Gene

KWMTBOMO08561  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009382

Annotation

ligatin_[Danaus_plexippus]

Location

Bomo_Chr14(+):13212695-13219563      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 2D      

Alternative Name

Ligatin

Location in the cell

Cytoplasmic   Reliability : 1.566 Mitochondrial   Reliability : 1.846

CDS

ATGTTCGCAAAACCGTATAAGTTGAAATCCAATAACACGTTAAAGAATTCAGAAAAGAAACAGTTAGCGCAAAGGATCATTCATGAGTTTCCGACAATAACTGAAGAGAAAGTGAAGCAGCTGGTACCCGCCAAATCGATAGGCATTTGCATGAAATTGGTGTTGTCCTCTGGAGACATTGTAAATGTGTACGTGATAGACGGGGTGCCAATTATAATGGAAGTAGCAGAAGGGTTGGTCCCGACGGTGTGCGCGCTCTGGCAAGCTCCTGAAATGGTCCCACATATCATTATACATACACCGGTCTTTCCAAAGGTCCAAGGTGGAGCTCCTCTATACCTCCCAGGAGTAGAACTACCAGCAGGAGGTACAGGTTTCCCACAGTTTTGTAAAGGTGAATTAATTGCAGCACATACTAGTAATAATTCTGCCACAGTTATTGTTGGTCGAGCTATTCTTTCCAGCGGAGACATGCTACTGAGAACTGCTGGAGTATGCATGGAGACACTTCATGTATTTGGGGATCATTTAAGCAAAGATATAAAATTTGGTAAACTTGAACGTCCGAAGCTTGGACCTCCTGCATATGGTGGTGGCAATGCAGCTCAAAACTTGGCCAACAATATACAGAAGTTAAGCATACAACCAGCTGTAAAGGAGGAATGGCCTGCACTCGGCCAGCCGCCTGCTCCTGTACCAAACGAACCACAACTGATACCTGAACCACCGAACCCAGTAGTTGATACACCTACCCAATTAGAGGATGGAAACTGTTTAGCCATAGATTCCGATGAGGAAGATAATGTGCCTACCGACATGGACGGGTTGCTGAGGTGGTGCATGCTGTCCTTCCTCAAGCTGGAAGGGAACAAGGTCGAACTGCCGCTCAAAACCAACCTGCTCTACAGAAATCATCTGATGGCTCTGTGCCCGGCGGAGCGGACGCTGGACGTCAAAAAGTCATCCTTTAAGAAAATGGGGAAGTTTTTAGAGGCCATGGAAAAGGAAGGCCTGGTCCGAGTCTGCGAGCTGGAGAAGGGCGTGGACGCCGTCGTGCAGCTGTCCCCCTCCCACCCCGCCGTGCGCGCGCACCCGCCCCCCCGCGCGCCCGCCCGCCCCGCCCCCCGCGCCGCGCCCCCCGCCCCCCCGCGGCTCCGCGAGGTGCAGTGCGTGACGGCGGCCGTGGCGCCGCTGTTCGCCCCCCTCAAGAAGGGCACCGCGCTGACACCCGCGGACGTCCGCGCGACCCTGACGGGGCACGTGAGGTCCGCGGGGCTCGCTGTCCCGGGGCAGAGCGCCGTCCGCCTCGACCTCACGCTGGCCACAGTGTTGGGTCGGCAGCCCGGGGAACACCTAACGTGGGAGGAGCTGATGTCGGGTGTTCTGAAGAAAATGACTCCGAGTACTGAGATACAGTTCGCCGACGGAGAGCTGAGGCTGTCCAGGAGCCGCCTCGAGCCCGTCACCATGCAGGTCGCCAGCCGCAGCGGAAACAAAAAGGTGACTCTAGTGTCTAACCTGGAAGCATATGGATTCAACCTGTTGGAGCTGAGCGCAGTTTGTCAGCGAGGAGTGGCAGCCTCCTGCGGCGTCACGCGCTCTCCTGGCGCTAAACACGACCAGCTCATGCTGCAAGGAGACCAGACACATTTTGTTGCTAAACTACTGATCGAAAAATATGGACTGCCAAAAAAATTTGTAGAAGGTGCTGACAAGGCATTAAACAGGAAGAAGTAG

