Gene

KWMTBOMO08445  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009402

Annotation

MESH_BOMMO_RecName:_Full%3DProtein_mesh

Location

Bomo_Chr14(-):9314874-9332261      View in EpiBrowser

Full name

Protein mesh      

Location in the cell

PlasmaMembrane   Reliability : 1.922

CDS

ATGGGCTCGACGACCTACCAGAACAATGGACAGCCATACGTCATCACCACCCAGCGCCTGCAGCAGATCCGCTCCAATTTTATGTACTGGTTCTACGATCAAGGAGGCAGCGATAACATCGGTGACTACCAGAGAGACATACACACTTCCACGCCGCAGATTCACAAGAATTTCAACTTTCAACTGCCATTCTTTGGGTTCAGATTCAATTACACAAGGATCTCGATGAATGGGTACATTTACTTCAGTGACCCCCCAGACCACTACACCTACCCATTGTCGTTTCCCGTGCGAGACTGGCCGAATATCAACGATCCTTCTTTCATAGGGATATTCTTCAGCAAGTGTCGTATTGGTAACATGAGACCCGAAGAGCCTGATCCGAGAAGACCTGGAATATACTTCAGATTGGACAGAGACTTACAGACACGTACGGACCAACTGGGAGTCGAGATGCGAGAACGCGTGACGTGGGACATCCGTGAGGGCGTCATCGGCTCTGAGACCTTCTTCCCGAAACATACAATAACGATCACGTGGAAGAACATGTCGTTTGCCGGCGGTATTGACAACTCGCTGTTTATGACAAACACATTCCAAATGGTTCTAGCAACGGATGAAGTCTTCACTTATGCGATTTTCAATTATCTCGAAATAAATTGGAGTTCTCACACTGAAGCTGGCGGAGACACCACTACCGGTGAAGGAGGCATACCGGCCTATATTGGCTTCAACGCTGGTAACGGGACACGAAGTTACGAATACAAACCGTATTCTCAAGCTTCTGTGCTTCGAGATTTGACCGGCAGAGGCTGGGCCAATGGCTTTCCAGGGCGACACATATTCAGAATTGACGAGAATATACTAATGGGCACTTGTAATAAGGATATCGACGGCGCCAACCTGCCCCTGATGTTTGCGCCAGAGAGTGGTAACATGCTCGGCGGCACAATCGTCAATATCACGGGTCCATGCTTCAATCCCAACGATAGAATAACGTGCAGATTCGATACAGAATCCGTTCTCGGAGCTGTTGTGGACGTCAACAGGGCTATCTGTGTGCAACCAAGATTCTGGCACAATGGTTACGCAAGATTTGAAGTTGCCATTAACAATGAACCTTATAAATGGAAAGGAAGATATTTTGTTGAAACCCCTGCGACCGCAACCGAAAAGATATTTTTCCCAGATAATTCTGTACACGAAAGATATCCCCCAGAAGTCCGAATAACTTGGGACCGATTTAATCTGACAACAAACCTAAACGTTCAGCTCCAAATCAGTTTGTGGGGCTACAAAGAAGTCACGATCCGACCTCAATTAGAATACATCGATATGATAGAAGTCGGAGTTGCGAACACCGGTGAATACGTGATAAATCCACAAAATTTCCGGAACAGGGAAAACATCATGCACAACGACATGCAATTCGGTTTTCTGCAAATCAATTTGACCACTCCCGAAGTATTCAAAGGGGTTCCTATATCTCCGATTCTATGGAGTCGTCCGATCCCACTAGGTTGGTATTTCGCCCCACAGTGGGAAAGGCTTCACGGACAGCGCTGGTCGAACTCCATGTGTAACAACTGGCTTCGAACCGATCGTTTCCTTAAGAACTTTGCAGCTCAAGTTTGGGTCTGCCCCTGTACTTTGGAACACGCGCTTCTTGATAAAGGTCGCTTCATGCCGGACTTGGACTGCGACAGAGACACGAACCCTACTTGTAGATATCATTGGGGTGGTATTCATTGCGTCAGGAGTGGTGCTCCAAGTTCGGAAGGTTCTGGCCAGCAATGCTGCTACGACAAAAACGGCTTCCTCATGTTATCCTACGACCAGATGTGGGGCTCAAAGCCGTCAAGATCTCACGATTTCGGATTTACACCTTACAACGAAGCCAATAAGGTTCCGTCGTTATCTCGCTGGTTCCACGACATGATTCCGTTCTATCAATGTTGTTTGTGGCAAGAAGAACAAGCTGTCGGTTGCGAGACTTTCAGGTTTGAACGTCGACCGTCTCAAGACTGCGTGGCCTATCAATCTCCAGGAGTCGCGGGTATCTTCGGTGATCCACATATAGTCACCTTTGACGACCTGCAGTACACTTTCAATGGCAAAGGTGAATACGTCCTAGTGAGGGTGGATCATTCACAACTCAAGCTCGACGTTCAAGGTAGATTTGAACAGGTACCAAGAAATATTCACGGTGCGGTCAACGCGACACACTTAACGTCAGTCGTAGCAGCGTCCAACAACTCTCAAACCATTGAGGTACGCCTTCGACCACAACACGCTCAGTGGAGGTACAGGCTCGATGTTTTCGCCAATGGCAAGAGAGTCTACTTCGACAGGACTGCACTAAGAGTACAATATTTCCCAGGTGTCACCGTGTACCAGCCTATGTACGTCCTAAACCAGTCGGAAATCGTCGTTATGTTCTCGTCTGGGGCCGGATTGGAAGTAGTCGAGAATCGCGGCTTCATGACTGCGAGAGTTTATTTACCATGGACGTTTATGAATCAAACTCGAGGATTATTCGGCAACTGGTCTCTGGATGTGAACGATGACTTCACAAGACCCGATGGCACGCTGGCATCGGTCGATCTGAACAATTTCCAATCCGCCCACAGAGATTTTGCACAGCACTGGCAACTCACAGATCGTGAGCAACGGGACATCGGCGTGGCGATGTTCGTTAGAGAATATGGTCGGACGGCGGCTTATTACAACGACAATGAATTTATACCGAACTTCATACGAGAACCGGCGAACTTCTTGCCGGTGAACCGTTCTCACGACGTGACGAGAGCTATCGAGATATGCCAAGATTCTTATCAGTGTCGATACGATTACGGCATGACCCTCAATCGGGATATGGCTGAATTTACGAAGAATTATCTCTCATCGATTACTAATATAAAAGAGCAGAACGCAAGGCGGGTCATCAGTTGCGGTATTCTGGAGACGCCACGTTTTGGAAGAAAGAGTAACTTCTTCTTCACGCCTGGAACCAGGGTAAACTTCGAATGTAATCAAGACTTCATTCTGACCGGGGACAAAAGACGAGTGTGTGAAGACAACGGCAGATGGAATCTCCCTGACTATGGATACACAGAGTGTCTACGTCAACAGGAATTCTCCCAACGTGCCCTATTCCTAACTTGGGGCGTCATAGTGGCAGTTATTCTACCATTAGGCCTCTTGATTTGCCTCCTCTGGTTCTGGTGCTGGCACAAACCAAGGTCCGAGGGCAAGGAGGGCTTCCGTTTCGAAGACTTACCGCGTTCAAAATCCGCATCTAGATTAAATCTTAGGTCTTCGTCAATGGGAAATATCACAGACACTATGAAATCTTCGACGATACCCGGTTCTGAGAAAAAATCCCCCGAAACCCCTACTGAGGAAACCCCGGCCAGGATAGTAGGCAGGTCAGTCCTCGCTCCTCCCGCGGACGGAGACAGCTCAGGAATAGGCTACCCAGACTCTGGCAAAAGTGATTCCGGTAAATCTGACAAGTCCTCCGGTCTGCCTAAAAAGCGTAGGGCTTACGATAAAACATATCGTACCAATGAGCCATTACCGAATGCACCCGATGTAGAATTCCCAGAAAAACTATGGGATCTGTCCGAGGAAGACTTGTTGTCACTGACTTCACCATCAGATTCTGAATCTAATAGAGATTCCACTCTAACTCGTCCGGCTAAAGACATACAGTATCTAAACAAACCGCGACAAACCGGTCGTCAGGCCATACCGTCCGACTCAGGCTATTCCACGAAGGAGGGATCTGAGGATCCTTACGCGCCGAAATTCGACGACCAATACAGTCCAATACCTTCTCAGTATTCTCCCACGTACTCTGAAATTTATTCGCCTCCAATCAGCCCGGCCTCCGATTCGAGTCCCCGGAATACATATAATAATCCCGGCATTCCCGAAGCACCTAAAAGCGCCCCTGTTGATGGCATTAAAACTTTTACCATGCCAACGAACAAGGGTAAACAGGAGTACTCGTCTCGGACTCTTGGTGCGACATGGGGCATCATTAGTGCTGTGATGCTGCCAATTATAATAATCTTAATCTGCGTCGCTTGGAGGATCTTGCAGAGGCGGAAAGCTGAAGAAAGAGAAGAAAACGAATTCTTGGATGTGAAGACCCGTGCAATCGATCCTGACGATTCAGTTAAAGTGACTTCAGACGATGAAAGCATTCCTTACAAGAAAGACGTAACAGAAGAGACGCCTGAGCCCACAGAAGGCGTCCAGGCGGTGGAACCCTCCAATCCGAACTACAATTACGGTCGCCCCTACGTTGACCTCCAACCGGGACAACCGAGGCAATGGGGTGGAGAAACTGAAATTAATTAA

