Gene

KWMTBOMO08358

Pre Gene Modal

BGIBMGA009230

Annotation

PREDICTED:_cathepsin_O-like_[Amyelois_transitella]

Location

Bomo_Chr14(-):6496180-6509556      View in EpiBrowser

Full name

Tryptophan 2,3-dioxygenase      

Alternative Name

Tryptamin 2,3-dioxygenase
Tryptophan oxygenase
Tryptophan pyrrolase
Tryptophanase

Location in the cell

Extracellular   Reliability : 1.167

CDS

ATGAAAAAATGGTGGAACTGGGTACTCGGTTTTGCTTTGATTTGTTTATTATTCGTAGCTGTTCCTCTTACGTTGTCCAATCAAAAAGGCAAAGAAGAGTTAAAGCCGATGTTTGATGAATATATTCAAAAGTATAATAAAAGTTACAAAAATAAACCCGATGAATACGCAGTGAGATTTGAACATTTTGTGGCATCTGTGCGCGAAATTGAAGAACTAAATGCGGCTGCGCGTGGCCCTGAGGAGCACAGAGCCAGATATGGTTTAACCAGAATCTCGGATATGTCCAAGCTCGAATACAAAGAGATTCACTTATCAGATGAGAGACTTAAGAAATCACCTCATTTGTATGGCAAGAGTTGGAGCAAGTTCAGAGATCAGAAACCTGAAAATACTGTTGGAAATGATGATAATGATACACCCCACAGCAGCCACCAGAGAAATAGAACGCCATGTGCAAATGAACCTCATAATAATGTTTATGTAATAATTAGGAAAAAACGTGCTACTCTTCCATTGAAGGTCGATTGGAGAACGAAAGGAGTTATAGGACCTGTAAGAGATCAGGGTCTATGTGGAGCGTGCTGGGCGTTCAGTACAGTTGGCACTATCGAGTCTATGCAAGCCATCAAGACTGGCACTCTAATGCCACTCAGTGTGCAGGAAGTGATTGACTGCGCCGGTCTAGGCAACAGCGGATGCGCGGGTGGGGACATATGTCTTTTGCTAGACTGGTTGACCATAACCAACACGGCTATACAGCACGAGAAAGAGTACCCGCTCCGTCTCATGAGCGGCGCATGCAAGGCCACTAAGAACGCGACCGGCGTGCGAATATCCACTTTTACTTGTGACGATTTCGTCGGTGCAGAGGAGAAGATATTGGAAGCGTTGGCCACACACGGCCCGGTCACGGTCGCTGTCAACGCCCTAACTTGGCAGAATTATCTCGGCGGAGTCATACAGTATCATTGCAGCGGTGCACCGGCTGACTTGAATCACGCGGTCCAACTTGTTGGCTACGATTTGACGGCCGAAGTGCCTTACTACATCGCCAAGAACTCGTGGGGAGCCGACTACGGAAACGGTGGCTATCTGATGTTGGCCGTGGGCACCAACATTTGTGGTCTGGCCAACGAAGTCGCGACCGTAGACGTTCTATAA

Protein

MKKWWNWVLGFALICLLFVAVPLTLSNQKGKEELKPMFDEYIQKYNKSYKNKPDEYAVRFEHFVASVREIEELNAAARGPEEHRARYGLTRISDMSKLEYKEIHLSDERLKKSPHLYGKSWSKFRDQKPENTVGNDDNDTPHSSHQRNRTPCANEPHNNVYVIIRKKRATLPLKVDWRTKGVIGPVRDQGLCGACWAFSTVGTIESMQAIKTGTLMPLSVQEVIDCAGLGNSGCAGGDICLLLDWLTITNTAIQHEKEYPLRLMSGACKATKNATGVRISTFTCDDFVGAEEKILEALATHGPVTVAVNALTWQNYLGGVIQYHCSGAPADLNHAVQLVGYDLTAEVPYYIAKNSWGADYGNGGYLMLAVGTNICGLANEVATVDVL

Description

Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.

Catalytic Activity

L-tryptophan + O2 = N-formyl-L-kynurenine

Cofactor

heme

Subunit

Homotetramer. Dimer of dimers.

Similarity

Belongs to the peptidase C1 family.
Belongs to the tryptophan 2,3-dioxygenase family.

