Gene

KWMTBOMO08586  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA007977

Annotation

PREDICTED:_protein_FAM188A_[Papilio_polytes]

Location

Bomo_Chr15(-):366098-367737      View in EpiBrowser

Full name

Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog      

Alternative Name

Deubiquitinating enzyme MINDY-3
Protein CARP homolog

Location in the cell

Cytoplasmic   Reliability : 1.35 PlasmaMembrane   Reliability : 1.415

CDS

ATGAGTGCGAGTAGCGTGGCGCTGGAGCGCGAGCTGGCAGGCACGCGACGCTTGCTGTGGGGGGACCACGTCAAAGAAGATGTTTTCCGACGTTGGGCGCAAGGTTTTCAATTCAGTCCTGATGAACCCAGCGCCCTCATTCAGCAGGAGGGTGGACCTTGCGCTGCGATCGCCCCAGTACAAGGATTTTTGCTTAAGATTCTCCTATCAGAGACTCCAGGACATAGTTTTCAAGACTTAACATCGGAGAAGTGCAACTCTTTACTTGTGAGAGCTGTGTGTACGATTTTAAGCCAGTGTCTAGCACCTAAATACAATGTAGCTGTTTACCGGAAGAATGAGTCTGGTGCGGAAACAAGTGGAAGTAACAGCGTTAGTGTGGATGAACACTCTAGTGATACCATTGAACATTTCCATCGAAGAATCCAGGTACATTCGTTTCAAAATCTGTCAGAAGTGGAGGCATTTTACACAAGGAACATTAGGATATTGAAGGACAAATATGGTGTTCTACTTCTGTTATATAGTGTGATTCTCAGTAAGGGTATAAGTACAGTAGAAGCAGAGCTCTCTGAACTCTCAGACCCCCTGATACATTCCACATATGGGTATGGATCACAAGGTCTCATCAATTTGATGCTGACTGGACGAGCAGTGGCACATGTGTGGGATCATGATCAAGTTGTCAGTGGTTTAAGACTTAGAGGCATAGAAAAACAAAATGACATTGGTTTCCTGACTATCATGGAGCATATGCAATACTGCACTGTAGGGTCGTTTTACAAGAGCCCTAAACATCCTGTTTGGGTACTGGCTTCCGAGACTCACCTGACTGTGCTTTTCTCTCTAGAGCGTCGATTGGCAGCACCAGAGAGTGCAGGAGAATCTGCTGAACGAATATTCAGATCATTTGATCCTGAAGGCAACAATTTCATTCCTTCAGTAGCTTTGCAGGATGTTCTGTGCGCTGCAGACTTAGTCAGTGAACCAGAATATGTGGAATTAATGAGGCGGAAATTAGACACTGAAAACTTGGGAATAATTTTGTTAAGTACTTTCATGGATGAATTTTTCCCAGGATGTGAACGTGGTGCTCCTGACACATTCACCCTTCACCATTACAATGGTCTTGAGCGTAGTAACCCAGGTGGCAGAGTTGTGTACCGCACTGGTCGAGCAGCTTTGCTCGAGTGCCCGATGCGTGCTGCCACCACAGACCCCATGTTGACCTGTCTGCAGACTAAGTGGCCCAGCATTGATGTTGTCTGGGACGATGGACATTCACCCTCGCTCAATTAA

Protein

MSASSVALERELAGTRRLLWGDHVKEDVFRRWAQGFQFSPDEPSALIQQEGGPCAAIAPVQGFLLKILLSETPGHSFQDLTSEKCNSLLVRAVCTILSQCLAPKYNVAVYRKNESGAETSGSNSVSVDEHSSDTIEHFHRRIQVHSFQNLSEVEAFYTRNIRILKDKYGVLLLLYSVILSKGISTVEAELSELSDPLIHSTYGYGSQGLINLMLTGRAVAHVWDHDQVVSGLRLRGIEKQNDIGFLTIMEHMQYCTVGSFYKSPKHPVWVLASETHLTVLFSLERRLAAPESAGESAERIFRSFDPEGNNFIPSVALQDVLCAADLVSEPEYVELMRRKLDTENLGIILLSTFMDEFFPGCERGAPDTFTLHHYNGLERSNPGGRVVYRTGRAALLECPMRAATTDPMLTCLQTKWPSIDVVWDDGHSPSLN

Description

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

Catalytic Activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Similarity

Belongs to the MINDY deubiquitinase family. FAM188 subfamily.

