Gene

KWMTBOMO08404  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009207

Annotation

PREDICTED:_polycomb_protein_l(1)G0020_[Papilio_xuthus]

Location

Bomo_Chr14(-):8044981-8064290      View in EpiBrowser

Full name

RNA cytidine acetyltransferase      

Alternative Name

18S rRNA cytosine acetyltransferase
Polycomb protein l(1)G0020
p110

Location in the cell

Cytoplasmic   Reliability : 1.137 Mitochondrial   Reliability : 1.127 Nuclear   Reliability : 1.09

CDS

ATGGTGAAAAAGAAAATTGATAATCGTATCAGGGTTATGATAGAGAATGGAGTTAAACTTGGCCATCGCACCATGTTTCTTCTCATTGGAGACAAAAGCAGAGATCAGGTGCCCATTTTATATGATATGTTAGTCAAATCGACAGTAAAGGCTAGGCCAACAGTACTCTGGTGCTATAAGAACAAAGATGAAGCAATTAGCAATCATGGTCGTAAAAGAGCCAAGAAAATAGCAGCTGGAAAACTGGAAGTCTCCGAAGAATCACTGTTTGATGCATTCAGAGTGGCCACTACTATTCACGGTAGATATTATTCAGAAAGTCATGCAATGCTCGGTCAGACATATGGAGTTTGCGTTTTGCAAGATTTTGAAGCTCTCACCCCCAATTTGATGGCACGAACAATTGAAACTGTAGAAGGGGGTGGTCTTATAATATTCTTACTTAAAACCATGGATTCTCTGAGACAACTACATTCAATAACAATGGATGTACACTCAAGATTCAAAACTGAAGCTTATGACACAGTGGTCAATCGTTTCAATGAAAGATTTCTATTGTCTCTAGCAGATAACCCTAGATGTTTGGTACTTGATGATTCACTGACGGTTCTGCCGATATCATCCAAAACCGCCCAAATCGACCCTGTAGATGCTACACCAGAGCGTGTTAACCCAAAATTGACTGAGCTCATATCATCACTATCCGACTCTCCACCTGCAGGACCGTTAGTGGCTTTAACTCGGACATATGACCAGGCAACGGCCCTGATTGCACTCATCAACACACTAGCAGACAAGCAATCAAGGCCTCCGCACTGCTTGACGGCCGCCCGTGGTCGCGGTAAGTCTGCATGCCTGGGGCTCGCCGTAGCGGCCGCCGTAGCTCTCGGCTACGTCAACATCTACGTGACCTCTCCCCATCCCGAGAACTTGATCACCCTATTCGAGTTCCTACTCAGGGGTCTCGACGCTTGCTTGTACCAAGAGCACATTGATTATAACATCGTGAGGTCAACGAATCCGGATTTCAAGAAGGCCATTGTCAGAGTCAATATCGCTAGGAACTCTAGACAGACCGTACAATACATAACCCCAGACGATCACTCCCTACTGTCGGCTGCTGACCTGGTGCTGGTGGATGAAGCCGCAGCCATCCCGCTGGTGCACGTAGCCGCGGCCGCACAGAAGGCCCCACTTGCTCTGCTGTCGTCCACTGTCTCCGGATATGAAGGCACCGGACGGGCTCTGTCCTTGAAGCTCTTCGCACAGCTACAGACCCAACATAATGCCCCTCCTCCGATAAAACTGGACGAACCGATTCGTTATCGCACCGGGGATCCAATAGAATCATGGCTGAACTCGCTCCTGTGCCTGGAGGCGCCGCCCCCGTCCATGGGGGTGGGCGCTCCGCCCCCCGCCGCCTGCGAGCTGTACCGAGTGAACAGAGACGCGCTGTTCTGCTATCACAAGGCGGCCGAGGCGTTCTTACATCGACTAGTCTCCATTTACGTAGCCAGTCACTATAAGAACAGTCCCAACGACCTACAGCTGCTGGCGGACGCGCCTGCGCACTGCCTCTTCGTGCTGCTAGCCCCCCCGCCCCGCGCCGCCGCCCTGCCCGAGCTGCTGTGCGTGCTGCAACTGTGCCTAGAGGGAAACATATCCGACAAGTCGGTGCGGGACAGCCTCGGCCGGGGTCGCAAGGCGGCGGGCGACCTCATACCCTGGAACATCTGCGAGCAGTTTGGCGACAAGGACTTCCCGAAGCTGTCCGGCGCCAGGATCGTGAGGATCGCCACGCATCCTGCCTACCAGCGGATGGGGTACGGCAAGAGAGCTCTGCAGCAGCTGGCCGCCTACTACAGCGGAGACATTCCGTGCCTGGACGAGGACGCCTCCGACGCAGAGACAGACAGACAGACAGACGCACAGAGCACGCTGCAGACAGAGACCATCGCTCCGAGATCGAAACCGCCGACACTGCTGAAACGTTTGACAGAAGTCCGGCCCGAGAACTTGGACTACCTCGGCACCAGCTTCGGTCTCACCGAAGATCTGTTGAGGTTCTGGAAGTCGCAGAAATACGTTCCGGTTTATCTGAGTCAAAAGGCGAACGAGCTGACGGGCGAGCACTCGTGCATAATGCTGCGGGCGCTGCGCGACGCCGCGTGGCTGGGCGCCTACAGCGCGGACTTCACGCGGCGGGCGGCGCGCCTGCTGCCGCGGACGCTGCGGAGGCTGCCCGCCGCGCTGGCACTGTCCACGCTCGTCACTGACAGCGTCAAAACTAACAAACCCGTGCTGACAAAGGACTTGATAGAGCAGTACCTGACAGGACACGACCTGTCCAGGCTCGAGGCCTACTCCAAGCAACAGGCCGACTACAGGCTCATCACGGACCTGCTGCAGCCGCTGGCCGAACTCGTCTTCCACACTAAGTCGACCATCAAGCTGGATGCAGTTCAGAAGGTAATCTTCATAGCAATGGGATTCCAAATGAAAGACGTCGACGACATAGCGTCCGAACTGGGCCTGCCCGGCTCTCAGATCCTGGCGAAGTTCTACGAGGCCTCGAAGAAGATCAACGCGGCTCTGAACGCGGTTCTAGAAGATTCCGCCGCGAAAGAGATAGGAATAGAGGACAAGGCGGCCTCGGGCGCGGCGCAGCCAGTGCAGCAGAGTCTACAAGACGAACTGTCTAAAGCCGCCAAGGACTTAGAGCGCAAACAACGTAAAGAATTATCGAAACTGATGGGAGAGGATTTATCTCAGTACCGCATCAAGGGGAGTGACCTAGATTGGGGACAGGCTCTAGCCAGCACCAAACAGAAGACCATACTGTCCGTCAAAAGTGGTGAGAAGCGTTTAGGTGAAGACATGAAGGAAATAGACGATTTGCTTGACTTGCAGACGAATAAGAAGAAAAAGAAGAAAAAGAGTTTTAAAAATTAA

