SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO08498
Annotation
PREDICTED:_hemicentin-1-like_isoform_X1_[Bombyx_mori]
Full name
Hemicentin-1      
Alternative Name
Fibulin-6
Location in the cell
Nuclear   Reliability : 2.503
 

Sequence

CDS
ATGAAGGAGGAAAACGTGGGAACCTACACGTGTAATGCTGACAACGTTGCCGGCGTCAGTAGAATATTAGTCCGGGTGGTTCTTCTTGTGGACCCACCGGAGGTATTGATCGAACCAAAAAACAGAACTTTGGAAATCGGAGATGACCTCAACGTAACATGCACGGCGATCAGTGAGGCCTTGCTGCTGAAACATCGACTTATCTTCAAAGGGAAGGACTTTGAAAACTCGACGGATATTCATTTGGAGCCAAACATGGAAGGCTATTACGCTGCCAATATAATCATACGAAACGTGACAGAGAAGTATGCTGGAAACTACACCTGTCTAGCCAGTAATAGAGGTGGCGAAGCAAATCAAACAACGTACATAAAAATCAATGCAAAACCAAAATCCCGAATATTAGGTCCGCACACGCTGTCCCCACAACTGAACACTGATGTGCAGCTCGTGTGTCATGTCGACAACGCGGAGTCCGTGCAGTGGCTGGCTCCCAACGGGACTGCGGTGAGGGAGCGGTCCGTAGACCACAGCTCTGATGATGTTCTCGACGTGAGGAGTGTTAGTGAAGACGGTCAGTGGACGTGTGTGGCCCGTCGAGGATACCTTAATGTGTCAGATTCGGTGTCAATAAGCGTTCAAATTAAACCGAGGGTGACTATAATTGGATCCAAGAGCATCACCATATTAAATGGGACGGCCTATGACGTCACTTGTGAAGTACTAGCCAAGCCTGCCCCTAGAGTTGTATGGCACAGGGAGACAGAGAAGTTTCTGAACTGCAGCACGACACTGATTGCGTCTAATCTATATCGGAGCGTGCTGCGTCTGGACAGCAGCAAAGAGCCAGTGAACGGCACGTACTTCTGCTTCGGAGAGAACTCCGACGGTATATCCCAGGACAGCGTCGCCGTGCGCCTCCGGACACGGATGCGTCTGCGCCACGGATTCAGTAATACGCAATTACAATTGTATTCGCAAATGGATCTCCGATGTGACGTGGCTTCGCTTCCGGCGCCCGTAACGAGATGGTTCCACAACCGAACCGAGCTGCAGAACGACACCAACACGATCATCTCGAGCGACAACTCTTCTCTACATATCAACAGAATGGATTTCTCCAACTTCGGACGGTACACTTGTGTAGCCGACAATGGATATGAAACAATGTCAGTTGATGGCACTATGAGCGCAATTATAGTAGATCCACCGCGAGTGTCGATAGAGCCTGAAAACAAAACCATTGACGCTGGAGAGGATCTAAACGTGACATGCACGGTGGTCAGCGAAGCGTCGTTTCTTAAACACCGACTTGTCTTCAAAGGGGACAACTTCGAAAACTCCTCCGAAATACCCCCAGAACCGGGCACGGGAGGACGTCACTCTTTCAGTGTTATCATACACAACGTCACGGAGAAGTACACTGGGAACTATACGTGCTCAGCAATTAATGCAGGAGGTGAAACGAACAAAACAACCTACATCAAGATAAACCCAAAACTGAAATCCCAAATATTAGGTCCGCACGCGCTGTCCCCACAACTGAACACTGATGTGCAGCTCGTGTGTCATGTCGACAACGCGGAGTCCGTGCAGTGGCTGGCTCCCAACGGGACTGCGGTAAGGGAGCGGTCCGTGGACCACAGCTCTGATGACGTTTTCGACGTGAGGAGCGTTAGTGAAGATGGGCTGTGGACTTGTGTGGCCCGTCGAGGAAACCTTAATGTGTCAGATTCGGTGTCAATAAGCGTTCAAATTAAACCAAGGGTGACTATAATTGGATCCAAGAACATCACCATATTAAATGGGACGACCTATGACGTCACTTGTGAAGTACTAGCCAAGCCTCCTCCTAGAGTTCTATGGCACAGGGAGACAGAGAAGTTTCTGAACTGCAGCACGTCACTGATTGCGTCTAATCTATATCGGAGCGTGCTGCGTCTGGACAGCAGCAAGGAGTCAGTGAACGGCACGTACTTCTGCTTCGGAGAGAACTCCGACGGTATATCCCAGGACAGTGTCGCCGTGCGCGTCCGGACACGGATGCGTCTGCGCCACGGATTCAATAATACGCAATTACAATTGTATTCGCAAATGGATCTCCGATGTGACGTGGATTCCCTTCCGGCGCCCGTAACGAGATGGTTCCACAACCGAACCGAGCTGCAGAACGACACCAACACGATCATCTCGAGCGACAACTCGTCTCTACATATCAACAGAATGGATTTCTCCAACTTCGGACGGTACACTTGTGTAGCCAACAATGGATATGAAACAATGTCAGTTGATGGTACTATGAGCGCAATTATAGTAGATCCACCGCGAGTGTCGATAGAGCCTGAAAACAAAACCATTGACGCTGGAGAGGATCTGAACGTGACATGCACGGTGGTCAGCGAAGCGTCGTTTCTTAAACACCGACTGGTCTTCAAAGGGGACAACTTCGAAAACTCCTCCGAAATACCCCCAGAACCGGATACGGGAGGACGTCACTCTTTCAGTGTTATCATACGCAACGTCACGGAGAAGTACACTGGGAACTATACGTGCTCAGCAATTAATGCAGGAGGTGAAACGAACAAAACAACCTACATCAAGATAAACCCAAAACTGAAATCCCAAATATTAGGTCCGCACGCGCTGTTCCCACAACTGAACACTGATGTGCAGCTCGTGTGTCATGTCGACAACGCGGAGTCCGTGCAGTGGCTGGCTCCCAACGGGACTGCGGTAAGGGAGCGGTCCGTGGACCACAGCTCTGATGATGTTCTCGACGTGAGGAGCGTTAGTGAAGATGGGCTGTGGACTTGTGTGGCCCGTCGAGGAAACCTTAATGTGTCAGATTCGGTGTCAATAAGCGTTCAAATTAAACCAAGGGTGACTATAATTGGATTAAAGAACATTACCATATTAAATGGGACGACCTATGACGTCACATGTGAAGTACTAGCCAAGCCTCCTCCTAGAGTTCTATGGCACCGGGAGACAGATAAGTTTCTGAACTGCAGCACGTCACTGATTGCGTCTAATTTATATCGGAGCGTGCTGCGTCTGGACAGCAGCAAAGAGCCAGTGAACGGCACGTACTTCTGCTTCGGAGAGAACGCCGACGGTATATCCCAGGACAGCGTCGCCGTGCGCGTCCGGACACGGATGCGTCTGCGCCACGGATTCAATAATACGCAATTACAATTGTATTCGCAAATGGATCTCCGATGTGACGTGGATTCGCTTCCGGCGCCCGTAATGAGATGGTTCCACAACCGAACCGAGCTGCAGAACGACACCAACACGATCATCTCGAGCGACAACTCGTCTCTACATATCAACAGAATGGATTTCTCCAACTTCGGACGGTACACTTGTGTAGCCGACAATGGATATGAAACAATGTCAGTTGATGGCACTATGAGCGCAATTATAGTAGATCCTCCACGAGTGTCGATACAGCCTGAAAACAAAACCATTGACGCTGGAGAGGATCTGAACGTGACATGCACGGTGGTCAGCGAAGCGTCGTTTCTTAAACACCGACTGGTCTTCAAAGGGGACAACTTCGAAAACTCCTCCGAAATACCCCCAGAACCGGACACGGGGGGACGTCACTCTTTCAGTGTTATCATACGCAACGTCACGGAGAAGTACACTGGGAACTATACGTGCTCAGCAATTAATGCAGGAGGTGAAACGAACAAAACAACCTACATCAAGATAAACCCAAAACTGAAATCCCAAATATTAGGTCCGCACGCGCTGTCCCCACAACTGAACACTGATGTGCAGCTCGTGTGTCATGTCGACAACGCGGAGTCCGTGCAGTGGCTGGCTCCCAACGGGACTGTGGTGAGGAAGCGGTCCATGGACCACAGCTCTGATGACGTTCTGGACGTGAGGAGTGTTAGTGAAGATGGGCTGTGGACTTGTGTGGCCCGTCGAGGAAACCTTAATGTGTCAGATTCGGTGTTAATAAACGTTCAAATTAAACCGAGGGTGACTATAATTGGATCCAAGAACATTACCATAGTAAACGGCTCGACCTATGACGTCACTTGTGAAGTACTAGCCAAGCCTCCCCCTAGAGTTGTATGGCACAGGGAGACAGAGAAGTTTCTAAACTGCAGCACGTCACTGATGGTGTCTAATCTATATCGGAGCGTGCTGCGTCTGGACAGCAGCAAAGAGCCAGTGAACGGCACGTACTTCTGCTTCGGAGAGAACTCCGACGGTATATCCCAAGACAGCGTCTCCGTGCGCGTCCGGACACGGATGCGTCTGCGCCATGGATTCAATGATACGCAATTACAATTGTATTCGCAAATGGATCTCCGATGTGACGTGGATTCGCTTCCGGCGCCCGTAACGAGATGGTTCCACAACCGAACCGAGCTGCAGAACGACACCAACACGATCATCTCGAGCGACAACTCTTCTCTACATATCAACAGAATGGATTTCTCCAACTTCGGACGGTACACTTGTGTAGCCGACAATGGATATGAAACAATGTCAGTTGATGCTACAGTAACGGTCACTGGGTTAGAATTTCCCGTAATATCGAAAAGGATCAAGAGCCAGGCTGTCCGTAAAGGAAATTCAACAGATATCACATGTAGTGTCTTAAAAGGAAGTCCGGTTCCAACTATAACGTGGATGTACAAAAACGATACTACGAATGGATTCGTCAACTTGCCCACGGACGGTATCGATCGGGGAAATTTAAGTATTTCAAATGTCACGTTGGAACATTCTGGCATCTATAGATGTGTCGCTGAAAACGTTATAGGACAAGATACGCACAAAATCGAATTGGTGGTTCAGTATGCTCCTCAATTGGCTCCACTGATAGGTGAGGTAGGAGACGGGCCACGCGTAGTAGAAGTCGGTAAACGAGTTGTGTTCTCGTGTAACGTAACTGGCTTCCCTCCGCCGGTCGTAGTGTGGACGAGAAATGGACTACCCGTTGTTTATTCGAAAAATGTCCATTTAAATGAATCCCAAGCTTTGATAATAGAAAATGCGACAGACCACGAAGCCGGCTCGTACATTTGCAATGCGACCAGCGCGCTGGGATCGACTCACAGAAATTTCACGCTCAAAGTTTATGTGAGTCCAAAGATCTTACCGATAAATTCGGAACCTATACAGCAATTCTTAGAAGGCCAACTGGTAGAGTTGCCGTGTAAATCAAAGGGCCTGCCGGTGCCGCGGGTGGAGTGGACCCACAACGGAGACACGATACTTGATGATAAAAGACACATCGACGAAGATGGACTTAGGTTCGTGGCGAATATAACGGACTTCGGGAATTACACGTGTGTTGCCAGGAATGAATATGGAAGCGATTCGATATCGTATTCTTTGTTTATTTGGGTGACACCGAGAATAGAGCCTCCGCTTGAGACGATGAAACAAGTACTGTCAGGTGACAATGTGACGTTACAGTGTGACGTCATGGGCTTCCCCATCCCTAATGTAATATGGGAGTATGAAGGGAAATCTCTCACTGAAAATACAACAACGTTAAGGTAA