Keywords

Complete proteome   Hydrolase   Phosphoprotein   Protease   Reference proteome   Thiol protease   Ubl conjugation pathway  

Feature

chain  Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog

Uniprot

H9JEN0   A0A3S2L923   A0A0N1IQ86   A0A194PPS2   A0A2W1BD68   A0A2A4JG99   + More
A0A2H1VV89   S4Q0A4   A0A0L7LE07   A0A0K8TKV3   A0A1A9X4J8   A0A1A9UU33   A0A1B0FK59   A0A1A9ZB82   A0A1A9XKB8   A0A1B0ALY5   A0A067R0Q9   W8AT25   A0A0K8UNR8   A0A0K8TWG7   A0A034W2B7   A0A2J7QUX6   A0A1I8MBV1   A0A0A1XJA2   A0A0A1XRV6   A0A1I8P9S4   A0A195CWK4   A0A1L8DAV1   E2BWV3   B4L3A7   A0A0Q9WMI6   F4WZI4   A0A158NH15   Q16VR7   A0A195DQ81   A0A195ETZ9   A0A195BXV1   W5JN04   E9IE64   Q7QFC9   A0A182YCS4   A0A026VZY2   B4M3T3   A0A182FMN6   A0A182RKY3   X2JL49   Q9VWN5   D2A5F4   A0A1B6M376   A0A2M3ZI78   A0A182KGW2   A0A2M4BJM0   E2AGX5   A0A2M4BJQ1   B4I6Z0   B4PWH1   A0A1W4U9Y0   B3NUQ4   A0A0L0C0L0   A0A182QYT7   A0A0J7NI26   A0A1B6G384   A0A1B6HXE0   A0A182P181   A0A023ETI2   T1HC57   A0A0N7Z936   A0A182MVQ0   A0A1Y1NHQ8   A0A069DU89   A0A0L7QN75   A0A023F2W2   A0A224XCX8   B0XCH7   A0A182W5T3   A0A0T6BGQ4   A0A088AEQ0   K7IT19   A0A1B6DPN6   A0A2A3ECX4   A0A1Q3F7X3   A0A232F6D5   A0A1Q3F7R6   A0A1Q3F7U5   A0A0N8NZN7   A0A182HAP8   N6TTA5   A0A3L8DFF7   B7S8F1   A0A2M3ZZZ6   A0A2M4A039   A0A146LSQ5   A0A0A9YG83   A0A0K8S6T2   A0A1J1J3Y8   T1IVP6   U4UXQ6   A0A182U586   A0A1S3CWF9  

EC Number

3.4.19.12

Pubmed

19121390    26354079    28756777    23622113    26227816    26369729    + More
24845553    24495485    25348373    25315136    25830018    20798317    17994087    21719571    21347285    17510324    20920257    23761445    21282665    12364791    14747013    17210077    25244985    24508170    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12537569    18327897    18362917    19820115    17550304    26108605    24945155    27129103    28004739    26334808    25474469    20075255    28648823    26483478    23537049    30249741    26823975    25401762   

EMBL

BABH01003338    RSAL01000083    RVE48438.1    KQ459717    KPJ20313.1    KQ459596    + More
KPI95312.1    KZ150445    PZC70850.1    NWSH01001686    PCG70422.1    ODYU01004604    SOQ44666.1    GAIX01000133    JAA92427.1    JTDY01001529    KOB73635.1    GDAI01002837    JAI14766.1    CCAG010004878    JXJN01000215    KK853123    KDR11065.1    GAMC01014595    JAB91960.1    GDHF01031509    GDHF01023985    GDHF01015813    JAI20805.1    JAI28329.1    JAI36501.1    GDHF01033683    JAI18631.1    GAKP01010118    JAC48834.1    NEVH01010480    PNF32390.1    GBXI01003322    JAD10970.1    GBXI01000561    JAD13731.1    KQ977259    KYN04534.1    GFDF01010495    JAV03589.1    GL451188    EFN79817.1    CH933810    EDW07035.1    KRF93917.1    GL888479    EGI60428.1    ADTU01001620    CH477583    EAT38655.1    KQ980612    KYN15080.1    KQ981979    KYN31382.1    KQ976398    KYM92771.1    ADMH02001081    ETN64154.1    GL762556    EFZ21187.1    AAAB01008846    EAA06126.5    KK107519    EZA49363.1    CH940651    EDW65458.2    AE014298    AHN59887.1    AY058544    KQ971345    EFA05086.2    GEBQ01009601    JAT30376.1    GGFM01007387    MBW28138.1    GGFJ01004106    MBW53247.1    GL439433    EFN67311.1    GGFJ01004093    MBW53234.1    CH480823    EDW56088.1    CM000162    EDX02789.1    CH954180    EDV46651.1    JRES01001065    KNC25817.1    AXCN02002227    LBMM01004724    KMQ92140.1    GECZ01012897    JAS56872.1    GECU01028367    JAS79339.1    GAPW01000980    JAC12618.1    ACPB03010146    GDKW01001643    JAI54952.1    AXCM01006171    GEZM01001969    JAV97433.1    GBGD01001553    JAC87336.1    KQ414874    KOC59931.1    GBBI01003266    JAC15446.1    GFTR01006151    JAW10275.1    DS232696    EDS44839.1    LJIG01000404    KRT86536.1    AAZX01005110    GEDC01009652    JAS27646.1    KZ288301    PBC28871.1    GFDL01011380    JAV23665.1    NNAY01000889    OXU26050.1    GFDL01011431    JAV23614.1    GFDL01011401    JAV23644.1    CH902635    KPU74836.1    JXUM01123047    KQ566673    KXJ69917.1    APGK01052864    KB741216    ENN72495.1    QOIP01000009    RLU18628.1    EF710645    ACE75176.1    GGFK01000750    MBW34071.1    GGFK01000865    MBW34186.1    GDHC01007821    JAQ10808.1    GBHO01011529    GBHO01011527    GBHO01011524    JAG32075.1    JAG32077.1    JAG32080.1    GBRD01017382    JAG48445.1    CVRI01000070    CRL07128.1    JH431589    KB632404    ERL95075.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000053268    UP000218220    UP000037510    + More
UP000091820    UP000078200    UP000092444    UP000092445    UP000092443    UP000092460    UP000027135    UP000235965    UP000095301    UP000095300    UP000078542    UP000008237    UP000009192    UP000007755    UP000005205    UP000008820    UP000078492    UP000078541    UP000078540    UP000000673    UP000007062    UP000076408    UP000053097    UP000008792    UP000069272    UP000075900    UP000000803    UP000007266    UP000075881    UP000000311    UP000001292    UP000002282    UP000192221    UP000008711    UP000037069    UP000075886    UP000036403    UP000075885    UP000015103    UP000075883    UP000053825    UP000002320    UP000075920    UP000005203    UP000002358    UP000242457    UP000215335    UP000007801    UP000069940    UP000249989    UP000019118    UP000279307    UP000183832    UP000030742    UP000075902    UP000079169   

