Gene

KWMTBOMO08366

Pre Gene Modal

BGIBMGA014560

Annotation

PREDICTED:_putative_Ras-related_protein_Rab-33_[Papilio_polytes]

Location

Bomo_Chr14(+):6897587-6900397      View in EpiBrowser

Full name

Ras-related protein Rab-33B      

Location in the cell

Cytoplasmic   Reliability : 1.318 Nuclear   Reliability : 1.92

CDS

ATGTCAGTTAACGCCAGCCAGGATATACCTGGATTGAAGCAAAAAAAAGTATTTAAAATTATAGTTCTCGGTGATTCAGGTGTTGGGAAAACTTGTCTAACTTATCGTTTTTGTGAGGGCCAGTTTTTAAATAAATCTGAAGCTACAATCGGTGTTGATTTCAGAGAGAGAATCATTAAAATTCGTAATGAGGATATCAAGCTCCAGTTATGGGACACTGCTGGACAAGAAAGATTTCGAAAATCAATGGTGCAGCACTACTATAGAAATGTTCATGCAGTTGTCATTGTTTATGATGTTACAAAGCCAGAAACGTTTCATTCTATATCAGCTTGGATGCAAGAGATCGAATCCCATGGCTTAATGAATGCTCCTAGAGTCCTTGTGGGCAATAAATGTGACTGTGGTACTCCTGAATCCAGGCTAGCCACCACTTATGCTCAGAGATTAGCTGATAAATATGGCATGCCTCTATTTGAAACATCGGCACTGTTGGATTCAGAATGTGATAATGTGGAGTCAATATTCTTGACCTTAGCACATAAATTGTACTCTAAACAGCCATTGAGAGTTATTAGTGTGGCGGGAGAAGTCAGTAAGGGTGTGGTCACATTGTCAAGACAGAGGAAAGTTGGTTGCAGTTCCGATCAGAATAGCTGTCTATGCAACTGA

Protein

MSVNASQDIPGLKQKKVFKIIVLGDSGVGKTCLTYRFCEGQFLNKSEATIGVDFRERIIKIRNEDIKLQLWDTAGQERFRKSMVQHYYRNVHAVVIVYDVTKPETFHSISAWMQEIESHGLMNAPRVLVGNKCDCGTPESRLATTYAQRLADKYGMPLFETSALLDSECDNVESIFLTLAHKLYSKQPLRVISVAGEVSKGVVTLSRQRKVGCSSDQNSCLCN

Description

Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation.
Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity).

Subunit

Interacts with RIC1 (via C-terminus domain); the interaction is direct with a preference for RAB33B-GTP. Interacts with RGP1 (By similarity). Interacts with ATG16L; the interaction is important for autophagosome formation (PubMed:18448665).

Similarity

Belongs to the small GTPase superfamily. Rab family.

Keywords

3D-structure   Autophagy   Complete proteome   Direct protein sequencing   Golgi apparatus   GTP-binding   Lipoprotein   Membrane   Methylation   Nucleotide-binding   Prenylation   Protein transport   Reference proteome   Transport  

Feature

chain  Ras-related protein Rab-33B

Uniprot

H9JYE0   A0A437BQ60   A0A2H1VG14   A0A2A4J5L7   A0A2W1BKT3   A0A0N1I699   + More
A0A194PY47   A0A212F3D0   A0A2J7QS58   A0A1B6F5Y9   A0A1S3JMT9   A0A293LDM3   A0A2R5L6Z2   A0A267GJK6   A0A1I8HD21   A0A0P4WCR5   A0A1B6KUP7   A0A0P4WGY1   A0A1B6D9N4   A0A423SCL7   T1INF3   A0A1W4XFY6   A0A3Q0T7R5   A0A1E1X4H0   B7QDW6   A0A131XF31   V5I242   L7M7G3   A0A1E1XVC0   A0A224Z7B4   A0A131Z1W0   C3YRQ1   A0A0C9RTV5   I3K0B4   V5HUM1   A0A087U3V2   A0A3Q1IP20   A0A3P9JBH1   A0A3B4G554   A0A3P8NUC4   A0A3P9AW42   W5MWZ7   A0A3B3Z317   A0A087X3F4   A0A3B3VZ10   G3Q7G7   A0A0P7WUN0   A0A3B3R2Y5   K9IS94   A0A1A8D2M4   A0A1A8U6Q3   A0A164SS12   A0A0P5F596   A0A1A8F881   A0A2P2I0G7   A0A267E776   A0A3B4ZWX1   A0A2I4ALS2   M3ZPL0   A0A286X7N7   H2SXZ9   A0A0L8H5W5   H0YW33   A0A060XGQ1   A0A3Q3KF24   U3JQM3   A0A3B3ZI94   A0A3M0JF77   A0A0P4XCP6   A0A2D0R6C8   A0A1I8IAU3   G1P7U5   S7NC69   T0NU35   K1QRK0   A0A3B4T8L6   L5L1F3   A0A3Q3GQK5   Q0PD21   O35963   L5LSS1   A0A1A7YML2   A0A3B1KGT1   A0A060XJE8   A0A1S3G9Q6   Q3TCY0   A0A091E4E5   A0A401SK65   A0A3Q3C1P3   A0A250YD01   A0A210QD37   A0A341BGR5   A0A2U4ARD9   A0A2Y9LLJ5   A0A2P4SYP3   Q5ZHV1   A0A3Q1FHP3   F7DEB6   I3LK86   A0A3Q2P1H4  

