Gene
KWMTBOMO08365
Pre Gene Modal
BGIBMGA009225
Annotation
PREDICTED:_myotubularin-related_protein_5_[Bombyx_mori]
Full name
Myotubularin-related protein 13
Alternative Name
Inactive phosphatidylinositol 3-phosphatase 13
SET-binding factor 2
SET-binding factor 2
Location in the cell
Nuclear Reliability : 2.015
Sequence
CDS
ATGTCCAGGCTCGTCGACTACTTTGTTATAGTGGGATTCGACCACGAAAAAGAAAGAGGCGGCCTGAACAGCGGCGTTGTCCTCCAGCGATTTCCCGAAACAAACTGGGACGACGTACCATTTCACGACGGCATAGGATGGTTTTGTCAGCCGCAAGGATGGGCTCTATCGACGGAACGAACGGAGCCGCGGTTCTACGTGTCTGTGCTGACGGACGTGGACGCGAACCGTCATTACTGCGCTTGTTTGTGCTTCAACGAAACTGTTGCCATCACGCCAACGAAACCCGCAGACGAGGACGAAGAGTCCCTAGATTCCTCAAGACCCGTAGCAAACATCACACATCACAGCATTATGTACGCGCCGAAATGTCTTGTTATAGTTTCACGTCAGGACTACATAGATACCTTCAGGAACTGCTTAGGCATAATATACACTGTCTGGGTAGAGAATCTGGGCGTGCCTCTCGAGACGCTTGTCGGTAATCTGGTGGGTGGCGTGTTAGTACCTGAACCAGGGGGACCGCAGGTGCGCTTCAGTATCGGTGCCGGGGACCGACAGGCTCTACAGCCGCCCGCTGCACCGCCCATGCCGGTTACACACACCTCCGTTTACATGCTGCTTCGGCTGTTAGGTATACACAACGCAGTGACGCTGTGGTGTGCAGTAATGAGCGAGCACAAGGTGTTGCTCGTGTCGCTGGCGGCGGCCCGGCTCGCCGGCGTGTGTCGGGCGCTGGCGGCCCTCATGTTCCCGTTCCGATACGCGCACGTGTACATACCGCTGCTGCCCGCCGGCCTGGCCGAAGTCCTGGCGACGCCGACGCCCTTCCTCATTGGCGTACATTCTAATTTAAAAGAGGATGTTTCCGAATTGCTAGACGTCATAGTAGCGGACTTAGACGTCGGCTCTCTCCACATTCCAGCGGGTGTGAACATTCCACGACCGGAAGGCAAGCTGTTGTCGTCGCTGCAGAACGCGTTAGCTCTGGTGTTGCAGCCGGAACTGCGTTCGGCGGATTCGGCCTTCGCCCCGCCGCCGCCCTCCGCCTCGCCGCCGCACATGCTAGACAAGGAAATCAGGGCGGTGTTCATGAGGACCTTGGCGAAACTGTTACAAGGCTACAGACACTGCCTGACGCTGGTCCGCATCCACCCGGCCCCGGTGCTGACGTTCCACAAGCTGGGGTTCGTGGGGGCGCGCGGGCTGGCGCAGTGCGAGTTCACGGCGCGACTGCTCGACTCCATGTTCTTCTCCGGACTCGTAGCTGAACGAGGCCCTCCATGGAGACCGGTCGACCTCTTCGACGACTTGCTACAAAATCTCCCGGAACAACTAAGACTAGAATCTCTGAATCCCGAATTGGAACTACAACATATACAGGATCTCGCGATGCAGTTACATCTCAACGAAAATCCTAATCCGCAGCCGTTTCAGCAAAGAATACTCCGTCCGCCAGAGGGCGCGTCCTCCCGCATCCACCAGCCCCCCCTCCCCGCCATCGACGCGCGGAAGGTGCGTGACGTCATGGACGAGGTCTCGGCCAGAAGTGCCAATAATCCCAAGTTAACAGCACTCCGGCCGCCTCAGCCCAGGATAGTTTCGCTGTCAGCCCCTCCGACGGGAGCCGTGGAGCACAACCAGCTGCCGCCCACTAATTCGGCCAGGAGACTCGAGGTGCTGAGCGCGTGCGTGGCGGCCATATTCGAGTGCCGGTACGCAGATGGGCGCAAGTCGGTGGCGGGCGTGGTGCGCGCGCTGCGTGCGCCGGCCGCGCGCGCTGCGCTCGTGCGGGACCTCGCCGCCCGCCTGCCCACCAACAAGCACCTGCTGCACCACCACCAGTTCGAGCTCGTCGTCAGATTAATGAACTGCGCCTTGCAATCGACAACGGCCATAGACGAGCACTCGATAGCGGCGGCCATGTTGCCGCTCGCGACCGCCTACTGCAGGAAACTCTGCACCGGAGTCATTCAGTACGCGTACATGTGCATACAGGAACATCCGGTATGGACGAGTCAACAGTTTTGGGAGGCGGCTTTCTATCAAGACGTGCAGAAGGATATAAAAGCGTTGTACTTACCCAGTCCTACACATCACCCAAGAGTCCCTACTCCAAGGGACGACGAAGATTACATATCTTTACTGAAAGCTCAAGAGCCGAGCGCTTTAGAGATAGCAGCTGAACAGATGAGATTATGGCCGAGTTTGTCACCAGAGAAACAAAAAGAACTAATAGCAAGCGAGGAATCGACTTTATACAGTCAAGCGATACACTATGCGAACAGAATGGTTTACTTGTTACTGCCGCTAGAGGGCGCCGGGAGGAGAGCCGATGTCCGAGGCGACGATGTCGACAGAGCCAGCAATAGTATCACCAACAGTGTCGCAGAATCAGACAGCGTGGACGCCGAATCAGGCTTCGAGGAGGCCGACCCGGGGGAGGCAGGCAATAACGTTATCAAAATGGTCTCGAGATTCGTTGATAAGGTGTGCACCGAGGGCGGCGTGACGGCGGAGCACGTGCGCTGCCTGCACCAGATGATCCCGGGCGTGGTGCACATGCACCTGGAGACGCTGGACGCCGTGGCGCGCGAGAGCCGCCGCCTGCCCCCCGTGCAGAAGCCGCGCATCGTGTCTCCGGTACTGGTGGGCGGCGAGGCGGTGTCGGGCCCGGCCCTGCGCGCCTACCTGGTGTGCGACGGCCGGCCCTCCTCGCTGCTGCCGGCGGAGGGCGCGCTCTTCCTCACCAACTACAGACTCATTTTCAAGGGAACGCCCACCGACCCTTTCGCTTGCGAGCAAACAGTAGTTCGTTCGTTCCCTTTGTGCTCGCTGACGAGGGAGAAGGCGATACGGACGCACTACATACCGCATCTAGAACAATCGCTGCAAGACGGCCTGCAGCTCAGATCCGCAACATTCCAACTCATTAAGGTAGCTCTAGACGAGGAGGTGAGCAGCGAGCTGACGGAGAGCTTCCGCAAGCAGCTGGCGCGGCTGCGGCACCCGGAGCACCCGCTGCTGCACTTCGCGCTGACGCCGCGCCCCGTGCCGCCGCCCGCGCACCACCAAGCCAAGCACAACACTTTAAAAGGTTTCGCGAAGAAGACCTTATTGAAGACAGCAAGGAAGGCCGGCTTGAAACCCAAACCTTCGAAACGGCAGAAGTACGTGTTGCCTTCGGCGGACGCGAGGTCACTCACCTCTCCCCCACTCATGTCTTCGTTATCCGCTGACACTCTATCGTTGGAAGAGTTAGATCTTGGTAGCAGTGAACCGACGGAAGCTCCCGCAGCCCGGACGCTGGAGAGGGTTCGGGAACGTATCTACGCTAAAGATTGGGCCAGACTGGGGTTGGCCTCACCGCCCTTCAGACTCGCGCATGCTAATGCTGTGTACACTCTTTGTAGAAGTTACCCGGCAGTGATCCCGGTCCCGGAGAGCATCGGCGACGAGTCGCTGCGGCGCGTGGCGCGCTGCTACCGACAGGGCCGCCTGCCGCTCGTCACGTGGCGACACCCGCGCACGCACGCGCTGCTCGCCAGGTCTTCGGCGTCACATCACAAAGGAGTGATGGGTATGCTGAAGGCTACCCATCAAACCCAGGGTACCACCCAAAGTGGAACGGAGACTACATCCAGCTTAGAACAGGAGCGGTACATAGCAACCCTAGTGGCGTGCACTCCGGCGTCGCGAGGCGACCTCGAGGACTCCAGCCTGAGCTTAGACTCGCTCCTGTTGTGCTGCGATGAACAGCAGCCTACCCACACGCCTTTGTTGACCAAGGCCGCCGGGACGCTGAGCGTGCTACGTAACAGCGGAGGGAAGGGCGGCGGCACCAGCGGAGGCCGAGCCTTCGGTCGCTGGGGCTCGCTCAAGGACCGGAGACAACCCTCGCACCTCGAGCTGTACGCGCCCAGACAGAGACTCTCCACGGCGGACCTCGACTCCATGTCGGCCGAGGGCGGCGTGACGCGGCGCGCGGCGCTGTACGTGGTGGGCGAGAAGGGGGCGGGCGCGGGGTGCGCGGCGGGCGCGGAGGCGGTGCCGGCCGACTACCCGGAGACGCGACACACGCGGCACGCCTTCAAGAAGCTCATGCGGTGCGCCGTGCCCTCCGCGCCCGCACTCGACCCCACCACCTTCCTCAGACAAGTGGAAGAGTCTGGCTGGTTGTGGCAGCTCCGACAATTGTTTCAACTGTCTGGTGCTGTGGTAGACTTGTTAGATGTGCAAGGTTCATCTGTGCTGTTGTCCCTGGAAGACGGATGGGATGTCACTGCACAGATATCATCGTTAGCTCAGATCTGCCTGGAGCCCTACTACAGGACGCTGGAGGGGTTCCGGATCATCGTCGAGAAGGAGTGGCTGGCCCTGGGGCACAAGTTCCAGCAGCGGTGTAACATCGGAGCCACACCGCAACAAGGCTTCACACCCACATTCCTCATGTTCTTGGATGCCGTACATCAGCTACAGAAACAGTTCCCGCTGGCGTTCGAGTTCAACGAGTACTACCTGCGGTTCGTCGCGTACCACAGCGTGTCCTGCCGCTTCCGGACCTTCCTGCTGGACAGCGAGGCGCAGCGCGCGGAGCTCGGCATCACCGCGGCCGACGACAAGCGCGCCGACACCAACCGACTCGGCGTGGAGACGGGTGCGGGGGTGGAGGAGGAGGCGGGCGGGGGGCGCGGGCCGCCGCTCGGCCACTCGCTGTTCGACTACATCGACAAGCAGCACCAGAAGTCGCCCGTCTTCTACAACTTCCTCTACACGCCCGACCTTGACAATCCCGTCCTTCGTCCTGTTTCGTCTATATGCGCATTTGAAGTATGGGGCTACTACACCAGCGAGGAATTGTCCCACGGAGCTCCCTACGACTTGGAAGTGTTGTCGTCCTGCGAACAGGACGTGAAACAACCGCAGAGGAGGGTCGTCACTGCTGGGTACGACAGTATAAGTCGTTGCATGCCGGACTCGTTTACCGGTCTGCTGGAGAGGATCCGGCAGCTAGAACTGGAGCTGGGTCACCTACCTCAGAAGTGGAAGGTCAGATGGGATCAGCTCGAACTACCCAACACTGTGGAGCTTCAGCGCGCGGGCTCCGTGTGCGGGTCGGCGGCGCGCGCGGCGGCCGCGTGTGCGCACCGGCGGGACACGCTGGAGGTGCTGGTGCGGGGCCGCCTCGCCGCCGCGCCGCCCCCCGACCCCGCGCACCGCTTCCTGCCCGCCGCCGCCGCCGCGCCCGCGCGCTGCGACCACTGCCACCACCTGCTCTGGGGACCGCTCAAGACGGGCGTTCGTTGCGTGGACTGCGGCGCCGCGTGTCACGAGCGATGCGCGGAGACGTTCGCGCCGCCCTGCACCAAGTACAAGGCGCCCGCGCCCCCCGACCGCGACCTGCGCCCCGCCCTGCACGACAGTACGACACACGCTCATACCCTGCACTCTCTATACATTCAGTGCTAA
Protein
MSRLVDYFVIVGFDHEKERGGLNSGVVLQRFPETNWDDVPFHDGIGWFCQPQGWALSTERTEPRFYVSVLTDVDANRHYCACLCFNETVAITPTKPADEDEESLDSSRPVANITHHSIMYAPKCLVIVSRQDYIDTFRNCLGIIYTVWVENLGVPLETLVGNLVGGVLVPEPGGPQVRFSIGAGDRQALQPPAAPPMPVTHTSVYMLLRLLGIHNAVTLWCAVMSEHKVLLVSLAAARLAGVCRALAALMFPFRYAHVYIPLLPAGLAEVLATPTPFLIGVHSNLKEDVSELLDVIVADLDVGSLHIPAGVNIPRPEGKLLSSLQNALALVLQPELRSADSAFAPPPPSASPPHMLDKEIRAVFMRTLAKLLQGYRHCLTLVRIHPAPVLTFHKLGFVGARGLAQCEFTARLLDSMFFSGLVAERGPPWRPVDLFDDLLQNLPEQLRLESLNPELELQHIQDLAMQLHLNENPNPQPFQQRILRPPEGASSRIHQPPLPAIDARKVRDVMDEVSARSANNPKLTALRPPQPRIVSLSAPPTGAVEHNQLPPTNSARRLEVLSACVAAIFECRYADGRKSVAGVVRALRAPAARAALVRDLAARLPTNKHLLHHHQFELVVRLMNCALQSTTAIDEHSIAAAMLPLATAYCRKLCTGVIQYAYMCIQEHPVWTSQQFWEAAFYQDVQKDIKALYLPSPTHHPRVPTPRDDEDYISLLKAQEPSALEIAAEQMRLWPSLSPEKQKELIASEESTLYSQAIHYANRMVYLLLPLEGAGRRADVRGDDVDRASNSITNSVAESDSVDAESGFEEADPGEAGNNVIKMVSRFVDKVCTEGGVTAEHVRCLHQMIPGVVHMHLETLDAVARESRRLPPVQKPRIVSPVLVGGEAVSGPALRAYLVCDGRPSSLLPAEGALFLTNYRLIFKGTPTDPFACEQTVVRSFPLCSLTREKAIRTHYIPHLEQSLQDGLQLRSATFQLIKVALDEEVSSELTESFRKQLARLRHPEHPLLHFALTPRPVPPPAHHQAKHNTLKGFAKKTLLKTARKAGLKPKPSKRQKYVLPSADARSLTSPPLMSSLSADTLSLEELDLGSSEPTEAPAARTLERVRERIYAKDWARLGLASPPFRLAHANAVYTLCRSYPAVIPVPESIGDESLRRVARCYRQGRLPLVTWRHPRTHALLARSSASHHKGVMGMLKATHQTQGTTQSGTETTSSLEQERYIATLVACTPASRGDLEDSSLSLDSLLLCCDEQQPTHTPLLTKAAGTLSVLRNSGGKGGGTSGGRAFGRWGSLKDRRQPSHLELYAPRQRLSTADLDSMSAEGGVTRRAALYVVGEKGAGAGCAAGAEAVPADYPETRHTRHAFKKLMRCAVPSAPALDPTTFLRQVEESGWLWQLRQLFQLSGAVVDLLDVQGSSVLLSLEDGWDVTAQISSLAQICLEPYYRTLEGFRIIVEKEWLALGHKFQQRCNIGATPQQGFTPTFLMFLDAVHQLQKQFPLAFEFNEYYLRFVAYHSVSCRFRTFLLDSEAQRAELGITAADDKRADTNRLGVETGAGVEEEAGGGRGPPLGHSLFDYIDKQHQKSPVFYNFLYTPDLDNPVLRPVSSICAFEVWGYYTSEELSHGAPYDLEVLSSCEQDVKQPQRRVVTAGYDSISRCMPDSFTGLLERIRQLELELGHLPQKWKVRWDQLELPNTVELQRAGSVCGSAARAAAACAHRRDTLEVLVRGRLAAAPPPDPAHRFLPAAAAAPARCDHCHHLLWGPLKTGVRCVDCGAACHERCAETFAPPCTKYKAPAPPDRDLRPALHDSTTHAHTLHSLYIQC
