Gene

KWMTBOMO08546

Annotation

neurobeachin_[Danaus_plexippus]

Location

Bomo_Chr14(-):12626936-12630322      View in EpiBrowser

Full name

Neurobeachin      

Alternative Name

A-kinase anchor protein 550
Protein rugose
dAKAP550

Location in the cell

Mitochondrial   Reliability : 2.315

CDS

ATGTTAGCAACGTCGTCAGGCTTGAGCCCGGTACTGAAATATTGTGAGCATCTACACGGGAAATGGTACTTCAGCGAGATACGAGCTATTTTCTCGAGACGCTACCTTCTCCAGAATGTCGCCGTCGAGCTGTTCCTCGCCAGCAGAACTTCAATATTCTTCGCATTTCCCGACCAAGCGACAGTCAAGAAAGTAATCAAAGCGCTACCCCGAGTTGGTGTCGGCATCAAGTATGGCATCCCGCAGACCAGGAACAGAACTGGAGAGTTAAATAAAAGTAACAATTTAAAGAAACACTAA

Protein

MLATSSGLSPVLKYCEHLHGKWYFSEIRAIFSRRYLLQNVAVELFLASRTSIFFAFPDQATVKKVIKALPRVGVGIKYGIPQTRNRTGELNKSNNLKKH

Description

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.

Subunit

Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways.

Similarity

Belongs to the WD repeat neurobeachin family.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Membrane   Reference proteome   Repeat   WD repeat  

Feature

chain  Neurobeachin
splice variant  In isoform R.

Uniprot

A0A212FNE6   A0A2H1W5K8   A0A2A4J9X3   A0A194Q745   A0A0N1I6E7   B5M0U3   + More
A0A3S2NYH0   A0A182S8U8   V9IKF6   A0A088AMU7   A0A1B6JDW0   A0A1Y1K804   A0A1Y1KFR1   A0A154PR26   A0A1Y1K827   A0A1Y1KDW4   A0A1B6GW90   A0A1B6FHD0   V5GIF1   A0A2M3YXT7   A0A1B6FFQ9   A0A1J1HWS7   D2A310   A0A232FFE5   A0A1B6GFL2   A0A1J1HSF2   A0A1W4XBX6   A0A1W4X1B0   A0A0K8TWW3   A0A1W4X1F6   A0A1W4XAS7   A0A2M4CNN2   A0A1B0BVL9   A0A1W4XAT3   A0A1W4X1B5   A0A1W4XBX0   A0A1W4X1G1   A0A1W4XC55   A0A2M4CYZ2   B0WJ16   A0A182KDJ8   A0A2M4CWG4   A0A2M4CJL6   A0A146KQW0   A0A0R1E9Z0   A0A182GPN4   A0A1B6M2V4   A0A146M1B0   A0A1I8M1Z8   A0A2M4B839   Q16FK4   A0A1I8MXG7   A0A2M4CIX4   A0A1I8M1Z5   A0A1I8M200   A0A1I8M1Z6   A0A182J3V0   A0A0A9W0E0   A0A1I8M202   A0A1I8Q9G3   A0A1I8Q9K7   A0A1W4VI88   A0A0M4EQT7   A0A1I8M203   A0A1I8Q9G7   A0A2M4CIC8   A0A1B6KZC9   A0A1B0GJH6   A0A1I8Q9H2   W5JH14   B4MJ67   A0A2M4DP17   A0A2M4CID1   B4M6T2   A0A2M4CIB8   A0A1I8Q9J9   A0A1B0G0Z8   A0A1I8Q9K4   A0A0R1EB30   B7Z0X3   A0A182X590   A0A0R1E9C2   X2JE60   A0A0R1E994   A0A1I8Q9E6   A0A182PM49   A0A453YNR8   A0A1I8Q9G8   A0A224XGR8   B4PZS6   Q9W4E2   A0A182TRD9   A0A453YNQ3   A0A182MH65   A0A182H8Q6   A0A0R1E9M6   T1HIN8   A0A3F2Z1F0   A0A1I8Q9F1   A0A1I8Q9L3  

