Gene

KWMTBOMO08611

Pre Gene Modal

BGIBMGA007963

Annotation

PREDICTED:_raf_kinase?_effector_of_Ras_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr15(-):951314-958622      View in EpiBrowser

Full name

Raf homolog serine/threonine-protein kinase Raf      

Alternative Name

Protein pole-hole

Location in the cell

Nuclear   Reliability : 4.661

CDS

ATGTCGACGTCGACGGACAGTGATGAGACTGCGGATCCGGAGTACGAGATCAGGAATATACAGAACATTATAAACGTGACTCGCCACAACATCGATGCGCTGAATGCTAAATTCGCTGGTTTCCAGCACCCACCTTCGTTATATCTAATTGAGTATCAGGAGCTAACGTCAAAGCTACATACGCTGGAGCAGCGGGAGAGGCATTTACGAGAATTATTACAAACCGATTCTCCAGATCATAGCGAAGAGTACTCGTTTTTTGATGACTCAAAAAAGTTTGACACTCTAACTCGTCAGCGGAAAGTTTTTCTGCGAGCCCATCTTCCGAACCAGCAGCGAACCAGTGTACAGGTCAAAGAGGGAGTGACACTGCGTGTGGCTCTCTCCAAAGCGCTCAAATTGCGGAACCTGACCTGCGAGATGTGTGAGGTTGTGAGGACGGGCTACAACCAAGTTATACCGTGGGACATTGATATAACCACTATTGATGCAGAAGAGGTAACAGTTCGGACTCTTGACGGGCTACCTATAATGACTCACATCTCACATCAATTCGCCCGTAAGACATTCTTCACATTAGCTTTCTGTGAGTGCTGCAGGCGACTACTCTTCAATGGATTTTACTGCTCGCAGTGTAACTTCAAGTTTCACCAGAGATGCGCTGATAAAGTTCCTAGTATGTGCCATCAGGTACGTATGACAGATACATATTATGCAGCACTGTTGGCACAGAACCCAGAAACTCAAGCTGGCATTCTACACTATCCTCCCCACTTCGGGTACCATCCTGGGATGAGAGGAGACCAAAGCAAACAACCACACCCACGTTCATTGAACCAGCAAGACCGATCAAATTCTGCTCCAAATGTTTGCATCAACATGGTGCAGAAGCCTTTGACGCTAGCTGAACATCAAAAATGCTACAGTCAGCACGGCAGCGACAACTCCACGCAGTCGTCGAACTATCTGAGCTCGAGCGGGCCCAGCAAGGACGAGGCGGACGACAGCGACCATCCGCACAGCCACAGCACGCAGACGTCTCCGACGGGCACGCTGCGGCCGCGGCGGGCGCGCGCGCGCTCTGCGGACGAGTCGTGGAAGAACGCGCTGTCGCCGCGGGAGAGCTACGATGACTGGGTCATCCCGGCCGACGAGATACTCATCGGCGCCAGGATAGGCTCCGGGAGCTTCGGGACGGTGTACAAGGCGCACTGGCACGGCCCGGTCGCTGTGAAGACGTTGAATGTCAAAACACCCACTCCGGCACAACTGCAAGCTTTCAAAAATGAGTAG

Protein

MSTSTDSDETADPEYEIRNIQNIINVTRHNIDALNAKFAGFQHPPSLYLIEYQELTSKLHTLEQRERHLRELLQTDSPDHSEEYSFFDDSKKFDTLTRQRKVFLRAHLPNQQRTSVQVKEGVTLRVALSKALKLRNLTCEMCEVVRTGYNQVIPWDIDITTIDAEEVTVRTLDGLPIMTHISHQFARKTFFTLAFCECCRRLLFNGFYCSQCNFKFHQRCADKVPSMCHQVRMTDTYYAALLAQNPETQAGILHYPPHFGYHPGMRGDQSKQPHPRSLNQQDRSNSAPNVCINMVQKPLTLAEHQKCYSQHGSDNSTQSSNYLSSSGPSKDEADDSDHPHSHSTQTSPTGTLRPRRARARSADESWKNALSPRESYDDWVIPADEILIGARIGSGSFGTVYKAHWHGPVAVKTLNVKTPTPAQLQAFKNE