Summary
Description
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (By similarity). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Acts as an adapter for the phosphatase MTMR2 (PubMed:16399794). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (PubMed:16399794).
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity).
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28 (PubMed:20937701, PubMed:25648148). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701, PubMed:25648148). In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Acts as an adapter for the phosphatase MTMR2 (By similarity). Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate (By similarity).
Subunit
Homodimer (PubMed:16399794). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:16399794). Interacts with class II PI3-kinase PIK3C2A (PubMed:22648168). Interacts (via DENN domain) with RAB21 (in GDP-bound form) in response to starvation; the interaction activates RAB21 (By similarity). Interacts with VAMP8 in response to starvation (By similarity).
Homodimer (By similarity). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:15998640). Interacts with class II PI3-kinase PIK3C2A (By similarity). Interacts (via DENN domain) with RAB21 (in GDP-bound form) in response to starvation; the interaction activates RAB21 (PubMed:25648148). Interacts with VAMP8 in response to starvation (PubMed:25648148).
Homodimer (By similarity). Heterotetramer consisting of one MTMR2 dimer and one SBF2/MTMR13 dimer (PubMed:15998640). Interacts with class II PI3-kinase PIK3C2A (By similarity). Interacts (via DENN domain) with RAB21 (in GDP-bound form) in response to starvation; the interaction activates RAB21 (PubMed:25648148). Interacts with VAMP8 in response to starvation (PubMed:25648148).
Similarity
Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
Keywords
Alternative splicing
Autophagy
Cell projection
Complete proteome
Cytoplasm
Endosome
Guanine-nucleotide releasing factor
Membrane
Phosphoprotein
Reference proteome
Charcot-Marie-Tooth disease
Neurodegeneration
Neuropathy
Polymorphism
Feature
chain Myotubularin-related protein 13
splice variant In isoform 2.
sequence variant In dbSNP:rs16907355.
splice variant In isoform 2.
sequence variant In dbSNP:rs16907355.