Pubmed

22118469    26354079    19166301    28004739    18362917    19820115    + More
28648823    26823975    17994087    17550304    26483478    25315136    17510324    25401762    20920257    23761445    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    12364791    11102458    9334242    12537569    12072466    12124948    23100440    23790035   

EMBL

AGBW02006209    OWR55229.1    ODYU01006172    SOQ47794.1    NWSH01002199    PCG68927.1    + More
KQ459337    KPJ01367.1    KQ460817    KPJ12121.1    EU930279    ACH56907.1    RSAL01000024    RVE52214.1    JR049953    AEY61137.1    GECU01010389    JAS97317.1    GEZM01089253    GEZM01089252    JAV57592.1    GEZM01089254    GEZM01089249    JAV57597.1    KQ435066    KZC14375.1    GEZM01089251    GEZM01089248    JAV57599.1    GEZM01089250    JAV57596.1    GECZ01003156    JAS66613.1    GECZ01020160    JAS49609.1    GALX01004627    JAB63839.1    GGFM01000341    MBW21092.1    GECZ01020723    JAS49046.1    CVRI01000020    CRK90982.1    KQ971338    EFA01972.2    NNAY01000293    OXU29415.1    GECZ01008527    JAS61242.1    CRK90983.1    GDHF01033362    JAI18952.1    GGFL01002725    MBW66903.1    JXJN01021367    JXJN01021368    GGFL01005900    MBW70078.1    DS231955    EDS28895.1    GGFL01005431    MBW69609.1    GGFL01001257    MBW65435.1    GDHC01021007    JAP97621.1    CM000162    KRK05983.1    JXUM01078790    KQ563088    KXJ74501.1    GEBQ01009747    JAT30230.1    GDHC01005584    JAQ13045.1    GGFJ01000019    MBW49160.1    CH478422    EAT33014.1    GGFL01001027    MBW65205.1    GBHO01041707    JAG01897.1    CP012528    ALC48352.1    GGFL01000919    MBW65097.1    GEBQ01023170    JAT16807.1    AJWK01021725    AJWK01021726    AJWK01021727    AJWK01021728    AJWK01021729    AJWK01021730    AJWK01021731    AJWK01021732    AJWK01021733    AJWK01021734    ADMH02001415    ETN62613.1    CH963738    EDW72156.2    GGFL01015148    MBW79326.1    GGFL01000916    MBW65094.1    CH940653    EDW62499.2    GGFL01000918    MBW65096.1    CCAG010000760    CCAG010000761    CCAG010000762    CCAG010000763    CCAG010000764    KRK05982.1    AE014298    ACL82890.2    KRK05980.1    AHN59349.1    KRK05984.1    AAAB01008846    GFTR01008776    JAW07650.1    EDX01143.2    Y18278    AF003622    AY051596    AXCM01002696    AXCM01002697    JXUM01029235    JXUM01029236    JXUM01029237    JXUM01029238    JXUM01029239    JXUM01029240    JXUM01029241    JXUM01029242    JXUM01029243    JXUM01029244    KRK05981.1    ACPB03011228    ACPB03011229    ACPB03011230   

Proteomes

UP000007151    UP000218220    UP000053268    UP000053240    UP000283053    UP000075901    + More
UP000005203    UP000076502    UP000183832    UP000007266    UP000215335    UP000192223    UP000092460    UP000002320    UP000075881    UP000002282    UP000069940    UP000249989    UP000095301    UP000008820    UP000075880    UP000095300    UP000192221    UP000092553    UP000092461    UP000000673    UP000007798    UP000008792    UP000092444    UP000000803    UP000076407    UP000075885    UP000075902    UP000075883    UP000015103   

PRIDE

Q9W4E2   

Pfam

PF14844   PH_BEACH        + More
PF02138   Beach
PF06469   DUF1088
PF00400   WD40
PF15787   DUF4704
PF11971   CAMSAP_CH
PF17095   CAMSAP_CC1

