Gene

KWMTBOMO08544

Pre Gene Modal

BGIBMGA009317

Annotation

PREDICTED:_LOW_QUALITY_PROTEIN:_neurobeachin-like_[Bombyx_mori]

Location

Bomo_Chr14(-):12528257-12553662      View in EpiBrowser

Full name

Neurobeachin      

Alternative Name

A-kinase anchor protein 550
Protein rugose
dAKAP550

Location in the cell

PlasmaMembrane   Reliability : 2.672

CDS

ATGACGCAGAAGTGGCAGCGACGGGAGATCTCCAACTTCGAGTACCTTATGTTCCTGAATACCATTGCAGGTCGCACGTACAACGATCTGAACCAGTACCCCGTGTTCCCGTGGATCCTCACCAACTATGAGAGCGAAGAACTCGACCTTAGCCAGCCTTCAAACTTCAGGGATCTATCAAAGCCCATAGGTGCATTGAACCCCAGCCGACGTGCGTACTTCGAAGAGAGATATAACACGTGGGAGCACGAGTCCACGCCTCCCTTCCACTACGGCACACACTACTCCACTGCTGCTTTCGTGCTCAACTGGCTCGTTCGAATCGAGCCAATGACGACAATGTTCCTAGCGCTGCAGGGAGGTAAATTCGATCATCCGAACAGACTGTTTTCCTCCATTGCCATGTCCTGGAAGAACTGCCAACGCGACACATCCGATGTTAAGGAACTGATCCCAGAGCTGTTCTTCTTGCCTGAAATGCTGATAAACAGCTCCGGCTATAAGCTGGGCATCCCGGAGTCTCCGTCCGGCGACGTCATTCTTCCACCATGGGCTTCATCCCCTGAAGAGTTCATCCGCATCAACCGCATGGCCTTGGAGTCGGAGTTCGTCAGCTGCCAACTTCACCAGTGGATCGATCTCATCTTTGGATACAAACAGCGAGGGCCGGAAGCAGTACGGGCCACGAACGTGTTCTACTACCTCACGTACGAGGGCGGAGTCAGGCTCGACCAAATCACGGAGCCCGTGACCAGGACCGCCGTGGAGGACCAGATCCGCAGCTTCGGCCAGACCCCTGCGCAGCTACTGAGCGAGCCGCATCCGCCGCGCGCGTCTGCGCTACACCTGGCGCCGCTGATGTTCGCGGCGGCCCCCGACGACGTCTGTCTCCGCCTCAAGCTGCCCTCCAATGCGGCCGTCGTGCACGTCTCCGCCAACACCTACCCGCAGCTGGCGATGCCTGCTGCTGTCACGGTGAGCGCGGCGCGTGCCTTCGCGGCCCACCGCTGGGCGGCGGGGGGCTGCGCGCACTCCGCCCGCCACGCGCCCGACGCGCATCCGCCCCCCCACCCCCACCCGCTACTCATGGACCCAGTCTGGGCCGCTGGAGGAGCGCAGGCGCTGGCGCGGAGACAGCTCGGCGACAACTTCAGCCAGCGGGTCCGCGCGCGCTCAAACTGCTTCGTGACGACAGTCGACTCCAAGTTCCTCATCGCGGCCGGCTTCTGGGATAATAGCTTTAGGGTCTTCTCAACTGAAACTGCTAAAATAGTGCAAATAATATTCGGTCACTACGGCGTGGTGACGTGCGTTTGCCGGTCCGAGTGCAACATCACCTCGGACTGCTACATCGCGTCCGGCTCCGAGGACTGCACCGTGCTGCTCTGGCATTGGTCCGCCCGGCACGGCGGCATCGTCGGCGAGGGCGACAGTCCGGCGCCGCGCGTGACGCTCACGGGACACGACGCGCCCGTCAACGGCGTGCTCGTCTCTGCAGAACTCGGACTCGTCATCTCCTCCTCGCTCAACGGTCCGGTGCTGATCCACACGACGTTCGGCGAGGTGCTGCGCTCACTGAGCAGCGGGGAGGCGTCGGGTCCGCAGCAGCTGGCACTGTCCCGGGAGGGCGTGCTGGTGGTCGCGTACGCCAAGGGACACCTCGCCGCCTACACCCTCAACGGACGGAGGCTCAGGCATGAGACGCACAACGATAACTTCCAGGTAATCATTGCTACCGGAAGGCTACATGATGCAACGCGATGCCACTAA