Protein

MGSTTYQNNGQPYVITTQRLQQIRSNFMYWFYDQGGSDNIGDYQRDIHTSTPQIHKNFNFQLPFFGFRFNYTRISMNGYIYFSDPPDHYTYPLSFPVRDWPNINDPSFIGIFFSKCRIGNMRPEEPDPRRPGIYFRLDRDLQTRTDQLGVEMRERVTWDIREGVIGSETFFPKHTITITWKNMSFAGGIDNSLFMTNTFQMVLATDEVFTYAIFNYLEINWSSHTEAGGDTTTGEGGIPAYIGFNAGNGTRSYEYKPYSQASVLRDLTGRGWANGFPGRHIFRIDENILMGTCNKDIDGANLPLMFAPESGNMLGGTIVNITGPCFNPNDRITCRFDTESVLGAVVDVNRAICVQPRFWHNGYARFEVAINNEPYKWKGRYFVETPATATEKIFFPDNSVHERYPPEVRITWDRFNLTTNLNVQLQISLWGYKEVTIRPQLEYIDMIEVGVANTGEYVINPQNFRNRENIMHNDMQFGFLQINLTTPEVFKGVPISPILWSRPIPLGWYFAPQWERLHGQRWSNSMCNNWLRTDRFLKNFAAQVWVCPCTLEHALLDKGRFMPDLDCDRDTNPTCRYHWGGIHCVRSGAPSSEGSGQQCCYDKNGFLMLSYDQMWGSKPSRSHDFGFTPYNEANKVPSLSRWFHDMIPFYQCCLWQEEQAVGCETFRFERRPSQDCVAYQSPGVAGIFGDPHIVTFDDLQYTFNGKGEYVLVRVDHSQLKLDVQGRFEQVPRNIHGAVNATHLTSVVAASNNSQTIEVRLRPQHAQWRYRLDVFANGKRVYFDRTALRVQYFPGVTVYQPMYVLNQSEIVVMFSSGAGLEVVENRGFMTARVYLPWTFMNQTRGLFGNWSLDVNDDFTRPDGTLASVDLNNFQSAHRDFAQHWQLTDREQRDIGVAMFVREYGRTAAYYNDNEFIPNFIREPANFLPVNRSHDVTRAIEICQDSYQCRYDYGMTLNRDMAEFTKNYLSSITNIKEQNARRVISCGILETPRFGRKSNFFFTPGTRVNFECNQDFILTGDKRRVCEDNGRWNLPDYGYTECLRQQEFSQRALFLTWGVIVAVILPLGLLICLLWFWCWHKPRSEGKEGFRFEDLPRSKSASRLNLRSSSMGNITDTMKSSTIPGSEKKSPETPTEETPARIVGRSVLAPPADGDSSGIGYPDSGKSDSGKSDKSSGLPKKRRAYDKTYRTNEPLPNAPDVEFPEKLWDLSEEDLLSLTSPSDSESNRDSTLTRPAKDIQYLNKPRQTGRQAIPSDSGYSTKEGSEDPYAPKFDDQYSPIPSQYSPTYSEIYSPPISPASDSSPRNTYNNPGIPEAPKSAPVDGIKTFTMPTNKGKQEYSSRTLGATWGIISAVMLPIIIILICVAWRILQRRKAEEREENEFLDVKTRAIDPDDSVKVTSDDESIPYKKDVTEETPEPTEGVQAVEPSNPNYNYGRPYVDLQPGQPRQWGGETEIN