Uniprot
A0A194Q4B9
A0A2J7PZ14
A0A2J7PZ15
A0A067QKD8
A0A2J7PYZ2
A0A347ZJ92
+ More
A0A2A3ETU6 A0A088AH85 A0A026WZT7 E9ISR5 E2ADV6 D2A1W9 A0A158NQW7 A0A1B6D2X0 A0A195E6E1 A0A154P8W7 E2C3V7 F4WP75 A0A0C9RLA2 A0A232FAK5 A0A0C9QHJ8 A0A1Y1NIY3 A0A0M8ZZ59 A0A0L7QWF8 A0A2P8YE34 X1WW11 A0A2H8TTA1 A0A0A9Y3Z1 A0A2S2QWS2 A0A2P6LBV2 A0A0J7L3G4 A0A164SU02 A0A0P5V2Z8 A0A2J7PZ01 W8AL29 W8AEF8 A0A0K8V365 A0A131YTC2 A0A224Z605 A0A1E1XLZ0 A0A195CM83 A0A151WM77 A0A195EUF8 A0A195B0H2 V5HL36 A0A2R5L4X1 T1HH24 A0A3B4CB89 W5NJH7 U3EI45 A0A0P6JX00 A0A452FA59 U3APH5 E9PXF8-2 A0A287AD22 F1PZ30 A0A340YJ40 A0A3Q7VG63 A0A3Q7MC74 A0A2Y9SEX4 A0A2U3VIF3 H2NE44 K7ASI2 F7HJS9 A0A096NFW7 K7DTM0 G3R071 A0A2R9BRQ7 A0A2K6E306 F6R9C2 Q86WG5 A0A2Y9M1Z9 A0A2Y9L7X2 A0A286Y4Q3 A0A3Q1LVT0 A0A1Q3F0D9 A0A0P5ZE07 A0A0P5Y005 A0A0N8CGG0
A0A2A3ETU6 A0A088AH85 A0A026WZT7 E9ISR5 E2ADV6 D2A1W9 A0A158NQW7 A0A1B6D2X0 A0A195E6E1 A0A154P8W7 E2C3V7 F4WP75 A0A0C9RLA2 A0A232FAK5 A0A0C9QHJ8 A0A1Y1NIY3 A0A0M8ZZ59 A0A0L7QWF8 A0A2P8YE34 X1WW11 A0A2H8TTA1 A0A0A9Y3Z1 A0A2S2QWS2 A0A2P6LBV2 A0A0J7L3G4 A0A164SU02 A0A0P5V2Z8 A0A2J7PZ01 W8AL29 W8AEF8 A0A0K8V365 A0A131YTC2 A0A224Z605 A0A1E1XLZ0 A0A195CM83 A0A151WM77 A0A195EUF8 A0A195B0H2 V5HL36 A0A2R5L4X1 T1HH24 A0A3B4CB89 W5NJH7 U3EI45 A0A0P6JX00 A0A452FA59 U3APH5 E9PXF8-2 A0A287AD22 F1PZ30 A0A340YJ40 A0A3Q7VG63 A0A3Q7MC74 A0A2Y9SEX4 A0A2U3VIF3 H2NE44 K7ASI2 F7HJS9 A0A096NFW7 K7DTM0 G3R071 A0A2R9BRQ7 A0A2K6E306 F6R9C2 Q86WG5 A0A2Y9M1Z9 A0A2Y9L7X2 A0A286Y4Q3 A0A3Q1LVT0 A0A1Q3F0D9 A0A0P5ZE07 A0A0P5Y005 A0A0N8CGG0
Pubmed
26354079
24845553
24508170
30249741
21282665
20798317
+ More
18362917 19820115 21347285 21719571 28648823 28004739 29403074 25401762 24495485 26830274 28797301 29209593 25765539 25243066 19468303 16141072 15489334 16750429 16399794 17855448 18349142 21183079 22648168 23297362 16341006 17431167 25319552 16136131 22398555 22722832 19892987 12554688 11214970 17974005 12687498 15304601 15477569 15998640 18669648 20937701 20068231 23186163 25648148 21993624 19393038
18362917 19820115 21347285 21719571 28648823 28004739 29403074 25401762 24495485 26830274 28797301 29209593 25765539 25243066 19468303 16141072 15489334 16750429 16399794 17855448 18349142 21183079 22648168 23297362 16341006 17431167 25319552 16136131 22398555 22722832 19892987 12554688 11214970 17974005 12687498 15304601 15477569 15998640 18669648 20937701 20068231 23186163 25648148 21993624 19393038
EMBL
KQ459585
KPI98255.1
NEVH01020341
PNF21566.1
PNF21562.1
KK853238
+ More
KDR09530.1 PNF21564.1 FX985660 BBA84398.1 KZ288189 PBC34636.1 KK107073 QOIP01000003 EZA60629.1 RLU24762.1 GL765434 EFZ16445.1 GL438820 EFN68468.1 KQ971338 EFA02135.1 ADTU01023676 ADTU01023677 GEDC01017383 JAS19915.1 KQ979608 KYN20414.1 KQ434827 KZC07590.1 GL452364 EFN77343.1 GL888243 EGI64006.1 GBYB01014117 JAG83884.1 NNAY01000561 OXU27652.1 GBYB01014118 JAG83885.1 GEZM01001405 GEZM01001400 JAV97854.1 KQ435794 KOX73887.1 KQ414713 KOC62963.1 PYGN01000670 PSN42503.1 ABLF02032798 GFXV01005658 MBW17463.1 GBHO01019369 GBHO01019368 JAG24235.1 JAG24236.1 GGMS01012985 MBY82188.1 MWRG01000458 PRD36061.1 LBMM01000932 KMQ97196.1 LRGB01001937 KZS09941.1 GDIP01121316 JAL82398.1 PNF21563.1 GAMC01019988 JAB86567.1 GAMC01019985 JAB86570.1 