Gene

KWMTBOMO08481

Pre Gene Modal

BGIBMGA007650

Annotation

PREDICTED:_piggyBac_transposable_element-derived_protein_3-like_[Papilio_xuthus]

Location

Bomo_Chr14(-):10611995-10614566      View in EpiBrowser

Full name

PiggyBac transposable element-derived protein 3       + More
Chimeric ERCC6-PGBD3 protein      
PiggyBac transposable element-derived protein 2      

Alternative Name

Chimeric CSB-PGBD3 protein

Location in the cell

Cytoplasmic   Reliability : 2.053 Nuclear   Reliability : 2.667

CDS

ATGGCAAATGACAGACCGTTAGCTGCGCATGAAATTTTAGATGCTTTAGAAAATGTTTCTGATAATGAAGAAGATTATAGAGAACGACTGATATGTATTCTACCTCCTCCTGTTGATCCTGACTGTCTCACTGACGAAGATTCGGGTGAAGAAGATTATGTAACTTTGAATAATTTGCCACGAAACATTCTGCTTCAACCGGCTGAAGTAATGATTCAAGGGCAGATTATGGTGAGTGATACAGAAGAACCTTCTGATTCTACAGATGTTCAAGGCGCTTGCCAAGATAAGCGCCCAATTGAGTGGTTTGAAAACTTCTTAGATGAAGATGTTATTTCGTTGTTGGTGTCAGAGAGCAATAAATATGCTGTCAAAAAGAATTTGCCTGGAGACATAACCACTGAAGATATGAAATGTTTCATCGGCATATTGTTGGTTAGTGGTTATTCATGGCTCCCCCGTAGAATAATGTATTGGGAAAACTCCCCTGATACAAAGAATGAATTGATCAGCTCGGCTATGACTAGGGATAGATTTGACTTTATTTTTCGCCACCTTCATGTCAATGATAATCTGGATTTGCAAGACAAATACACAAAAGTACGCCCCCTAGTTACACTTCTAAATAAAAAGTTCTTAGAGTTTTCTCCTCTTGAAGAGCATTACGGTGTAGATGAGGCCATGATCCCCTACTATGGTAGACATGGCTGCAAACAGCACATAAAAGGTAAACCTATTAGGTACGGGTTCAAAGCTTGGGTTGGTGCTACACGGTTAGGTGAAAAGAGAAACATTGTCATAGAAGAACCACATATGGTGTCCATCTATAACAAATATATGGGAGGAGTGGATCGGTCTGATGAAAATATTTCACATTACCGAATTGGTATACGAGAAAATTTTAGTTTCAGGCTTATCTGGGATATAGACGTGACTGAGTTAAATGAAGTTTTTAATTCACCTGGACATATTGAAGGCTGTTTTTTGTCAAACCCTTTCAGGATTAATGAGTTTAAAATAGCTTTAGAATCTAGAAAAGATAGTACTCCTAGTCTCGATGACATCCCTTAG

Protein

MANDRPLAAHEILDALENVSDNEEDYRERLICILPPPVDPDCLTDEDSGEEDYVTLNNLPRNILLQPAEVMIQGQIMVSDTEEPSDSTDVQGACQDKRPIEWFENFLDEDVISLLVSESNKYAVKKNLPGDITTEDMKCFIGILLVSGYSWLPRRIMYWENSPDTKNELISSAMTRDRFDFIFRHLHVNDNLDLQDKYTKVRPLVTLLNKKFLEFSPLEEHYGVDEAMIPYYGRHGCKQHIKGKPIRYGFKAWVGATRLGEKRNIVIEEPHMVSIYNKYMGGVDRSDENISHYRIGIRENFSFRLIWDIDVTELNEVFNSPGHIEGCFLSNPFRINEFKIALESRKDSTPSLDDIP

Description

Binds in vitro to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.
Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF.

Miscellaneous

PGBD3 gene is located within ERCC6 intron 5.

Keywords

Alternative splicing   Complete proteome   DNA-binding   Nucleus   Phosphoprotein   Polymorphism   Reference proteome   Disease mutation   Isopeptide bond   Premature ovarian failure   Ubl conjugation  

Feature

chain  PiggyBac transposable element-derived protein 3
sequence variant  In dbSNP:rs4253072.
splice variant  In isoform 2.