Description

May be required for the proper organization of smooth septate junctions and for the barrier function of the midgut epithelium.
Required, together with Ssk and Tsp2A, for the proper organization of smooth septate junctions (sSJs), probably by mediating cell adhesion via its homophilic interaction (PubMed:22854041, PubMed:26848177). Also required for the correct subcellular localization of several sSJ components, such as Ssk, cora and l(2)gl, and for the barrier function of the midgut epithelium (PubMed:22854041). Required for maintaining the three-layered structure of the proventriculus (PubMed:22854041).

Subunit

Forms a complex with Ssk and Tsp2A (PubMed:26848177). Interacts with Ssk; the interaction may be necessary for the localization of both proteins to the cell apicolateral region (PubMed:22854041).

Keywords

Cell junction   Cell membrane   Complete proteome   Disulfide bond   Membrane   Phosphoprotein   Reference proteome   Signal   Sushi   Transmembrane   Transmembrane helix   Alternative splicing   Cell adhesion   Developmental protein   Glycoprotein  

Feature

chain  Protein mesh
splice variant  In isoform 2.

Uniprot

H9JIQ1   A0A0N1IBZ5   A0A0N0PAJ1   A0A2A4JZQ1   A0A212FC21   A0A1E1WKK5   + More
A0A1E1WUZ1   A0A2A4K0U0   A0A1S4FAM4   A0A1S4FAU2   A0A1L8DPS8   A0A1L8DPH4   Q17A21   Q17A20   A0A182G1X8   A0A0L7KX63   K7J8G5   A0A1Q3FIW5   A0A1Q3FJ17   A0A1Q3FJ00   A0A1Q3FJ26   A0A084VQK1   A0A336M1P2   A0A182P7W7   B0XCS0   A0A182IA85   A0A182JSU7   A0A182UY80   Q7QFL4   A0A182FIZ9   A0A182QHW0   A0A1S4G989   A0A182W4P0   A0A182JG23   A0A1J1HSW6   A0A182MJE9   A0A182RBH7   W5JLJ6   A0A1J1HSV2   A0A336M555   A0A0M9A432   A0A1W4X666   A0A1W4XFP3   A0A1W4XGL2   A0A2H8TDI6   J9JV68   A0A2S2QM76   A0A182Y7J4   A0A0C9QJR1   A0A151I9C3   A0A182N115   A0A1B6DF11   A0A1B6ECQ7   A0A2A3ETZ4   A0A0L0BY61   E2AP22   A0A088AMW9   F4X0V1   A0A151HZ41   A0A158N9E9   E2BB29   A0A1Y1KJZ8   A0A026WGR5   A0A067RID9   A0A1A9WZ27   T1PGP1   A0A195E220   A0A151JV66   A0A1L8EAD8   E0VDP6   A0A1I8P1Y8   A0A224XA01   A0A1I8P260   A0A1L8EHL7   A0A1B0FP21   T1PEZ0   A0A151X2L5   A0A1Y1KK87   T1PEU8   T1PHE4   A0A1L8EAN0   A0A034UZJ8   A0A1L8EA36   B4K6G9   A0A1W4U686   A0A1I8M7B4   A0A1W4UHW4   A0A1W4UHZ5   A0A3B0JKH5   B4HZZ6   A0A3B0JEL6   A0A0K8WM51   B3P7S3   B4M5V3   A0A3B0JJ83   Q0KHY3   Q0KHY3-1   I5AMT6  