Protein

MTQKWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPWILTNYESEELDLSQPSNFRDLSKPIGALNPSRRAYFEERYNTWEHESTPPFHYGTHYSTAAFVLNWLVRIEPMTTMFLALQGGKFDHPNRLFSSIAMSWKNCQRDTSDVKELIPELFFLPEMLINSSGYKLGIPESPSGDVILPPWASSPEEFIRINRMALESEFVSCQLHQWIDLIFGYKQRGPEAVRATNVFYYLTYEGGVRLDQITEPVTRTAVEDQIRSFGQTPAQLLSEPHPPRASALHLAPLMFAAAPDDVCLRLKLPSNAAVVHVSANTYPQLAMPAAVTVSAARAFAAHRWAAGGCAHSARHAPDAHPPPHPHPLLMDPVWAAGGAQALARRQLGDNFSQRVRARSNCFVTTVDSKFLIAAGFWDNSFRVFSTETAKIVQIIFGHYGVVTCVCRSECNITSDCYIASGSEDCTVLLWHWSARHGGIVGEGDSPAPRVTLTGHDAPVNGVLVSAELGLVISSSLNGPVLIHTTFGEVLRSLSSGEASGPQQLALSREGVLVVAYAKGHLAAYTLNGRRLRHETHNDNFQVIIATGRLHDATRCH

Description

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body.

Subunit

Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways.

Similarity

Belongs to the WD repeat neurobeachin family.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Membrane   Reference proteome   Repeat   WD repeat  

Feature

chain  Neurobeachin
splice variant  In isoform R.

Uniprot

H9JIG7   A0A3S2NYH0   A0A2H1WTR7   A0A0N1PGJ6   A0A088AMU7   A0A158N9E3   + More
A0A151JZB6   A0A195BGQ2   V9IKF6   A0A3L8DS32   A0A1B6FFQ9   A0A1B6FHD0   A0A1B6GFL2   A0A1B6GW90   E0VB80   K7J4I4   F4WJX1   A0A1B6M2V4   A0A1B6KZC9   A0A154PR26   A0A026WJE4   A0A1Y1KDW4   A0A146KQW0   A0A1Y1KFR1   A0A1Y1K804   A0A1Y1K827   A0A146M1B0   A0A067QFC6   E2AP05   A0A0L7R5X0   A0A0A9W0E0   A0A023F547   A0A224XGR8   A0A1W4XAT3   A0A1W4XBX6   A0A1W4X1F6   A0A1W4X1G1   A0A1W4X1B0   A0A1W4XBX0   A0A1W4XAS7   A0A1W4X1B5   A0A1W4XC55   A0A2J7PKZ6   D2A310   A0A2A3ERV9   A0A1B6DX44   A0A1B6DPZ3   A0A0T6BHE2   A0A1B0BVL9   A0A0K8TWW3   A0A1B0GJH6   A0A0R1E9Z0   A0A1B0G0Z8   X2JE60   A0A0R1E994   A0A1B0D3F4   A0A1I8M1Z6   A0A1I8M200   B7Z0X3   A0A0R1E9C2   A0A0R1EB30   B4MJ67   A0A1I8M202   Q0KHV9   A0A0R1E9K4   B4PZS6   A0A0R1E9M6   Q9W4E2   A0A1W4VI88   A0A1I8M203   A0A1I8M1Z8   A0A1I8M1Z5   A0A0Q5T5L6   B3NV21   Q9W4E2-6   X2JAH8   A0A0Q5T2R4   A0A0Q5TDD9   A0A0Q5THK5   A0A1W4V6H3   A0A1W4VI95   B7Z0W8   J9JVW6   A0A1I8Q9G7   A0A0Q5TID7   A0A0Q5T957   A0A0Q5T2S4   A0A1W4VIU7   A0A1W4V620   A0A1W4VJN1   A0A1W4VJM6   A0A1W4V635   A0A3B0K3L2   A0A3B0K3P9   A0A3B0K3M1   A0A1I8Q9G3   A0A1W4V6I2   A0A1W4VIV7   A0A1W4VIV2   A0A1W4V631  

