Gene

KWMTBOMO08507

Pre Gene Modal

BGIBMGA009340

Annotation

PREDICTED:_speckle-type_POZ_protein-like_[Plutella_xylostella]

Location

Bomo_Chr14(-):11040960-11042303      View in EpiBrowser

Full name

Speckle-type POZ protein-like      

Alternative Name

HIB homolog 2

Location in the cell

Cytoplasmic   Reliability : 1.314 Nuclear   Reliability : 1.768

CDS

ATGTCGAGCACAAATTATACAACGCGCACGGAGGGACAGACAAAAATATGTACTATAATATGGACCATACCTACGTTCGTCAATCTGTTGGAAAATGTGACCAAGAGGGAATTTCGAGTTGAAAAAGCTAAAGACCCAAAAACGGAATTTACTCACTCTAAGTTCCAATTGAAAATGCAATTTTTGGGCCGTTATAATGACATAATAGAGATTTCTTATCTATCACCAAATCCGGTTTTTTTGAAGTCCATTCTAACAATTTGTTTAAAAAGATTTGAAGAAAGAACAATAGTAATAAAGGAGTATCACACGGTTCAGGCAAACAAATGGCAGTACTTGGCTACATTATTCAAACGAGATATAGCAAGCTATGATGGCCGTGATATATTCCTCCTTAGTGATGGAAGTTTACGACTTAAAGTACAATTTATGGTCACCAATGATATAAAAATAGACCGTTCAACAGTACCTGAAGCACAACTCAGCAATGACTTAGAGAATTTACTCAATGATGGGTTGTTCTCTGATGTAATAATCAAGTCTGCAGAGGGTATCGAGTTCAAAGTCCACAAGGCTGTGTTGGCCAGCCGTAGTGCTGTTCTAAAAGCTCATTTTGAACACAACACCACAGAATGCTACACTAATGTTATTGAATCGCTTTTAGAATCAACAGTATTACAAGAAGTACTAACATTTATTTATAGTGACAAAGCTCCTAGAGTTGATGACATTCCAGAAAAGCTTCTAGCAGCTGCCGATTACTACCAACTTAACAGACTAAAGAGCTTATGCGAGGAAGCATTGCATAAAAAATTGACAGTAGAGAATGCTATAGAAACATTACAATTAGCTGATTTACATTCAGCAAATACATTGAAACAACTCACTCTTGAATTTATAAAAGATGGACAAGCAAAGCTTATAACAAAAACTGAAGGATGGGCCCAAGTAAAATCTGTTGATTTAATCAAAAGAATCTATGAATACATCATGGCAGATGATTTCGATGCTGATATAAAATGA

Protein

MSSTNYTTRTEGQTKICTIIWTIPTFVNLLENVTKREFRVEKAKDPKTEFTHSKFQLKMQFLGRYNDIIEISYLSPNPVFLKSILTICLKRFEERTIVIKEYHTVQANKWQYLATLFKRDIASYDGRDIFLLSDGSLRLKVQFMVTNDIKIDRSTVPEAQLSNDLENLLNDGLFSDVIIKSAEGIEFKVHKAVLASRSAVLKAHFEHNTTECYTNVIESLLESTVLQEVLTFIYSDKAPRVDDIPEKLLAAADYYQLNRLKSLCEEALHKKLTVENAIETLQLADLHSANTLKQLTLEFIKDGQAKLITKTEGWAQVKSVDLIKRIYEYIMADDFDADIK

Description

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP (By similarity).

Subunit

Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY (By similarity).

Similarity

Belongs to the Tdpoz family.

Keywords

Alternative splicing   Complete proteome   Nucleus   Reference proteome   Ubl conjugation pathway  

Feature

chain  Speckle-type POZ protein-like
splice variant  In isoform 2.

Uniprot

H9JIJ0   A0A1E1VZH7   A0A2H1V014   A0A2W1B8X2   A0A2A4JXA8   A0A194Q7N3   + More
A0A0N0PEL5   S4P812   A0A0L7LKY6   A0A0L7L2A6   A0A0L7L4E2   A0A0L7LJ77   A0A0L7KZP8   A0A0L7L4M6   A0A0L7KJH1   A0A0L7K445   A0A0L7KZG9   A0A0L7LBZ1   A0A0L7KML2   A0A0L7LKA0   A0A0L7L5K4   A0A0L7K1Z2   A0A0L7KDP9   A0A0L7KZA4   A0A0L7KZ63   A0A0L7LA12   A0A0L7K4F4   A0A0L7KKQ4   A0A0L7LUK8   A0A0L7LE50   A0A0L7LAC9   V4ABW3   A0A194RS66   B2RZC7   Q2M2N2   A0A194PFB6   A0A1U8CJW3   G3IE83   H9JSI4   A0A1E1VZR2   A0A2P6K791   R7UX04   A0A1E1WJF8   A0A1E1W5S0   A0A2K5QG11   A0A212F9Z7   A0A267FS63   A0A437BNH0  

