Gene

KWMTBOMO08415

Pre Gene Modal

BGIBMGA009300

Annotation

PREDICTED:_soluble_guanylyl_cyclae_alpha-1_subunit_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr14(+):8400993-8409996      View in EpiBrowser

Full name

Head-specific guanylate cyclase      

Alternative Name

Gycalpha99B

Location in the cell

Cytoplasmic   Reliability : 3.163

CDS

ATGGTGTTCCCTATGTTCTGTTTTCTCCTACAGGGCTTAGAAATAAAGGGCCAAATGGTGTTTTGTTCCGAATCGGATTCCCTTCTCTTCGTGGGCTCTCCGTTCCTTGATGGACTTGAAGGCTTAACTGGGAGAGGCCTTTTCATATCAGATATTCCACTCCACGATGCAACAAGGGATGTCATTCTAGTGGGAGAACAGGCTCGGGCACAGGACGGACTTCGAAGGCGTATGGACAAACTTAAGAACTCAATCGAAGAAGCAAGTAAAGCGGTAGACAAAGAGCGCGAGAAGAATGTCAGTCTTCTGCATTTAATATTCCCACCTCACATCGCTAAAAGGCTGTGGCTAGGTGAGAAGATAGAAGCGAAAAGCCACGATGACGTCACAATGCTGTTCAGTGACATCGTCGGCTTCACATCCATCTGTGCTACTGCAACACCGATGATGGTTATTGCGATGCTGGAGGATCTGTACAGCGTATTTGATATATTCTGTGAGGAGCTTGACGTTTATAAGGTGGAAACAATAGGTGATGCATATTGCGTTGCAAGTGGCTTACACCGCAAAATCGAGACGCACGCACCCCAGATCGCATGGATGGCGTTACGCATGGTCGAAACATGCGCACAGCATTTGACGCATGAAGGAAATCCCATCAAGATGCGCTTAGGACTGCATACTGGTACAGTACTAGCCGGGGTCGTCGGTAAAACTATGCAGAAATACTGCCTTTTCGGTCATAACGTGACCCTTGCAAATAAATTTGAATCCGGCTCAGAACCACTGAAGATCAACGTCAGTCCCACCACTTACGAGTGGCTAATACAATTCCCGGGCTTCGAAATGGAATCGCGAGACCGTTCCTGTCTCCCGAATTCATTCCCCAAGGACATCCCGGGAACATGTTATTTCCTTCACAAGTACGTACACCCGGGAACGGACCCTGCGGCGTCCCAGGTCAAACATATACAGGATGCGTTAAAATATTATGAAATAGGACAATTCGGACAAAGTAATCCAGTTGAAAATGACCCGGAGCCAACATAG

Protein

MVFPMFCFLLQGLEIKGQMVFCSESDSLLFVGSPFLDGLEGLTGRGLFISDIPLHDATRDVILVGEQARAQDGLRRRMDKLKNSIEEASKAVDKEREKNVSLLHLIFPPHIAKRLWLGEKIEAKSHDDVTMLFSDIVGFTSICATATPMMVIAMLEDLYSVFDIFCEELDVYKVETIGDAYCVASGLHRKIETHAPQIAWMALRMVETCAQHLTHEGNPIKMRLGLHTGTVLAGVVGKTMQKYCLFGHNVTLANKFESGSEPLKINVSPTTYEWLIQFPGFEMESRDRSCLPNSFPKDIPGTCYFLHKYVHPGTDPAASQVKHIQDALKYYEIGQFGQSNPVENDPEPT

Description

May have a role in phototransduction. A second subunit may be required for enzyme activity.

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Subunit

Dimer.

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

cGMP biosynthesis   Complete proteome   Cytoplasm   GTP-binding   Lyase   Nucleotide-binding   Reference proteome   Sensory transduction   Vision  