Uniprot

A0A3S2N5S4   A0A212FJ76   A0A1A9Z8F7   A0A1Y1LG12   T2M9K1   F7EM96   + More
A0A2J8JGQ8   Q8N328   U3B6D7   U3E686   U3ENV5   U3CPS9   A0A2K6E0X9   A0A2J8RT17   K7C897   A0A2R8Z9V9   A0A2K5QFQ3   A0A147BBG9   G3SEC0   A0A2K6E0V7   P0DP91   A8K4Q3   A0A2K5V985   A0A2I3RAX8   A0A2J8JGN8   A0A2K5DEG0   A0A2K5JRR6   A0A2K6PI71   A0A2K6LGX8   F6RSP5   A0A2K6ST22   Q4R4A3   A0A2J8RT31   A0A096P4A2   A0A2K6AE02   A0A2I3HPQ9   D7EK33   A0A2K5LL76   N6T2W4   A0A087U8G4   F6ZNL0   A0A336M992   M3XQ58   A0A3P4RWH6   M3X8R6   G3VIF3   A0A2Y9MDI9   A0A2Y9MJ53   S9WNB2   A0A212ERY7   A0A2Y9S0G5   A0A2U4BIF0   A0A2U4BI88   A0A452DQQ1   A0A341BUQ3   A0A341BW94   G5E5N2   A0A2K6F4D2   F7I1C5   L8IPN2   A0A2K6UA69   A0A212D1C8   A0A2Y9HA29   A0A340X956   A0A2U3W5X2   A0A2Y9IGG0   W5PEK4   A0A2K5KAR4   A0A383Z4K2   K9J215   A0A3Q7MPJ8   A0A2K5Q526   A0A2U3XGG7   A0A2K5Q520   A0A3Q2HLG4   F6X578   G3SS70   B4DPA1   A0A3Q7RRM6   A0A2K6KZJ0   G1QWB6   Q6P3X8   H2N335   A0A2J8RJL9   I3N029   K7AM28   A0A0D9R971   H2Q1I5   G3RPE5   D2I5Z2   A0A2K6A111  

Pubmed

22118469    28004739    24065732    17431167    25319552    14702039    + More
15164054    15489334    18369450    22483866    23186163    26218421    16959974    25243066    22722832    29652888    22398555    17081983    16964243    18691976    18669648    20068231    21406692    28112733    11181995    16136131    25362486    15944441    18362917    19820115    23537049    17495919    17975172    21709235    23149746    19393038    22751099    20809919    19892987    17974005    16710414    20010809   

EMBL

RSAL01000353    RVE42252.1    AGBW02008302    OWR53786.1    GEZM01060808    GEZM01060807    + More
JAV70895.1    HAAD01002582    CDG68814.1    JSUE03043349    JU470545    AFH27349.1    NBAG03000461    PNI21937.1    AK074682    AL138760    BC028954    BC063690    GAMT01003553    GAMT01003551    GAMQ01002282    JAB08308.1    JAB39569.1    GAMS01002010    JAB21126.1    GAMP01000187    JAB52568.1    GAMR01006104    JAB27828.1    NDHI03003654    PNJ11666.1    GABF01001690    JAA20455.1    GEGO01007284    JAR88120.1    CABD030070918    BC034479    AK291018    CH471187    BAF83707.1    EAW93095.1    AQIA01070964    AACZ04060518    PNI21935.1    PNI21936.1    AB179012    BAE02063.1    PNJ11664.1    PNJ11665.1    AHZZ02035229    ADFV01105741    ADFV01105742    ADFV01105743    ADFV01105744    ADFV01105745    DS497727    EFA12977.1    APGK01046441    KB741054    KB632013    ENN74459.1    ERL88014.1    KK118708    KFM73653.1    UFQT01000583    SSX25489.1    AEYP01099555    AEYP01099556    CYRY02043934    VCX38622.1    AANG04001781    AEFK01164926    AEFK01164927    KB017432    EPY77693.1    AGBW02012897    OWR44258.1    LWLT01000008    GAMT01004683    GAMP01007477    JAB07178.1    JAB45278.1    JH880825    ELR58540.1    MKHE01000009    OWK12058.1    AMGL01092670    GABZ01005161    JAA48364.1    AK298248    BAG60513.1    ADFV01037738    ADFV01037739    ADFV01037740    ADFV01037741    ADFV01037742    AK123219    BX647065    AL672183    CH471257    BC063785    ABGA01061445    ABGA01061446    ABGA01061447    NDHI03003683    PNJ08718.1    AGTP01101535    AGTP01101536    AACZ04070590    GABC01008499    GABE01003522    JAA02839.1    JAA41217.1    AQIB01155464    CABD030010211    CABD030010212    CABD030010213    GL194834    EFB16732.1   