PRIDE

H9JEN0    X2JL49    Q9VWN5   

Pfam

PF13898   DUF4205        + More
PF12478   DUF3697
PF13405   EF-hand_6
PF18266   Ncstrn_small
PF05450   Nicastrin

Interpro

IPR025257   DUF4205        + More
IPR011992   EF-hand-dom_pair       
IPR039785   MINY3/4       
IPR002048   EF_hand_dom       
IPR022166   UBAP2/Lig       
IPR008710   Nicastrin       
IPR041084   Ncstrn_small       

SUPFAM

SSF47473   SSF47473       

ProteinModelPortal

H9JEN0   A0A3S2L923   A0A0N1IQ86   A0A194PPS2   A0A2W1BD68   A0A2A4JG99   + More
A0A2H1VV89   S4Q0A4   A0A0L7LE07   A0A0K8TKV3   A0A1A9X4J8   A0A1A9UU33   A0A1B0FK59   A0A1A9ZB82   A0A1A9XKB8   A0A1B0ALY5   A0A067R0Q9   W8AT25   A0A0K8UNR8   A0A0K8TWG7   A0A034W2B7   A0A2J7QUX6   A0A1I8MBV1   A0A0A1XJA2   A0A0A1XRV6   A0A1I8P9S4   A0A195CWK4   A0A1L8DAV1   E2BWV3   B4L3A7   A0A0Q9WMI6   F4WZI4   A0A158NH15   Q16VR7   A0A195DQ81   A0A195ETZ9   A0A195BXV1   W5JN04   E9IE64   Q7QFC9   A0A182YCS4   A0A026VZY2   B4M3T3   A0A182FMN6   A0A182RKY3   X2JL49   Q9VWN5   D2A5F4   A0A1B6M376   A0A2M3ZI78   A0A182KGW2   A0A2M4BJM0   E2AGX5   A0A2M4BJQ1   B4I6Z0   B4PWH1   A0A1W4U9Y0   B3NUQ4   A0A0L0C0L0   A0A182QYT7   A0A0J7NI26   A0A1B6G384   A0A1B6HXE0   A0A182P181   A0A023ETI2   T1HC57   A0A0N7Z936   A0A182MVQ0   A0A1Y1NHQ8   A0A069DU89   A0A0L7QN75   A0A023F2W2   A0A224XCX8   B0XCH7   A0A182W5T3   A0A0T6BGQ4   A0A088AEQ0   K7IT19   A0A1B6DPN6   A0A2A3ECX4   A0A1Q3F7X3   A0A232F6D5   A0A1Q3F7R6   A0A1Q3F7U5   A0A0N8NZN7   A0A182HAP8   N6TTA5   A0A3L8DFF7   B7S8F1   A0A2M3ZZZ6   A0A2M4A039   A0A146LSQ5   A0A0A9YG83   A0A0K8S6T2   A0A1J1J3Y8   T1IVP6   U4UXQ6   A0A182U586   A0A1S3CWF9  

KEGG

101740373    K22647 ubiquitin carboxyl-terminal hydrolase MINDY-3/4 [EC:3.4.19.12] | (RefSeq) protein FAM188A hom

GO

GO:0005509   GO:0016787   GO:1990380   GO:0016807   GO:0036459   GO:0016021   GO:0016485  

PANTHER

PTHR12473  

Length:

432

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.44509

Exp number, first 60 AAs:

0.00045

Total prob of N-in:

0.02451

outside

1  -  432

 

 

Pi

145.783613

Theta

168.555348

Tajima's D

-0.30607

CLR

16.425682

CSRT

0.288335583220839

Interpretation

Uncertain