Description

Serine/threonine kinase required in the early embryo for the formation of terminal structure (PubMed:3135183, PubMed:8423783). Also required during the proliferation of imaginal cells (PubMed:3135183). May act downstream of Ras85D in the tor signal transduction pathway (PubMed:8423783). During larval development, mediates Ptth/tor signaling leading to the production of ecdysone, a hormone required for the initiation of metamorphosis (PubMed:19965758).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Zn(2+)

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

Keywords

ATP-binding   Coiled coil   Complete proteome   Kinase   Metal-binding   Nucleotide-binding   Phosphoprotein   Polymorphism   Reference proteome   Transferase   Zinc   Zinc-finger  

Feature

chain  Raf homolog serine/threonine-protein kinase Raf

Uniprot

E9JEI8   A0A437AVG9   A0A2A4JB06   A0A2A4JB31   A0A194PPH7   A0A0N0PES0   + More
A0A088ACF7   A0A2A3EFS2   A0A0C9RME2   A0A0J7NMM0   E1ZXD4   A0A3L8E3V7   A0A310SGR0   A0A1L8DL42   A0A1B0CNY2   A0A0M4M1V7   D6X4G2   A0A1W4WXJ6   A0A1Y1M7Y0   A0A182SU64   A0A1B6L5M9   A0A182VJ19   A0A182TPA0   A0A0T6B854   Q7Q2L5   A0A0A1X8T6   A0A0M9AAS9   A0A1S4GMK6   A0A182LD89   A0A182HYC5   A0A182ML59   A0A0K8V1V4   A0A034WUF5   A0A182QWW8   W8BRG2   A0A1B6CP05   A0A182IN34   A0A084W1A1   A0A336L0X1   A0A224XNX4   A0A1S4G0Q3   A0A0L7R5I4   A0A0A9X2K4   T1HJK8   A0A1Q3F2X7   A0A182H0T5   A0A1Q3F2R8   A0A1I8P278   A0A069DZF9   A0A023F485   A0A2M4BFX8   W5JTG9   A0A1A9WX23   K7ITS2   A0A2R7WGR4   A0A154PI51   A0A067QRW6   B0WBK1   A0A0L0BU75   A0A1W4UWJ7   B4R3I0   B4I9U9   P11346   E0VW01   Q1DH71   A0A1I8M2E9   A0A0V0GAM4   A0A1A9XBP2   A0A1B0ATG5   A0A1B0FAQ4   A0A1A9ZEN9   A0A1A9VCP8   A0A2J7PSA6   A0A1B0D0I5   A0A182NN68   A0A182R2W3   A0A182PMR7   A0A182K313   A0A182WAW2   A0A182YI83   A0A3B0J8S8   A0A0R3NYT4   B3MYV0   Q8ISD4   Q8ISE4   A0A3B0J9N8   A0A131ZCH7   B4Q169   B3P911   B4H2V3   A0A0Q9WPJ8   Q29IQ6   A0A0Q9X079   B4L222   A0A131XP02   B4JL97   E2B9S9  

EC Number

2.7.11.1

Pubmed

19121390    21040523    26354079    20798317    30249741    18362917    + More
19820115    28004739    12364791    25830018    20966253    25348373    24495485    24438588    17510324    25401762    26823975    26483478    26334808    25474469    20920257    23761445    20075255    24845553    26108605    17994087    3135183    10731132    12537572    10731137    12537569    12694293    3037346    8423783    18327897    19965758    20566863    25315136    25244985    15632085    26830274    17550304    28049606   

