Gene

KWMTBOMO08497

Pre Gene Modal

BGIBMGA009343

Annotation

PREDICTED:_hemicentin-1-like_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr14(-):10842395-10863463      View in EpiBrowser

Full name

Hemicentin-1      

Alternative Name

Fibulin-6

Location in the cell

Extracellular   Reliability : 2.588

CDS

ATGTTTCATTCCAGTTTCAATGACTACGGTAATCTGTACATAGTGAACGCTAGTGTCCAAACAGAAGGAGTTTACAGTTGCATCGCTGGTAACATCGCCGGTGTTGCCGTGAAGACGATTTTCCTTAGCGTTAATGCACCACCGAAAATTCTAGAAGATAATTATACCGGCTCGTATGTGGCCACCGATATGGATCATTCATTGACAATATATTGTTCCGCAACCGGCAAACCTAAGCCGTATGTCCTTTGGTCTAAGGACGAGTTTTATTTGAATCACGATCCTCGTTACGACGTGGACTTCAATGGTAGGCTAACGATACAGTCGCCCGCCGAGGAGCTAAGCGGAAACTACACTTGCGAAGCCAGAAACAAGTTCGGGTATACGAACAAGACAGTCGAAGTAAACATTTATTCCGTGCCGAAACAAGTACAATCAGCCGAAAGCTATGCGAAGGTGACAGCACTCGAAGGAACCGACATTGTCATCGCGTGTCCCATCCGAGCTACAAACGTGCGATCAATATCATGGTACAAGGAAGCAAAATTAATATCAAAAGGTGATCTTCAGCTAAAAAACGTTTCGCGAAATGACACGTCCGTGTACGCGTGCGTCGCGACGAACACTGCGGGCAGCGCGCACGCGTCCGTAGCGCTCGACGTGCAATGGCCGCCCGCGTTCGTGACGAGGGTAGACGGAAATATTGAGGTCATCAAAGGAGAGGACGCGTGGTTCAGCTGTGCAGTCGACGCTAAACCTTTGGCTAAGATAAAATGGTTATTCAATTCTAAGCCATTGATCTTCGAGGATAAGGATGTTTTTAAAGTATTAAACGCACAACAAAGAAACGCGGGCGTTTATAAATGTGTTGTTAGCAACATTCATGGAACTATAATCAAGGCGTTCAAATTGTCCGTCCTGGAGCCTCCATACCTAATGGAGTTTGACTTTTTGGATGTATTGCTGAAGGAAGGGAGTAATGCTACACTTGAGTGTGTGGCTAAAGGAGTTCCCGCACCGACTGTCCAATGGATCTACAACAACACTCAGTGGGTGGCAGACGGTCCAGCCATAACCAGCACGAATACAACAACGGAAGCGGAAGGCCTGTATCGGTGCGAGGCTGCGAACAAAGCCGGAAGCGCGCACGTGGTCTACAGGGTGGTGGTGCTCGCGGCGCCGTCTGTGCTCCACGTCACGTCCTACAGCGACGGACGAGGGAGCACCGTCGACGAAGCCGTCGAAGTTATTCTCAACAAACGTGCCAGAATATCGTGTAAAGCAAAAGGGAGACCGGAACCCATCATACAGTGGTTCAAGAACGGTCGCGTCGTTGGTCAAAATCTACCTGGAATTAGCAGCGCCGATGTGGTACTGGATAGCGTGCAGGCCTCACATGCCGGGGCCTACACGTGTGTCGCCACTAATGAAGGCGGTAGTGATCAGAAGCGAATCAGACTTGAGGTCTTAGAAAAACCAAACATATTCCGCACTATTTTCCAAAGCGAAAACATAACGAGTAACACGATTAAATTAGACGTGTTAGTGGGGCAAGCGTTTTATATCCACTGCCACCCGACGGGCAGCCCGCCGCCGGACATCTACTGGTTCAAAGACGGGCTCCCGCTGATGCTGTACGATGACACTATGGTCTCGACTGAATTCAACGAGGTCTTAGTCTCGAAGGCCGCTCTGGAGGACCAGGCCGGGAACTATACTTGCATCGTGAGGAATAAGGTTGGCAATAACAGCGTCAATTATCTAGTCGACGTCTTAGTGCCTCCGCCAATACAGAAAGAGAAAACGAAACGGGTGTCAGCTCGACTGGGAATGTCTGTGGTATTGACATGTCCGGTGGAGGGCAGTCCCCTACCAGACGTGATGTGGATTAAACACCCTTACACCGAAATAGCCGAGGGCTCTGATAAAATGTCGCTCTCTGATGACAATGTTACTCTGATAATAAACAACACTGACGTATCGGATACCGGGAAATACTCGTGCGTTATGACAAACAAGGTTGGCACCACTGAAGTTGTGTTCGACGTGATCATATTGAAGGCGCCGTCCATTGCCGCTAATGTAGGAGGTAGCGCGATAGAAAGACACGTTGTACCATTGAAAAGGAGCGTTGTACTCAAATGCGAAGCGGACGGTCACCCGACACCGAAAATTACCTGGTTAAAGGACACGCAGCGTCTGAGCGAGAGTGCGTCGAACGTCGTGCGCGTCCTCGGCAACAGCTTGCTCTACGTCCGGGGCGGGTCCTCCCGCGACGCCGGCCACTACATCTGCGTGGCGGAGAACGAGGCCGGCACCGCGCACCGGAGGTACAACCTCGCCGTGCAGGTTCCGGGCAAATGGAGCGATTGGTCTAAATGGTCTTACTGCAACGTCACGTGCGGCCCTGGATACCAGTTCCGGTCCAGATCGTGTCACTACATCGACGAATACAACAACACCATAGATAATACAACTCAGTCGGACACGGTCATAGTTGACGAGAGCGCGTGCAAGGGAGAGAGTGGGGACAAACGAAAATGCAGGATGCCACAATGTGAGGATGAAGAGAGCCATCCGAAGTGGTCAGTGTGGTCGCGCTGGTCGCAGTGCAGCTCGAGCTGCGGCTCCGGGACGCAGACCAGGACAAGACGGTGCCGGACCAAGGTCAAATGTACCGGGGACAATGTTCAAGTTAGGAAATGTCCCGATCTACCGAAATGCGATAATACGGCGGATACGACGAGTACTTCTGACAATGACGTTTTGGACAGACATTCACACCACAACGACGATGAAGTGTATACGCCGGAGGCAGTCTACGAAATGGAACCAGAGATAATAAAATCTAAATATTCGCCTAACGTTGAACAGTTCTACGTGGCGGCGGGAACACGAGCGACGACAGCCTACTATGACGTCAACGTCACCAGCAACCTCGACCGAAGCGAGAGAGGCCGCTGCAACCCAGGGTACACGTACGAGCGGACCACGGACACGTGCCACGGTAATCTTATCTATCTCTTCGATTTGCAAAAATCGGTGAAAATTGTTGAAAAATATACGACTATCACCCCTCTAATTTTGATGGCAGAAACATTCCCTGGAGTGCCAGGCAGAGCCGGTGCTGAAGATTCATTGTAA