Protein

MVKKKIDNRIRVMIENGVKLGHRTMFLLIGDKSRDQVPILYDMLVKSTVKARPTVLWCYKNKDEAISNHGRKRAKKIAAGKLEVSEESLFDAFRVATTIHGRYYSESHAMLGQTYGVCVLQDFEALTPNLMARTIETVEGGGLIIFLLKTMDSLRQLHSITMDVHSRFKTEAYDTVVNRFNERFLLSLADNPRCLVLDDSLTVLPISSKTAQIDPVDATPERVNPKLTELISSLSDSPPAGPLVALTRTYDQATALIALINTLADKQSRPPHCLTAARGRGKSACLGLAVAAAVALGYVNIYVTSPHPENLITLFEFLLRGLDACLYQEHIDYNIVRSTNPDFKKAIVRVNIARNSRQTVQYITPDDHSLLSAADLVLVDEAAAIPLVHVAAAAQKAPLALLSSTVSGYEGTGRALSLKLFAQLQTQHNAPPPIKLDEPIRYRTGDPIESWLNSLLCLEAPPPSMGVGAPPPAACELYRVNRDALFCYHKAAEAFLHRLVSIYVASHYKNSPNDLQLLADAPAHCLFVLLAPPPRAAALPELLCVLQLCLEGNISDKSVRDSLGRGRKAAGDLIPWNICEQFGDKDFPKLSGARIVRIATHPAYQRMGYGKRALQQLAAYYSGDIPCLDEDASDAETDRQTDAQSTLQTETIAPRSKPPTLLKRLTEVRPENLDYLGTSFGLTEDLLRFWKSQKYVPVYLSQKANELTGEHSCIMLRALRDAAWLGAYSADFTRRAARLLPRTLRRLPAALALSTLVTDSVKTNKPVLTKDLIEQYLTGHDLSRLEAYSKQQADYRLITDLLQPLAELVFHTKSTIKLDAVQKVIFIAMGFQMKDVDDIASELGLPGSQILAKFYEASKKINAALNAVLEDSAAKEIGIEDKAASGAAQPVQQSLQDELSKAAKDLERKQRKELSKLMGEDLSQYRIKGSDLDWGQALASTKQKTILSVKSGEKRLGEDMKEIDDLLDLQTNKKKKKKKSFKN