Pubmed

19121390    26354079    21347285    30249741    20566863    20075255    + More
21719571    24508170    28004739    26823975    24845553    20798317    25401762    25474469    18362917    19820115    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    25315136    11102458    9334242    12537569    12072466    12124948    23100440    23790035   

EMBL

BABH01027226    BABH01027227    RSAL01000024    RVE52214.1    ODYU01010995    SOQ56460.1    + More
KQ460817    KPJ12124.1    ADTU01009499    ADTU01009500    ADTU01009501    ADTU01009502    ADTU01009503    ADTU01009504    ADTU01009505    ADTU01009506    ADTU01009507    ADTU01009508    KQ981404    KYN41948.1    KQ976476    KYM83838.1    JR049953    AEY61137.1    QOIP01000005    RLU22983.1    GECZ01020723    JAS49046.1    GECZ01020160    JAS49609.1    GECZ01008527    JAS61242.1    GECZ01003156    JAS66613.1    DS235023    EEB10636.1    AAZX01002336    AAZX01003751    AAZX01006319    AAZX01008405    AAZX01009296    AAZX01009746    AAZX01011198    AAZX01012336    AAZX01015153    AAZX01016889    GL888187    EGI65493.1    GEBQ01009747    JAT30230.1    GEBQ01023170    JAT16807.1    KQ435066    KZC14375.1    KK107214    EZA55239.1    GEZM01089250    JAV57596.1    GDHC01021007    JAP97621.1    GEZM01089254    GEZM01089249    JAV57597.1    GEZM01089253    GEZM01089252    JAV57592.1    GEZM01089251    GEZM01089248    JAV57599.1    GDHC01005584    JAQ13045.1    KK853659    KDR02350.1    GL441439    EFN64837.1    KQ414648    KOC66214.1    GBHO01041707    JAG01897.1    GBBI01002524    JAC16188.1    GFTR01008776    JAW07650.1    NEVH01024529    PNF17001.1    KQ971338    EFA01972.2    KZ288190    PBC34533.1    GEDC01007044    JAS30254.1    GEDC01030294    GEDC01009543    JAS07004.1    JAS27755.1    LJIG01000188    KRT86752.1    JXJN01021367    JXJN01021368    GDHF01033362    JAI18952.1    AJWK01021725    AJWK01021726    AJWK01021727    AJWK01021728    AJWK01021729    AJWK01021730    AJWK01021731    AJWK01021732    AJWK01021733    AJWK01021734    CM000162    KRK05983.1    CCAG010000760    CCAG010000761    CCAG010000762    CCAG010000763    CCAG010000764    AE014298    AHN59349.1    KRK05984.1    AJVK01023522    AJVK01023523    AJVK01023524    ACL82890.2    KRK05980.1    KRK05982.1    CH963738    EDW72156.2    ABI30968.3    KRK05979.1    EDX01143.2    KRK05981.1    Y18278    AF003622    AY051596    CH954180    KQS29728.1    EDV45869.2    AHN59350.1    KQS29731.1    KQS29733.1    KQS29732.1    ACL82891.2    ABLF02025882    ABLF02025883    KQS29734.1    KQS29729.1    KQS29730.1    OUUW01000016    SPP88827.1    SPP88824.1    SPP88825.1   

Proteomes

UP000005204    UP000283053    UP000053240    UP000005203    UP000005205    UP000078541    + More
UP000078540    UP000279307    UP000009046    UP000002358    UP000007755    UP000076502    UP000053097    UP000027135    UP000000311    UP000053825    UP000192223    UP000235965    UP000007266    UP000242457    UP000092460    UP000092461    UP000002282    UP000092444    UP000000803    UP000092462    UP000095301    UP000007798    UP000192221    UP000008711    UP000007819    UP000095300    UP000268350   

PRIDE

H9JIG7    Q0KHV9    Q9W4E2   

Pfam

PF02138   Beach        + More
PF00400   WD40
PF14844   PH_BEACH
PF06469   DUF1088
PF15787   DUF4704