Protein

MFHSSFNDYGNLYIVNASVQTEGVYSCIAGNIAGVAVKTIFLSVNAPPKILEDNYTGSYVATDMDHSLTIYCSATGKPKPYVLWSKDEFYLNHDPRYDVDFNGRLTIQSPAEELSGNYTCEARNKFGYTNKTVEVNIYSVPKQVQSAESYAKVTALEGTDIVIACPIRATNVRSISWYKEAKLISKGDLQLKNVSRNDTSVYACVATNTAGSAHASVALDVQWPPAFVTRVDGNIEVIKGEDAWFSCAVDAKPLAKIKWLFNSKPLIFEDKDVFKVLNAQQRNAGVYKCVVSNIHGTIIKAFKLSVLEPPYLMEFDFLDVLLKEGSNATLECVAKGVPAPTVQWIYNNTQWVADGPAITSTNTTTEAEGLYRCEAANKAGSAHVVYRVVVLAAPSVLHVTSYSDGRGSTVDEAVEVILNKRARISCKAKGRPEPIIQWFKNGRVVGQNLPGISSADVVLDSVQASHAGAYTCVATNEGGSDQKRIRLEVLEKPNIFRTIFQSENITSNTIKLDVLVGQAFYIHCHPTGSPPPDIYWFKDGLPLMLYDDTMVSTEFNEVLVSKAALEDQAGNYTCIVRNKVGNNSVNYLVDVLVPPPIQKEKTKRVSARLGMSVVLTCPVEGSPLPDVMWIKHPYTEIAEGSDKMSLSDDNVTLIINNTDVSDTGKYSCVMTNKVGTTEVVFDVIILKAPSIAANVGGSAIERHVVPLKRSVVLKCEADGHPTPKITWLKDTQRLSESASNVVRVLGNSLLYVRGGSSRDAGHYICVAENEAGTAHRRYNLAVQVPGKWSDWSKWSYCNVTCGPGYQFRSRSCHYIDEYNNTIDNTTQSDTVIVDESACKGESGDKRKCRMPQCEDEESHPKWSVWSRWSQCSSSCGSGTQTRTRRCRTKVKCTGDNVQVRKCPDLPKCDNTADTTSTSDNDVLDRHSHHNDDEVYTPEAVYEMEPEIIKSKYSPNVEQFYVAAGTRATTAYYDVNVTSNLDRSERGRCNPGYTYERTTDTCHGNLIYLFDLQKSVKIVEKYTTITPLILMAETFPGVPGRAGAEDSL

Description

Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration.
Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos (PubMed:21215633). May play a role in the architecture of adhesive and flexible epithelial cell junctions (PubMed:17015624). May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration (PubMed:24951538).

Keywords

Age-related macular degeneration   Alternative splicing   Basement membrane   Calcium   Cell cycle   Cell division   Cell junction   Complete proteome   Cytoplasm   Disease mutation   Disulfide bond   EGF-like domain   Extracellular matrix   Glycoprotein   Immunoglobulin domain   Polymorphism   Reference proteome   Repeat   Secreted   Sensory transduction   Signal   Vision  

Feature

chain  Hemicentin-1
splice variant  In isoform 3.
sequence variant  In dbSNP:rs7539719.

Uniprot

H9JIJ3   A0A2W1BAW8   A0A2A4JKA5   A0A194Q7A1   A0A3S2L5P2   A0A2H1VVZ8   + More
A0A2H1VB14   A0A2Z5U737   A0A0N1PJS4   A0A2J7R082   A0A2J7R083   A0A1B6L2U6   A0A2Y9PQD3   A0A341BXZ8   A0A2U4CQ22   A0A2Y9TH90   A0A340WQW6   G1T5K0   Q96RW7   Q96RW7-2   A0A2J8V894   G3QH37   H2Q0S6   K7CJZ0   A0A2J8N6C6   H2N4D8   A0A1B6G7Y9   A0A287DE85   I3MFI4   A0A383YVW7   M3X1M2   F6QWR8   F1PXF9   G1MRA1   A0A2K5NVX0   A0A444UCA5   A0A3Q0CW37   A0A091V0J0   A0A2K5NWC4   A0A2K6RDI0   F7HTR8   A0A099ZVY6   A0A0D9RKF6   A0A2K6JQ42   A0A2K5ZYP4   A0A2K5K644   A0A3B3RV35   A0A2K5K656   A0A2K5TLR4   G7MF24   A0A3Q7XQ40   M3YKJ2   A0A384CL93   A0A2K5TLS7   A0A2Y9GGI7   A0A2K6BJH9   F7BH35   G3RN13   A0A2K6BJK2   A0A096NP62   F7BH08   A0A3B4GRR4   A0A1V4JZI6   A0A1V4JZF2   F6TQY1   A0A2I3MCW5   A0A3Q3GU11   A0A3P8PUT5   A0A2K6S2B6   A0A2R8ZPW9   A0A2K6S293   A0A3P9BQE6   W5M0S1   F6UCP4   V8P2G0   A0A452FS37   A0A2I3SUI4   A0A1I7U001   A0A1U7UYH7   A0A3P9NWC9   D3YXG0   F6R9N9   D3YXG0-2   A0A2U3WBH9   A0A1I7U000   A0A2I4B518   S9XZ12   A0A2K5SD05   A0A2Y9JST8   A0A3Q7T881   A0A2K5EMD4   A0A401PF95   L5KZE1   K7G868   W5P565   A0A3B4E5X1   A0A146YJD2   M7BBY2   A0A146YJH4   H0XAK9  

