Gene

KWMTBOMO08412

Pre Gene Modal

BGIBMGA009299

Annotation

soluble_guanylyl_cyclae_alpha-1_subunit_[Bombyx_mori]

Location

Bomo_Chr14(+):8342903-8387458      View in EpiBrowser

Full name

Head-specific guanylate cyclase      

Alternative Name

Gycalpha99B

Location in the cell

Nuclear   Reliability : 2.334

CDS

ATGACGTGTCCGTTCCGACGCGCCTCGTCGCAACATCAGTTCGCAAATGGCGCCGGCTCGACGAGCAAGAGGCCAGAGTTTCGTTCCCGCACTTCGTCAGTCCACCTGCCTGGCCCCGAGGAAGAAGACAACGAACGCAACACATTGACGCTTAAGCATCTAAGTGAAGCCCTGCAACTGTTAACTGCGCCTTCGAACGAGTGCTTACACGCTGCGGTAACATCTCTTACGAAGAACCAAGCGGAACACTACGACAAATACAATTGTTTACGCAGATTACCCGATGAAGTGAAGACCTGTAGAAATTATGCGTATCTCCAAGAAATCTACGACGCGGTGCGAGCGACAGACAGTGTTAGCACTAAAGATTTTATGGCGAAATTAGGAGAATATTTAATATTAACAGCGTTTTCACACAATTGCCGATTGGAGAGGGCTTTCAAATGTTTAGGCACCAATTTGACTGAATTCCTGACCACATTAGACAGTGTACATGACGTATTGCACGACCAGGACGATTCACTCAAAGACGAAACTATTGAATACGAAGCTAATTTCGTATGCACAACATCACAAGAGGGGAAGATACAACTTCATCTCACGACCGAAAGCGAGCCGGTCGCTTACCTACTGGTGGGAAGTCTTAGAGCAATAGCCCGAAGGCTGTACGATACACGGACAGATATAAGACTGATGAGCTACACCAACGACCCAAGAAGATTTAGATATGAAATAAACGCTGCCCCGCTAAACCTTAAAACCAAAGAGGAAAACTGCGATACAACGAATGAACCTGCTCCAATTGCCACGTCAACCAAAGTGACAGATCTGAAGATAGGCGTCGCCAGTTTCTGCAAAGCCTTCCCTTGGCATTTTGTTACAGATAAGCGTTTGGAACTCGTCCAGCTCGGTGGAGGTTTCATGCGTCTCTTCGGAATGCACCTCGCCTCTCATGGTTCGTCTCTCAACACGTTCTTCAGACTGCTTCGTCCTCGTGGAGTCCCCTTAGACTTCCGCGAGATACTGAAAAGGGTCAATACTCCCTTCATGTTTTGCTTGAAGATACCAGGGTCTACTTCTTTGGCTGAGACCCAGAGGCTCCAAACGATCCGAGAGAATGGGATTATCGACAATCCGAACGGCCCTCCTCTGTATGGAGTCAAATGGAAGAAGCTGGTATTTGGGAGCCCCGGCCCAGAGATGGGAGCAGTACTCCATGCGAGGCCGGACTTGTGCTTTATAAAGCAAAAGTCTTTGTCCAGGCGTGAAGTACCGCTTCGCTCTGTTGAGGACTCCCAGCATTTTGGACGCCAACTTGGCTTTGCCTTCCAAATGACTCCGAAACTGGACATCGCTCGAAACGTCGACCCCAAGTATCCCGATACTCTCGGAAGGTTGCAGGGATACTCCTTGGAATTGCGGCGCCATGACAAAGGGGTCCTTCTTCGCAGTGAACGCGCAAACTTGTGTCTTTATCGGGTTGAATTGAACCAAGTTCAATTCACCCCATTCGGAGACTCGCCCCAGAGAGTTCTCCACTTCAGACACAAGTTTTGA

Protein

MTCPFRRASSQHQFANGAGSTSKRPEFRSRTSSVHLPGPEEEDNERNTLTLKHLSEALQLLTAPSNECLHAAVTSLTKNQAEHYDKYNCLRRLPDEVKTCRNYAYLQEIYDAVRATDSVSTKDFMAKLGEYLILTAFSHNCRLERAFKCLGTNLTEFLTTLDSVHDVLHDQDDSLKDETIEYEANFVCTTSQEGKIQLHLTTESEPVAYLLVGSLRAIARRLYDTRTDIRLMSYTNDPRRFRYEINAAPLNLKTKEENCDTTNEPAPIATSTKVTDLKIGVASFCKAFPWHFVTDKRLELVQLGGGFMRLFGMHLASHGSSLNTFFRLLRPRGVPLDFREILKRVNTPFMFCLKIPGSTSLAETQRLQTIRENGIIDNPNGPPLYGVKWKKLVFGSPGPEMGAVLHARPDLCFIKQKSLSRREVPLRSVEDSQHFGRQLGFAFQMTPKLDIARNVDPKYPDTLGRLQGYSLELRRHDKGVLLRSERANLCLYRVELNQVQFTPFGDSPQRVLHFRHKF

Description

May have a role in phototransduction. A second subunit may be required for enzyme activity.

Catalytic Activity

GTP = 3',5'-cyclic GMP + diphosphate

Subunit

Dimer.

