Gene

KWMTBOMO08583

Annotation

PREDICTED:_apoptosis_regulatory_protein_Siva-like_[Amyelois_transitella]

Location

Bomo_Chr15(-):319144-322137      View in EpiBrowser

Full name

Apoptosis regulatory protein Siva      

Alternative Name

CD27-binding protein

Location in the cell

Extracellular   Reliability : 2.055 Nuclear   Reliability : 2.427

CDS

ATGACAAAACGAACGAACCCTTTTATCGATGATTTTCTTCCGCAAAGTAAAATTCATGTTAGTTTAAAAAAGTACGATAAACACAGCACAGACAATGAAAAACGACTGAAGAAAGTTTATGAAAAAACCCTACAAATGTTATTTAATGGCGCCAAAAAGGGTACAACTACTGAAACCAACAACAACTTGCAGGATAGTAAAGTGAGAAAAGACAAAAAAAAACAATTATTTATCGGCAAAGATGGCAATCTACTACATTCTGGTTGTCTGATAGAGACCCAATCAATAAGAAAAAACTGTCATTGCGGTGTTACATCAGAGACCAAGTGTGCATATTGTGAATTTGTACTATGTGATTCATGTCTCCACACCTGCGCTGGTTGTGAGCAGGTTTACTGTAACAAATGCTTGTTTGTAGGGTCAGAAGGTTCTGAAATCTGTGTATCCTGTTATAGTTAA

Protein

MTKRTNPFIDDFLPQSKIHVSLKKYDKHSTDNEKRLKKVYEKTLQMLFNGAKKGTTTETNNNLQDSKVRKDKKKQLFIGKDGNLLHSGCLIETQSIRKNCHCGVTSETKCAYCEFVLCDSCLHTCAGCEQVYCNKCLFVGSEGSEICVSCYS

Description

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity).
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Cofactor

Zn(2+)

Subunit

Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Isoform 1 binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX.
Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX (By similarity).
(Microbial infection) Interacts with coxsackievirus B3 capsid protein VP2; this interaction inhibits the binding of SIVA1 to CD27.

Keywords

Alternative splicing   Apoptosis   Complete proteome   Cytoplasm   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Zinc   Host-virus interaction   Pharmaceutical  

Feature

chain  Apoptosis regulatory protein Siva
splice variant  In isoform 2.

Uniprot

A0A3S2NTU8   A0A2H1VTR3   A0A2W1B8P2   A0A2A4JWK7   A0A0N1IK27   A0A194PPD8   + More
S4NMZ4   A0A310SII5   A0A423T5T0   A0A0C9R2L2   A0A3Q8CBS8   O54926   Q3TFC3   A0A088ARN6   A0A026WT68   A0A286Y1S5   A0A2A3ELS2   A0A3Q2YAG8   A0A1E1X0W2   A0A2Y9T932   A0A340X8V0   A0A0N0U4X4   A4FTX4   A0A2U4B8G8   A0A3B3VE50   A0A444SCK9   A0A2U3V608   A0A0L7RDK0   I3MN94   A0A154PA52   A0A2R5LG96   P59692   A0A091CUX7   A0A3B5KGM8   A0A250YB36   A0A341CPU3   Q4RLN8   E9I8P0   A0A3Q3LDP7   V5HE68   G3X7B3   A0A452FIV7   A0A3Q7QA12   A0A1B0GLE0   A0A087XWY1   A0A3B3WND7   A0A3P9QBY1   A0A3B3RIN6   A0A2Y9NJS2   A0A2U3VL24   A0A2U3Y3U7   A0A3B5LRK6   A0A1B6C316   A0A1U7TIP2   A0A1S2ZF59   M3ZWX5   K9IWK9   A0A060WLI1   G5AWI6   A0A1B0CA90   A0A158NHF5   A0A315UYW8   M3VK34   A0A2R8MJ08   A0A2Y9G8P6   G3V439   A0A452IW01   A0A3P8UHT9   B7ZAZ2   B4DTY2   D2I109   H2MR92   A0A452QY36   A0A3Q7WD01   G1LMR9   G3V3U1   A0A2I2YVG9   F7HYP0   A0A3P9LR78   F7E257   J9JMK6   G3RB25   H2Q902   O15304   A0A1U7QL07   U3AQ02   A0A195D4F3   A0A3Q7U526   C4WUU7   A0A1A8HLF8   A0A151XFC9   A0A3Q7TTI3   A0A2K6S859   A0A3Q7TFG3   A0A2J8QLA6   A0A2J8QL97   A0A2J8SZ82   A0A2J8SZ79   A0A2J8QLI8   A0A1A8JQS9  