Protein

MFAKPYKLKSNNTLKNSEKKQLAQRIIHEFPTITEEKVKQLVPAKSIGICMKLVLSSGDIVNVYVIDGVPIIMEVAEGLVPTVCALWQAPEMVPHIIIHTPVFPKVQGGAPLYLPGVELPAGGTGFPQFCKGELIAAHTSNNSATVIVGRAILSSGDMLLRTAGVCMETLHVFGDHLSKDIKFGKLERPKLGPPAYGGGNAAQNLANNIQKLSIQPAVKEEWPALGQPPAPVPNEPQLIPEPPNPVVDTPTQLEDGNCLAIDSDEEDNVPTDMDGLLRWCMLSFLKLEGNKVELPLKTNLLYRNHLMALCPAERTLDVKKSSFKKMGKFLEAMEKEGLVRVCELEKGVDAVVQLSPSHPAVRAHPPPRAPARPAPRAAPPAPPRLREVQCVTAAVAPLFAPLKKGTALTPADVRATLTGHVRSAGLAVPGQSAVRLDLTLATVLGRQPGEHLTWEELMSGVLKKMTPSTEIQFADGELRLSRSRLEPVTMQVASRSGNKKVTLVSNLEAYGFNLLELSAVCQRGVAASCGVTRSPGAKHDQLMLQGDQTHFVAKLLIEKYGLPKKFVEGADKALNRKK

Description

Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits (By similarity).

Similarity

Belongs to the eIF2D family.

Keywords

Acetylation   Complete proteome   Cytoplasm   Initiation factor   Phosphoprotein   Protein biosynthesis   Reference proteome  

Feature

chain  Eukaryotic translation initiation factor 2D

Uniprot

H9JIN2   A0A2H1VTH1   A0A2A4K3D8   S4PFS5   A0A212FFS6   A0A194Q7J5   + More
A0A437B689   A0A194RB28   A0A067QYP9   A0A2J7PXW8   A0A2P8XTV6   E9GLT4   N6U6J2   U4TZQ4   A0A0P6DA09   A0A164XR31   A0A139WNU2   A0A0P6C1P9   A0A0P6JJC7   A0A232FC55   D7EIK7   A0A0P6AL47   K7IPW9   A0A158NDW2   A0A1W4WQ12   A0A1W4X109   A0A452SB30   A0A195BR84   A0A151X4C3   A0A3Q7UJD6   A0A195ESA2   A0A087ZTQ3   A0A0L7RBI1   A0A0T6AU92   A0A0J7KFV6   F4W7V5   C3ZJ25   A0A195C4Z6   W5N343   A0A1S3FAH5   K9IMH5   A0A3Q7RYA2   K9ILP3   A0A195D7W7   A0A452SB07   E2AXJ4   A0A3Q7V015   P0CL18   A0A452E064   H0VDH5   Q5PPG7   A0A452E018   A0A2Y9K462   A0A154PLU8   B4NBG8   A0A1B6CUD5   A0A1A8F650   M3YKZ0   A0A2A3EBV3   G5BP24   E9IGR3   E2C5I3   A0A452DZP7   A0A1W4U5D6   A0A250Y350   A0A2Y9DIX6   A7RTR9   A0A3L8DGZ3   A0A3B3SN44   A0A0M3QXT1   A0A3R7QX09   A0A2R9AWK3   K7C945   Q58CR3   G7MER3   A0A2Y9JU02   G3RGZ7   L8IVZ3   H2N3X8   B4KAZ0   A0A0M8ZVG6   A0A3M6TFL1   A0A1A8V8U8   G3SLV4   L5JXR6   K7F6S9   Q9NG60   W5P7E3   G8JKW9   A0A1A8EIN3   A0A034VV88   G1QIW0   A0A437D6E0   A0A3B3BVD3   Q9GU72   B4PQ62   A0A1A8JS25   A0A0L8H398   Q29AB1  

