Gene

KWMTBOMO08461  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009420

Annotation

Electron_transfer_flavoprotein-ubiquinone_oxidoreductase?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr14(+):9618977-9634324      View in EpiBrowser

Full name

Dihydrolipoyl dehydrogenase      

Location in the cell

Cytoplasmic   Reliability : 1.276 Mitochondrial   Reliability : 1.905

CDS

ATGGCGGTGGCTATTGTTAGTTCGGCTCGACAGGTGGGGAGGCTAACAAACGCAGCCAGGAGGCTTTATTCTGATGTATATCCTAAAATATCAACCCATTATACAATACATCCAAGAGATAAGGATCCAAGATGGAAAGAGATAAATATGGAACGCGTAGCGGAGGAGACGGACATCCTCATTATCGGTGGGGGCCCAGCGGGTATGGCAGCTGCAATCCGAGCAAGACAAATAGCAGCTGAAAAGGGGGCAGAAGTAAGAGTGACTTTACTGGAAAAGGCAGCAGAGACTGGAGGGCATATATTGTCAGGAGCCTGTGTTGATCCAATAGCTTTGAATGAGTTAATCCCAGACTGGAAAGAGCGAGGAGCTCCTATGAATACTCCAGTTACATCGGACAAGTTTGGTCTGTTGACGAAGAGTAGCAGAATACCTATACCTGTATTTCCTGGTTTACCGAATTACAATCATGGTAACTACGTTGTGAGACTGGGACATCTAGTTAAATGGCTTGGTGAGCAAGCTGAAGAACTCGGTGCTGAGGTGTGGCCGGGATGCGCTGGAGCCGAGGTGCTGTACCGCGAGGACGGGTCGGTGCGCGGGGTGGCCACGGGGTGTCATGGACATTTAACGAAAATGGTCTCGAACAAGTTCAATCTCAGGGAGAAGAGCGAGCCACAGTCTTATGGTATTGGATTGAAAGAGCTTTGGGAAGTTAAGCCAGAGAACCACAAACCAGGTTTAGTTGAACACACAATAGGTTGGCCATTAGATAAGAACACATACGGGGGATCGTTCATATACCACTTAAATGTGGCAGAGGGCGAATCACCCCTAGTGGCCGTCGGCTTCGTGGTGGGGCTGGACTACACCAACCCTTACATTAGTCCCTTCAGAGAATTCCAGAGATTCAAGTTGCATCCTTATGTTAATCCTGTGTTCGAAGGCGGGTCCCGCATCGCGTACGGCGCGCGGGCGCTGGTGGAGGGCGGCTGGCAGTGCCTGCCCCGGCCGGTGTTCCCGGGGGGCGTGCTGGCCGGGGACACGGCGGGCTTCCTCAACGTGCCCCGGATCAAGGGCACGCACAACGCCATGAAGAGTGGCATGCTAGCCGCCGAGTCCGCCATGGAGCTGGTGCTGTCCGGGGACGCGACACACGATCGCGGAGTCGTTCCGGAGTCTTACGAAGAGAAACTAAAAAATTCATTCGTCTACAAAGAACTCAAGGAGGTTCGCAACTGTCGGCCATCGTTCCACACGAAGCTGGGCCTGTACGGAGGCGTCGCGTACTCCGCCTTCAGCACGCTCGTGCGCGGGAAGGAACCCTGGACCCTCAGCCACGGAGGTGCAGATCACTCACGCCTGCGGCCGGCGCAGGAGTGCCAACCCATCGAGTACCCCAAGCCGGACGGGGTGGTTACCTTCGATCTGCTGTCCTCTGTTGCGCTCACAGGCACAAATCACGAAGCGGACCAGCCTCCGCATCTGACGTTAAAAGACGATACGGTGCCGGTTAAGACCAATCTAGGAGTATACGATGGACCCGAAGCCAGGTTTTGTCCTGCAGGTGTATACGAGTTCGTACCGTTGGAGGAGGGTGATGGTCAGAGGTTGCAGATCAATGCTCAGAACTGCATCCACTGTAAAACGTGCGACATTAAAGACCCGTCGCAGAACATCAACTGGGTTGTGCCCGAGGGCGGCGGCGGACCTGCCTACAACGGAATGTAA