Protein
MKEENVGTYTCNADNVAGVSRILVRVVLLVDPPEVLIEPKNRTLEIGDDLNVTCTAISEALLLKHRLIFKGKDFENSTDIHLEPNMEGYYAANIIIRNVTEKYAGNYTCLASNRGGEANQTTYIKINAKPKSRILGPHTLSPQLNTDVQLVCHVDNAESVQWLAPNGTAVRERSVDHSSDDVLDVRSVSEDGQWTCVARRGYLNVSDSVSISVQIKPRVTIIGSKSITILNGTAYDVTCEVLAKPAPRVVWHRETEKFLNCSTTLIASNLYRSVLRLDSSKEPVNGTYFCFGENSDGISQDSVAVRLRTRMRLRHGFSNTQLQLYSQMDLRCDVASLPAPVTRWFHNRTELQNDTNTIISSDNSSLHINRMDFSNFGRYTCVADNGYETMSVDGTMSAIIVDPPRVSIEPENKTIDAGEDLNVTCTVVSEASFLKHRLVFKGDNFENSSEIPPEPGTGGRHSFSVIIHNVTEKYTGNYTCSAINAGGETNKTTYIKINPKLKSQILGPHALSPQLNTDVQLVCHVDNAESVQWLAPNGTAVRERSVDHSSDDVFDVRSVSEDGLWTCVARRGNLNVSDSVSISVQIKPRVTIIGSKNITILNGTTYDVTCEVLAKPPPRVLWHRETEKFLNCSTSLIASNLYRSVLRLDSSKESVNGTYFCFGENSDGISQDSVAVRVRTRMRLRHGFNNTQLQLYSQMDLRCDVDSLPAPVTRWFHNRTELQNDTNTIISSDNSSLHINRMDFSNFGRYTCVANNGYETMSVDGTMSAIIVDPPRVSIEPENKTIDAGEDLNVTCTVVSEASFLKHRLVFKGDNFENSSEIPPEPDTGGRHSFSVIIRNVTEKYTGNYTCSAINAGGETNKTTYIKINPKLKSQILGPHALFPQLNTDVQLVCHVDNAESVQWLAPNGTAVRERSVDHSSDDVLDVRSVSEDGLWTCVARRGNLNVSDSVSISVQIKPRVTIIGLKNITILNGTTYDVTCEVLAKPPPRVLWHRETDKFLNCSTSLIASNLYRSVLRLDSSKEPVNGTYFCFGENADGISQDSVAVRVRTRMRLRHGFNNTQLQLYSQMDLRCDVDSLPAPVMRWFHNRTELQNDTNTIISSDNSSLHINRMDFSNFGRYTCVADNGYETMSVDGTMSAIIVDPPRVSIQPENKTIDAGEDLNVTCTVVSEASFLKHRLVFKGDNFENSSEIPPEPDTGGRHSFSVIIRNVTEKYTGNYTCSAINAGGETNKTTYIKINPKLKSQILGPHALSPQLNTDVQLVCHVDNAESVQWLAPNGTVVRKRSMDHSSDDVLDVRSVSEDGLWTCVARRGNLNVSDSVLINVQIKPRVTIIGSKNITIVNGSTYDVTCEVLAKPPPRVVWHRETEKFLNCSTSLMVSNLYRSVLRLDSSKEPVNGTYFCFGENSDGISQDSVSVRVRTRMRLRHGFNDTQLQLYSQMDLRCDVDSLPAPVTRWFHNRTELQNDTNTIISSDNSSLHINRMDFSNFGRYTCVADNGYETMSVDATVTVTGLEFPVISKRIKSQAVRKGNSTDITCSVLKGSPVPTITWMYKNDTTNGFVNLPTDGIDRGNLSISNVTLEHSGIYRCVAENVIGQDTHKIELVVQYAPQLAPLIGEVGDGPRVVEVGKRVVFSCNVTGFPPPVVVWTRNGLPVVYSKNVHLNESQALIIENATDHEAGSYICNATSALGSTHRNFTLKVYVSPKILPINSEPIQQFLEGQLVELPCKSKGLPVPRVEWTHNGDTILDDKRHIDEDGLRFVANITDFGNYTCVARNEYGSDSISYSLFIWVTPRIEPPLETMKQVLSGDNVTLQCDVMGFPIPNVIWEYEGKSLTENTTTLR