Pubmed

28756777    26354079    23622113    10597319    16141072    15489334    + More
9177220    10756043    12478477    15105421    10349636    11042159    11076861    11217851    12466851    16141073    24508170    21993624    28503490    15057822    9853261    21551351    28087693    15496914    21282665    25765539    19393038    29240929    23542700    24755649    21993625    21347285    29703783    12508121    24275569    28562605    24487278    20010809    17554307    22398555    25243066    19892987    16136131    11278261    11601913    12011449    14739602    15034012    15958577    16683188    16491128   

EMBL

RSAL01000083    RVE48433.1    ODYU01004391    SOQ44219.1    KZ150445    PZC70845.1    + More
NWSH01000539    PCG75780.1    KQ459717    KPJ20318.1    KQ459596    KPI95306.1    GAIX01012439    JAA80121.1    KQ760869    OAD58766.1    QCYY01002239    ROT71847.1    GBYB01007077    JAG76844.1    KY056151    ATX63073.1    AF033115    AF033113    AF033112    AF033114    AK010562    AK017570    AK153115    BC012279    AK169200    BAE40975.1    KK107109    EZA59207.1    AAKN02051999    KZ288222    PBC32109.1    GFAC01006314    JAT92874.1    KQ435814    KOX72674.1    AABR07073265    AC141959    BC088866    AAH88866.1    SAUD01042300    RXG51111.1    KQ414614    KOC68860.1    AGTP01078354    KQ434856    KZC08732.1    GGLE01004415    MBY08541.1    KN124093    KFO22302.1    GFFW01003978    JAV40810.1    CAAE01015019    CAG10694.1    GL761591    EFZ23069.1    GANP01011001    JAB73467.1    LWLT01000019    AJWK01034780    AYCK01003396    GEDC01029703    JAS07595.1    GABZ01008224    JAA45301.1    FR904523    CDQ65949.1    JH167269    GEBF01000643    EHB01397.1    JAO02990.1    AJWK01003422    ADTU01015734    NHOQ01002481    PWA16605.1    GACC01000340    JAA74244.1    AL583722    AK316457    BAH14828.1    AK300415    AK316550    BAG62144.1    BAG65628.1    GL193937    EFB21661.1    ACTA01012284    ACTA01020284    CABD030094324    GAMP01007779    JAB44976.1    ABLF02022108    AACZ04057246    GABF01002560    GABD01000115    JAA19585.1    JAA32985.1    U82938    AF033111    BC034562    AF401214    BK000018    GAMT01009688    GAMS01008581    GAMQ01006549    JAB02173.1    JAB14555.1    JAB35302.1    KQ976870    KYN07780.1    AK341228    BAH71667.1    HAEB01007997    HAEC01016050    SBQ84271.1    KQ982194    KYQ59094.1    NBAG03000028    PNI97066.1    PNI97065.1    NDHI03003534    PNJ26075.1    PNJ26076.1    PNI97061.1    HAED01017306    HAEE01002247    SBR22267.1   

Proteomes

UP000283053    UP000218220    UP000053240    UP000053268    UP000283509    UP000000589    + More
UP000005203    UP000053097    UP000005447    UP000242457    UP000264820    UP000248484    UP000265300    UP000053105    UP000002494    UP000245320    UP000261500    UP000288706    UP000053825    UP000005215    UP000076502    UP000028990    UP000005226    UP000252040    UP000007303    UP000261640    UP000009136    UP000291000    UP000286641    UP000092461    UP000028760    UP000261480    UP000242638    UP000261540    UP000248483    UP000245340    UP000245341    UP000261380    UP000189704    UP000079721    UP000002852    UP000193380    UP000006813    UP000005205    UP000008227    UP000008225    UP000248481    UP000005640    UP000291020    UP000265120    UP000001038    UP000291022    UP000286642    UP000008912    UP000001519    UP000265180    UP000002281    UP000007819    UP000002277    UP000189706    UP000078542    UP000286640    UP000075809    UP000233220   