Protein

MAVAIVSSARQVGRLTNAARRLYSDVYPKISTHYTIHPRDKDPRWKEINMERVAEETDILIIGGGPAGMAAAIRARQIAAEKGAEVRVTLLEKAAETGGHILSGACVDPIALNELIPDWKERGAPMNTPVTSDKFGLLTKSSRIPIPVFPGLPNYNHGNYVVRLGHLVKWLGEQAEELGAEVWPGCAGAEVLYREDGSVRGVATGCHGHLTKMVSNKFNLREKSEPQSYGIGLKELWEVKPENHKPGLVEHTIGWPLDKNTYGGSFIYHLNVAEGESPLVAVGFVVGLDYTNPYISPFREFQRFKLHPYVNPVFEGGSRIAYGARALVEGGWQCLPRPVFPGGVLAGDTAGFLNVPRIKGTHNAMKSGMLAAESAMELVLSGDATHDRGVVPESYEEKLKNSFVYKELKEVRNCRPSFHTKLGLYGGVAYSAFSTLVRGKEPWTLSHGGADHSRLRPAQECQPIEYPKPDGVVTFDLLSSVALTGTNHEADQPPHLTLKDDTVPVKTNLGVYDGPEARFCPAGVYEFVPLEEGDGQRLQINAQNCIHCKTCDIKDPSQNINWVVPEGGGGPAYNGM

Catalytic Activity

(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH

Cofactor

FAD

Miscellaneous

The active site is a redox-active disulfide bond.

Similarity

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Uniprot

H9JIR9   A0A194Q7R1   A0A1Z2RRI8   A0A3S2PF61   A0A212EWT6   A0A0C9RK51   + More
A0A232FMI1   K7IXE6   A0A2J7PZJ7   J3JTE9   V5GUY2   A0A1B6C0L4   A0A182RUZ2   A0A151XJD1   A0A182NMH1   F4X3U3   A0A182Q739   A0A3L8DXW6   A0A026WNE4   A0A182M6W2   A0A182Y2X4   A0A158P050   A0A0P6J107   D2A0Q9   E2A3X9   A0A195E0P7   A0A195F1N3   A0A067RE05   A0A182PPA5   U5ES10   A0A182FE41   A0A195BFJ9   A0A084W2Q5   A0A2M4BHQ0   A0A1Y1KN64   W5JFW5   A0A182VKC9   A0A182IN15   A0A2M3Z244   A0A182XM95   A0A195CA52   A0A182WMD0   A0A182I230   A0A182GB59   A0A2A3E9F3   A0A2M4A6L1   A0A182TP92   Q7Q6E7   A0A2M4A6I3   A0A0B4J2M5   A0A182JRN1   A0A310SP62   A0A0A9WLX0   B0VZ76   R4WSM6   A0A1Q3FI44   T1DPN1   A0A0T6B555   A0A154NWP3   A0A182KPU7   A0A0L7QW90   J9JTH9   A0A0P4VSJ0   T1HF19   A0A2R5LJQ2   A0A0C9Q061   A0A1L8E0P0   A0A336KS65   A0A336M9M1   A0A224XDK6   A0A0V0G5A3   A0A2S2QCW4   Q171U3   E0VBI1   A0A1W4WSQ7   A0A2M4BIZ2   A0A1W4X2C3   A0A023FAJ2   W8BP19   A7RNA5   A0A1Z5KUI9   B3N6T6   A0A1S3HNC5   E2BZN2   B4NX17   A0A1I8NP62   Q7JWF1   A0A034VR82   B4HMA2   A0A2B4SE12   A0A0L0BTW1   A0A1J1ITA4   T1P906   A0A0P6CVR2   A0A1D2MYL7   A0A0K8VCZ2   A0A3B0J4R6   A0A0J9R992   A0A1I8MF92   A0A091KYP4  

EC Number

1.8.1.4

Pubmed

19121390    26354079    28605547    22118469    28648823    20075255    + More
22516182    23537049    21719571    30249741    24508170    25244985    21347285    26999592    18362917    19820115    20798317    24845553    24438588    28004739    20920257    23761445    26483478    12364791    14747013    17210077    25401762    26823975    23691247    20966253    27129103    17510324    20566863    25474469    24495485    17615350    28528879    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    25348373    26108605    27289101    22936249    25315136   