Description

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation (Probable). Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility (PubMed:11493925).
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

Catalytic Activity

a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in 18S rRNA + CoA + H(+) + phosphate
a cytidine in tRNA + acetyl-CoA + ATP + H2O = ADP + an N(4)-acetylcytidine in tRNA + CoA + H(+) + phosphate

Subunit

Component of the PRC1 complex (PSC, PC, PH and dRING1) in 0-12 hours Drosophila embryos. This complex is distinct from the Esc/E(z) complex, which contains many other PcG proteins like Esc, E(z), Su(z)12, Rpd3, Caf1 and probably Pho. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing.
Interacts with THUMPD1.

Similarity

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Keywords

Acyltransferase   ATP-binding   Complete proteome   Developmental protein   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Repressor   rRNA processing   Transcription   Transcription regulation   Transferase   tRNA processing  

Feature

chain  RNA cytidine acetyltransferase

Uniprot

H9JI59   A0A2H1W8F2   S4PXW0   A0A437BCS5   A0A2A4JQT3   A0A0N1IN42   + More
A0A0K8W843   A0A1I8N921   B3MZH0   B4IWV2   W8C5Y8   A0A0P8XYZ0   B4JJ54   A0A0A1WRP6   B4MD85   A0A0M4ET63   Q176B3   A0A182JQQ3   A0A1Q3EX46   A0A1W4UQI0   A0A1I8NMF9   A0A0L0CQN8   A0A182GHT6   B4Q011   H0RNM5   Q9W3C1   Q29GS1   A0A2M4BBX0   A0A2M4AEE2   A0A182Q3C4   A0A2M4AED0   A0A2M4AEC9   A0A2M4BBU6   B3NUK9   X2JD07   A0A1B0A084   A0A0Q5TH34   A0A1B0G0S2   A0A0R3P0I4   A0A182J3W1   U5EMW5   A0A182YFA3   A0A1A9VRF6   A0A1B0B8I7   A0A1A9XDV7   A0A182NDD7   B4NPZ5   B4L3L0   A0A0Q9WMQ2   A0A182FTG2   W5JRV1   A0A3B0K7G1   A0A182PUH1   A0A182V9U8   A0A182WUX3   A0A1B0D2E7   A0A182LPW9   Q7Q8Y1   A0A182UK28   A0A182HYG8   A0A084WAJ0   A0A182RIV0   B0WP12   A0A182VT51   A0A182LY11   A0A336LK77   A0A336K2H7   B4R6R6   A0A1J1J3K2   A0A1J1J0S6   B4IK03   A0A154PE31   K1RFK2   A0A067QQ61   A0A1Y1NE09   A0A2J7R1U3   A0A1W5B3V0   D1ZZM0   A0A3L8DHE1   A0A2A3EPS0   U4U665   A0A1Y1NEF7   A0A026WYD4   A0A195ENV5   A0A226E783   A0A151XIT8   A0A158NEK8   A0A1B6CC83   A0A195BXX0   A0A195BWN5   A0A1D2NJL5   E0VDN5   A0A2R2MQ86   A0A2R7X6M2   N6TI62   A0A3B4CRJ8   K7IYJ4   A0A0C9QQQ8   A0A2S2R2W5   A0A232EU25  

EC Number

2.3.1.-

Pubmed

19121390    23622113    26354079    25315136    17994087    18057021    + More
24495485    25830018    17510324    26108605    26483478    17550304    10731132    12537572    11493925    18327897    15632085    12537568    12537573    12537574    16110336    17569856    17569867    25244985    20920257    23761445    20966253    12364791    14747013    17210077    24438588    22992520    24845553    28004739    18362917    19820115    30249741    23537049    24508170    21347285    27289101    20566863    20075255    28648823   

