Gene

KWMTBOMO08539  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009322

Annotation

PREDICTED:_protein_YIPF2_[Papilio_xuthus]

Location

Bomo_Chr14(-):12456827-12460952      View in EpiBrowser

Full name

Protein YIPF       + More
Probable tRNA N6-adenosine threonylcarbamoyltransferase      

Alternative Name

t(6)A37 threonylcarbamoyladenosine biosynthesis protein
tRNA threonylcarbamoyladenosine biosynthesis protein

Location in the cell

PlasmaMembrane   Reliability : 4.71

CDS

ATGTCGAACGTCCATACGGGCGAGTTGTTAAATTTCCAGGACTATTCCCCGGAACACAATGAGCGAACTGCGCGTATTGATGTAGAGGCAGTACATACAAATCAATACAATAATAGTAATATTTCTAATCAAAATTACTCCTTTGACGAAACGCCCGGAGCTGTTCCAGAAGCAGAGACTCAACCTCAATCGAATCACAACTTCTGGACAATAGAGTACTATCAGAAATACTTTGATGTGCAGACCAGTGAAGTTGTGGAGAGGATTATATCATCAGTATTGCCCCAGAAAGTCTCTAGAAACTATTTTGATGAGAAGATAAAAGGCAAACCCGACTTGTATGGACCTATCTGGATTTCATTGACTCTGATCTTCACAATTGCCGTGAGCGGGAACATAGCAAGTTATCTACAGAATGTTAACAAGGCAGTCCACTGGCGCTATGATTTTCATTTGGTGTCTTACGCAGCAACAGCCATAGTATGTTACGTTTGGTTGGTCCCTCTGGCACTGTGGGGTGTCTTGAAATGGACTACGCTTCCCGATGGACAAGATGAGATTGAGACGCAGACCTCAAACTCTCCAACTATGATATCTCTCTTCTGTTTATATGGCTATTCGCTTTCCATTTACATCCCTGTGGCTATATTCTGGACCATCCAGATCTCTTGGCTCCAGTGGTTGTTTGTGTTGATGGCTGCCTTTGTGTCCGGAGCAGTCCTCATATTCTGGCTGCTGCCAGCTTTGAAGAAATCAAAATATTTTTATATACTTGTCGGATCTATTCTTGCTTTTCATTTCTTGTTGGCAACTGGTTTTATGTTATACTTCTTTCACGGACCAAACGCACATGACTAA

Protein

MSNVHTGELLNFQDYSPEHNERTARIDVEAVHTNQYNNSNISNQNYSFDETPGAVPEAETQPQSNHNFWTIEYYQKYFDVQTSEVVERIISSVLPQKVSRNYFDEKIKGKPDLYGPIWISLTLIFTIAVSGNIASYLQNVNKAVHWRYDFHLVSYAATAIVCYVWLVPLALWGVLKWTTLPDGQDEIETQTSNSPTMISLFCLYGYSLSIYIPVAIFWTIQISWLQWLFVLMAAFVSGAVLIFWLLPALKKSKYFYILVGSILAFHFLLATGFMLYFFHGPNAHD

Description

Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

Catalytic Activity

adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA

Cofactor

a divalent metal cation

Subunit

Component of the EKC/KEOPS complex; the whole complex dimerizes.

Similarity

Belongs to the YIP1 family.
Belongs to the KAE1 / TsaD family.

Uniprot

H9JIH2   A0A194Q7K8   A0A212FNC7   A0A1E1W2L8   A0A437BPI1   A0A2H1WTQ9   + More
A0A0L7LLL3   D2A1I7   A0A1L8D906   A0A1B0EUT3   N6TWP7   J3JXS0   A0A0K8TQQ8   A0A1Y1LWU4   A0A034W9N0   A0A1I8JUP4   A0A088AV47   A0A2A3ESL8   W5JT29   A0A0K8VAS3   A0A182Y2C7   A0A0A1WEQ1   A0A2M3ZGX7   A0A2M3Z3K9   A0A0J7K9B8   A0A1L8E8A9   A0A1L8E7Q2   E1ZZ84   A0A1L8E8E4   A0A1L8ED40   A0A2M4AC14   A0A2M4ABJ0   A0A2M4ABC9   A0A1I8ML86   A0A2M4ABT8   T1PJC1   A0A154NXJ2   A0A1W4XTR1   A0A182MTJ3   A0A1I8NY11   A0A182QGV3   A0A0M8ZU17   A0A2P8XV93   B4L603   B4M750   A0A0L0C396   A0A1A9WWX0   E9J1A9   A0A182S7F9   A0A2M4BUL5   A0A2M4BUQ2   A0A0M3QZ01   A0A2M4BUN7   A0A023EQ34   A0A023EMS2   A0A026W3P5   B4JM02   A0A182J7G1   A0A0C9RY25   A0A1J1IXL2   A0A3B0KZ32   Q17KU7   B3MS24   B4IGK6   A0A182UW57   A0A1A9VWP9   Q29FT9   B4NEI2   Q7QIM4   B4Q1Y9   A0A182JP76   A0A453YK63   A0A182UIG1   B3NX85   Q9VYI1   A0A1W4VL09   A0A182PII2   A0A084WEZ4   A0A1B0G811   A0A067R3Z1   A0A2J7R3C6   K7J5P4   A0A182WWJ0   A0A1B6DHK5   A0A182L3M2   A0A232FJ33   F4X8R3   A0A195FCS3   A0A195DSE0   A0A1B6ME12   E0V988   A0A182WBJ2   A0A195B9L7   A0A158NBG3   A0A1B6JCZ7   A0A0L7R7P9   W8CB19  