Pubmed

19121390    28756777    26354079    22118469    26392545    28503490    + More
28049606    25765539    25576852    29209593    28797301    26830274    18563158    26131772    25186727    17554307    29240929    23542700    21993624    21551351    20360741    24755649    25463417    23149746    22992520    23258410    11773082    11856727    12040188    12578829    16923123    21183079    9512502    16141072    15489334    18448665    16034420    25329095    10349636    11042159    11076861    11217851    12466851    16141073    30297745    28087693    28812685    15642098    19892987   

EMBL

BABH01043217    RSAL01000021    RVE52550.1    ODYU01002170    SOQ39322.1    NWSH01003251    + More
PCG66692.1    KZ150057    PZC74295.1    KQ461193    KPJ07003.1    KQ459585    KPI98257.1    AGBW02010576    OWR48248.1    NEVH01011878    PNF31405.1    GECZ01024141    GECZ01012678    JAS45628.1    JAS57091.1    GFWV01001241    MAA25971.1    GGLE01001061    MBY05187.1    NIVC01000327    PAA85432.1    NIVC01001833    NIVC01000100    PAA63554.1    PAA90931.1    GDRN01062773    JAI65043.1    GEBQ01028500    GEBQ01024812    JAT11477.1    JAT15165.1    GDRN01062774    JAI65042.1    GEDC01022796    GEDC01016535    GEDC01015136    GEDC01014904    GEDC01012496    GEDC01011997    GEDC01003846    GEDC01000930    JAS14502.1    JAS20763.1    JAS22162.1    JAS22394.1    JAS24802.1    JAS25301.1    JAS33452.1    JAS36368.1    QCYY01003902    ROT61967.1    JH431165    GFAC01005060    JAT94128.1    ABJB010101098    ABJB010139939    ABJB011092873    DS916551    EEC17038.1    GEFH01002808    JAP65773.1    GANP01000971    JAB83497.1    GACK01005961    JAA59073.1    GFAA01000358    JAU03077.1    GFPF01011228    MAA22374.1    GEDV01003832    JAP84725.1    GG666548    EEN56806.1    EEN56807.1    GBZX01001919    JAG90821.1    AERX01033546    AERX01033547    GANP01006485    JAB77983.1    KK118034    KFM72041.1    AHAT01001305    AYCK01025343    JARO02004910    KPP67692.1    GABZ01002513    JAA51012.1    HADZ01021444    HAEA01000059    SBP85385.1    HADY01008988    HAEJ01003323    SBS43780.1    LRGB01001937    KZS09887.1    GDIQ01260170    GDIQ01228263    JAJ91554.1    HAEB01009038    HAEC01012659    SBQ55565.1    IACF01001860    LAB67537.1    NIVC01002579    PAA56744.1    AAKN02011790    KQ419141    KOF84494.1    ABQF01049053    FR905365    CDQ78743.1    AGTO01010474    QRBI01000148    RMB99651.1    GDIP01243711    JAI79690.1    NIVC01001210    PAA70705.1    AAPE02001446    AAPE02001447    KE164069    EPQ14869.1    KB017895    EQB79047.1    JH817380    EKC36363.1    KB030405    ELK17447.1    AB232629    CH466530    BAF02891.1    EDL35212.1    AB004665    AB004664    AK004974    AK087967    AK139821    AK159674    BC065076    KB109155    ELK28498.1    HADW01019624    HADX01009214    SBP31446.1    FR905228    CDQ77424.1    AK170483    BAE41825.1    KN120798    KFO37593.1    BEZZ01000324    GCC30777.1    GFFW01003354    JAV41434.1    NEDP02004118    OWF46601.1    PPHD01016093    POI29229.1    AJ721033    AEMK02000067   