Feature

chain  Head-specific guanylate cyclase

Uniprot

H9JIF0   A0A2A4K9R7   A0A0N0PA12   A0A0N1I9V6   O77105   A0A437BH12   + More
F8WS79   A0A212EUS7   A0A0L7LB52   D1ZZC5   F5HSB9   A0A067QTW8   A0A1Y1KL30   A0A1Y1KNE3   A0A1B6HW21   A0A0C9RY60   A0A1B6F0N5   A0A232EH27   K7J3A4   A0A026WHV8   A0A1D2NMJ9   A0A1S4E8I9   E2BB35   E2AP14   A0A3L8DQ36   A0A158N9E4   A0A2S2PET4   F4WJW0   A0A2H8TI48   J9K5C7   A0A151JZH4   T1HN04   A0A195CGS2   A0A2S2Q520   A0A088AMV1   Q5W7P2   A0A2A3ES47   E9FT53   A0A195BGN4   A0A154PR62   A0A151XI26   A0A195E615   W8B6M7   A0A1A9WB53   A0A0L0CEM3   Q7YZQ2   A0A0K8VIW2   A0A034WES2   A0A0A1XFX4   A0A1A9VYA9   A0A0P5KT04   A0A1B6CQ32   A0A164LKH5   A0A1A9Y948   A0A1B0AGI7   B4NBJ6   A0A1B0FR75   A0A1I8Q0Y3   A0A1I8N3V3   A0A084VNW7   A0A182JIE4   A0A182QMV2   T1P7Y8   A0A182MG85   A0A182N8F9   A0A182PSU5   W5JKG2   A0A182FIT2   B0WSU5   A0A182KEJ3   Q17L76   A0A182W5M0   A0A182T0S2   A0A0L7R5P2   A0A1S4EYY2   A0A182TFT6   A0A182XBY3   F5HJM4   A0A182UNC6   Q7QF31   A0A182IAK2   A0A182HD00   A0A1Q3FZX7   A0A182RHK6   A0A1B0GK38   A0A182KLP8   A0A0P6H817   A0A182YH65   A0A1B0C539   A0A147BLC7   A0A0M4EI23   B3P5F2   B4R067   A0A3B0JKP3   A0A1W4UPX8   B4PPM5   B3MTG6   H5V8C6   Q07093  

EC Number

4.6.1.2

Pubmed

19121390    26354079    9736646    23934793    22118469    26227816    + More
18362917    19820115    24845553    28004739    28648823    20075255    24508170    27289101    20798317    30249741    21347285    21719571    21292972    24495485    26108605    25348373    25830018    17994087    25315136    24438588    20920257    23761445    17510324    12364791    14747013    17210077    26483478    20966253    25244985    29652888    17550304    8095978    7797526    10731132    12537572    12537569   

EMBL

BABH01022496    BABH01022497    BABH01022498    NWSH01000007    PCG80971.1    KQ459256    + More
KPJ02078.1    KQ460472    KPJ14572.1    AF062750    AAC61263.1    RSAL01000059    RVE49671.1    AB645768    BAK52272.1    AGBW02012298    OWR45245.1    JTDY01001858    KOB72703.1    KQ971338    EFA02348.1    AB630170    BAK23250.1    KK853463    KDR07447.1    GEZM01084965    JAV60365.1    GEZM01084963    JAV60367.1    GECU01028870    JAS78836.1    GBYB01014205    JAG83972.1    GECZ01025950    JAS43819.1    NNAY01004604    OXU17667.1    KK107214    EZA55251.1    LJIJ01000004    ODN06500.1    GL446901    EFN87126.1    GL441439    EFN64846.1    QOIP01000005    RLU22481.1    ADTU01009527    ADTU01009528    GGMR01015296    MBY27915.1    GL888187    EGI65482.1    GFXV01001914    MBW13719.1    ABLF02027805    ABLF02027806    ABLF02027807    ABLF02027808    ABLF02027809    ABLF02029742    ABLF02029743    ABLF02029745    KQ981404    KYN41941.1    ACPB03002869    KQ977791    KYM99935.1    GGMS01003625    MBY72828.1    AB193550    BAD66824.1    KZ288190    PBC34527.1    GL732524    EFX89707.1    KQ976476    KYM83831.1    KQ435066    KZC14382.1    KQ982093    KYQ60049.1    KQ979592    KYN20608.1    GAMC01013862    JAB92693.1    JRES01000501    KNC30705.1    AY324653    AAP85539.1    GDHF01013483    JAI38831.1    GAKP01004871    JAC54081.1    GBXI01004446    JAD09846.1    GDIQ01185249    JAK66476.1    GEDC01021686    JAS15612.1    LRGB01003123    KZS04198.1    CH964232    EDW81160.1    CCAG010005441    ATLV01014933    KE524996    KFB39661.1    AXCN02002153    KA644667    AFP59296.1    AXCM01005054    ADMH02001274    ETN63264.1    DS232076    EDS34055.1    CH477218    EAT47419.1    KQ414648    KOC66207.1    AAAB01008846    EGK96485.1    EAA06502.5    APCN01001259    JXUM01034566    KQ561028    KXJ79976.1    GFDL01001965    JAV33080.1    AJWK01022543    GDIQ01023305    JAN71432.1    JXJN01025806    JXJN01025807    JXJN01025808    JXJN01025809    JXJN01025810    GEGO01003811    JAR91593.1    CP012526    ALC46196.1    CH954182    EDV53202.1    CM000364    EDX14873.1    OUUW01000007    SPP82897.1    CM000160    EDW98275.1    CH902623    EDV30556.1    BT133227    AFA36410.1    S57126    U27117    AE014297    AY060654   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000283053    UP000007151    + More
UP000037510    UP000007266    UP000027135    UP000215335    UP000002358    UP000053097    UP000094527    UP000079169    UP000008237    UP000000311    UP000279307    UP000005205    UP000007755    UP000007819    UP000078541    UP000015103    UP000078542    UP000005203    UP000242457    UP000000305    UP000078540    UP000076502    UP000075809    UP000078492    UP000091820    UP000037069    UP000078200    UP000076858    UP000092443    UP000092445    UP000007798    UP000092444    UP000095300    UP000095301    UP000030765    UP000075880    UP000075886    UP000075883    UP000075884    UP000075885    UP000000673    UP000069272    UP000002320    UP000075881    UP000008820    UP000075920    UP000075901    UP000053825    UP000075902    UP000076407    UP000007062    UP000075903    UP000075840    UP000069940    UP000249989    UP000075900    UP000092461    UP000075882    UP000076408    UP000092460    UP000092553    UP000008711    UP000000304    UP000268350    UP000192221    UP000002282    UP000007801    UP000000803   