Pubmed

19121390    28756777    26354079    23622113    26227816    23254933    + More
15489334    15057822    15632090    16141072    19468303    16740475    21804562    29704459    22118469   

EMBL

BABH01027092    GDQN01010970    JAT80084.1    ODYU01000049    SOQ34159.1    KZ150432    + More
PZC70895.1    NWSH01000476    PCG76133.1    KQ459337    KPJ01399.1    KQ459928    KPJ19303.1    GAIX01006156    JAA86404.1    JTDY01000719    KOB76102.1    JTDY01003440    KOB69555.1    JTDY01003036    KOB70280.1    JTDY01000901    KOB75502.1    JTDY01004130    KOB68551.1    KOB70281.1    JTDY01009633    KOB63191.1    JTDY01012845    KOB52227.1    KOB68550.1    JTDY01001850    KOB72721.1    JTDY01008517    KOB64537.1    JTDY01000759    KOB75988.1    JTDY01002755    KOB70783.1    JTDY01017745    KOB51836.1    JTDY01010117    KOB61024.1    KOB68552.1    KOB68553.1    JTDY01002058    KOB72215.1    JTDY01011163    KOB57450.1    JTDY01009464    KOB63459.1    JTDY01000095    KOB78896.1    JTDY01001520    KOB73665.1    JTDY01001956    KOB72453.1    KB201847    ESO94307.1    KQ459984    KPJ18911.1    AABR07051193    BC167106    CH474001    AAI67106.1    EDL93676.1    AK162056    AL773534    CH466542    BC111867    KQ459606    KPI91389.1    JH002147    RAZU01000235    EGW06666.1    RLQ63825.1    BABH01027901    BABH01027902    GDQN01011347    GDQN01010836    JAT79707.1    JAT80218.1    MWRG01022350    PRD22211.1    AMQN01005851    KB296957    ELU11118.1    GDQN01003932    JAT87122.1    GDQN01008738    JAT82316.1    AGBW02009539    OWR50554.1    NIVC01002410    NIVC01000807    PAA58105.1    PAA76635.1    RSAL01000027    RVE51918.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000037510    UP000030746    + More
UP000002494    UP000000589    UP000189706    UP000001075    UP000273346    UP000014760    UP000233040    UP000007151    UP000215902    UP000283053   

PRIDE

H9JIJ0    Q2M2N2    G3IE83    H9JSI4   

Pfam

PF00651   BTB        + More
PF16040   DUF4792
PF16041   DUF4793
PF00917   MATH

Interpro

IPR000210   BTB/POZ_dom        + More
IPR011333   SKP1/BTB/POZ_sf       
IPR034089   SPOP_C       
IPR032008   DUF4792       
IPR032010   DUF4793       
IPR008974   TRAF-like       
IPR002083   MATH/TRAF_dom       

SUPFAM

SSF54695   SSF54695        + More
SSF49599   SSF49599       

Gene 3D

2.60.210.10    

CDD

cd14734  SPOP_C

ProteinModelPortal

H9JIJ0   A0A1E1VZH7   A0A2H1V014   A0A2W1B8X2   A0A2A4JXA8   A0A194Q7N3   + More
A0A0N0PEL5   S4P812   A0A0L7LKY6   A0A0L7L2A6   A0A0L7L4E2   A0A0L7LJ77   A0A0L7KZP8   A0A0L7L4M6   A0A0L7KJH1   A0A0L7K445   A0A0L7KZG9   A0A0L7LBZ1   A0A0L7KML2   A0A0L7LKA0   A0A0L7L5K4   A0A0L7K1Z2   A0A0L7KDP9   A0A0L7KZA4   A0A0L7KZ63   A0A0L7LA12   A0A0L7K4F4   A0A0L7KKQ4   A0A0L7LUK8   A0A0L7LE50   A0A0L7LAC9   V4ABW3   A0A194RS66   B2RZC7   Q2M2N2   A0A194PFB6   A0A1U8CJW3   G3IE83   H9JSI4   A0A1E1VZR2   A0A2P6K791   R7UX04   A0A1E1WJF8   A0A1E1W5S0   A0A2K5QG11   A0A212F9Z7   A0A267FS63   A0A437BNH0  

PDB

4J8Z     E-value=6.25887e-31,     Score=334

KEGG

101737144    K10523 speckle-type POZ protein | (RefSeq) speckle-type POZ protein-like

PATHWAY

04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0031625   GO:0043161   GO:0030162   GO:0005634   GO:0005737   GO:0006511   GO:0031397   GO:0031463   GO:0016567   GO:0005515   GO:0003743   GO:0006413   GO:0005760   GO:0019012   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Nucleus  

Length:

340

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.402410000000001

Exp number, first 60 AAs:

0.31925

Total prob of N-in:

0.14270

outside

1  -  340

 

 

Pi

188.522167

Theta

190.96841

Tajima's D

-0.083092

CLR

348.629733

CSRT

0.348782560871956

Interpretation

Uncertain