Gene

KWMTBOMO08604

Pre Gene Modal

BGIBMGA007967

Annotation

PREDICTED:_dual_specificity_protein_phosphatase_12-like_[Papilio_machaon]

Location

Bomo_Chr15(-):834419-841482      View in EpiBrowser

Full name

Dual specificity protein phosphatase MPK-4      

Location in the cell

Cytoplasmic   Reliability : 1.257 Nuclear   Reliability : 1.734

CDS

ATGGCGAAACAAGTTGCTGAAGTAGAAATACATGCTTCAGACTCCCAGGAGACCCTTGTGGACGACAATCTGGAGGTCAGCGTGGATCTGATTGACAAAAATCTTTATTTAGGAAACCTGGCATGTGCACACAGTCAAGCGACAATACAAACGCTTGGAATAACTCACATCTTGACAGTGGACTTGGTTCCTTTACCGAGGATTATACTGGAACGTCCTCATCTCATATTTAGATATGTGAAATTGGCTGATGTGCCCAAAGAAGACCTAATAAGTCATCTTCCCACTACGAACAATTATATAAGTGAAGCCATCGACAGTGGAGGAACTATATTAGTGCATTGTTATTTTGGTGTATCCCGTTCAGCAGCTGTTGTTATAGCATACATAATGAAGAAGTACGGGCTGTGTTACGAGGAAGCCTTCTCGCTGGTCAAAAACAAGAGACGGTTCATAGGTCCAAATGTAGGATTTGTGGCACAGCTCAAATTGTACGGGCACATGGGATGTGCGATTAACAAAGATGACCCTAGATACAAACAGTTTAGGTTGAAAATGGCGGGCCAAAAGTTAAAACAAGTGAAGATCCTGCCGCAAGTGTTCTGGGAGCTGGTGAAGCCGGACCCGGGCGTGGTCCGCGAGCGCCCCTCGCCGCACGTGTACCGCTGCGTGCGCTGCCGCCGCGTGCTCGCCGCGCACAACAACCTCATCCCCCACCTGCCGCGCCCGCTCAAGCTGCAACTCGCCAAGAAAGGTATAAGGCCCCCTCCGAGTAAACTGACGGGTTTGACCTGCGTTGAAAACGGCGAGATCCTGATACAGAAGTTGAAGAGCCTCGCCTGTCAGATCCTCGAGAGCGACGAGCAGGCTGACGGGGGACACGGCGGCGACGAAATGGAAGGAAGCAATCAGGAGTTACTGGACGGTTACAACGAGCAGAACCTGGTGGACGGCAGTGTAGTGCCGCGGGAATGCGAGACGATATGCCGACAGATGTGGTTCGTGGAGCCGATGGCGTGGATGAGTGACGTCACGCACCAGCCCAGCGGGAAGCTGCACTGTCCCAATTGCAAGAACAAGATCGGGAGCTTTAGTTGGGTTATGGGTTGCAAATGTCCGTGCGGTCAGAAAGTGGCTCCAGCTTTCTATTTAGTACCATCCAAAGTGGAGAGATCTAATATAGTTCAAAACGTACAAACCACTGTATAG

Protein

MAKQVAEVEIHASDSQETLVDDNLEVSVDLIDKNLYLGNLACAHSQATIQTLGITHILTVDLVPLPRIILERPHLIFRYVKLADVPKEDLISHLPTTNNYISEAIDSGGTILVHCYFGVSRSAAVVIAYIMKKYGLCYEEAFSLVKNKRRFIGPNVGFVAQLKLYGHMGCAINKDDPRYKQFRLKMAGQKLKQVKILPQVFWELVKPDPGVVRERPSPHVYRCVRCRRVLAAHNNLIPHLPRPLKLQLAKKGIRPPPSKLTGLTCVENGEILIQKLKSLACQILESDEQADGGHGGDEMEGSNQELLDGYNEQNLVDGSVVPRECETICRQMWFVEPMAWMSDVTHQPSGKLHCPNCKNKIGSFSWVMGCKCPCGQKVAPAFYLVPSKVERSNIVQNVQTTV

Description

Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. May suppress bsk/JNK activation during the immune response.

Catalytic Activity

H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate
H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate
H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate

Subunit

Interacts (via tyrosine-protein phosphatase domain) with bsk/JNK; the interaction dephosphorylates bsk.