EMBL

BABH01003305    GQ426305    ADM32531.1    RSAL01000379    RVE42064.1    NWSH01002297    + More
PCG68602.1    PCG68603.1    KQ459596    KPI95346.1    KQ459717    KPJ20286.1    KZ288256    PBC30605.1    GBYB01009489    GBYB01009490    GBYB01009492    JAG79256.1    JAG79257.1    JAG79259.1    LBMM01003264    KMQ93735.1    GL435030    EFN74224.1    QOIP01000001    RLU27095.1    KQ760132    OAD61803.1    GFDF01007024    JAV07060.1    AJWK01021148    KR075836    ALE20555.1    KQ971380    EEZ97554.2    GEZM01037775    JAV81939.1    GEBQ01021183    JAT18794.1    LJIG01009213    KRT83530.1    AAAB01008968    EAA13186.4    GBXI01011957    GBXI01007137    JAD02335.1    JAD07155.1    KQ435712    KOX79359.1    APCN01006919    AXCM01001310    GDHF01019402    GDHF01017651    GDHF01009403    GDHF01008431    GDHF01005532    JAI32912.1    JAI34663.1    JAI42911.1    JAI43883.1    JAI46782.1    GAKP01001127    JAC57825.1    AXCN02001895    GAMC01002626    GAMC01002625    JAC03931.1    GEDC01022273    JAS15025.1    ATLV01019249    KE525266    KFB43995.1    UFQS01001210    UFQS01001692    UFQT01001210    UFQT01001692    SSX09808.1    SSX11882.1    SSX29531.1    GFTR01006705    JAW09721.1    KQ414654    KOC66021.1    GBHO01032269    GDHC01008017    JAG11335.1    JAQ10612.1    ACPB03007057    GFDL01013197    JAV21848.1    JXUM01102040    KQ564695    KXJ71888.1    GFDL01013204    JAV21841.1    GBGD01000710    JAC88179.1    GBBI01002883    JAC15829.1    GGFJ01002819    MBW51960.1    ADMH02000191    ETN67416.1    KK854799    PTY18844.1    KQ434923    KZC11492.1    KK853027    KDR12291.1    DS231879    EDS42440.1    JRES01001343    KNC23538.1    CM000366    EDX16932.1    CH480825    EDW43980.1    X07181    AE014298    AL133503    AY089490    AY135031    AY135032    AY135033    AY135034    AY135035    AY135036    AY135037    AY135038    AY135039    AY135040    AY135041    AY135042    AY135043    AY135044    AY135045    AY135046    AY135047    AY135048    AY135049    AY135050    AY135051    AY135052    M16598    AAZO01005734    DS235816    EEB17557.1    CH899794    EAT32508.1    GECL01001009    JAP05115.1    JXJN01003302    CCAG010014706    NEVH01021937    PNF19209.1    AJVK01009937    AJVK01009938    OUUW01000003    SPP78644.1    CH379063    KRT06154.1    CH902632    EDV32794.2    AY135135    AAN17563.1    AY135030    AAN17540.1    SPP78645.1    GEDV01000055    JAP88502.1    CM000162    EDX01376.1    CH954183    EDV45616.1    CH479204    EDW30670.1    CH933810    KRF94187.1    EAL32597.2    KRF94186.1    EDW07743.1    GEFH01001280    JAP67301.1    CH916370    EDW00350.1    GL446605    EFN87516.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000053240    UP000005203    + More
UP000242457    UP000036403    UP000000311    UP000279307    UP000092461    UP000007266    UP000192223    UP000075901    UP000075903    UP000075902    UP000007062    UP000053105    UP000075882    UP000075840    UP000075883    UP000075886    UP000075880    UP000030765    UP000053825    UP000015103    UP000069940    UP000249989    UP000095300    UP000000673    UP000091820    UP000002358    UP000076502    UP000027135    UP000002320    UP000037069    UP000192221    UP000000304    UP000001292    UP000000803    UP000009046    UP000008820    UP000095301    UP000092443    UP000092460    UP000092444    UP000092445    UP000078200    UP000235965    UP000092462    UP000075884    UP000075900    UP000075885    UP000075881    UP000075920    UP000076408    UP000268350    UP000001819    UP000007801    UP000002282    UP000008711    UP000008744    UP000009192    UP000001070    UP000008237   

PRIDE

E9JEI8    P11346   

Pfam

PF00130   C1_1        + More
PF02196   RBD
PF07714   Pkinase_Tyr
PF00069   Pkinase

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR008271   Ser/Thr_kinase_AS       
IPR029071   Ubiquitin-like_domsf       
IPR001245   Ser-Thr/Tyr_kinase_cat_dom       
IPR002219   PE/DAG-bd       
IPR017441   Protein_kinase_ATP_BS       
IPR000719   Prot_kinase_dom       
IPR003116   RBD_dom       
IPR020454   DAG/PE-bd       