GDHF01027911 GDHF01019033 JAI24403.1 JAI33281.1 GEDV01006084 JAP82473.1 GFPF01010544 MAA21690.1 GFAA01003084 JAU00351.1 KQ977574 KYN01823.1 KQ982944 KYQ48956.1 KQ981965 KYN31791.1 KQ976691 KYM77978.1 GANP01008446 JAB76022.1 GGLE01000397 MBY04523.1 ACPB03011538 AHAT01023621 AHAT01023622 AHAT01023623 GAMS01004129 GAMR01002431 GAMP01008532 GAMP01008531 GAMP01008530 GAMP01008529 GAMP01008528 GAMP01008527 JAB19007.1 JAB31501.1 JAB44227.1 GEBF01002320 JAO01313.1 LWLT01000015 GAMT01009918 JAB01943.1 AC122921 AC124472 AC154911 AK029568 AK080952 AK087396 BC015069 AAH15069.1 BAC39860.1 AEMK02000009 AAEX03012895 AAEX03012896 AAEX03012897 AAEX03012898 AAEX03012899 ABGA01123855 ABGA01123856 ABGA01123857 ABGA01123858 ABGA01123859 ABGA01123860 ABGA01123861 ABGA01123862 ABGA01123863 ABGA01123864 NDHI03003449 PNJ47270.1 GABC01006579 GABF01007690 GABD01008005 NBAG03000219 JAA04759.1 JAA14455.1 JAA25095.1 PNI79334.1 JSUE03012715 JSUE03012716 JSUE03012717 JSUE03012718 JSUE03012719 JSUE03012720 JSUE03012721 JSUE03012722 JSUE03012723 JSUE03012724 JU321510 AFE65266.1 AHZZ02006966 AHZZ02006967 AHZZ02006968 AHZZ02006969 AHZZ02006970 AHZZ02006971 AHZZ02006972 AACZ04016601 AACZ04016602 AACZ04016603 AACZ04016604 AACZ04016605 GABE01001237 JAA43502.1 CABD030077490 CABD030077491 CABD030077492 CABD030077493 CABD030077494 CABD030077495 CABD030077496 CABD030077497 CABD030077498 CABD030077499 AJFE02062074 AJFE02062075 AJFE02062076 AJFE02062077 AJFE02062078 AJFE02062079 AJFE02062080 AJFE02062081 AJFE02062082 AJFE02062083 AY234241 BC011143 BC043389 BC053867 BC063656 BC101466 AB051553 BX538184 CR749312 AAKN02045461 AAKN02045462 AAKN02045463 AAKN02045464 AAKN02045465 AAKN02045466 AAKN02045467 AAKN02045468 AAKN02045469 AAKN02045470 GFDL01014046 JAV20999.1 GDIP01046785 JAM56930.1 GDIP01064828 JAM38887.1 GDIP01134167 JAL69547.1
KDR09530.1 PNF21564.1 FX985660 BBA84398.1 KZ288189 PBC34636.1 KK107073 QOIP01000003 EZA60629.1 RLU24762.1 GL765434 EFZ16445.1 GL438820 EFN68468.1 KQ971338 EFA02135.1 ADTU01023676 ADTU01023677 GEDC01017383 JAS19915.1 KQ979608 KYN20414.1 KQ434827 KZC07590.1 GL452364 EFN77343.1 GL888243 EGI64006.1 GBYB01014117 JAG83884.1 NNAY01000561 OXU27652.1 GBYB01014118 JAG83885.1 GEZM01001405 GEZM01001400 JAV97854.1 KQ435794 KOX73887.1 KQ414713 KOC62963.1 PYGN01000670 PSN42503.1 ABLF02032798 GFXV01005658 MBW17463.1 GBHO01019369 GBHO01019368 JAG24235.1 JAG24236.1 GGMS01012985 MBY82188.1 MWRG01000458 PRD36061.1 LBMM01000932 KMQ97196.1 LRGB01001937 KZS09941.1 GDIP01121316 JAL82398.1 PNF21563.1 GAMC01019988 JAB86567.1 GAMC01019985 JAB86570.1 GDHF01027911 GDHF01019033 JAI24403.1 JAI33281.1 GEDV01006084 JAP82473.1 GFPF01010544 MAA21690.1 GFAA01003084 JAU00351.1 KQ977574 KYN01823.1 KQ982944 KYQ48956.1 KQ981965 KYN31791.1 KQ976691 KYM77978.1 GANP01008446 JAB76022.1 GGLE01000397 MBY04523.1 ACPB03011538 AHAT01023621 AHAT01023622 AHAT01023623 GAMS01004129 GAMR01002431 GAMP01008532 GAMP01008531 GAMP01008530 GAMP01008529 GAMP01008528 GAMP01008527 JAB19007.1 JAB31501.1 JAB44227.1 GEBF01002320 JAO01313.1 LWLT01000015 GAMT01009918 JAB01943.1 AC122921 AC124472 AC154911 AK029568 AK080952 AK087396 BC015069 AAH15069.1 BAC39860.1 AEMK02000009 AAEX03012895 AAEX03012896 AAEX03012897 AAEX03012898 