Proteomes

UP000283053    UP000007151    UP000092445    UP000006718    UP000005640    UP000233120    + More
UP000240080    UP000233040    UP000001519    UP000233100    UP000002277    UP000233020    UP000233080    UP000233200    UP000233180    UP000008225    UP000233220    UP000028761    UP000233140    UP000001073    UP000007266    UP000233060    UP000019118    UP000030742    UP000054359    UP000002280    UP000000715    UP000011712    UP000007648    UP000248483    UP000248484    UP000245320    UP000291000    UP000252040    UP000009136    UP000233160    UP000248481    UP000265300    UP000245340    UP000248482    UP000002356    UP000261681    UP000286641    UP000245341    UP000002281    UP000007646    UP000286640    UP000001595    UP000005215    UP000029965   

PRIDE

Q8N328    P0DP91    A8K4Q3    B4DPA1    Q6P3X8   

Pfam

PF13843   DDE_Tnp_1_7

Interpro

IPR029526   PGBD       

ProteinModelPortal

A0A3S2N5S4   A0A212FJ76   A0A1A9Z8F7   A0A1Y1LG12   T2M9K1   F7EM96   + More
A0A2J8JGQ8   Q8N328   U3B6D7   U3E686   U3ENV5   U3CPS9   A0A2K6E0X9   A0A2J8RT17   K7C897   A0A2R8Z9V9   A0A2K5QFQ3   A0A147BBG9   G3SEC0   A0A2K6E0V7   P0DP91   A8K4Q3   A0A2K5V985   A0A2I3RAX8   A0A2J8JGN8   A0A2K5DEG0   A0A2K5JRR6   A0A2K6PI71   A0A2K6LGX8   F6RSP5   A0A2K6ST22   Q4R4A3   A0A2J8RT31   A0A096P4A2   A0A2K6AE02   A0A2I3HPQ9   D7EK33   A0A2K5LL76   N6T2W4   A0A087U8G4   F6ZNL0   A0A336M992   M3XQ58   A0A3P4RWH6   M3X8R6   G3VIF3   A0A2Y9MDI9   A0A2Y9MJ53   S9WNB2   A0A212ERY7   A0A2Y9S0G5   A0A2U4BIF0   A0A2U4BI88   A0A452DQQ1   A0A341BUQ3   A0A341BW94   G5E5N2   A0A2K6F4D2   F7I1C5   L8IPN2   A0A2K6UA69   A0A212D1C8   A0A2Y9HA29   A0A340X956   A0A2U3W5X2   A0A2Y9IGG0   W5PEK4   A0A2K5KAR4   A0A383Z4K2   K9J215   A0A3Q7MPJ8   A0A2K5Q526   A0A2U3XGG7   A0A2K5Q520   A0A3Q2HLG4   F6X578   G3SS70   B4DPA1   A0A3Q7RRM6   A0A2K6KZJ0   G1QWB6   Q6P3X8   H2N335   A0A2J8RJL9   I3N029   K7AM28   A0A0D9R971   H2Q1I5   G3RPE5   D2I5Z2   A0A2K6A111  

KEGG

105842712    no KO assigned | (RefSeq) piggyBac transposable element-derived protein 3-like

GO

GO:0005654   GO:0016604   GO:0043565   GO:0010628   GO:0005634   GO:0045739   GO:0002230   GO:0033141  

Subcellular location

Nucleus  

Length:

356

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02877

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01543

outside

1  -  356

 

 

Pi

395.177149

Theta

200.316456

Tajima's D

3.029588

CLR

0.380344

CSRT

0.978501074946253

Interpretation

Possibly Balancing Selection