Gene

KWMTBOMO08390  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA009211

Annotation

PREDICTED:_juvenile_hormone_epoxide_hydrolase-like_protein_2_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr14(-):7389257-7397191      View in EpiBrowser

Full name

Epoxide hydrolase       + More
Juvenile hormone epoxide hydrolase      
Glutathione peroxidase      
Juvenile hormone epoxide hydrolase 2      
Juvenile hormone epoxide hydrolase 1      

Alternative Name

CfEH2
Juvenile hormone epoxide hydrolase II
Juvenile hormone-specific epoxide hydrolase II
CfEH1
Juvenile hormone epoxide hydrolase I
Juvenile hormone-specific epoxide hydrolase I

Location in the cell

PlasmaMembrane   Reliability : 2.101

CDS

ATGGGTGGACTCTTCGGGTTAGTGATAACGTCTTGTCTAACAATAGAACTTCTGGCGTCTCAAAATACAGAACCAGCATACAAGTTGGATCCTAACGCTTGGTGGGGACCGGAATGCACGAAATACCACAATGATACCAGCATACGACCCTTTGAAATTGTTTTCCATGATAAGATGATAGCGGACCTCAGATATCGACTTAATAATCATCGCAAACCCGTGCCACCGTTAGAAGGGATCGGATTTGAGTACGGCTTTAACTCTAATATCTTAGATGGCTGGCTTCGATTTTGGGCAGAAGAGTATCCCTTTAAGGAAAGGGAAATATTCTTGAACAAATATCCCCAATATGTGACCAACATACAGGGATTGGACATACATTTTATTAAGTACAGACAGAAGGCTTATGCCCATCAAGAAATAGTTCCGTTATTGATTCTTCACGGCTGGCCAGGATCTGTGAGGGAATTCTACGAAACAATACCACACTTGACAAGTGTAAATAAAAGCAGAGATTTTGCTGTCGAAGTAATAGCTCCTACTCTACCAGGGTTTGGATATTCAGACGCTGCGGTCAGACCAGGGCTAGGTATGCACGAAATCGCTGTAGTCTTCAGTAACTTAATGAAAAGGCTTGGCTATAAGAAATACTATGTTCAAGGAGGCGACTGGGGTGCTTTTATTGGTTCCTCAATAGCAACTTCATTTCCCAATGAAGTCCTTGGCTATCATACCAACTTAGGGTTATCGCTTACACAGAAAGCCTTGTCCTTAACCCTATTTGGTTCTCTATTTCCATCGCCAGTAGTCGATCCAGCATTGGCTGATCGAACGGATCTATTGTCAGGGCACATAAGGGATGCAATGATCACGGAGTTTGGATACATGCACATACAAGCCACTAAGCCTGATACTCTAGGAATAGCAATGACAGACTCACCAGGAGGTCTACTAGCATACTTCCTCCAATTAATCTCAACTGGGACTCGAAGTTATTTCTTGAACCTCGAAGACGGAGGCATAGATAAATACTACACTCGAGATCAGTTGTTGGATAATATCATGATGTATTGGGCGCCGAAAAGTATAACCACCTCATTTAGGATCTATGCTGAATCTCTTAACCGGAGAACGCTGGCGTTGGGAATTTCTGAAATACCTACTCCAGTTCCAACAATCACGATTCACGCCAGCGATGAAATTGCCTACCAATCGCCTTTGCTTCTCAGAACTAAGTTCACTAACTTATTGTATACTACAAACATAGATACCGGTGGTCATTTTTTGGCCTTAGAAATGCCGATACTCTTTGCTAATGATGTTTTAAATGCCATCGCCGAATTTAGGAACTGGCACGCAAAAGGAGGTCACGGTAATGGAGAATTACTTCCCAACAATAATGGATAA