Pubmed

19121390    23622113    22118469    26354079    24845553    29403074    + More
21292972    23537049    18362917    19820115    28648823    20075255    21347285    21719571    18563158    20798317    20713520    21993624    15489334    22673903    17994087    21993625    21282665    28087693    17615350    30249741    29240929    22722832    16305752    22002653    22398555    22751099    30382153    23258410    17381049    10731132    11157774    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20809919    19393038    25348373    29451363    17550304    15632085   

EMBL

BABH01027274    ODYU01004328    SOQ44078.1    NWSH01000219    PCG78283.1    GAIX01003897    + More
JAA88663.1    AGBW02008766    OWR52591.1    KQ459337    KPJ01359.1    RSAL01000154    RVE45673.1    KQ460436    KPJ14699.1    KK852819    KDR15625.1    NEVH01020852    PNF21188.1    PYGN01001358    PSN35430.1    GL732551    EFX79561.1    APGK01040754    KB740984    ENN76271.1    KB631904    ERL87099.1    GDIQ01081144    JAN13593.1    LRGB01000944    KZS14484.1    KQ971307    KYB29678.1    GDIP01008131    JAM95584.1    GDIQ01005823    JAN88914.1    NNAY01000436    OXU28401.1    EFA12044.2    GDIP01041307    JAM62408.1    ADTU01013048    ADTU01013049    ADTU01013050    KQ976424    KYM88471.1    KQ982548    KYQ55272.1    KQ981993    KYN30782.1    KQ414617    KOC68198.1    LJIG01022783    KRT78739.1    LBMM01008077    KMQ89162.1    GL887888    EGI69625.1    GG666631    EEN47454.1    KQ978251    KYM95944.1    AHAT01016655    AHAT01016656    GABZ01005188    JAA48337.1    GABZ01005187    JAA48338.1    KQ981153    KYN08966.1    GL443590    EFN61832.1    LWLT01000016    AAKN02017887    BC087701    KQ434977    KZC12822.1    CH964232    EDW81132.1    GEDC01020264    JAS17034.1    HAEB01008060    HAEC01015932    SBQ54587.1    AEYP01041303    AEYP01041304    KZ288291    PBC29215.1    JH171215    EHB11035.1    GL763054    EFZ20228.1    GL452770    EFN76796.1    GFFV01001922    JAV38023.1    DS469538    EDO45078.1    QOIP01000008    RLU19591.1    CP012526    ALC46409.1    QCYY01000993    ROT81300.1    AJFE02080111    GABF01006718    JAA15427.1    BT021884    BC114158    CM001253    EHH15610.1    CABD030008537    CABD030008538    JH880730    ELR59317.1    ABGA01259996    ABGA01259997    ABGA01259998    NDHI03003431    PNJ53237.1    CH933806    EDW14668.1    KQ435851    KOX70836.1    RCHS01003687    RMX40099.1    HADY01003631    HAEJ01016323    SBS56780.1    KB031109    ELK03296.1    AGCU01190819    AGCU01190820    AGCU01190821    AF260235    AY051703    AE014297    AAF67203.1    AAK93127.1    AAN14162.1    AMGL01020019    AMGL01020020    HAEA01016464    SBQ44945.1    GAKP01013489    JAC45463.1    ADFV01074387    CM012443    RVE70725.1    AF186594    AAG16724.1    CM000160    EDW98331.1    HAED01017231    HAEE01002174    SBR22194.1    KQ419539    KOF83240.1    CM000070    EAL27439.1   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000283053    UP000053240    + More
UP000027135    UP000235965    UP000245037    UP000000305    UP000019118    UP000030742    UP000076858    UP000007266    UP000215335    UP000002358    UP000005205    UP000192223    UP000291022    UP000078540    UP000075809    UP000286642    UP000078541    UP000005203    UP000053825    UP000036403    UP000007755    UP000001554    UP000078542    UP000018468    UP000081671    UP000286640    UP000078492    UP000000311    UP000001811    UP000291000    UP000005447    UP000002494    UP000248482    UP000076502    UP000007798    UP000000715    UP000242457    UP000006813    UP000008237    UP000192221    UP000248480    UP000001593    UP000279307    UP000261540    UP000092553    UP000283509    UP000240080    UP000009136    UP000001519    UP000001595    UP000009192    UP000053105    UP000275408    UP000007646    UP000010552    UP000007267    UP000000803    UP000002356    UP000001073    UP000261560    UP000002282    UP000053454    UP000001819   