EMBL

BABH01032924    BABH01032925    BABH01032926    KQ459337    KPJ01429.1    KY938822    + More
ASA46463.1    RSAL01000059    RVE49687.1    AGBW02011894    OWR45962.1    GBYB01007221    JAG76988.1    NNAY01000020    OXU31882.1    AAZX01000010    NEVH01020335    PNF21740.1    BT126505    KB632306    AEE61469.1    ERL91896.1    GALX01002994    JAB65472.1    GEDC01030523    JAS06775.1    KQ982074    KYQ60522.1    GL888624    EGI58890.1    AXCN02000923    QOIP01000003    RLU25132.1    KK107144    EZA57555.1    AXCM01000805    ADTU01005358    GDUN01000272    JAN95647.1    KQ971338    EFA02551.1    GL436519    EFN71831.1    KQ979955    KYN18454.1    KQ981856    KYN34485.1    KK852566    KDR21248.1    GANO01002577    JAB57294.1    KQ976490    KYM83373.1    ATLV01019678    KE525277    KFB44499.1    GGFJ01003426    MBW52567.1    GEZM01081057    JAV61921.1    ADMH02001272    ETN63267.1    GGFM01001848    MBW22599.1    KQ978081    KYM97076.1    APCN01000109    JXUM01052081    KQ561718    KXJ77724.1    KZ288323    PBC28104.1    GGFK01002947    MBW36268.1    AAAB01008960    EAA11780.3    GGFK01003044    MBW36365.1    KQ760603    OAD59749.1    GBHO01035183    GBRD01003254    GDHC01008338    JAG08421.1    JAG62567.1    JAQ10291.1    DS231813    EDS25721.1    AK417712    BAN20927.1    GFDL01007831    JAV27214.1    GAMD01003204    JAA98386.1    LJIG01009737    KRT82482.1    KQ434775    KZC04106.1    KQ414716    KOC62872.1    ABLF02038315    ABLF02038324    ABLF02038335    ABLF02038338    GDKW01001680    JAI54915.1    ACPB03015449    GGLE01005529    MBY09655.1    GBYB01007223    JAG76990.1    GFDF01001784    JAV12300.1    UFQS01000777    UFQT01000777    SSX06811.1    SSX27156.1    UFQS01000761    UFQT01000761    SSX06698.1    SSX27044.1    GFTR01007352    JAW09074.1    GECL01002891    JAP03233.1    GGMS01006402    MBY75605.1    CH477446    EAT40764.1    EAT40765.1    DS235030    EEB10737.1    GGFJ01003812    MBW52953.1    GBBI01000240    JAC18472.1    GAMC01015106    JAB91449.1    DS469522    EDO47030.1    GFJQ02008275    JAV98694.1    CH954177    EDV58185.1    GL451645    EFN78847.1    CM000157    EDW89578.1    AE013599    AY113586    AAF58873.1    AAM29591.1    AFH07986.1    GAKP01014637    JAC44315.1    CH480816    EDW47179.1    LSMT01000120    PFX26675.1    JRES01001351    KNC23451.1    CVRI01000059    CRL03344.1    KA645179    AFP59808.1    GDIQ01087831    JAN06906.1    LJIJ01000379    ODM98143.1    GDHF01015889    GDHF01001522    JAI36425.1    JAI50792.1    OUUW01000001    SPP74553.1    CM002911    KMY92621.1    KK761821    KFP45177.1   

Proteomes

UP000005204    UP000053268    UP000283053    UP000007151    UP000215335    UP000002358    + More
UP000235965    UP000030742    UP000075900    UP000075809    UP000075884    UP000007755    UP000075886    UP000279307    UP000053097    UP000075883    UP000076408    UP000005205    UP000007266    UP000000311    UP000078492    UP000078541    UP000027135    UP000075885    UP000069272    UP000078540    UP000030765    UP000000673    UP000075903    UP000075880    UP000076407    UP000078542    UP000075920    UP000075840    UP000069940    UP000249989    UP000242457    UP000075902    UP000007062    UP000005203    UP000075881    UP000002320    UP000076502    UP000075882    UP000053825    UP000007819    UP000015103    UP000008820    UP000009046    UP000192223    UP000001593    UP000008711    UP000085678    UP000008237    UP000002282    UP000095300    UP000000803    UP000001292    UP000225706    UP000037069    UP000183832    UP000094527    UP000268350    UP000095301   