Similarity

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Keywords

Complete proteome   Cytoplasm   Hydrolase   Nucleus   Protein phosphatase   Reference proteome  

Feature

chain  Dual specificity protein phosphatase MPK-4

Uniprot

H9JEM0   A0A0N1IIT2   A0A194PW30   A0A2A4J9H9   A0A2H1WMR1   A0A212F6B2   + More
A0A212F5D4   A0A0K8WHM0   A0A034W6R8   A0A437BDN4   B4NBU5   A0A0A1XRF2   A0A1I8Q332   A0A1W4VTG2   A0A1I8MD03   A0A0L0BVQ5   A0A1A9ZKU1   A0A1B0G8N9   A0A1B0BDL7   A0A1A9YMH8   B3MQB2   A0A0M5J635   E9IMS5   Q9VWF4   W8BQB5   B4I785   Q29IU9   B4PZF3   B3NVR0   A0A310SQ12   W5JB05   A0A0K8TNP7   F4WSV4   A0A2A3EGY1   A0A151J252   A0A195AZ10   A0A195D197   A0A088AW72   A0A158NH25   A0A182PNB8   A0A182XGH0   A0A1W5CAG9   A0A182QTS2   B4JM13   A0A182HZV6   A0A182M4P1   A0A195F5L2   B4MAI9   A0A1A9WVL4   A0A2M4BQ41   A0A182K5T2   A0A182JAV3   A0A182F7Z0   A0A182LQY6   A0A1S4GEJ6   A0A151XDD5   E2B2B0   A0A182N6A3   B4L676   A0A084W9U4   A0A182USS8   A0A182RT75   A0A1J1IGV1   Q7PYU3   A0A026W1G7   A0A182SKL9   A0A1A9UW41   Q16JJ4   A0A182XW25   A0A182G1Q7   E2AJC7   A0A182VRE3   A0A0K8UFZ6   A0A1Q3EWD7   B0XGR0   A0A0C9PJ41   A0A0L0CEX1   A0A226EX64   A0A3B0L0B5  

EC Number

3.1.3.16
3.1.3.48

Pubmed

19121390    26354079    22118469    25348373    17994087    25830018    + More
25315136    26108605    21282665    10731132    12537572    12537569    18456458    24495485    15632085    17550304    20920257    23761445    26369729    21719571    21347285    12364791    20966253    20798317    24438588    24508170    30249741    17510324    25244985    26483478   

EMBL

BABH01003312    BABH01003313    KQ459717    KPJ20291.1    KQ459596    KPI95340.1    + More
NWSH01002297    PCG68611.1    ODYU01009703    SOQ54318.1    AGBW02010064    OWR49276.1    AGBW02010203    OWR48940.1    GDHF01001663    JAI50651.1    GAKP01009122    JAC49830.1    RSAL01000083    RVE48458.1    CH964239    EDW82304.1    GBXI01012330    GBXI01000453    JAD01962.1    JAD13839.1    JRES01001264    KNC24101.1    CCAG010000297    JXJN01012511    CH902621    EDV44538.1    CP012528    ALC49024.1    GL764255    EFZ18155.1    AE014298    BT031134    AY059453    AAL13359.1    ABX00756.1    GAMC01007563    GAMC01007562    JAB98993.1    CH480823    EDW56183.1    CH379063    EAL32554.2    CM000162    EDX02109.1    CH954180    EDV46725.1    KQ761783    OAD56995.1    ADMH02002023    ETN59944.1    GDAI01001857    JAI15746.1    GL888327    EGI62761.1    KZ288256    PBC30542.1    KQ980447    KYN16030.1    KQ976698    KYM77441.1    KQ976973    KYN06678.1    ADTU01015494    AAAB01008987    EGK97380.1    AXCN02000278    CH916371    EDV91774.1    APCN01002014    AXCM01000395    KQ981768    KYN35880.1    CH940655    EDW66248.1    GGFJ01005900    MBW55041.1    KQ982294    KYQ58359.1    GL445130    EFN90147.1    CH933812    EDW05872.1    ATLV01021913    KE525325    KFB46988.1    CVRI01000050    CRK99432.1    EAA00982.5    KK107566    QOIP01000006    EZA48904.1    RLU21917.1    CH478006    EAT34447.1    JXUM01038855    JXUM01038856    KQ561182    KXJ79453.1    GL439972    EFN66448.1    GDHF01026788    JAI25526.1    GFDL01015416    JAV19629.1    DS233057    EDS27783.1    GBYB01000983    GBYB01000984    GBYB01000986    JAG70750.1    JAG70751.1    JAG70753.1    JRES01000586    KNC30034.1    LNIX01000001    OXA62139.1    OUUW01000035    SPP89828.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000283053    + More
UP000007798    UP000095300    UP000192221    UP000095301    UP000037069    UP000092445    UP000092444    UP000092460    UP000092443    UP000007801    UP000092553    UP000000803    UP000001292    UP000001819    UP000002282    UP000008711    UP000000673    UP000007755    UP000242457    UP000078492    UP000078540    UP000078542    UP000005203    UP000005205    UP000075885    UP000076407    UP000007062    UP000075886    UP000001070    UP000075840    UP000075883    UP000078541    UP000008792    UP000091820    UP000075881    UP000075880    UP000069272    UP000075882    UP000075809    UP000008237    UP000075884    UP000009192    UP000030765    UP000075903    UP000075900    UP000183832    UP000053097    UP000279307    UP000075901    UP000078200    UP000008820    UP000076408    UP000069940    UP000249989    UP000000311    UP000075920    UP000002320    UP000198287    UP000268350   