Interpro

IPR023362   PH-BEACH_dom        + More
IPR000409   BEACH_dom       
IPR036372   BEACH_dom_sf       
IPR036322   WD40_repeat_dom_sf       
IPR001680   WD40_repeat       
IPR017986   WD40_repeat_dom       
IPR010508   DUF1088       
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR016024   ARM-type_fold       
IPR031570   DUF4704       
IPR013320   ConA-like_dom_sf       
IPR000253   FHA_dom       
IPR022613   CAMSAP_CH       
IPR031372   CAMSAP_CC1       
IPR001715   CH-domain       
IPR036872   CH_dom_sf       

SUPFAM

SSF81837   SSF81837        + More
SSF50978   SSF50978       
SSF48371   SSF48371       
SSF49899   SSF49899       
SSF47576   SSF47576       

Gene 3D

1.10.1540.10     2.130.10.10     1.10.418.10    

CDD

cd01201  PH_BEACH
cd06071  Beach

ProteinModelPortal

A0A212FNE6   A0A2H1W5K8   A0A2A4J9X3   A0A194Q745   A0A0N1I6E7   B5M0U3   + More
A0A3S2NYH0   A0A182S8U8   V9IKF6   A0A088AMU7   A0A1B6JDW0   A0A1Y1K804   A0A1Y1KFR1   A0A154PR26   A0A1Y1K827   A0A1Y1KDW4   A0A1B6GW90   A0A1B6FHD0   V5GIF1   A0A2M3YXT7   A0A1B6FFQ9   A0A1J1HWS7   D2A310   A0A232FFE5   A0A1B6GFL2   A0A1J1HSF2   A0A1W4XBX6   A0A1W4X1B0   A0A0K8TWW3   A0A1W4X1F6   A0A1W4XAS7   A0A2M4CNN2   A0A1B0BVL9   A0A1W4XAT3   A0A1W4X1B5   A0A1W4XBX0   A0A1W4X1G1   A0A1W4XC55   A0A2M4CYZ2   B0WJ16   A0A182KDJ8   A0A2M4CWG4   A0A2M4CJL6   A0A146KQW0   A0A0R1E9Z0   A0A182GPN4   A0A1B6M2V4   A0A146M1B0   A0A1I8M1Z8   A0A2M4B839   Q16FK4   A0A1I8MXG7   A0A2M4CIX4   A0A1I8M1Z5   A0A1I8M200   A0A1I8M1Z6   A0A182J3V0   A0A0A9W0E0   A0A1I8M202   A0A1I8Q9G3   A0A1I8Q9K7   A0A1W4VI88   A0A0M4EQT7   A0A1I8M203   A0A1I8Q9G7   A0A2M4CIC8   A0A1B6KZC9   A0A1B0GJH6   A0A1I8Q9H2   W5JH14   B4MJ67   A0A2M4DP17   A0A2M4CID1   B4M6T2   A0A2M4CIB8   A0A1I8Q9J9   A0A1B0G0Z8   A0A1I8Q9K4   A0A0R1EB30   B7Z0X3   A0A182X590   A0A0R1E9C2   X2JE60   A0A0R1E994   A0A1I8Q9E6   A0A182PM49   A0A453YNR8   A0A1I8Q9G8   A0A224XGR8   B4PZS6   Q9W4E2   A0A182TRD9   A0A453YNQ3   A0A182MH65   A0A182H8Q6   A0A0R1E9M6   T1HIN8   A0A3F2Z1F0   A0A1I8Q9F1   A0A1I8Q9L3  

PDB

1MI1     E-value=2.12924e-28,     Score=306

KEGG

101744498    no KO assigned | (RefSeq) neurobeachin-like

GO

GO:0016301   GO:0016021   GO:0031175   GO:0005516   GO:0030507   GO:0051018   GO:0007614   GO:0005737   GO:0043204   GO:0008355   GO:0007528   GO:0043025   GO:0016319   GO:0042462   GO:0042675  

Subcellular location

Cytoplasm  
Membrane  
Perikaryon  

Length:

99

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.81342

Exp number, first 60 AAs:

0.81138

Total prob of N-in:

0.07324

outside

1  -  99

 

 

Pi

195.066226

Theta

153.446468

Tajima's D

0.619573

CLR

1.219875

CSRT

0.551722413879306

Interpretation

Uncertain