Gene

KWMTBOMO08409

Pre Gene Modal

BGIBMGA009206

Annotation

succinate_dehydrogenase?_iron-sulfur_subunit_[Danaus_plexippus]

Location

Bomo_Chr14(-):8155278-8156320      View in EpiBrowser

Full name

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial      

Alternative Name

Iron-sulfur subunit of complex II

Location in the cell

Extracellular   Reliability : 1.105 Mitochondrial   Reliability : 1.732 Nuclear   Reliability : 1.396

CDS

ATGCCTAAACTAAGCGAACGATTTCACAAAATCATCAGATTCTCTTTCAGGAACTATAGTTCGAAAACAGAAACGAAACCAAAGAAAGACGTGGACCCTTGTAGGACGTTCAAAATATATCGCTTCGGAGGTATTCTTTCAAAGGAACAACCCAAAATACAGAGCTATGAACTAGACGTTTCAACATGCGGCAAAATGGTTCTAGACGCTTTAATTAAAATAAAAGACAAGGACCCAACTCTGACGTTCCGGAGATCCTGTCGTGAAGGTATCTGCGGCTCTTGTGCGATCAACTTACAAGGAATGAACTGCTTGTCCTGCATCACTGAGATACCTCCAGCCAAGACCATCACCATACTCCCATTACCCCATATGTATGTCATCAGAGACCTGGTGGTTGACATGACACATTTTTTCAATGGCTACGATAGTATTCGACCGTATCTTGTGAGGAAAAACGATGGAGCCATTGGAAAAACTCAGTTAGCCCAAAGCATCAAAGACAATGAGAAAATGGTCGGATTATATGAGTGCGTTTTGTGCTCATGCTGTTCTACATCGTGTCCGAGTTACTGGTGGAACGGCAGGAGGTTCTTAGGCCCCGCCACGTTACTCCATGCGTATAGATGGGTCATAGATTCAAGAGACGACGACACGGAACAAAGACTGTATGAATTACGGGACAGTTTCAAAGCATTCAAATGTCACACCATCATGAACTGCTCGTTGGCTTGTCCCAAAGGCTTACATCCAGCAAAGGCTATTATGAACCTAAAAAGACTAATTTCAGGCCTAGACAAAAAACCTGTTCCAGAAATAGATCCTGGCAAGTTCAAGTCTGGCGGAGACAGTGGCAGTGGCAAAAACAAGAAATGTTGCCCATGA

Protein

MPKLSERFHKIIRFSFRNYSSKTETKPKKDVDPCRTFKIYRFGGILSKEQPKIQSYELDVSTCGKMVLDALIKIKDKDPTLTFRRSCREGICGSCAINLQGMNCLSCITEIPPAKTITILPLPHMYVIRDLVVDMTHFFNGYDSIRPYLVRKNDGAIGKTQLAQSIKDNEKMVGLYECVLCSCCSTSCPSYWWNGRRFLGPATLLHAYRWVIDSRDDDTEQRLYELRDSFKAFKCHTIMNCSLACPKGLHPAKAIMNLKRLISGLDKKPVPEIDPGKFKSGGDSGSGKNKKCCP

Description

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Catalytic Activity

a quinone + succinate = a quinol + fumarate

Cofactor

[2Fe-2S] cluster
[3Fe-4S] cluster
[4Fe-4S] cluster

Subunit

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.

Similarity

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Keywords

2Fe-2S   3Fe-4S   4Fe-4S   Complete proteome   Electron transport   Iron   Iron-sulfur   Membrane   Metal-binding   Mitochondrion   Mitochondrion inner membrane   Oxidoreductase   Reference proteome   Transit peptide   Transport   Tricarboxylic acid cycle  

Feature

chain  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Uniprot

H9JI58   A0A212EYY1   A0A0N1PJ14   A0A0N1PE48   A0A0L7LNZ8   A0A2A4JRG7   + More
A0A2H1V470   E0W3X5   A0A1Y1MTF2   A0A1A9WEH1   A0A2R7VS39   B3NB16   A0A0M5IZT2   A0A1I8M520   T1PF50   A0A0N7ZRN7   A0A0P5K0W9   A0A1A9V700   A0A1A9Z829   D3TR09   A0A3S3RLH3   A0A1A9YKJ6   A0A0P4XQR5   A0A1B0FII9   A0A1L8EH78   B4QDQ8   P21914   B4P190   B4HQC4   A0A1W4VE97   A0A0K8SDS3   A0A0A9Y4R5   A0A0P5J103   A0A0P5HKN3   A0A146L024   A0A162QUE8   A0A1B0BYT9   A0A0P5G4Q0   A0A336KDL9   A0A336MIX3   A0A0N8BEC9   A0A0P6FY31   E9GMA8   B4KNG7   B4LK89   A0A0A1WNK2   A0A0N8DAQ9   A0A224XVN4   A0A0L0CDM2   B3MIM9   A0A1B6C235   A0A1B6KLQ3   Q292X9   B4GC97   E7D1B9   B4J6T2   A0A0P6IDW0   C1BUY8   A0A034VQX5   B4MY40   A0A067RP06   C1BV23   C1C2I4   A0A0P4VKP3   A0A0K1SB10   A0A0K8UXQ3   A0A3B0J261   A0A437D5R5   W8BSL4   A0A1W4W8F1   Q4PMD5   A0A2P6K3I3   T1JTX0   T1I5F0   A0A0P4WIX1   A0A1B6GN00   V5SKI1   A0A1Y3ALC8   A0A131ZXW6   A0A3Q2XR25   A0A023F4K3   A0A336M8I4   A0A023FV34   A0A023GHH9   G3MPS0   A0A0P5QK97   A0A0J7NTY9   A0A016S0T8   A0A023FH84   A0A2J7Q9L0   T1RTD7   A0A1I7SSM3   T1GM75   A0A151WW28   A0A0M3ICL7   F1L950   A0A226EUH1   A0A0M8ZPV7   A0A2U9BYP2   A0A1I8CDT5  