Protein

MGGLFGLVITSCLTIELLASQNTEPAYKLDPNAWWGPECTKYHNDTSIRPFEIVFHDKMIADLRYRLNNHRKPVPPLEGIGFEYGFNSNILDGWLRFWAEEYPFKEREIFLNKYPQYVTNIQGLDIHFIKYRQKAYAHQEIVPLLILHGWPGSVREFYETIPHLTSVNKSRDFAVEVIAPTLPGFGYSDAAVRPGLGMHEIAVVFSNLMKRLGYKKYYVQGGDWGAFIGSSIATSFPNEVLGYHTNLGLSLTQKALSLTLFGSLFPSPVVDPALADRTDLLSGHIRDAMITEFGYMHIQATKPDTLGIAMTDSPGGLLAYFLQLISTGTRSYFLNLEDGGIDKYYTRDQLLDNIMMYWAPKSITTSFRIYAESLNRRTLALGISEIPTPVPTITIHASDEIAYQSPLLLRTKFTNLLYTTNIDTGGHFLALEMPILFANDVLNAIAEFRNWHAKGGHGNGELLPNNNG

Description

Catalyzes juvenile hormone hydrolysis.
Catalyzes juvenile hormone hydrolysis. Degrades juvenile hormone III (JH III) about 3 times and 5 times slower than juvenile hormone I (JH I) and II (JH II), respectively. Degrades cis-stilbene oxide and trans-stilbene oxide about 18 and 43 times slower than JH III, respectively.

Catalytic Activity

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin

Biophysicochemical Properties

0.52 uM for juvenile hormone III

Subunit

Homodimer.

Similarity

Belongs to the peptidase S33 family.
Belongs to the glutathione peroxidase family.

Keywords

3D-structure   Aromatic hydrocarbons catabolism   Complete proteome   Endoplasmic reticulum   Hydrolase   Membrane   Microsome   Reference proteome   Transmembrane   Transmembrane helix   Direct protein sequencing  

Feature

chain  Epoxide hydrolase

Uniprot

C6KWM6   H9JI63   Q6U6J0   H9JWL6   C0KH33   A0A2W1B6Y8   + More
A0A2A4K8F5   A0A2A4JI09   Q94806   O44124   A0A194PZ44   A0A3S2LEJ8   A0A0N0PEI4   A0A437B3W7   A0A2W1B693   A0A194Q5D4   L7R9X8   A0A2A4K9D8   A0A194Q0T4   A0A0N1IBG8   A0A2W1B2C5   D4Q9H4   A0A212F9W9   Q1W696   A0A194PZZ0   A0A2A4J6Z6   I4DKH4   A0A194PZ48   A0A194PZ55   A0A3S2P9A9   A0A0N1IIM0   A0A212F9X4   A0A212F9Y7   A0A3S2NYE4   A0A0N0PCA1   A0A0N1ICQ7   A0A0T6BH94   A0A0N0PD06   A0A2W1BCV7   A0A0R6CEE9   A0A088M9L0   D6WGJ2   H9JWT0   A0A1Y1K345   C6KWM7   D0W012   D0W014   D0W015   A0A224XNL2   U5EUG0   D6WGJ4   R4G4K1   A0A0V0G516   A0A2A4JKY8   A0A1Y1K079   A0A0N1IJV9   A0A069DUW8   A0A2C9DK11   A0A2J7PHG7   A0A3S2NQU9   V5G055   Q8MZR5   A0A3G6VF49   D0W011   V5G602   A0A151I9X6   A0A151WUE8   L7ZB10   A0A067QLM6   A0A195DS73   A0A0K8SHU3   A0A0A9WSP4   K7IW06   A0A146KNU3   A0A1W6BRF0   A0A2M4BMA4   A0A2M4BM59   D6WGJ1   J3JY41   A0A2M3ZA99   A0A2M4BM88   A0A2M4BMG5   D6WGJ3   A0A3L8DM46   A0A0T6B3Y6   Q8MZR6   A0A2M3Z944   D0W013   A0A2A4JV24   A0A2M4BMN3   A0A2M4BM54   A0A195CR36   A0A2M4CM88   W5JHA0   A0A1V0M8A5   Q16QD6   A0A2M4AFY5   A0A2M4AFT2   A0A195DZH4   A0A195EXA2  

