-cap structure of mRNAs. May methylate the ribose of the second nucleotide of a m(7)GpppG-capped mRNA (cap0) to produce m(7)GpppRmpNm (cap2) (By similarity). Regulates expression of tracheal genes required for pathfinding on the segmental nerve (PubMed:10068643).

Catalytic Activity

a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(ribonucleotide)-[mRNA] + S-adenosyl-L-methionine = a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-(2'-O-methyl-ribonucleotide)-[mRNA] + H(+) + S-adenosyl-L-homocysteine

Keywords

Complete proteome   Methyltransferase   mRNA capping   mRNA processing   Nucleus   Reference proteome   S-adenosyl-L-methionine   Transferase  

Feature

chain  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

Uniprot

H9JDM4   A0A2H1W7T6   A0A2A4J9U8   A0A437AV96   A0A0N1IH66   A0A194PW40   + More
A0A1B3PD74   A0A067QWQ8   A0A336LHW8   A0A182PL76   A0A084WDA9   A0A182Y0Q9   K7IXC0   A0A182T9P5   A0A182FHP5   A0A1Q3G139   A0A2P8ZED2   E0VPC7   Q174Y1   A0A182HM95   A0A182XCW6   Q7Q7A5   A0A2M4AM29   A0A336M145   A0A182UQT5   A0A232EI20   A0A182JZC2   A0A182QG34   A0A182MR21   A0A182WLT5   A0A182LJU1   W5JIT7   A0A182TN86   A0A182IL64   A0A2M4BER6   A0A151K098   A0A182NJY7   A0A1B3PDM5   A0A195BRL5   A0A151XIA7   A0A182RC32   A0A158NF86   F4WYN2   A0A3L8E3Y6   A0A1B6HI99   A0A151J8H2   A0A026WD51   A0A1I8PKZ7   A0A0L7QLK5   E2A158   A0A146M402   E9IAA2   A0A0V0G5M1   A0A1B0AMJ3   A0A1A9XH99   A0A224XJN1   T1PPH3   A0A0L0BPS5   A0A069DZE6   A0A1I8NDE1   A0A1B0AFR8   A0A1A9URB5   A0A1B0G1V7   A0A444T1Y3   A0A1B6BY81   Q9UAS6   S5G1K6   A0A091NBQ8   D6X511   A0A218V6L0   B4QBR4   A0A401Q195   I3MSR2   A0A2Y9RSW6   B4HN83   A0A1A9WYW9   A0A3B0J5B3   A0A0A1WJY9   H0Z6G6  

EC Number

2.1.1.296

Pubmed

19121390    26354079    24845553    24438588    25244985    20075255    + More
29403074    20566863    17510324    12364791    14747013    17210077    28648823    20966253    20920257    23761445    21347285    21719571    30249741    24508170    20798317    26823975    21282665    26108605    26334808    25315136    10068643    10731132    12537572    10731137    12537569    18362917    19820115    17994087    22936249    30297745    25830018    20360741   

EMBL

BABH01003300    BABH01003301    ODYU01006885    SOQ49130.1    NWSH01002297    PCG68619.1    + More
RSAL01000379    RVE42067.1    KQ459717    KPJ20281.1    KQ459596    KPI95350.1    KU659876    AOG17675.1    KK853274    KDR09094.1    UFQS01002149    UFQT01002149    SSX13342.1    SSX32776.1    ATLV01022979    KE525339    KFB48203.1    AAZX01013363    GFDL01001530    JAV33515.1    PYGN01000082    PSN54810.1    DS235363    EEB15233.1    CH477404    EAT41650.1    APCN01004381    AAAB01008960    EAA11922.4    GGFK01008486    MBW41807.1    UFQT01000305    SSX23051.1    NNAY01004368    OXU17995.1    AXCN02000491    AXCM01001849    ADMH02001054    ETN64292.1    GGFJ01002393    MBW51534.1    KQ981319    KYN42730.1    KU660000    AOG17798.1    KQ976417    KYM89655.1    KQ982080    KYQ60142.1    ADTU01014037    GL888454    EGI60695.1    QOIP01000001    RLU27367.1    GECU01033355    JAS74351.1    KQ979533    KYN21119.1    KK107260    EZA54000.1    KQ414924    KOC59396.1    GL435707    EFN72825.1    GDHC01004634    GDHC01002522    JAQ13995.1    JAQ16107.1    GL761997    EFZ22498.1    GECL01002853    JAP03271.1    JXJN01000465    GFTR01007624    JAW08802.1    KA650050    AFP64679.1    JRES01001644    KNC21224.1    GBGD01000775    JAC88114.1    CCAG010001059    SAUD01015087    RXG59651.1    GEDC01031090    JAS06208.1    AF117649    AE013599    AL035311    AY050236    BT150145    AGQ54568.1    KK844412    KFP86289.1    KQ971381    EEZ97212.2    MUZQ01000037    OWK61707.1    CM000362    CM002911    EDX07574.1    KMY94686.1    BFAA01011947    GCB79199.1    AGTP01010066    CH480816    EDW48365.1    OUUW01000001    SPP74913.1    GBXI01015574    JAC98717.1    ABQF01035986   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000053268    UP000027135    + More
UP000075885    UP000030765    UP000076408    UP000002358    UP000075901    UP000069272    UP000245037    UP000009046    UP000008820    UP000075840    UP000076407    UP000007062    UP000075903    UP000215335    UP000075881    UP000075886    UP000075883    UP000075920    UP000075882    UP000000673    UP000075902    UP000075880    UP000078541    UP000075884    UP000078540    UP000075809    UP000075900    UP000005205    UP000007755    UP000279307    UP000078492    UP000053097    UP000095300    UP000053825    UP000000311    UP000092460    UP000092443    UP000037069    UP000095301    UP000092445    UP000078200    UP000092444    UP000288706    UP000000803    UP000007266    UP000197619    UP000000304    UP000288216    UP000005215    UP000248480    UP000001292    UP000091820    UP000268350    UP000007754   