AAEX03012899 ABGA01123855 ABGA01123856 ABGA01123857 ABGA01123858 ABGA01123859 ABGA01123860 ABGA01123861 ABGA01123862 ABGA01123863 ABGA01123864 NDHI03003449 PNJ47270.1 GABC01006579 GABF01007690 GABD01008005 NBAG03000219 JAA04759.1 JAA14455.1 JAA25095.1 PNI79334.1 JSUE03012715 JSUE03012716 JSUE03012717 JSUE03012718 JSUE03012719 JSUE03012720 JSUE03012721 JSUE03012722 JSUE03012723 JSUE03012724 JU321510 AFE65266.1 AHZZ02006966 AHZZ02006967 AHZZ02006968 AHZZ02006969 AHZZ02006970 AHZZ02006971 AHZZ02006972 AACZ04016601 AACZ04016602 AACZ04016603 AACZ04016604 AACZ04016605 GABE01001237 JAA43502.1 CABD030077490 CABD030077491 CABD030077492 CABD030077493 CABD030077494 CABD030077495 CABD030077496 CABD030077497 CABD030077498 CABD030077499 AJFE02062074 AJFE02062075 AJFE02062076 AJFE02062077 AJFE02062078 AJFE02062079 AJFE02062080 AJFE02062081 AJFE02062082 AJFE02062083 AY234241 BC011143 BC043389 BC053867 BC063656 BC101466 AB051553 BX538184 CR749312 AAKN02045461 AAKN02045462 AAKN02045463 AAKN02045464 AAKN02045465 AAKN02045466 AAKN02045467 AAKN02045468 AAKN02045469 AAKN02045470 GFDL01014046 JAV20999.1 GDIP01046785 JAM56930.1 GDIP01064828 JAM38887.1 GDIP01134167 JAL69547.1
Proteomes
UP000053268
UP000235965
UP000027135
UP000242457
UP000005203
UP000053097
+ More
UP000279307 UP000000311 UP000007266 UP000005205 UP000078492 UP000076502 UP000008237 UP000007755 UP000215335 UP000053105 UP000053825 UP000245037 UP000007819 UP000036403 UP000076858 UP000078542 UP000075809 UP000078541 UP000078540 UP000015103 UP000261440 UP000018468 UP000291000 UP000000589 UP000008227 UP000002254 UP000265300 UP000286642 UP000286641 UP000248484 UP000245340 UP000001595 UP000006718 UP000028761 UP000002277 UP000001519 UP000240080 UP000233120 UP000002281 UP000005640 UP000248483 UP000248482 UP000005447 UP000009136
UP000279307 UP000000311 UP000007266 UP000005205 UP000078492 UP000076502 UP000008237 UP000007755 UP000215335 UP000053105 UP000053825 UP000245037 UP000007819 UP000036403 UP000076858 UP000078542 UP000075809 UP000078541 UP000078540 UP000015103 UP000261440 UP000018468 UP000291000 UP000000589 UP000008227 UP000002254 UP000265300 UP000286642 UP000286641 UP000248484 UP000245340 UP000001595 UP000006718 UP000028761 UP000002277 UP000001519 UP000240080 UP000233120 UP000002281 UP000005640 UP000248483 UP000248482 UP000005447 UP000009136
Pfam
Interpro
IPR004182
GRAM
+ More
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037516 Tripartite_DENN
IPR022096 SBF1/SBF2
IPR029021 Prot-tyrosine_phosphatase-like
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR005113 uDENN_dom
IPR012295 TBP_dom_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR016024 ARM-type_fold
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR015151 B-adaptin_app_sub_C
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR011989 ARM-like
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd
IPR020454 DAG/PE-bd
IPR030567 MTMR13
IPR037823 MTMR13_PH-GRAM
IPR030574 MTMR5
IPR001194 cDENN_dom
IPR005112 dDENN_dom
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037516 Tripartite_DENN
IPR022096 SBF1/SBF2
IPR029021 Prot-tyrosine_phosphatase-like
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR005113 uDENN_dom
IPR012295 TBP_dom_sf