EC Number

3.3.2.9

Pubmed

20622465    19121390    15681225    25143157    28756777    9927177    + More
26354079    23276675    22118469    22651552    26385554    18362917    19820115    28004739    26334808    28536442    12125060    24845553    25401762    20075255    26823975    28400585    22516182    30249741    20920257    23761445    28349297    17510324   

EMBL

AB293555    BAH97089.1    BABH01022402    AY377854    AB362775    AAQ87024.1    + More
BAF81491.1    BABH01018379    FJ602793    ACM78602.2    KZ150418    PZC70941.1    NWSH01000031    PCG80507.1    NWSH01001318    PCG71725.1    U73680    AAB18243.1    AF035482    AAB88192.1    KQ459583    KPI98602.1    RSAL01000177    RVE45005.1    KQ459764    KPJ20089.1    RVE45004.1    KZ150284    PZC70943.1    PZC71622.1    KPI98605.1    JX681816    AGC00788.1    PCG80508.1    KPI98604.1    KQ459630    KPJ20526.1    PZC70942.1    AB299279    BAI94514.1    AGBW02009550    OWR50536.1    DQ431847    ABD85119.1    KPI98603.1    NWSH01002656    PCG67731.1    AK401792    BAM18414.1    KPI98607.1    KPI98601.1    RVE45007.1    KPJ20091.1    OWR50537.1    OWR50538.1    RSAL01000025    RVE52162.1    KQ460733    KPJ12641.1    KPJ20092.1    LJIG01000290    KRT86650.1    KQ460417    KPJ14867.1    KZ150476    PZC70740.1    KM926340    AJR27470.1    KJ579233    AIN34709.1    KQ971321    EFA00568.1    BABH01018608    GEZM01096422    JAV54921.1    AB293556    BAH97090.1    AB534186    BAI49687.1    AB534188    BAI49689.1    AB534189    BAI49690.1    GFTR01006406    JAW10020.1    GANO01002338    JAB57533.1    EFA00569.1    ACPB03008739    GAHY01001290    JAA76220.1    GECL01002991    JAP03133.1    NWSH01001212    PCG72103.1    GEZM01096421    JAV54922.1    KPJ20090.1    GBGD01001402    JAC87487.1    KX855995    ARE68677.1    NEVH01025136    PNF15772.1    RSAL01000008    RVE53920.1    GALX01005126    JAB63340.1    AF503909    AAM22695.1    MH932586    AZB52850.1    AB534185    BAI49686.1    GALX01002976    JAB65490.1    KQ978260    KYM95872.1    KQ982745    KYQ51387.1    KC148541    AGE12571.1    KK853182    KDR10172.1    KQ980530    KYN15652.1    GBRD01012965    JAG52861.1    GBHO01035734    JAG07870.1    GDHC01020455    JAP98173.1    KY810195    ARJ54611.1    GGFJ01005078    MBW54219.1    GGFJ01005025    MBW54166.1    EFA00567.1    BT128165    AEE63126.1    GGFM01004705    MBW25456.1    GGFJ01005024    MBW54165.1    GGFJ01005081    MBW54222.1    EFA00170.1    QOIP01000006    RLU21451.1    LJIG01009934    KRT82088.1    AF503908    AAM22694.1    GGFM01004306    MBW25057.1    AB534187    BAI49688.1    NWSH01000520    PCG75887.1    GGFJ01005082    MBW54223.1    GGFJ01005028    MBW54169.1    KQ977381    KYN03166.1    GGFL01002133    MBW66311.1    ADMH02001380    ETN62698.1    KU755500    ARD71210.1    JF295126    CH477751    ADZ76080.1    EAT36616.1    GGFK01006372    MBW39693.1    GGFK01006323    MBW39644.1    KQ979999    KYN18300.1    KQ981953    KYN32509.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000283053    UP000053240    UP000007151    + More
UP000007266    UP000015103    UP000235965    UP000078542    UP000075809    UP000027135    UP000078492    UP000002358    UP000279307    UP000000673    UP000008820    UP000078541   