PRIDE

H9JDM4    Q9UAS6    S5G1K6   

Pfam

PF01728   FtsJ        + More
PF11894   Nup192
PF07992   Pyr_redox_2

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR025807   Adrift-typ_MeTrfase       
IPR002877   rRNA_MeTrfase_FtsJ_dom       
IPR021827   Nup186/Nup192/Nup205       
IPR013783   Ig-like_fold       
IPR008962   PapD-like_sf       
IPR036188   FAD/NAD-bd_sf       
IPR023753   FAD/NAD-binding_dom       

SUPFAM

SSF53335   SSF53335        + More
SSF49354   SSF49354       

Gene 3D

2.60.40.10     3.50.50.60    

ProteinModelPortal

H9JDM4   A0A2H1W7T6   A0A2A4J9U8   A0A437AV96   A0A0N1IH66   A0A194PW40   + More
A0A1B3PD74   A0A067QWQ8   A0A336LHW8   A0A182PL76   A0A084WDA9   A0A182Y0Q9   K7IXC0   A0A182T9P5   A0A182FHP5   A0A1Q3G139   A0A2P8ZED2   E0VPC7   Q174Y1   A0A182HM95   A0A182XCW6   Q7Q7A5   A0A2M4AM29   A0A336M145   A0A182UQT5   A0A232EI20   A0A182JZC2   A0A182QG34   A0A182MR21   A0A182WLT5   A0A182LJU1   W5JIT7   A0A182TN86   A0A182IL64   A0A2M4BER6   A0A151K098   A0A182NJY7   A0A1B3PDM5   A0A195BRL5   A0A151XIA7   A0A182RC32   A0A158NF86   F4WYN2   A0A3L8E3Y6   A0A1B6HI99   A0A151J8H2   A0A026WD51   A0A1I8PKZ7   A0A0L7QLK5   E2A158   A0A146M402   E9IAA2   A0A0V0G5M1   A0A1B0AMJ3   A0A1A9XH99   A0A224XJN1   T1PPH3   A0A0L0BPS5   A0A069DZE6   A0A1I8NDE1   A0A1B0AFR8   A0A1A9URB5   A0A1B0G1V7   A0A444T1Y3   A0A1B6BY81   Q9UAS6   S5G1K6   A0A091NBQ8   D6X511   A0A218V6L0   B4QBR4   A0A401Q195   I3MSR2   A0A2Y9RSW6   B4HN83   A0A1A9WYW9   A0A3B0J5B3   A0A0A1WJY9   H0Z6G6  

PDB

4N4A     E-value=4.46595e-09,     Score=148

KEGG

101737449    K14590 cap2 methyltransferase [EC:2.1.1.296] | (RefSeq) cap-specific mRNA (nucleoside-2'-O-)-methylt

GO

GO:0008168   GO:0005643   GO:0016021   GO:0097309   GO:0097310   GO:0004483   GO:0005737   GO:0006370   GO:0005634   GO:0016491   GO:0007424   GO:0032259   GO:0019843   GO:0005057   GO:0007165   GO:0016620   GO:0006418   GO:0003676   GO:0016876   GO:0043039  

Subcellular location

Nucleus  

Length:

576

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.53621

Exp number, first 60 AAs:

0.07994

Total prob of N-in:

0.01607

outside

1  -  576

 

 

Pi

210.416914

Theta

199.599911

Tajima's D

0.157973

CLR

108.811759

CSRT

0.420178991050447

Interpretation

Uncertain