Pubmed

19121390    28756777    26354079    21993624    14702039    16710414    + More
14570714    22398555    16136131    17975172    17495919    16341006    20838655    26319212    25362486    29240929    22002653    17431167    19892987    22722832    25186727    24297900    19468303    17015624    21183079    21215633    24951538    18464734    23149746    30297745    23258410    17381049    20809919    23624526   

EMBL

BABH01027071    BABH01027072    BABH01027073    BABH01027074    BABH01027075    BABH01027076    + More
BABH01027077    BABH01027078    BABH01027079    BABH01027080    KZ150210    PZC72208.1    NWSH01001280    PCG71863.1    KQ459337    KPJ01408.1    RSAL01000133    RVE46324.1    ODYU01004773    SOQ45009.1    ODYU01001595    SOQ38038.1    AP017486    BBB06744.1    KQ459928    KPJ19296.1    NEVH01008283    PNF34248.1    PNF34243.1    GEBQ01022123    JAT17854.1    AAGW02054358    AAGW02054359    AAGW02054360    AAGW02054361    AAGW02054362    AAGW02054363    AF156100    AK056336    AK056557    AL118512    AL121996    AL133515    AL133553    AL135796    AL135797    AL391824    BX928748    AJ306906    NDHI03003429    PNJ53742.1    CABD030007797    CABD030007798    CABD030007799    CABD030007800    CABD030007801    CABD030007802    CABD030007803    CABD030007804    CABD030007805    CABD030007806    AACZ04056152    AACZ04056153    AACZ04056154    GABE01001833    NBAG03000235    JAA42906.1    PNI67324.1    PNI67325.1    ABGA01049740    ABGA01049741    ABGA01049742    ABGA01049743    ABGA01049744    ABGA01049745    ABGA01049746    ABGA01049747    ABGA01049748    ABGA01049749    GECZ01011376    JAS58393.1    AGTP01014814    AGTP01014815    AANG04001043    AAEX03005163    AAEX03005164    SCEB01214843    RXM32791.1    KL410290    KFQ95785.1    KL869911    KGL86449.1    AQIB01112956    AQIB01112957    AQIB01112958    AQIB01112959    AQIB01112960    AQIB01112961    AQIA01001031    AQIA01001032    AQIA01001033    AQIA01001034    AQIA01001035    AQIA01001036    CM001253    EHH15721.1    AEYP01068968    AEYP01068969    AEYP01068970    AEYP01068971    AEYP01068972    AEYP01068973    AEYP01068974    AEYP01068975    AEYP01068976    AEYP01068977    JSUE03003236    JSUE03003237    JSUE03003238    JSUE03003239    JSUE03003240    AHZZ02017566    AHZZ02017567    AHZZ02017568    AHZZ02017569    LSYS01005418    OPJ77523.1    OPJ77524.1    AJFE02052069    AJFE02052070    AJFE02052071    AJFE02052072    AJFE02052073    AJFE02052074    AJFE02052075    AHAT01034683    AHAT01034684    AHAT01034685    AHAT01034686    AZIM01000955    ETE68709.1    LWLT01000016    AC111145    AC113326    AC115051    AC124120    KB017072    EPY80556.1    BFAA01000395    GCB71820.1    KB030474    ELK16173.1    AGCU01004760    AGCU01004761    AGCU01004762    AGCU01004763    AGCU01004764    AGCU01004765    AGCU01004766    AGCU01004767    AGCU01004768    AGCU01004769    AMGL01022558    AMGL01022559    AMGL01022560    AMGL01022561    AMGL01022562    AMGL01022563    AMGL01022564    AMGL01022565    AMGL01022566    AMGL01022567    GCES01032043    JAR54280.1    KB532021    EMP34679.1    GCES01032044    JAR54279.1    AAQR03037752    AAQR03037753    AAQR03037754    AAQR03037755    AAQR03037756    AAQR03037757    AAQR03037758    AAQR03037759    AAQR03037760    AAQR03037761   