Similarity

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

cGMP biosynthesis   Complete proteome   Cytoplasm   GTP-binding   Lyase   Nucleotide-binding   Reference proteome   Sensory transduction   Vision  

Feature

chain  Head-specific guanylate cyclase

Uniprot

F8WS79   O77105   A0A0N0PA12   A0A0N1I9V6   A0A1B6EC55   A0A154PR62   + More
Q5W7P2   A0A0C9RY60   A0A0A1XFX4   K7J3A4   A0A0K8VIW2   A0A034WES2   Q7YZQ2   F5HSB9   Q29BU7   B4GPM0   B4K7X3   A0A3B0KB48   W8B6M7   A0A2A3ES47   B4R067   H5V8C6   Q07093   A0A1W4UPX8   B3P5F2   B4HZC4   B3MTG6   B4PPM5   B4NBJ6   B4M5P0   B4JH14   A0A0M4EI23   A0A1B0AGI7   A0A1B0FR75   A0A1I8Q0Y3   A0A151JZH4   A0A182KEJ3   A0A1S4EYY2   A0A1A9WB53   Q17L76   A0A182QMV2   A0A182HD00   A0A182FIT2   A0A182TFT6   F5HJM4   A0A182JIE4   A0A195CGS2   A0A084VNW7   Q7QF31   A0A182IAK2   A0A182UNC6   A0A182YH65  

EC Number

4.6.1.2

Pubmed

9736646    23934793    26354079    25830018    20075255    25348373    + More
15632085    17994087    18057021    24495485    8095978    7797526    10731132    12537572    12537569    17550304    17510324    26483478    12364791    14747013    17210077    24438588    25244985   

EMBL

AB645768    BAK52272.1    AF062750    AAC61263.1    KQ459256    KPJ02078.1    + More
KQ460472    KPJ14572.1    GEDC01001787    JAS35511.1    KQ435066    KZC14382.1    AB193550    BAD66824.1    GBYB01014205    JAG83972.1    GBXI01004446    JAD09846.1    GDHF01013483    JAI38831.1    GAKP01004871    JAC54081.1    AY324653    AAP85539.1    AB630170    BAK23250.1    CM000070    EAL26899.1    CH479186    EDW39103.1    CH933806    EDW14307.1    KRG00963.1    OUUW01000007    SPP82896.1    GAMC01013862    JAB92693.1    KZ288190    PBC34527.1    CM000364    EDX14873.1    BT133227    AFA36410.1    S57126    U27117    AE014297    AY060654    CH954182    EDV53202.1    CH480819    EDW53381.1    CH902623    EDV30556.1    CM000160    EDW98275.1    CH964232    EDW81160.1    CH940652    EDW58966.1    CH916369    EDV92705.1    CP012526    ALC46196.1    CCAG010005441    KQ981404    KYN41941.1    CH477218    EAT47419.1    AXCN02002153    JXUM01034566    KQ561028    KXJ79976.1    AAAB01008846    EGK96485.1    KQ977791    KYM99935.1    ATLV01014933    KE524996    KFB39661.1    EAA06502.5    APCN01001259   

Proteomes

UP000053268    UP000053240    UP000076502    UP000002358    UP000001819    UP000008744    + More
UP000009192    UP000268350    UP000242457    UP000000304    UP000000803    UP000192221    UP000008711    UP000001292    UP000007801    UP000002282    UP000007798    UP000008792    UP000001070    UP000092553    UP000092445    UP000092444    UP000095300    UP000078541    UP000075881    UP000091820    UP000008820    UP000075886    UP000069940    UP000249989    UP000069272    UP000075902    UP000007062    UP000075880    UP000078542    UP000030765    UP000075840    UP000075903    UP000076408   

PRIDE

F8WS79    H5V8C6    Q07093   

Pfam

PF00211   Guanylate_cyc        + More
PF07701   HNOBA
PF07700   HNOB

Interpro

IPR024096   NO_sig/Golgi_transp_ligand-bd        + More
IPR029787   Nucleotide_cyclase       
IPR011645   HNOB_dom_associated       
IPR001054   A/G_cyclase       
IPR011644   Heme_NO-bd       
IPR018297   A/G_cyclase_CS       
IPR038158   H-NOX_domain_sf       

SUPFAM

SSF55073   SSF55073        + More
SSF111126   SSF111126       

Gene 3D

3.30.70.1230     3.90.1520.10    

ProteinModelPortal

F8WS79   O77105   A0A0N0PA12   A0A0N1I9V6   A0A1B6EC55   A0A154PR62   + More
Q5W7P2   A0A0C9RY60   A0A0A1XFX4   K7J3A4   A0A0K8VIW2   A0A034WES2   Q7YZQ2   F5HSB9   Q29BU7   B4GPM0   B4K7X3   A0A3B0KB48   W8B6M7   A0A2A3ES47   B4R067   H5V8C6   Q07093   A0A1W4UPX8   B3P5F2   B4HZC4   B3MTG6   B4PPM5   B4NBJ6   B4M5P0   B4JH14   A0A0M4EI23   A0A1B0AGI7   A0A1B0FR75   A0A1I8Q0Y3   A0A151JZH4   A0A182KEJ3   A0A1S4EYY2   A0A1A9WB53   Q17L76   A0A182QMV2   A0A182HD00   A0A182FIT2   A0A182TFT6   F5HJM4   A0A182JIE4   A0A195CGS2   A0A084VNW7   Q7QF31   A0A182IAK2   A0A182UNC6   A0A182YH65  

PDB

4GJ4     E-value=2.68403e-41,     Score=425

KEGG

100642185    K12318 guanylate cyclase soluble subunit alpha [EC:4.6.1.2] | (RefSeq) GC-a1; soluble guanylyl cycla

GO

GO:0004383   GO:0020037   GO:0000166   GO:0035556   GO:0016021   GO:0046956   GO:0008074   GO:0016056   GO:0005525   GO:0007601   GO:0006182   GO:0006099   GO:0016491   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Cytoplasm  

Length:

518

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03412

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00446

outside

1  -  518

 

 

Pi

228.320369

Theta

193.747147

Tajima's D

0.445551

CLR

0.585252

CSRT

0.497725113744313

Interpretation

Uncertain