EC Number

1.3.5.1

Pubmed

19121390    22118469    26354079    26227816    20566863    28004739    + More
17994087    25315136    20353571    22936249    7958999    10731132    12537572    12537569    2494655    17550304    25401762    26823975    21292972    25830018    26108605    15632085    25348373    24845553    27129103    24495485    16431279    26555130    25474469    22216098    25730766    21909270    21685128    30926861    26829753   

EMBL

BABH01022468    AGBW02011400    OWR46708.1    KQ459986    KPJ18876.1    KQ459256    + More
KPJ02079.1    JTDY01000439    KOB77162.1    NWSH01000750    PCG74409.1    ODYU01000587    SOQ35633.1    DS235883    EEB20331.1    GEZM01021620    JAV88901.1    KK854044    PTY10169.1    CH954177    EDV59781.1    CP012524    ALC42186.1    KA647422    AFP62051.1    GDIP01219241    GDIP01077813    GDIQ01037538    JAJ04161.1    JAN57199.1    GDIQ01196321    JAK55404.1    EZ423861    ADD20137.1    NCKU01009156    RWS01466.1    GDIP01242061    JAI81340.1    CCAG010023101    GFDG01000794    JAV18005.1    CM000362    CM002911    EDX05920.1    KMY91816.1    L27705    AE013599    AY118923    CM000157    EDW89092.1    CH480816    EDW46663.1    GBRD01014388    JAG51438.1    GBHO01015547    JAG28057.1    GDIQ01231166    JAK20559.1    GDIQ01249013    JAK02712.1    GDHC01016851    JAQ01778.1    LRGB01000261    KZS19960.1    JXJN01022823    GDIQ01247313    JAK04412.1    UFQS01000246    UFQT01000246    SSX01972.1    SSX22349.1    UFQT01001398    SSX30374.1    GDIQ01186027    JAK65698.1    GDIQ01187483    GDIQ01043936    JAN50801.1    GL732552    EFX79333.1    CH933808    EDW08926.1    CH940648    EDW61680.1    GBXI01013663    JAD00629.1    GDIP01052175    JAM51540.1    GFTR01004415    JAW12011.1    JRES01000655    KNC29574.1    CH902619    EDV38105.1    GEDC01029715    JAS07583.1    GEBQ01027614    JAT12363.1    CM000071    EAL24732.1    CH479181    EDW31415.1    HQ005867    ADV40163.1    CH916367    EDW02013.1    GDIQ01006747    JAN87990.1    BT078417    ACO12841.1    GAKP01014974    JAC43978.1    CH963894    EDW77029.1    KK852510    KDR22350.1    BT078452    BT120985    ACO12876.1    ADD37915.1    BT081063    ACO15487.1    GDKW01001676    JAI54919.1    KP686430    AKV71235.1    GDHF01025242    GDHF01020870    JAI27072.1    JAI31444.1    OUUW01000001    SPP73043.1    CM012443    RVE70124.1    GAMC01004428    JAC02128.1    DQ066192    AAY66829.1    MWRG01032676    PRD20890.1    CAEY01000486    ACPB03016005    GDIP01254694    JAI68707.1    GECZ01005964    JAS63805.1    KF647636    AHB50498.1    MUJZ01071501    OTF69252.1    JXLN01005383    KPM03533.1    GBBI01002515    JAC16197.1    SSX01971.1    SSX22348.1    GBBL01001614    JAC25706.1    GBBM01001997    JAC33421.1    JO843871    AEO35488.1    GDIQ01113503    JAL38223.1    LBMM01001700    KMQ95880.1    KE124896    JARK01001662    EPB75561.1    EYB83957.1    GBBK01003187    GBBK01003186    JAC21296.1    NEVH01016348    PNF25275.1    KC569746    AGO46415.1    CAQQ02176024    KQ982691    KYQ52060.1    JI174300    ADY46654.1    LNIX01000001    MH799992    OXA61242.1    QBH74150.1    KQ435922    KOX68680.1    CP026253    AWP09291.1   