Pubmed

19121390    22854041    26354079    22118469    17510324    26483478    + More
26227816    20075255    24438588    12364791    20920257    23761445    25244985    26108605    20798317    21719571    21347285    28004739    24508170    30249741    24845553    20566863    25348373    17994087    25315136    10731132    12537572    12537569    17893096    18327897    26848177    15632085   

EMBL

KQ459986    KPJ18828.1    KQ458751    KPJ05298.1    NWSH01000337    PCG77289.1    + More
AGBW02009237    OWR51289.1    GDQN01003663    JAT87391.1    GDQN01000270    JAT90784.1    PCG77290.1    GFDF01005729    JAV08355.1    GFDF01005728    JAV08356.1    CH477341    EAT43085.1    EAT43086.1    JXUM01039553    KQ561209    KXJ79338.1    JTDY01004823    KOB67705.1    GFDL01007495    JAV27550.1    GFDL01007527    JAV27518.1    GFDL01007478    JAV27567.1    GFDL01007517    JAV27528.1    ATLV01015219    KE525003    KFB40245.1    UFQT01000418    SSX24154.1    DS232716    EDS45087.1    APCN01001132    AAAB01008846    EAA06289.5    AXCN02001386    CVRI01000020    CRK91151.1    AXCM01001653    ADMH02001211    ETN63649.1    CRK91152.1    UFQT01000413    SSX24083.1    KQ435740    KOX76807.1    GFXV01000325    MBW12130.1    ABLF02029367    ABLF02029368    GGMS01009437    MBY78640.1    GBYB01015053    JAG84820.1    KQ978285    KYM95672.1    GEDC01013076    JAS24222.1    GEDC01013156    GEDC01001644    JAS24142.1    JAS35654.1    KZ288190    PBC34521.1    JRES01001160    KNC24960.1    GL441439    EFN64854.1    GL888503    EGI59893.1    KQ976712    KYM77000.1    ADTU01009566    GL446901    EFN87120.1    GEZM01081254    JAV61733.1    KK107214    QOIP01000005    EZA55257.1    RLU22395.1    KK852614    KDR20197.1    KA647310    AFP61939.1    KQ979814    KYN18949.1    KQ981740    KYN36512.1    GFDG01003175    JAV15624.1    DS235083    EEB11502.1    GFTR01008692    JAW07734.1    GFDG01000592    JAV18207.1    CCAG010007645    CCAG010007646    KA647311    AFP61940.1    KQ982572    KYQ54687.1    GEZM01081253    JAV61734.1    KA647312    AFP61941.1    KA647313    AFP61942.1    GFDG01003176    JAV15623.1    GAKP01022511    JAC36441.1    GFDG01003202    JAV15597.1    CH933806    EDW16269.2    OUUW01000005    SPP80822.1    CH480819    EDW53603.1    SPP80824.1    GDHF01000101    JAI52213.1    CH954182    EDV52981.1    CH940652    EDW59029.2    SPP80823.1    AE014297    BT032891    BT133164    BT011360    AY122109    CM000070    EIM52271.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000218220    UP000007151    UP000008820    + More
UP000069940    UP000249989    UP000037510    UP000002358    UP000030765    UP000075885    UP000002320    UP000075840    UP000075881    UP000075903    UP000007062    UP000069272    UP000075886    UP000075920    UP000075880    UP000183832    UP000075883    UP000075900    UP000000673    UP000053105    UP000192223    UP000007819    UP000076408    UP000078542    UP000075884    UP000242457    UP000037069    UP000000311    UP000005203    UP000007755    UP000078540    UP000005205    UP000008237    UP000053097    UP000279307    UP000027135    UP000091820    UP000078492    UP000078541    UP000009046    UP000095300    UP000092444    UP000075809    UP000009192    UP000192221    UP000095301    UP000268350    UP000001292    UP000008711    UP000008792    UP000000803    UP000001819   