PRIDE

H9JEM0    Q9VWF4   

Pfam

PF00782   DSPc

Interpro

IPR016278   DUSP12        + More
IPR000387   TYR_PHOSPHATASE_dom       
IPR000340   Dual-sp_phosphatase_cat-dom       
IPR020422   TYR_PHOSPHATASE_DUAL_dom       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR016130   Tyr_Pase_AS       
IPR003595   Tyr_Pase_cat       
IPR013087   Znf_C2H2_type       
IPR020405   Atypical_DUSP_famA       
IPR020417   Atypical_DUSP       

SUPFAM

SSF52799   SSF52799       

Gene 3D

3.90.190.10    

CDD

cd00127  DSPc

ProteinModelPortal

H9JEM0   A0A0N1IIT2   A0A194PW30   A0A2A4J9H9   A0A2H1WMR1   A0A212F6B2   + More
A0A212F5D4   A0A0K8WHM0   A0A034W6R8   A0A437BDN4   B4NBU5   A0A0A1XRF2   A0A1I8Q332   A0A1W4VTG2   A0A1I8MD03   A0A0L0BVQ5   A0A1A9ZKU1   A0A1B0G8N9   A0A1B0BDL7   A0A1A9YMH8   B3MQB2   A0A0M5J635   E9IMS5   Q9VWF4   W8BQB5   B4I785   Q29IU9   B4PZF3   B3NVR0   A0A310SQ12   W5JB05   A0A0K8TNP7   F4WSV4   A0A2A3EGY1   A0A151J252   A0A195AZ10   A0A195D197   A0A088AW72   A0A158NH25   A0A182PNB8   A0A182XGH0   A0A1W5CAG9   A0A182QTS2   B4JM13   A0A182HZV6   A0A182M4P1   A0A195F5L2   B4MAI9   A0A1A9WVL4   A0A2M4BQ41   A0A182K5T2   A0A182JAV3   A0A182F7Z0   A0A182LQY6   A0A1S4GEJ6   A0A151XDD5   E2B2B0   A0A182N6A3   B4L676   A0A084W9U4   A0A182USS8   A0A182RT75   A0A1J1IGV1   Q7PYU3   A0A026W1G7   A0A182SKL9   A0A1A9UW41   Q16JJ4   A0A182XW25   A0A182G1Q7   E2AJC7   A0A182VRE3   A0A0K8UFZ6   A0A1Q3EWD7   B0XGR0   A0A0C9PJ41   A0A0L0CEX1   A0A226EX64   A0A3B0L0B5  

PDB

6N8O     E-value=6.64941e-23,     Score=265

KEGG

101738891    K14819 dual specificity phosphatase 12 [EC:3.1.3.16 3.1.3.48] | (RefSeq) dual specificity protein ph

GO

GO:0008138   GO:0004725   GO:0005634   GO:0043508   GO:0016311   GO:0005737   GO:0016791   GO:0006470   GO:0003676   GO:0016620   GO:0006418   GO:0016876   GO:0043039  

Subcellular location

Nucleus   Mainly found in the nucleus.   With evidence from 2 publications.
Cytoplasm   Mainly found in the nucleus.   With evidence from 2 publications.

Length:

402

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.861129999999999

Exp number, first 60 AAs:

0.08914

Total prob of N-in:

0.04225

outside

1  -  402

 

 

Pi

268.00354

Theta

182.586089

Tajima's D

1.561948

CLR

0.451874

CSRT

0.802109894505275

Interpretation

Uncertain