Proteomes

UP000005204    UP000218220    UP000053268    UP000283053    UP000053240    UP000235965    + More
UP000248483    UP000252040    UP000245320    UP000248484    UP000265300    UP000001811    UP000005640    UP000001519    UP000002277    UP000001595    UP000005215    UP000261681    UP000011712    UP000002280    UP000002254    UP000001645    UP000233060    UP000189706    UP000053283    UP000233200    UP000008225    UP000053858    UP000029965    UP000233180    UP000233140    UP000233080    UP000261540    UP000233100    UP000286642    UP000000715    UP000261680    UP000248481    UP000233120    UP000006718    UP000028761    UP000261460    UP000190648    UP000002281    UP000261660    UP000265100    UP000233220    UP000240080    UP000265160    UP000018468    UP000291000    UP000095282    UP000189704    UP000242638    UP000000589    UP000002279    UP000245340    UP000192220    UP000233040    UP000248482    UP000286640    UP000233020    UP000288216    UP000010552    UP000007267    UP000002356    UP000261440    UP000031443    UP000005225   

PRIDE

H9JIJ3    Q96RW7    F1PXF9    D3YXG0   

Pfam

PF07679   I-set        + More
PF00047   ig
PF00090   TSP_1
PF07645   EGF_CA
PF13895   Ig_2
PF07474   G2F
PF12662   cEGF

Interpro

IPR013783   Ig-like_fold        + More
IPR013151   Immunoglobulin       
IPR007110   Ig-like_dom       
IPR003599   Ig_sub       
IPR013098   Ig_I-set       
IPR001881   EGF-like_Ca-bd_dom       
IPR036383   TSP1_rpt_sf       
IPR000884   TSP1_rpt       
IPR000152   EGF-type_Asp/Asn_hydroxyl_site       
IPR036179   Ig-like_dom_sf       
IPR000742   EGF-like_dom       
IPR003598   Ig_sub2       
IPR013032   EGF-like_CS       
IPR018097   EGF_Ca-bd_CS       
IPR036465   vWFA_dom_sf       
IPR009030   Growth_fac_rcpt_cys_sf       
IPR009017   GFP       
IPR006605   G2_nidogen/fibulin_G2F       
IPR013106   Ig_V-set       
IPR009138   Neural_cell_adh       
IPR026823   cEGF       
IPR032984   Hemicentin-2       
IPR016130   Tyr_Pase_AS       

SUPFAM

SSF48726   SSF48726        + More
SSF82895   SSF82895       
SSF57184   SSF57184       
SSF53300   SSF53300       
SSF54511   SSF54511       