EMBL

BABH01022452    BABH01022453    BABH01022454    ODYU01006967    SOQ49293.1    GAIX01004353    + More
JAA88207.1    RSAL01000089    RVE48128.1    NWSH01000750    PCG74415.1    KQ459256    KPJ02086.1    GDHF01005264    JAI47050.1    CH902635    EDV33771.1    KPU74742.1    CH916366    EDV97353.1    GAMC01001414    GAMC01001412    JAC05144.1    KPU74743.1    CH916370    EDV99606.1    GBXI01012780    GBXI01009434    JAD01512.1    JAD04858.1    CH940660    EDW58157.1    CP012528    ALC49640.1    CH477391    EAT41945.1    GFDL01015154    JAV19891.1    JRES01000062    KNC34492.1    JXUM01064744    KQ562313    KXJ76163.1    CM000162    EDX02217.1    BT132962    AEW48253.1    AE014298    BT010228    CH379064    EAL32038.2    GGFJ01001382    MBW50523.1    GGFK01005835    MBW39156.1    AXCN02001767    GGFK01005823    MBW39144.1    GGFK01005824    MBW39145.1    GGFJ01001383    MBW50524.1    CH954180    EDV46332.2    AHN59496.1    KQS29934.1    CCAG010004515    KRT06791.1    GANO01000836    JAB59035.1    JXJN01009945    CH964291    EDW86220.1    CH933810    EDW07138.1    KRF93944.1    ADMH02000540    ETN66018.1    OUUW01000015    SPP88612.1    AJVK01022774    AAAB01008933    EAA09908.4    APCN01005907    ATLV01022200    KE525330    KFB47234.1    DS232018    EDS32039.1    AXCM01000018    UFQS01000027    UFQT01000027    SSW97709.1    SSX18095.1    SSW97708.1    SSX18094.1    CM000366    EDX17446.1    CVRI01000066    CRL06054.1    CRL06053.1    CH480850    EDW51359.1    KQ434886    KZC10103.1    JH817826    EKC40095.1    KK853147    KDR10713.1    GEZM01005734    JAV95959.1    NEVH01008202    PNF34804.1    KQ971338    EFA01833.1    QOIP01000008    RLU19268.1    KZ288202    PBC33504.1    KB632168    ERL89354.1    GEZM01005735    JAV95958.1    KK107064    EZA60853.1    KQ978625    KYN29592.1    LNIX01000006    OXA52954.1    KQ982080    KYQ60322.1    ADTU01013485    GEDC01026224    JAS11074.1    KQ978501    KYM93442.1    KQ976401    KYM92383.1    LJIJ01000023    ODN05444.1    DS235083    EEB11491.1    KK857728    PTY27437.1    APGK01025722    APGK01025723    KB740601    ENN80084.1    GBYB01006054    JAG75821.1    GGMS01014917    MBY84120.1    NNAY01002209    OXU21796.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053268    UP000095301    UP000007801    + More
UP000001070    UP000008792    UP000092553    UP000008820    UP000075881    UP000192221    UP000095300    UP000037069    UP000069940    UP000249989    UP000002282    UP000000803    UP000001819    UP000075886    UP000008711    UP000092445    UP000092444    UP000075880    UP000076408    UP000078200    UP000092460    UP000092443    UP000075884    UP000007798    UP000009192    UP000069272    UP000000673    UP000268350    UP000075885    UP000075903    UP000076407    UP000092462    UP000075882    UP000007062    UP000075902    UP000075840    UP000030765    UP000075900    UP000002320    UP000075920    UP000075883    UP000000304    UP000183832    UP000001292    UP000076502    UP000005408    UP000027135    UP000235965    UP000007266    UP000279307    UP000242457    UP000030742    UP000053097    UP000078492    UP000198287    UP000075809    UP000005205    UP000078542    UP000078540    UP000094527    UP000009046    UP000085678    UP000019118    UP000261440    UP000002358    UP000215335   

PRIDE

H9JI59    H0RNM5    Q9W3C1    X2JD07   

Pfam

PF13718   GNAT_acetyltr_2        + More
PF13725   tRNA_bind_2
PF05127   Helicase_RecD
PF08351   DUF1726
PF02338   OTU
PF15410   PH_9
PF00435   Spectrin
PF00788   RA
PF00787   PX
PF00307   CH
PF17820   PDZ_6