EC Number

2.3.1.234

Pubmed

19121390    26354079    22118469    26227816    18362917    19820115    + More
23537049    22516182    26369729    28004739    25348373    20920257    23761445    25244985    25830018    20798317    25315136    29403074    17994087    26108605    21282665    24945155    26483478    24508170    30249741    17510324    15632085    12364791    14747013    17210077    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    24438588    24845553    20075255    20966253    28648823    21719571    20566863    21347285    24495485   

EMBL

BABH01027219    KQ459337    KPJ01374.1    AGBW02006209    OWR55237.1    GDQN01009831    + More
JAT81223.1    RSAL01000023    RVE52292.1    ODYU01010995    SOQ56455.1    JTDY01000649    KOB76337.1    KQ971338    EFA01533.2    GFDF01011143    JAV02941.1    AJWK01034750    APGK01002895    APGK01058069    KB741286    KB735013    ENN70727.1    ENN83468.1    APGK01058067    BT128041    KB632373    AEE63002.1    ENN70725.1    ERL93792.1    GDAI01001115    JAI16488.1    GEZM01044978    JAV77999.1    GAKP01008459    JAC50493.1    KZ288192    PBC34272.1    ADMH02000528    ETN66095.1    GDHF01016368    JAI35946.1    GBXI01017121    JAC97170.1    GGFM01006984    MBW27735.1    GGFM01002358    MBW23109.1    LBMM01011370    KMQ86884.1    GFDG01003987    JAV14812.1    GFDG01004039    JAV14760.1    GL435311    EFN73499.1    GFDG01003943    JAV14856.1    GFDG01002235    JAV16564.1    GGFK01004941    MBW38262.1    GGFK01004834    MBW38155.1    GGFK01004774    MBW38095.1    GGFK01004926    MBW38247.1    KA648003    AFP62632.1    KQ434778    KZC04379.1    AXCM01000934    AXCN02000558    KQ435850    KOX70937.1    PYGN01001295    PSN35932.1    CH933812    EDW05799.1    CH940653    EDW62617.1    JRES01000955    KNC26805.1    GL767586    EFZ13413.1    GGFJ01007563    MBW56704.1    GGFJ01007581    MBW56722.1    CP012528    ALC48509.1    GGFJ01007582    MBW56723.1    GAPW01002939    JAC10659.1    JXUM01020992    JXUM01037730    GAPW01002940    KQ561140    KQ560588    JAC10658.1    KXJ79593.1    KXJ81769.1    KK107453    QOIP01000004    EZA50618.1    RLU24114.1    CH916371    EDV91763.1    GBYB01014175    JAG83942.1    CVRI01000060    CRL03902.1    OUUW01000021    SPP89388.1    CH477221    EAT47307.1    CH902622    EDV34579.1    CH480836    EDW48956.1    CH379065    EAL31490.1    CH964239    EDW82151.1    AAAB01008807    EAA04402.4    CM000162    EDX01510.1    APCN01003693    CH954180    EDV47257.1    AE014298    AY058677    AAF48214.2    AAL13906.1    ATLV01023266    KE525341    KFB48788.1    CCAG010000152    KK852773    KDR16819.1    NEVH01007822    PNF35326.1    GEDC01012198    GEDC01009944    JAS25100.1    JAS27354.1    NNAY01000131    OXU30685.1    GL888932    EGI57332.1    KQ981673    KYN38208.1    KQ980581    KYN15434.1    GEBQ01005815    JAT34162.1    DS234991    EEB09944.1    KQ976540    KYM81223.1    ADTU01011059    GECU01010709    JAS96997.1    KQ414638    KOC66900.1    GAMC01005226    JAC01330.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000283053    UP000037510    UP000007266    + More
UP000092461    UP000019118    UP000030742    UP000075900    UP000005203    UP000242457    UP000000673    UP000076408    UP000036403    UP000000311    UP000095301    UP000076502    UP000192223    UP000075883    UP000095300    UP000075886    UP000053105    UP000245037    UP000009192    UP000008792    UP000037069    UP000091820    UP000075901    UP000092553    UP000069940    UP000249989    UP000053097    UP000279307    UP000001070    UP000075880    UP000183832    UP000268350    UP000008820    UP000007801    UP000001292    UP000075903    UP000078200    UP000001819    UP000007798    UP000007062    UP000002282    UP000075881    UP000075840    UP000075902    UP000008711    UP000000803    UP000192221    UP000075885    UP000030765    UP000092444    UP000027135    UP000235965    UP000002358    UP000076407    UP000075882    UP000215335    UP000007755    UP000078541    UP000078492    UP000009046    UP000075920    UP000078540    UP000005205    UP000053825   