SUPFAM

SSF56112   SSF56112        + More
SSF54236   SSF54236       

CDD

cd00029  C1

ProteinModelPortal

E9JEI8   A0A437AVG9   A0A2A4JB06   A0A2A4JB31   A0A194PPH7   A0A0N0PES0   + More
A0A088ACF7   A0A2A3EFS2   A0A0C9RME2   A0A0J7NMM0   E1ZXD4   A0A3L8E3V7   A0A310SGR0   A0A1L8DL42   A0A1B0CNY2   A0A0M4M1V7   D6X4G2   A0A1W4WXJ6   A0A1Y1M7Y0   A0A182SU64   A0A1B6L5M9   A0A182VJ19   A0A182TPA0   A0A0T6B854   Q7Q2L5   A0A0A1X8T6   A0A0M9AAS9   A0A1S4GMK6   A0A182LD89   A0A182HYC5   A0A182ML59   A0A0K8V1V4   A0A034WUF5   A0A182QWW8   W8BRG2   A0A1B6CP05   A0A182IN34   A0A084W1A1   A0A336L0X1   A0A224XNX4   A0A1S4G0Q3   A0A0L7R5I4   A0A0A9X2K4   T1HJK8   A0A1Q3F2X7   A0A182H0T5   A0A1Q3F2R8   A0A1I8P278   A0A069DZF9   A0A023F485   A0A2M4BFX8   W5JTG9   A0A1A9WX23   K7ITS2   A0A2R7WGR4   A0A154PI51   A0A067QRW6   B0WBK1   A0A0L0BU75   A0A1W4UWJ7   B4R3I0   B4I9U9   P11346   E0VW01   Q1DH71   A0A1I8M2E9   A0A0V0GAM4   A0A1A9XBP2   A0A1B0ATG5   A0A1B0FAQ4   A0A1A9ZEN9   A0A1A9VCP8   A0A2J7PSA6   A0A1B0D0I5   A0A182NN68   A0A182R2W3   A0A182PMR7   A0A182K313   A0A182WAW2   A0A182YI83   A0A3B0J8S8   A0A0R3NYT4   B3MYV0   Q8ISD4   Q8ISE4   A0A3B0J9N8   A0A131ZCH7   B4Q169   B3P911   B4H2V3   A0A0Q9WPJ8   Q29IQ6   A0A0Q9X079   B4L222   A0A131XP02   B4JL97   E2B9S9  

PDB

4MNF     E-value=6.33077e-20,     Score=240

KEGG

100529216    K04365 B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1] | (RefSeq) raf; raf kinase

PATHWAY

04013    MAPK signaling pathway - fly - Bombyx mori (domestic silkworm)
04068    FoxO signaling pathway - Bombyx mori (domestic silkworm)
04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)
04214    Apoptosis - fly - Bombyx mori (domestic silkworm)
04320    Dorso-ventral axis formation - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0035556   GO:0005524   GO:0004674   GO:0004672   GO:0000165   GO:2001234   GO:0045500   GO:0007474   GO:0046777   GO:0016242   GO:0008069   GO:0007298   GO:0007362   GO:0035309   GO:0005623   GO:0007173   GO:0008543   GO:0008284   GO:0042051   GO:0002168   GO:0009267   GO:0007369   GO:0046534   GO:0008293   GO:0030641   GO:0046843   GO:0070371   GO:0035171   GO:0007283   GO:0040014   GO:0007430   GO:0048010   GO:0004709   GO:0007265   GO:0005886   GO:0007465   GO:0046530   GO:0007476   GO:0007472   GO:0007552   GO:0042386   GO:0007623   GO:0005737   GO:0005829   GO:0070374   GO:0042461   GO:0004715   GO:0016301   GO:0006468   GO:0005057   GO:0007165   GO:0016620   GO:0006418   GO:0003676   GO:0016876   GO:0043039  

Length:

430

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00346

Exp number, first 60 AAs:

0.00038

Total prob of N-in:

0.01141

outside

1  -  430

 

 

Pi

191.29551

Theta

166.804161

Tajima's D

1.078994

CLR

0.365049

CSRT

0.685165741712914

Interpretation

Uncertain