Proteomes

UP000005204    UP000007151    UP000053240    UP000053268    UP000037510    UP000218220    + More
UP000009046    UP000091820    UP000008711    UP000092553    UP000095301    UP000078200    UP000092445    UP000285301    UP000092443    UP000092444    UP000000304    UP000000803    UP000002282    UP000001292    UP000192221    UP000076858    UP000092460    UP000000305    UP000009192    UP000008792    UP000037069    UP000007801    UP000001819    UP000008744    UP000001070    UP000007798    UP000027135    UP000268350    UP000192223    UP000015104    UP000015103    UP000264820    UP000036403    UP000024635    UP000235965    UP000095284    UP000015102    UP000075809    UP000036681    UP000198287    UP000053105    UP000246464    UP000095286   

PRIDE

H9JI58    P21914   

Pfam

PF13085   Fer2_3

Interpro

IPR036010   2Fe-2S_ferredoxin-like_sf        + More
IPR001041   2Fe-2S_ferredoxin-type       
IPR004489   Succ_DH/fum_Rdtase_Fe-S       
IPR012675   Beta-grasp_dom_sf       
IPR006058   2Fe2S_fd_BS       
IPR017900   4Fe4S_Fe_S_CS       
IPR009051   Helical_ferredxn       
IPR025192   Succ_DH/fum_Rdtase_N       
IPR017896   4Fe4S_Fe-S-bd       

SUPFAM

SSF46548   SSF46548        + More
SSF54292   SSF54292       

Gene 3D

1.10.1060.10     3.10.20.30    

CDD

cd00207  fer2

ProteinModelPortal

H9JI58   A0A212EYY1   A0A0N1PJ14   A0A0N1PE48   A0A0L7LNZ8   A0A2A4JRG7   + More
A0A2H1V470   E0W3X5   A0A1Y1MTF2   A0A1A9WEH1   A0A2R7VS39   B3NB16   A0A0M5IZT2   A0A1I8M520   T1PF50   A0A0N7ZRN7   A0A0P5K0W9   A0A1A9V700   A0A1A9Z829   D3TR09   A0A3S3RLH3   A0A1A9YKJ6   A0A0P4XQR5   A0A1B0FII9   A0A1L8EH78   B4QDQ8   P21914   B4P190   B4HQC4   A0A1W4VE97   A0A0K8SDS3   A0A0A9Y4R5   A0A0P5J103   A0A0P5HKN3   A0A146L024   A0A162QUE8   A0A1B0BYT9   A0A0P5G4Q0   A0A336KDL9   A0A336MIX3   A0A0N8BEC9   A0A0P6FY31   E9GMA8   B4KNG7   B4LK89   A0A0A1WNK2   A0A0N8DAQ9   A0A224XVN4   A0A0L0CDM2   B3MIM9   A0A1B6C235   A0A1B6KLQ3   Q292X9   B4GC97   E7D1B9   B4J6T2   A0A0P6IDW0   C1BUY8   A0A034VQX5   B4MY40   A0A067RP06   C1BV23   C1C2I4   A0A0P4VKP3   A0A0K1SB10   A0A0K8UXQ3   A0A3B0J261   A0A437D5R5   W8BSL4   A0A1W4W8F1   Q4PMD5   A0A2P6K3I3   T1JTX0   T1I5F0   A0A0P4WIX1   A0A1B6GN00   V5SKI1   A0A1Y3ALC8   A0A131ZXW6   A0A3Q2XR25   A0A023F4K3   A0A336M8I4   A0A023FV34   A0A023GHH9   G3MPS0   A0A0P5QK97   A0A0J7NTY9   A0A016S0T8   A0A023FH84   A0A2J7Q9L0   T1RTD7   A0A1I7SSM3   T1GM75   A0A151WW28   A0A0M3ICL7   F1L950   A0A226EUH1   A0A0M8ZPV7   A0A2U9BYP2   A0A1I8CDT5  

PDB

2WQY     E-value=2.43146e-79,     Score=751

KEGG

101744970    K00235 succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1] | (RefSeq) succinate de

PATHWAY

00020    Citrate cycle (TCA cycle) - Bombyx mori (domestic silkworm)
00190    Oxidative phosphorylation - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)
01200    Carbon metabolism - Bombyx mori (domestic silkworm)

GO

GO:0006099   GO:0009055   GO:0051537   GO:0051539   GO:0046872   GO:0005743   GO:0008177   GO:0051538   GO:0006121   GO:0048039   GO:0005749   GO:0022904   GO:0031966   GO:0009060   GO:0051536   GO:0016491   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039   GO:0055114  

Subcellular location

Mitochondrion inner membrane  

Length:

294

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.08075

Exp number, first 60 AAs:

0

Total prob of N-in:

0.02936

outside

1  -  294

 

 

Pi

35.224117

Theta

26.496179

Tajima's D

1.026227

CLR

0.275809

CSRT

0.67641617919104

Interpretation

Uncertain