Proteomes

UP000005204    UP000283053    UP000218220    UP000053240    UP000053268    UP000007151    + More
UP000235965    UP000085678    UP000215902    UP000095280    UP000283509    UP000192223    UP000261340    UP000001555    UP000001554    UP000005207    UP000054359    UP000265040    UP000265200    UP000261460    UP000265100    UP000265160    UP000018468    UP000261480    UP000028760    UP000261500    UP000007635    UP000034805    UP000192224    UP000261540    UP000076858    UP000261400    UP000192220    UP000002852    UP000005447    UP000005226    UP000053454    UP000007754    UP000193380    UP000261600    UP000016665    UP000261520    UP000269221    UP000221080    UP000001074    UP000005408    UP000261420    UP000010552    UP000261660    UP000000589    UP000018467    UP000081671    UP000028990    UP000287033    UP000264840    UP000242188    UP000252040    UP000245320    UP000248483    UP000000539    UP000257200    UP000002281    UP000008227    UP000265000   

PRIDE

H9JYE0    B7QDW6    V5I242    L7M7G3    V5HUM1    O35963    + More
Q5ZHV1    I3LK86   

Pfam

PF00071   Ras

Interpro

IPR027417   P-loop_NTPase        + More
IPR001806   Small_GTPase       
IPR005225   Small_GTP-bd_dom       
IPR041822   Rab33A/B       

SUPFAM

SSF52540   SSF52540       

CDD

cd04115  Rab33B_Rab33A

ProteinModelPortal

H9JYE0   A0A437BQ60   A0A2H1VG14   A0A2A4J5L7   A0A2W1BKT3   A0A0N1I699   + More
A0A194PY47   A0A212F3D0   A0A2J7QS58   A0A1B6F5Y9   A0A1S3JMT9   A0A293LDM3   A0A2R5L6Z2   A0A267GJK6   A0A1I8HD21   A0A0P4WCR5   A0A1B6KUP7   A0A0P4WGY1   A0A1B6D9N4   A0A423SCL7   T1INF3   A0A1W4XFY6   A0A3Q0T7R5   A0A1E1X4H0   B7QDW6   A0A131XF31   V5I242   L7M7G3   A0A1E1XVC0   A0A224Z7B4   A0A131Z1W0   C3YRQ1   A0A0C9RTV5   I3K0B4   V5HUM1   A0A087U3V2   A0A3Q1IP20   A0A3P9JBH1   A0A3B4G554   A0A3P8NUC4   A0A3P9AW42   W5MWZ7   A0A3B3Z317   A0A087X3F4   A0A3B3VZ10   G3Q7G7   A0A0P7WUN0   A0A3B3R2Y5   K9IS94   A0A1A8D2M4   A0A1A8U6Q3   A0A164SS12   A0A0P5F596   A0A1A8F881   A0A2P2I0G7   A0A267E776   A0A3B4ZWX1   A0A2I4ALS2   M3ZPL0   A0A286X7N7   H2SXZ9   A0A0L8H5W5   H0YW33   A0A060XGQ1   A0A3Q3KF24   U3JQM3   A0A3B3ZI94   A0A3M0JF77   A0A0P4XCP6   A0A2D0R6C8   A0A1I8IAU3   G1P7U5   S7NC69   T0NU35   K1QRK0   A0A3B4T8L6   L5L1F3   A0A3Q3GQK5   Q0PD21   O35963   L5LSS1   A0A1A7YML2   A0A3B1KGT1   A0A060XJE8   A0A1S3G9Q6   Q3TCY0   A0A091E4E5   A0A401SK65   A0A3Q3C1P3   A0A250YD01   A0A210QD37   A0A341BGR5   A0A2U4ARD9   A0A2Y9LLJ5   A0A2P4SYP3   Q5ZHV1   A0A3Q1FHP3   F7DEB6   I3LK86   A0A3Q2P1H4  

PDB

1Z06     E-value=1.32148e-61,     Score=596

KEGG

101739850    K07920 Ras-related protein Rab-33B | (RefSeq) putative Ras-related protein Rab-33

PATHWAY

04140    Autophagy - animal - Bombyx mori (domestic silkworm)

GO

GO:0005525   GO:0003924   GO:0006888   GO:0004767   GO:0005789   GO:0006886   GO:0000139   GO:0032482   GO:1903358   GO:0048705   GO:0000045   GO:0005796   GO:2000156   GO:0006891   GO:0034067   GO:1903434   GO:0098793   GO:0005794   GO:0007264   GO:0030246   GO:0016853   GO:0019318   GO:0051603   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

Subcellular location

Golgi apparatus membrane   Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm (PubMed:18448665).   With evidence from 5 publications.
Golgi apparatus   Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm (PubMed:18448665).   With evidence from 5 publications.
cis-Golgi network   Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm (PubMed:18448665).   With evidence from 5 publications.

Length:

223

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02663

Exp number, first 60 AAs:

0.02174

Total prob of N-in:

0.06198

outside

1  -  223

 

 

Pi

301.150348

Theta

212.526876

Tajima's D

1.168403

CLR

0.655031

CSRT

0.705314734263287

Interpretation

Uncertain