PRIDE

C6KWM6    H9JI63    Q6U6J0    H9JWL6    D4Q9H4    H9JWT0    + More
C6KWM7   

Pfam

PF06441   EHN        + More
PF14529   Exo_endo_phos_2
PF00078   RVT_1
PF00255   GSHPx

Interpro

IPR010497   Epoxide_hydro_N        + More
IPR016292   Epoxide_hydrolase       
IPR029058   AB_hydrolase       
IPR000639   Epox_hydrolase-like       
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR000477   RT_dom       
IPR000889   Glutathione_peroxidase       
IPR029760   GPX_CS       
IPR036249   Thioredoxin-like_sf       
IPR029759   GPX_AS       

SUPFAM

SSF53474   SSF53474        + More
SSF56219   SSF56219       
SSF52833   SSF52833       

Gene 3D

3.40.50.1820     3.60.10.10    

CDD

cd00340  GSH_Peroxidase

ProteinModelPortal

C6KWM6   H9JI63   Q6U6J0   H9JWL6   C0KH33   A0A2W1B6Y8   + More
A0A2A4K8F5   A0A2A4JI09   Q94806   O44124   A0A194PZ44   A0A3S2LEJ8   A0A0N0PEI4   A0A437B3W7   A0A2W1B693   A0A194Q5D4   L7R9X8   A0A2A4K9D8   A0A194Q0T4   A0A0N1IBG8   A0A2W1B2C5   D4Q9H4   A0A212F9W9   Q1W696   A0A194PZZ0   A0A2A4J6Z6   I4DKH4   A0A194PZ48   A0A194PZ55   A0A3S2P9A9   A0A0N1IIM0   A0A212F9X4   A0A212F9Y7   A0A3S2NYE4   A0A0N0PCA1   A0A0N1ICQ7   A0A0T6BH94   A0A0N0PD06   A0A2W1BCV7   A0A0R6CEE9   A0A088M9L0   D6WGJ2   H9JWT0   A0A1Y1K345   C6KWM7   D0W012   D0W014   D0W015   A0A224XNL2   U5EUG0   D6WGJ4   R4G4K1   A0A0V0G516   A0A2A4JKY8   A0A1Y1K079   A0A0N1IJV9   A0A069DUW8   A0A2C9DK11   A0A2J7PHG7   A0A3S2NQU9   V5G055   Q8MZR5   A0A3G6VF49   D0W011   V5G602   A0A151I9X6   A0A151WUE8   L7ZB10   A0A067QLM6   A0A195DS73   A0A0K8SHU3   A0A0A9WSP4   K7IW06   A0A146KNU3   A0A1W6BRF0   A0A2M4BMA4   A0A2M4BM59   D6WGJ1   J3JY41   A0A2M3ZA99   A0A2M4BM88   A0A2M4BMG5   D6WGJ3   A0A3L8DM46   A0A0T6B3Y6   Q8MZR6   A0A2M3Z944   D0W013   A0A2A4JV24   A0A2M4BMN3   A0A2M4BM54   A0A195CR36   A0A2M4CM88   W5JHA0   A0A1V0M8A5   Q16QD6   A0A2M4AFY5   A0A2M4AFT2   A0A195DZH4   A0A195EXA2  

PDB

4QLA     E-value=5.96745e-146,     Score=1327

KEGG

100307009    K10719 juvenile hormone epoxide hydrolase | (RefSeq) Jheh-lp2; juvenile hormone epoxide hydrolase-li

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0019439   GO:0005789   GO:0033961   GO:0016021   GO:0016787   GO:0004601   GO:0006979   GO:0004602   GO:0016740   GO:0003824   GO:0015074   GO:0016311   GO:0016791   GO:0019318   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

SignalP

Position:   1 - 19,         Likelihood:  0.965364

 

 

Length:

468

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.17231

Exp number, first 60 AAs:

0.06038

Total prob of N-in:

0.00370

outside

1  -  468

 

 

Pi

277.888441

Theta

187.944784

Tajima's D

1.373993

CLR

0.011985

CSRT

0.754962251887406

Interpretation

Uncertain