IPR009028 Coatomer/calthrin_app_sub_C
IPR016024 ARM-type_fold
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR002553 Clathrin/coatomer_adapt-like_N
IPR013041 Clathrin_app_Ig-like_sf
IPR015151 B-adaptin_app_sub_C
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR011989 ARM-like
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd
IPR020454 DAG/PE-bd
IPR030567 MTMR13
IPR037823 MTMR13_PH-GRAM
IPR030574 MTMR5
SUPFAM
Gene 3D
ProteinModelPortal
A0A194Q4B9
A0A2J7PZ14
A0A2J7PZ15
A0A067QKD8
A0A2J7PYZ2
A0A347ZJ92
+ More
A0A2A3ETU6 A0A088AH85 A0A026WZT7 E9ISR5 E2ADV6 D2A1W9 A0A158NQW7 A0A1B6D2X0 A0A195E6E1 A0A154P8W7 E2C3V7 F4WP75 A0A0C9RLA2 A0A232FAK5 A0A0C9QHJ8 A0A1Y1NIY3 A0A0M8ZZ59 A0A0L7QWF8 A0A2P8YE34 X1WW11 A0A2H8TTA1 A0A0A9Y3Z1 A0A2S2QWS2 A0A2P6LBV2 A0A0J7L3G4 A0A164SU02 A0A0P5V2Z8 A0A2J7PZ01 W8AL29 W8AEF8 A0A0K8V365 A0A131YTC2 A0A224Z605 A0A1E1XLZ0 A0A195CM83 A0A151WM77 A0A195EUF8 A0A195B0H2 V5HL36 A0A2R5L4X1 T1HH24 A0A3B4CB89 W5NJH7 U3EI45 A0A0P6JX00 A0A452FA59 U3APH5 E9PXF8-2 A0A287AD22 F1PZ30 A0A340YJ40 A0A3Q7VG63 A0A3Q7MC74 A0A2Y9SEX4 A0A2U3VIF3 H2NE44 K7ASI2 F7HJS9 A0A096NFW7 K7DTM0 G3R071 A0A2R9BRQ7 A0A2K6E306 F6R9C2 Q86WG5 A0A2Y9M1Z9 A0A2Y9L7X2 A0A286Y4Q3 A0A3Q1LVT0 A0A1Q3F0D9 A0A0P5ZE07 A0A0P5Y005 A0A0N8CGG0
A0A2A3ETU6 A0A088AH85 A0A026WZT7 E9ISR5 E2ADV6 D2A1W9 A0A158NQW7 A0A1B6D2X0 A0A195E6E1 A0A154P8W7 E2C3V7 F4WP75 A0A0C9RLA2 A0A232FAK5 A0A0C9QHJ8 A0A1Y1NIY3 A0A0M8ZZ59 A0A0L7QWF8 A0A2P8YE34 X1WW11 A0A2H8TTA1 A0A0A9Y3Z1 A0A2S2QWS2 A0A2P6LBV2 A0A0J7L3G4 A0A164SU02 A0A0P5V2Z8 A0A2J7PZ01 W8AL29 W8AEF8 A0A0K8V365 A0A131YTC2 A0A224Z605 A0A1E1XLZ0 A0A195CM83 A0A151WM77 A0A195EUF8 A0A195B0H2 V5HL36 A0A2R5L4X1 T1HH24 A0A3B4CB89 W5NJH7 U3EI45 A0A0P6JX00 A0A452FA59 U3APH5 E9PXF8-2 A0A287AD22 F1PZ30 A0A340YJ40 A0A3Q7VG63 A0A3Q7MC74 A0A2Y9SEX4 A0A2U3VIF3 H2NE44 K7ASI2 F7HJS9 A0A096NFW7 K7DTM0 G3R071 A0A2R9BRQ7 A0A2K6E306 F6R9C2 Q86WG5 A0A2Y9M1Z9 A0A2Y9L7X2 A0A286Y4Q3 A0A3Q1LVT0 A0A1Q3F0D9 A0A0P5ZE07 A0A0P5Y005 A0A0N8CGG0
PDB
1ZVR
E-value=1.13771e-33,
Score=365
Ontologies
GO
PANTHER
Topology
Subcellular location
Cytoplasm
Perinuclear region Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Membrane Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Endosome membrane Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Cell projection Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Axon Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Perinuclear region Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Membrane Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Endosome membrane Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Cell projection Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Axon Associated with membranes (By similarity). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). Membrane localization is likely to be mediated via its interaction with MTMR2 (PubMed:23297362). With evidence from 2 publications.
Length:
1822
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
4.04756
Exp number, first 60 AAs:
0
Total prob of N-in:
0.04064
outside
1 - 1822
Population Genetic Test Statistics
Pi
235.254183
Theta
177.52471
Tajima's D
0.844426
CLR
0.177455
CSRT
0.606569671516424
Interpretation
Uncertain