Interpro

IPR032672   TmcA/NAT10/Kre33        + More
IPR016181   Acyl_CoA_acyltransferase       
IPR013562   TmcA_N       
IPR033688   NAT10       
IPR027992   tRNA_bind_dom       
IPR000182   GNAT_dom       
IPR007807   Helicase_dom       
IPR036871   PX_dom_sf       
IPR037833   SNX27_PX       
IPR036872   CH_dom_sf       
IPR018159   Spectrin/alpha-actinin       
IPR001715   CH-domain       
IPR001683   Phox       
IPR037827   SNX27_FERM-like_dom       
IPR003323   OTU_dom       
IPR001605   PH_dom-spectrin-type       
IPR001849   PH_domain       
IPR000159   RA_dom       
IPR001589   Actinin_actin-bd_CS       
IPR038765   Papain-like_cys_pep_sf       
IPR041681   PH_9       
IPR036034   PDZ_sf       
IPR011993   PH-like_dom_sf       
IPR001478   PDZ       
IPR002017   Spectrin_repeat       
IPR041489   PDZ_6       

SUPFAM

SSF55729   SSF55729        + More
SSF54001   SSF54001       
SSF50156   SSF50156       
SSF47576   SSF47576       
SSF64268   SSF64268       

Gene 3D

1.10.418.10     2.30.29.30     3.30.1520.10    

CDD

cd00014  CH
cd06886  PX_SNX27
cd13338  FERM-like_C_SNX27

ProteinModelPortal

H9JI59   A0A2H1W8F2   S4PXW0   A0A437BCS5   A0A2A4JQT3   A0A0N1IN42   + More
A0A0K8W843   A0A1I8N921   B3MZH0   B4IWV2   W8C5Y8   A0A0P8XYZ0   B4JJ54   A0A0A1WRP6   B4MD85   A0A0M4ET63   Q176B3   A0A182JQQ3   A0A1Q3EX46   A0A1W4UQI0   A0A1I8NMF9   A0A0L0CQN8   A0A182GHT6   B4Q011   H0RNM5   Q9W3C1   Q29GS1   A0A2M4BBX0   A0A2M4AEE2   A0A182Q3C4   A0A2M4AED0   A0A2M4AEC9   A0A2M4BBU6   B3NUK9   X2JD07   A0A1B0A084   A0A0Q5TH34   A0A1B0G0S2   A0A0R3P0I4   A0A182J3W1   U5EMW5   A0A182YFA3   A0A1A9VRF6   A0A1B0B8I7   A0A1A9XDV7   A0A182NDD7   B4NPZ5   B4L3L0   A0A0Q9WMQ2   A0A182FTG2   W5JRV1   A0A3B0K7G1   A0A182PUH1   A0A182V9U8   A0A182WUX3   A0A1B0D2E7   A0A182LPW9   Q7Q8Y1   A0A182UK28   A0A182HYG8   A0A084WAJ0   A0A182RIV0   B0WP12   A0A182VT51   A0A182LY11   A0A336LK77   A0A336K2H7   B4R6R6   A0A1J1J3K2   A0A1J1J0S6   B4IK03   A0A154PE31   K1RFK2   A0A067QQ61   A0A1Y1NE09   A0A2J7R1U3   A0A1W5B3V0   D1ZZM0   A0A3L8DHE1   A0A2A3EPS0   U4U665   A0A1Y1NEF7   A0A026WYD4   A0A195ENV5   A0A226E783   A0A151XIT8   A0A158NEK8   A0A1B6CC83   A0A195BXX0   A0A195BWN5   A0A1D2NJL5   E0VDN5   A0A2R2MQ86   A0A2R7X6M2   N6TI62   A0A3B4CRJ8   K7IYJ4   A0A0C9QQQ8   A0A2S2R2W5   A0A232EU25  

PDB

5OQL     E-value=0,     Score=1739

KEGG

101744824    K14521 N-acetyltransferase 10 [EC:2.3.1.-] | (RefSeq) polycomb protein l(1)G0020

PATHWAY

03008    Ribosome biogenesis in eukaryotes - Bombyx mori (domestic silkworm)

GO

GO:0005524   GO:0042274   GO:0005730   GO:0051391   GO:0008080   GO:0000154   GO:0016573   GO:0007275   GO:1904812   GO:1990883   GO:0032266   GO:0007165   GO:0003779   GO:0016021   GO:0034470   GO:0016072   GO:0006457   GO:0009408   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR10925  

Subcellular location

  

Length:

983

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

17.29501

Exp number, first 60 AAs:

0.00299

Total prob of N-in:

0.78743

outside

1  -  983

 

 

Pi

315.059242

Theta

181.508708

Tajima's D

2.190249

CLR

0.294714

CSRT

0.910804459777011

Interpretation

Uncertain