PRIDE

H9JIN2    Q5PPG7    Q58CR3    Q9GU72   

Pfam

PF17832   Pre-PUA        + More
PF01253   SUI1
PF02201   SWIB
PF01472   PUA

Interpro

IPR015947   PUA-like_sf        + More
IPR036974   PUA_sf       
IPR001950   SUI1       
IPR039757   EIF2D       
IPR041366   Pre-PUA       
IPR039759   eIF2D_SUI1       
IPR036877   SUI1_dom_sf       
IPR002478   PUA       
IPR036885   SWIB_MDM2_dom_sf       
IPR004521   Uncharacterised_CHP00451       
IPR003121   SWIB_MDM2_domain       
IPR025605   OST-HTH/LOTUS_dom       

SUPFAM

SSF55159   SSF55159        + More
SSF88697   SSF88697       
SSF47592   SSF47592       

Gene 3D

2.30.130.10     1.10.245.10    

CDD

cd11608  eIF2D_C

ProteinModelPortal

H9JIN2   A0A2H1VTH1   A0A2A4K3D8   S4PFS5   A0A212FFS6   A0A194Q7J5   + More
A0A437B689   A0A194RB28   A0A067QYP9   A0A2J7PXW8   A0A2P8XTV6   E9GLT4   N6U6J2   U4TZQ4   A0A0P6DA09   A0A164XR31   A0A139WNU2   A0A0P6C1P9   A0A0P6JJC7   A0A232FC55   D7EIK7   A0A0P6AL47   K7IPW9   A0A158NDW2   A0A1W4WQ12   A0A1W4X109   A0A452SB30   A0A195BR84   A0A151X4C3   A0A3Q7UJD6   A0A195ESA2   A0A087ZTQ3   A0A0L7RBI1   A0A0T6AU92   A0A0J7KFV6   F4W7V5   C3ZJ25   A0A195C4Z6   W5N343   A0A1S3FAH5   K9IMH5   A0A3Q7RYA2   K9ILP3   A0A195D7W7   A0A452SB07   E2AXJ4   A0A3Q7V015   P0CL18   A0A452E064   H0VDH5   Q5PPG7   A0A452E018   A0A2Y9K462   A0A154PLU8   B4NBG8   A0A1B6CUD5   A0A1A8F650   M3YKZ0   A0A2A3EBV3   G5BP24   E9IGR3   E2C5I3   A0A452DZP7   A0A1W4U5D6   A0A250Y350   A0A2Y9DIX6   A7RTR9   A0A3L8DGZ3   A0A3B3SN44   A0A0M3QXT1   A0A3R7QX09   A0A2R9AWK3   K7C945   Q58CR3   G7MER3   A0A2Y9JU02   G3RGZ7   L8IVZ3   H2N3X8   B4KAZ0   A0A0M8ZVG6   A0A3M6TFL1   A0A1A8V8U8   G3SLV4   L5JXR6   K7F6S9   Q9NG60   W5P7E3   G8JKW9   A0A1A8EIN3   A0A034VV88   G1QIW0   A0A437D6E0   A0A3B3BVD3   Q9GU72   B4PQ62   A0A1A8JS25   A0A0L8H398   Q29AB1  

PDB

5OA3     E-value=1.62285e-62,     Score=609

KEGG

101740535    K15027 translation initiation factor 2D | (RefSeq) eukaryotic translation initiation factor 2D

GO

GO:0001731   GO:0003743   GO:0022627   GO:0032790   GO:0075522   GO:0016604   GO:0005737   GO:0006413   GO:0004190   GO:0006508   GO:0022891   GO:0004812   GO:0006418   GO:0003676   GO:0016876   GO:0043039   GO:0003723  

PANTHER

PTHR12217  

Subcellular location

Cytoplasm  

Length:

578

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11175

Exp number, first 60 AAs:

0.0405

Total prob of N-in:

0.00678

outside

1  -  578

 

 

Pi

264.834042

Theta

213.605286

Tajima's D

0.423414

CLR

103.91952

CSRT

0.490425478726064

Interpretation

Uncertain