Interpro

IPR015943   WD40/YVTN_repeat-like_dom_sf        + More
IPR036372   BEACH_dom_sf       
IPR001680   WD40_repeat       
IPR000409   BEACH_dom       
IPR036322   WD40_repeat_dom_sf       
IPR017986   WD40_repeat_dom       
IPR023362   PH-BEACH_dom       
IPR010508   DUF1088       
IPR016024   ARM-type_fold       
IPR031570   DUF4704       
IPR013320   ConA-like_dom_sf       
IPR000253   FHA_dom       
IPR001611   Leu-rich_rpt       

SUPFAM

SSF81837   SSF81837        + More
SSF50978   SSF50978       
SSF48371   SSF48371       
SSF49899   SSF49899       

Gene 3D

1.10.1540.10     2.130.10.10    

CDD

cd06071  Beach
cd01201  PH_BEACH

ProteinModelPortal

H9JIG7   A0A3S2NYH0   A0A2H1WTR7   A0A0N1PGJ6   A0A088AMU7   A0A158N9E3   + More
A0A151JZB6   A0A195BGQ2   V9IKF6   A0A3L8DS32   A0A1B6FFQ9   A0A1B6FHD0   A0A1B6GFL2   A0A1B6GW90   E0VB80   K7J4I4   F4WJX1   A0A1B6M2V4   A0A1B6KZC9   A0A154PR26   A0A026WJE4   A0A1Y1KDW4   A0A146KQW0   A0A1Y1KFR1   A0A1Y1K804   A0A1Y1K827   A0A146M1B0   A0A067QFC6   E2AP05   A0A0L7R5X0   A0A0A9W0E0   A0A023F547   A0A224XGR8   A0A1W4XAT3   A0A1W4XBX6   A0A1W4X1F6   A0A1W4X1G1   A0A1W4X1B0   A0A1W4XBX0   A0A1W4XAS7   A0A1W4X1B5   A0A1W4XC55   A0A2J7PKZ6   D2A310   A0A2A3ERV9   A0A1B6DX44   A0A1B6DPZ3   A0A0T6BHE2   A0A1B0BVL9   A0A0K8TWW3   A0A1B0GJH6   A0A0R1E9Z0   A0A1B0G0Z8   X2JE60   A0A0R1E994   A0A1B0D3F4   A0A1I8M1Z6   A0A1I8M200   B7Z0X3   A0A0R1E9C2   A0A0R1EB30   B4MJ67   A0A1I8M202   Q0KHV9   A0A0R1E9K4   B4PZS6   A0A0R1E9M6   Q9W4E2   A0A1W4VI88   A0A1I8M203   A0A1I8M1Z8   A0A1I8M1Z5   A0A0Q5T5L6   B3NV21   Q9W4E2-6   X2JAH8   A0A0Q5T2R4   A0A0Q5TDD9   A0A0Q5THK5   A0A1W4V6H3   A0A1W4VI95   B7Z0W8   J9JVW6   A0A1I8Q9G7   A0A0Q5TID7   A0A0Q5T957   A0A0Q5T2S4   A0A1W4VIU7   A0A1W4V620   A0A1W4VJN1   A0A1W4VJM6   A0A1W4V635   A0A3B0K3L2   A0A3B0K3P9   A0A3B0K3M1   A0A1I8Q9G3   A0A1W4V6I2   A0A1W4VIV7   A0A1W4VIV2   A0A1W4V631  

PDB

1MI1     E-value=2.27491e-129,     Score=1185

KEGG

101744498    no KO assigned | (RefSeq) neurobeachin-like

GO

GO:0016021   GO:0051018   GO:0007614   GO:0005737   GO:0043204   GO:0008355   GO:0007528   GO:0043025   GO:0016319   GO:0042462   GO:0042675   GO:0005515   GO:0003735   GO:0005840   GO:0006412   GO:0015935   GO:0004812   GO:0006418   GO:0003676   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  
Membrane  
Perikaryon  

Length:

589

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.51525

Exp number, first 60 AAs:

0.05316

Total prob of N-in:

0.07819

outside

1  -  589

 

 

Pi

232.838996

Theta

162.344986

Tajima's D

1.272656

CLR

0.064906

CSRT

0.730213489325534

Interpretation

Uncertain