PRIDE

O54926    P59692    G3V439    G3V3U1    O15304   

Pfam

PF05458   Siva

Interpro

IPR022773   Siva        + More
IPR017907   Znf_RING_CS       
IPR000315   Znf_B-box       
IPR011011   Znf_FYVE_PHD       

SUPFAM

SSF57903   SSF57903       

ProteinModelPortal

A0A3S2NTU8   A0A2H1VTR3   A0A2W1B8P2   A0A2A4JWK7   A0A0N1IK27   A0A194PPD8   + More
S4NMZ4   A0A310SII5   A0A423T5T0   A0A0C9R2L2   A0A3Q8CBS8   O54926   Q3TFC3   A0A088ARN6   A0A026WT68   A0A286Y1S5   A0A2A3ELS2   A0A3Q2YAG8   A0A1E1X0W2   A0A2Y9T932   A0A340X8V0   A0A0N0U4X4   A4FTX4   A0A2U4B8G8   A0A3B3VE50   A0A444SCK9   A0A2U3V608   A0A0L7RDK0   I3MN94   A0A154PA52   A0A2R5LG96   P59692   A0A091CUX7   A0A3B5KGM8   A0A250YB36   A0A341CPU3   Q4RLN8   E9I8P0   A0A3Q3LDP7   V5HE68   G3X7B3   A0A452FIV7   A0A3Q7QA12   A0A1B0GLE0   A0A087XWY1   A0A3B3WND7   A0A3P9QBY1   A0A3B3RIN6   A0A2Y9NJS2   A0A2U3VL24   A0A2U3Y3U7   A0A3B5LRK6   A0A1B6C316   A0A1U7TIP2   A0A1S2ZF59   M3ZWX5   K9IWK9   A0A060WLI1   G5AWI6   A0A1B0CA90   A0A158NHF5   A0A315UYW8   M3VK34   A0A2R8MJ08   A0A2Y9G8P6   G3V439   A0A452IW01   A0A3P8UHT9   B7ZAZ2   B4DTY2   D2I109   H2MR92   A0A452QY36   A0A3Q7WD01   G1LMR9   G3V3U1   A0A2I2YVG9   F7HYP0   A0A3P9LR78   F7E257   J9JMK6   G3RB25   H2Q902   O15304   A0A1U7QL07   U3AQ02   A0A195D4F3   A0A3Q7U526   C4WUU7   A0A1A8HLF8   A0A151XFC9   A0A3Q7TTI3   A0A2K6S859   A0A3Q7TFG3   A0A2J8QLA6   A0A2J8QL97   A0A2J8SZ82   A0A2J8SZ79   A0A2J8QLI8   A0A1A8JQS9  

KEGG

101741254    K22744 apoptosis regulatory protein Siva | (RefSeq) apoptosis regulatory protein Siva-like

GO

GO:0005164   GO:0006924   GO:0032088   GO:0008270   GO:0005175   GO:1901030   GO:0097191   GO:0005739   GO:0005737   GO:0005654   GO:0001618   GO:0046872   GO:0097193  

PANTHER

PTHR14365  

Subcellular location

Cytoplasm   In the nucleus, accumulates in dot-like structures.   With evidence from 1 publications.
Nucleus   In the nucleus, accumulates in dot-like structures.   With evidence from 1 publications.

Length:

152

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00021

Exp number, first 60 AAs:

0

Total prob of N-in:

0.28865

outside

1  -  152

 

 

Pi

169.111145

Theta

169.151408

Tajima's D

0.200988

CLR

13.724163

CSRT

0.424878756062197

Interpretation

Uncertain