Gene 3D

2.20.100.10     2.60.40.10     3.40.50.410    

CDD

cd00255  nidG2

ProteinModelPortal

H9JIJ3   A0A2W1BAW8   A0A2A4JKA5   A0A194Q7A1   A0A3S2L5P2   A0A2H1VVZ8   + More
A0A2H1VB14   A0A2Z5U737   A0A0N1PJS4   A0A2J7R082   A0A2J7R083   A0A1B6L2U6   A0A2Y9PQD3   A0A341BXZ8   A0A2U4CQ22   A0A2Y9TH90   A0A340WQW6   G1T5K0   Q96RW7   Q96RW7-2   A0A2J8V894   G3QH37   H2Q0S6   K7CJZ0   A0A2J8N6C6   H2N4D8   A0A1B6G7Y9   A0A287DE85   I3MFI4   A0A383YVW7   M3X1M2   F6QWR8   F1PXF9   G1MRA1   A0A2K5NVX0   A0A444UCA5   A0A3Q0CW37   A0A091V0J0   A0A2K5NWC4   A0A2K6RDI0   F7HTR8   A0A099ZVY6   A0A0D9RKF6   A0A2K6JQ42   A0A2K5ZYP4   A0A2K5K644   A0A3B3RV35   A0A2K5K656   A0A2K5TLR4   G7MF24   A0A3Q7XQ40   M3YKJ2   A0A384CL93   A0A2K5TLS7   A0A2Y9GGI7   A0A2K6BJH9   F7BH35   G3RN13   A0A2K6BJK2   A0A096NP62   F7BH08   A0A3B4GRR4   A0A1V4JZI6   A0A1V4JZF2   F6TQY1   A0A2I3MCW5   A0A3Q3GU11   A0A3P8PUT5   A0A2K6S2B6   A0A2R8ZPW9   A0A2K6S293   A0A3P9BQE6   W5M0S1   F6UCP4   V8P2G0   A0A452FS37   A0A2I3SUI4   A0A1I7U001   A0A1U7UYH7   A0A3P9NWC9   D3YXG0   F6R9N9   D3YXG0-2   A0A2U3WBH9   A0A1I7U000   A0A2I4B518   S9XZ12   A0A2K5SD05   A0A2Y9JST8   A0A3Q7T881   A0A2K5EMD4   A0A401PF95   L5KZE1   K7G868   W5P565   A0A3B4E5X1   A0A146YJD2   M7BBY2   A0A146YJH4   H0XAK9  

PDB

3DMK     E-value=3.95064e-34,     Score=366

KEGG

101741619    K17341 hemicentin | (RefSeq) hemicentin-1-like

GO

GO:0005509   GO:0007155   GO:0016020   GO:0030054   GO:0009617   GO:0005604   GO:0005938   GO:0032154   GO:0038023   GO:0007156   GO:0005201   GO:0007157   GO:0051301   GO:0007049   GO:0062023   GO:0005913   GO:0050839   GO:0070062   GO:0007601   GO:0042803   GO:0033334   GO:0071711   GO:0016021   GO:0004725   GO:0043589   GO:0090497   GO:0035122   GO:0030198   GO:0005576   GO:0050808   GO:0032589   GO:0005515   GO:0005634   GO:0007067   GO:0006508   GO:0019012   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR45889:SF4  

Subcellular location

Secreted   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Extracellular space   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Extracellular matrix   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Basement membrane   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Cytoplasm   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Cell junction   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.
Cleavage furrow   The antibody used to determine subcellular location does not distinguish between HMCN1 and HMCN2.   With evidence from 2 publications.

Length:

1047

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.697879999999997

Exp number, first 60 AAs:

0.6868

Total prob of N-in:

0.03038

outside

1  -  1047

 

 

Pi

220.680202

Theta

169.282707

Tajima's D

0.923575

CLR

0.308353

CSRT

0.64216789160542

Interpretation

Uncertain