PRIDE

H9JIH2    Q9VYI1   

Pfam

PF04893   Yip1        + More
PF00814   Peptidase_M22
PF15008   DUF4518
PF00067   p450

Interpro

IPR039765   Yip5/YIPF1/YIPF2        + More
IPR006977   Yip1       
IPR017861   KAE1/TsaD       
IPR017860   Peptidase_M22_CS       
IPR000905   Gcp-like_dom       
IPR034680   Kae1/OSGEP       
IPR026698   UPF_C3orf38       
IPR036396   Cyt_P450_sf       
IPR017972   Cyt_P450_CS       
IPR001128   Cyt_P450       
IPR002401   Cyt_P450_E_grp-I       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

H9JIH2   A0A194Q7K8   A0A212FNC7   A0A1E1W2L8   A0A437BPI1   A0A2H1WTQ9   + More
A0A0L7LLL3   D2A1I7   A0A1L8D906   A0A1B0EUT3   N6TWP7   J3JXS0   A0A0K8TQQ8   A0A1Y1LWU4   A0A034W9N0   A0A1I8JUP4   A0A088AV47   A0A2A3ESL8   W5JT29   A0A0K8VAS3   A0A182Y2C7   A0A0A1WEQ1   A0A2M3ZGX7   A0A2M3Z3K9   A0A0J7K9B8   A0A1L8E8A9   A0A1L8E7Q2   E1ZZ84   A0A1L8E8E4   A0A1L8ED40   A0A2M4AC14   A0A2M4ABJ0   A0A2M4ABC9   A0A1I8ML86   A0A2M4ABT8   T1PJC1   A0A154NXJ2   A0A1W4XTR1   A0A182MTJ3   A0A1I8NY11   A0A182QGV3   A0A0M8ZU17   A0A2P8XV93   B4L603   B4M750   A0A0L0C396   A0A1A9WWX0   E9J1A9   A0A182S7F9   A0A2M4BUL5   A0A2M4BUQ2   A0A0M3QZ01   A0A2M4BUN7   A0A023EQ34   A0A023EMS2   A0A026W3P5   B4JM02   A0A182J7G1   A0A0C9RY25   A0A1J1IXL2   A0A3B0KZ32   Q17KU7   B3MS24   B4IGK6   A0A182UW57   A0A1A9VWP9   Q29FT9   B4NEI2   Q7QIM4   B4Q1Y9   A0A182JP76   A0A453YK63   A0A182UIG1   B3NX85   Q9VYI1   A0A1W4VL09   A0A182PII2   A0A084WEZ4   A0A1B0G811   A0A067R3Z1   A0A2J7R3C6   K7J5P4   A0A182WWJ0   A0A1B6DHK5   A0A182L3M2   A0A232FJ33   F4X8R3   A0A195FCS3   A0A195DSE0   A0A1B6ME12   E0V988   A0A182WBJ2   A0A195B9L7   A0A158NBG3   A0A1B6JCZ7   A0A0L7R7P9   W8CB19  

KEGG

101739390    K22940 protein YIPF1/2 | (RefSeq) protein YIPF2

GO

GO:0016192   GO:0005794   GO:0016021   GO:0017137   GO:0005634   GO:0046872   GO:0005737   GO:0000408   GO:0061711   GO:0002949   GO:0020037   GO:0005506   GO:0016705   GO:0016020   GO:0016491   GO:0004616   GO:0032008   GO:0032439   GO:0042632   GO:0043410   GO:0045121   GO:0016876   GO:0043039  

PANTHER

PTHR12822   PTHR11735:SF14   PTHR11735  

Subcellular location

Membrane  
Cytoplasm  
Nucleus  

Length:

285

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

113.31461

Exp number, first 60 AAs:

0

Total prob of N-in:

0.80723

inside

1  -  115

TMhelix

116  -  138

outside

139  -  152

TMhelix

153  -  175

inside

176  -  199

TMhelix

200  -  222

outside

223  -  226

TMhelix

227  -  249

inside

250  -  255

TMhelix

256  -  278

outside

279  -  285

 

 

Pi

408.331653

Theta

211.38471

Tajima's D

2.996675

CLR

0.168174

CSRT

0.979801009949502

Interpretation

Uncertain