PRIDE

H9JIF0    F8WS79    H5V8C6    Q07093   

Pfam

PF00211   Guanylate_cyc        + More
PF07701   HNOBA
PF07700   HNOB
PF00149   Metallophos

Interpro

IPR001054   A/G_cyclase        + More
IPR011645   HNOB_dom_associated       
IPR029787   Nucleotide_cyclase       
IPR018297   A/G_cyclase_CS       
IPR038158   H-NOX_domain_sf       
IPR024096   NO_sig/Golgi_transp_ligand-bd       
IPR011644   Heme_NO-bd       
IPR004843   Calcineurin-like_PHP_ApaH       
IPR008139   SaposinB_dom       
IPR029052   Metallo-depent_PP-like       
IPR011001   Saposin-like       
IPR041805   ASMase/PPN1_MPP       

SUPFAM

SSF55073   SSF55073        + More
SSF111126   SSF111126       
SSF47862   SSF47862       

Gene 3D

3.30.70.1230     3.90.1520.10     3.60.21.10    

CDD

cd00842  MPP_ASMase

ProteinModelPortal

H9JIF0   A0A2A4K9R7   A0A0N0PA12   A0A0N1I9V6   O77105   A0A437BH12   + More
F8WS79   A0A212EUS7   A0A0L7LB52   D1ZZC5   F5HSB9   A0A067QTW8   A0A1Y1KL30   A0A1Y1KNE3   A0A1B6HW21   A0A0C9RY60   A0A1B6F0N5   A0A232EH27   K7J3A4   A0A026WHV8   A0A1D2NMJ9   A0A1S4E8I9   E2BB35   E2AP14   A0A3L8DQ36   A0A158N9E4   A0A2S2PET4   F4WJW0   A0A2H8TI48   J9K5C7   A0A151JZH4   T1HN04   A0A195CGS2   A0A2S2Q520   A0A088AMV1   Q5W7P2   A0A2A3ES47   E9FT53   A0A195BGN4   A0A154PR62   A0A151XI26   A0A195E615   W8B6M7   A0A1A9WB53   A0A0L0CEM3   Q7YZQ2   A0A0K8VIW2   A0A034WES2   A0A0A1XFX4   A0A1A9VYA9   A0A0P5KT04   A0A1B6CQ32   A0A164LKH5   A0A1A9Y948   A0A1B0AGI7   B4NBJ6   A0A1B0FR75   A0A1I8Q0Y3   A0A1I8N3V3   A0A084VNW7   A0A182JIE4   A0A182QMV2   T1P7Y8   A0A182MG85   A0A182N8F9   A0A182PSU5   W5JKG2   A0A182FIT2   B0WSU5   A0A182KEJ3   Q17L76   A0A182W5M0   A0A182T0S2   A0A0L7R5P2   A0A1S4EYY2   A0A182TFT6   A0A182XBY3   F5HJM4   A0A182UNC6   Q7QF31   A0A182IAK2   A0A182HD00   A0A1Q3FZX7   A0A182RHK6   A0A1B0GK38   A0A182KLP8   A0A0P6H817   A0A182YH65   A0A1B0C539   A0A147BLC7   A0A0M4EI23   B3P5F2   B4R067   A0A3B0JKP3   A0A1W4UPX8   B4PPM5   B3MTG6   H5V8C6   Q07093  

PDB

3UVJ     E-value=7.60608e-66,     Score=635

KEGG

100642185    K12318 guanylate cyclase soluble subunit alpha [EC:4.6.1.2] | (RefSeq) GC-a1; soluble guanylyl cycla

PATHWAY

00230    Purine metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004383   GO:0035556   GO:0000166   GO:0016021   GO:0020037   GO:0016829   GO:0016056   GO:0008074   GO:0046956   GO:0016787   GO:0016301   GO:0005525   GO:0007601   GO:0009190   GO:0016849   GO:0006182   GO:0016491   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  

SignalP

Position:   1 - 17,         Likelihood:  0.590325

 

 

Length:

349

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.55729

Exp number, first 60 AAs:

0.01429

Total prob of N-in:

0.01574

outside

1  -  349

 

 

Pi

253.936441

Theta

204.881293

Tajima's D

1.665669

CLR

0.314106

CSRT

0.825958702064897

Interpretation

Possibly Positive selection