Summary

Description
Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos (PubMed:21215633). May play a role in the architecture of adhesive and flexible epithelial cell junctions (PubMed:17015624). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (PubMed:24951538).
Keywords
Alternative splicing   Basement membrane   Calcium   Cell cycle   Cell division   Cell junction   Complete proteome   Cytoplasm   Disulfide bond   EGF-like domain   Extracellular matrix   Glycoprotein   Reference proteome   Repeat   Secreted   Signal  
Feature
chain  Hemicentin-1
splice variant  In isoform 2.
EMBL
BABH01027071    BABH01027072    BABH01027073    BABH01027074    BABH01027075    BABH01027076    + More
BABH01027077    BABH01027078    BABH01027079    BABH01027080    BX548021    CR391979    CR457445    AAMC01026251    AAMC01026252    AAMC01026253    AAMC01026254    AAMC01026255    AAMC01026256    AAMC01026257    AAPE02019958    AAPE02019959    AAPE02019960    CM004472    OCT85460.1    LWLT01000016    ADON01133373    ADON01133374    ADON01133375    ADON01133376    AANG04001043    AABR07021361    AABR07021362    AABR07021363    AABR07021364    AABR07021365    AABR07021366    AABR07021367    AABR07021368    AABR07021369    AABR07021370    AMGL01022558    AMGL01022559    AMGL01022560    AMGL01022561    AMGL01022562    AMGL01022563    AMGL01022564    AMGL01022565    AMGL01022566    AMGL01022567    KB744663    EOA94654.1    AQIB01112956    AQIB01112957    AQIB01112958    AQIB01112959    AQIB01112960    AQIB01112961    AAGW02054358    AAGW02054359    AAGW02054360    AAGW02054361    AAGW02054362    AAGW02054363    AEYP01068968    AEYP01068969    AEYP01068970    AEYP01068971    AEYP01068972    AEYP01068973    AEYP01068974    AEYP01068975    AEYP01068976    AEYP01068977    AAEX03005163    AAEX03005164    KL869911    KGL86449.1    ACTA01076587    ACTA01084587    ACTA01092587    ACTA01100587    ACTA01108587    ACTA01116587    ACTA01124587    ACTA01132587    ACTA01140587    ACTA01148586    AC111145    AC113326    AC115051    AC124120    AAKN02018452    AAKN02018453    AAKN02018454    AAKN02018455    AAKN02018456    AAKN02018457    AAKN02018458    AAKN02018459    AAKN02018460    AAQR03037752    AAQR03037753    AAQR03037754    AAQR03037755    AAQR03037756    AAQR03037757    AAQR03037758    AAQR03037759    AAQR03037760    AAQR03037761    GL194636    EFB23306.1    CABD030007797    CABD030007798    CABD030007799    CABD030007800    CABD030007801    CABD030007802    CABD030007803    CABD030007804    CABD030007805    CABD030007806    AHZZ02017566    AHZZ02017567    AHZZ02017568    AHZZ02017569    LSYS01005418    OPJ77524.1    KB030474    ELK16173.1    AKHW03006215    KYO23292.1    ABGA01049740    ABGA01049741    ABGA01049742    ABGA01049743    ABGA01049744    ABGA01049745    ABGA01049746    ABGA01049747    ABGA01049748    ABGA01049749    KK501365    KFP14341.1    AACZ04056152    AACZ04056153    AACZ04056154    NDHI03003429    PNJ53742.1    AJFE02052069    AJFE02052070    AJFE02052071    AJFE02052072    AJFE02052073    AJFE02052074    AJFE02052075    KYO23291.1    OPJ77523.1    KL410290    KFQ95785.1    KL206226    KFV80044.1    AFYH01199621    AFYH01199622    AFYH01199623    AFYH01199624    AFYH01199625    AFYH01199626    AFYH01199627    AFYH01199628    AFYH01199629    AFYH01199630    GCES01032046    JAR54277.1    KK590748    KFV99920.1    KL448046    KFO79531.1    AADN05000650    JARO02003647    KPP70078.1    CP026254    AWP10692.1   
Pfam
PF07679   I-set        + More
PF00047   ig
PF00090   TSP_1
PF07645   EGF_CA
PF12662   cEGF
PF07474   G2F
PF13895   Ig_2
Interpro
IPR013783   Ig-like_fold        + More
IPR013151   Immunoglobulin       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR013098   Ig_I-set       
IPR001881   EGF-like_Ca-bd_dom       
IPR036383   TSP1_rpt_sf       
IPR000884   TSP1_rpt       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR036179   Ig-like_dom_sf       
IPR000742   EGF-like_dom       
IPR003598   Ig_sub2       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR013106   Ig_V-set       
IPR036465   vWFA_dom_sf       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR009017   GFP       
IPR006605   G2_nidogen/fibulin_G2F       
IPR026823   cEGF       
IPR016130   Tyr_Pase_AS       
IPR032984   Hemicentin-2       
IPR006573   NHR_dom       
SUPFAM
SSF48726   SSF48726        + More
SSF82895   SSF82895       
SSF54511   SSF54511       
SSF57184   SSF57184       
SSF53300   SSF53300       
Gene 3D
PDB
3DMK     E-value=2.59109e-28,     Score=318

Ontologies

Topology

Subcellular location
Secreted   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Extracellular space   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Extracellular matrix   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Basement membrane   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Cytoplasm   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Cell junction   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Cleavage furrow   The antibody used in PubMed:17015624 and PubMed:21215633 to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 7 publications.
Length:
1843
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.0104899999999999
Exp number, first 60 AAs:
0.00814
Total prob of N-in:
0.00050
outside
1  -  1843
 
 

Population Genetic Test Statistics

Pi
269.912236
Theta
161.450871
Tajima's D
2.783942
CLR
0.3634
CSRT
0.968701564921754
Interpretation
Uncertain
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