PRIDE

H9JIR9    A0A0B4J2M5    Q7JWF1   

Pfam

PF07992   Pyr_redox_2        + More
PF00890   FAD_binding_2
PF02852   Pyr_redox_dim

Interpro

IPR040156   ETF-QO        + More
IPR017896   4Fe4S_Fe-S-bd       
IPR036188   FAD/NAD-bd_sf       
IPR023753   FAD/NAD-binding_dom       
IPR003953   FAD-binding_2       
IPR006258   Lipoamide_DH       
IPR004099   Pyr_nucl-diS_OxRdtase_dimer       
IPR012999   Pyr_OxRdtase_I_AS       
IPR016156   FAD/NAD-linked_Rdtase_dimer_sf       

SUPFAM

SSF51905   SSF51905        + More
SSF55424   SSF55424       

Gene 3D

3.50.50.60     3.30.390.30    

ProteinModelPortal

H9JIR9   A0A194Q7R1   A0A1Z2RRI8   A0A3S2PF61   A0A212EWT6   A0A0C9RK51   + More
A0A232FMI1   K7IXE6   A0A2J7PZJ7   J3JTE9   V5GUY2   A0A1B6C0L4   A0A182RUZ2   A0A151XJD1   A0A182NMH1   F4X3U3   A0A182Q739   A0A3L8DXW6   A0A026WNE4   A0A182M6W2   A0A182Y2X4   A0A158P050   A0A0P6J107   D2A0Q9   E2A3X9   A0A195E0P7   A0A195F1N3   A0A067RE05   A0A182PPA5   U5ES10   A0A182FE41   A0A195BFJ9   A0A084W2Q5   A0A2M4BHQ0   A0A1Y1KN64   W5JFW5   A0A182VKC9   A0A182IN15   A0A2M3Z244   A0A182XM95   A0A195CA52   A0A182WMD0   A0A182I230   A0A182GB59   A0A2A3E9F3   A0A2M4A6L1   A0A182TP92   Q7Q6E7   A0A2M4A6I3   A0A0B4J2M5   A0A182JRN1   A0A310SP62   A0A0A9WLX0   B0VZ76   R4WSM6   A0A1Q3FI44   T1DPN1   A0A0T6B555   A0A154NWP3   A0A182KPU7   A0A0L7QW90   J9JTH9   A0A0P4VSJ0   T1HF19   A0A2R5LJQ2   A0A0C9Q061   A0A1L8E0P0   A0A336KS65   A0A336M9M1   A0A224XDK6   A0A0V0G5A3   A0A2S2QCW4   Q171U3   E0VBI1   A0A1W4WSQ7   A0A2M4BIZ2   A0A1W4X2C3   A0A023FAJ2   W8BP19   A7RNA5   A0A1Z5KUI9   B3N6T6   A0A1S3HNC5   E2BZN2   B4NX17   A0A1I8NP62   Q7JWF1   A0A034VR82   B4HMA2   A0A2B4SE12   A0A0L0BTW1   A0A1J1ITA4   T1P906   A0A0P6CVR2   A0A1D2MYL7   A0A0K8VCZ2   A0A3B0J4R6   A0A0J9R992   A0A1I8MF92   A0A091KYP4  

PDB

2GMJ     E-value=0,     Score=1926

KEGG

101743256    K00311 electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1] | (RefSeq) electron transfer fl

GO

GO:0004174   GO:0016021   GO:0009055   GO:0051539   GO:0043783   GO:0048039   GO:0031305   GO:0022904   GO:0006635   GO:0005739   GO:0005743   GO:0006119   GO:0004148   GO:0045454   GO:0050660   GO:0005623   GO:0051536   GO:0016491   GO:0006468   GO:0003676   GO:0006182   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR10617  

Length:

576

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0611100000000001

Exp number, first 60 AAs:

0.0067

Total prob of N-in:

0.00402

outside

1  -  576

 

 

Pi

238.844172

Theta

177.302851

Tajima's D

1.770648

CLR

0.645873

CSRT

0.840857957102145

Interpretation

Uncertain