PRIDE

H9JIQ1    Q0KHY3   

Pfam

PF06119   NIDO        + More
PF03782   AMOP
PF00094   VWD
PF00084   Sushi
PF01833   TIG
PF04388   Hamartin

Interpro

IPR013783   Ig-like_fold        + More
IPR014756   Ig_E-set       
IPR005533   AMOP_dom       
IPR035976   Sushi/SCR/CCP_sf       
IPR003886   NIDO_dom       
IPR001846   VWF_type-D       
IPR000436   Sushi_SCR_CCP_dom       
IPR002909   IPT_dom       
IPR016024   ARM-type_fold       
IPR007483   Hamartin       

SUPFAM

SSF57535   SSF57535        + More
SSF81296   SSF81296       
SSF48371   SSF48371       

Gene 3D

2.60.40.10    

CDD

cd00033  CCP

ProteinModelPortal

H9JIQ1   A0A0N1IBZ5   A0A0N0PAJ1   A0A2A4JZQ1   A0A212FC21   A0A1E1WKK5   + More
A0A1E1WUZ1   A0A2A4K0U0   A0A1S4FAM4   A0A1S4FAU2   A0A1L8DPS8   A0A1L8DPH4   Q17A21   Q17A20   A0A182G1X8   A0A0L7KX63   K7J8G5   A0A1Q3FIW5   A0A1Q3FJ17   A0A1Q3FJ00   A0A1Q3FJ26   A0A084VQK1   A0A336M1P2   A0A182P7W7   B0XCS0   A0A182IA85   A0A182JSU7   A0A182UY80   Q7QFL4   A0A182FIZ9   A0A182QHW0   A0A1S4G989   A0A182W4P0   A0A182JG23   A0A1J1HSW6   A0A182MJE9   A0A182RBH7   W5JLJ6   A0A1J1HSV2   A0A336M555   A0A0M9A432   A0A1W4X666   A0A1W4XFP3   A0A1W4XGL2   A0A2H8TDI6   J9JV68   A0A2S2QM76   A0A182Y7J4   A0A0C9QJR1   A0A151I9C3   A0A182N115   A0A1B6DF11   A0A1B6ECQ7   A0A2A3ETZ4   A0A0L0BY61   E2AP22   A0A088AMW9   F4X0V1   A0A151HZ41   A0A158N9E9   E2BB29   A0A1Y1KJZ8   A0A026WGR5   A0A067RID9   A0A1A9WZ27   T1PGP1   A0A195E220   A0A151JV66   A0A1L8EAD8   E0VDP6   A0A1I8P1Y8   A0A224XA01   A0A1I8P260   A0A1L8EHL7   A0A1B0FP21   T1PEZ0   A0A151X2L5   A0A1Y1KK87   T1PEU8   T1PHE4   A0A1L8EAN0   A0A034UZJ8   A0A1L8EA36   B4K6G9   A0A1W4U686   A0A1I8M7B4   A0A1W4UHW4   A0A1W4UHZ5   A0A3B0JKH5   B4HZZ6   A0A3B0JEL6   A0A0K8WM51   B3P7S3   B4M5V3   A0A3B0JJ83   Q0KHY3   Q0KHY3-1   I5AMT6  

KEGG

101741952    no KO assigned | (RefSeq) protein mesh

GO

GO:0007160   GO:0016021   GO:0005918   GO:0016328   GO:0090528   GO:0005920   GO:0007275   GO:0016327   GO:0005524   GO:0006468   GO:0003676   GO:0006182   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Membrane  
Cell junction  
Septate junction  
Lateral cell membrane  
Apicolateral cell membrane  

Length:

1455

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

45.88227

Exp number, first 60 AAs:

0.0015

Total prob of N-in:

0.00350

outside

1  -  1052

TMhelix

1053  -  1075

inside

1076  -  1341

TMhelix

1342  -  1364

outside

1365  -  1455

 

 

Pi

251.634775

Theta

191.91587

Tajima's D

1.037677

CLR

0.342809

CSRT

0.669216539173041

Interpretation

Uncertain