Feature

chain  Tryptophan 2,3-dioxygenase

Uniprot

A0A3Q8AYZ4   A0A2H1VBA2   A0A2A4JKQ2   A0A212EPL3   A0A194PY34   A0A437BN63   + More
J7HI12   A0A2A4IWR3   A0A0N1ICZ1   A0A2W1B435   A0A088AUI0   A0A026W1D4   A0A2A3ERB9   A0A1B6F717   R4WDB3   K7J8W5   A0A0M8ZTL2   E2AWA7   A0A154NZE0   A0A3L8D6J6   E2BJG2   A0A195BSX4   A0A158P1Z3   F4WME2   A0A195F3S1   A0A067R1K0   A0A232EN91   A0A151IL61   A0A195DC55   A0A1V1G5H8   A0A2P8XV78   A0A146LY49   A0A1Y1N308   A0A1B6E1M9   D2A0S2   J3JUX2   E9G115   A0A164LEG2   A0A0P6DUR6   A0A0N8CGR1   A0A0P4VPU0   T1HF18   A0A0P5QE26   A0A1D2MWW1   V5G6Y1   N6UR32   A0A151WQZ2   A0A443SQE0   A0A0N8DME0   A0A0P5DAQ1   N6TT28   B7P7I7   U4U3V2   U6JMC8   A0A0B5J1X2   A0A090XF85   R4G394   A0A1S3DEN6   A0A087V0D1   A0A0P5YPQ9   A0A0P5N3F3   A0A1B6LKV5   A0A226E7F2   A0A0L8FUN9   V4CPT5   A0A1Z5L8G2   A0A182IP04   A0A1S3IVU0   A0A293N5B9   Q17P70   A0A3S1BWC6   A0A0P5G700   A0A1Q3FZ96   A0A182H2Y3   A0A1S3IWG8   A0A2T7PMN4   W5JJ47   A0A0B7ATG4   A0A1I8JW56   Q7QCN0   A0A182IIH7   A0A182LE45   A0A182V6I6   A0A182TTT7   A0A132ACB0   A0A182Y400   A0A3Q3SJ83   A0A1W4ZLU7   W5MNN3   A0A182FQY9   A0A1B0CQA8   A0A2G8KAM0   A0A182VZT9   A0A3Q1CT53   A0A3B4ZKG5  

EC Number

1.13.11.11

Pubmed

22118469    26354079    28756777    24508170    23691247    20075255    + More
20798317    30249741    21347285    21719571    24845553    28648823    28410430    29403074    26823975    28004739    18362917    19820115    22516182    21292972    27129103    27289101    23537049    25875018    25970599    23254933    28528879    17510324    26483478    20920257    23761445    12364791    14747013    17210077    20966253    26555130    25244985    29023486   

EMBL

MF155621    ARV79892.1    ODYU01001628    SOQ38119.1    NWSH01001237    PCG72013.1    + More
AGBW02013432    OWR43445.1    KQ459585    KPI98242.1    RSAL01000028    RVE51843.1    JN400433    AFQ01136.1    NWSH01006263    PCG63553.1    KQ461193    KPJ06987.1    KZ150356    PZC71232.1    KK107488    EZA49885.1    KZ288192    PBC34315.1    GECZ01023730    GECZ01019517    GECZ01007984    JAS46039.1    JAS50252.1    JAS61785.1    AK417518    BAN20733.1    AAZX01013133    AAZX01019176    KQ435850    KOX70875.1    GL443280    EFN62267.1    KQ434778    KZC04434.1    QOIP01000012    RLU15874.1    GL448571    EFN84119.1    KQ976418    KYM89473.1    ADTU01001112    GL888217    EGI64786.1    KQ981855    KYN34827.1    KK852773    KDR16812.1    NNAY01003205    OXU19797.1    KQ977135    KYN05468.1    KQ980989    KYN10495.1    FX985413    BAX07426.1    PYGN01001295    PSN35919.1    GDHC01006146    JAQ12483.1    GEZM01013872    JAV92281.1    GEDC01005466    JAS31832.1    KQ971338    EFA02812.2    BT127037    AEE61999.1    GL732529    EFX86715.1    LRGB01003146    KZS04034.1    GDIQ01073595    JAN21142.1    GDIP01133359    JAL70355.1    GDKW01002189    JAI54406.1    ACPB03015471    GDIQ01122133    JAL29593.1    LJIJ01000446    ODM97411.1    GALX01002621    JAB65845.1    APGK01020083    APGK01020084    APGK01020085    APGK01020086    KB740160    ENN81212.1    KQ982831    KYQ50095.1    NCKV01000807    RWS29685.1    GDIP01019527    JAM84188.1    GDIP01162802    JAJ60600.1    ENN81213.1    ABJB010035484    DS652265    EEC02559.1    KB632077    ERL88569.1    HG710160    CDJ26736.1    KP303286    AJF94884.1    GBIH01000532    JAC94178.1    GAHY01001881    JAA75629.1    KK122590    KFM83070.1    GDIP01056165    JAM47550.1    GDIQ01150141    JAL01585.1    GEBQ01015657    JAT24320.1    LNIX01000006    OXA52877.1    KQ426357    KOF68348.1    KB199753    ESP04425.1    GFJQ02003253    JAW03717.1    GFWV01022862    MAA47589.1    CH477193    EAT48563.1    RQTK01000036    RUS90295.1    GDIQ01245398    JAK06327.1    GFDL01002161    JAV32884.1    JXUM01024214    KQ560683    KXJ81289.1    PZQS01000003    PVD34680.1    ADMH02001265    ETN63323.1    HACG01037454    HACG01037455    CEK84319.1    CEK84320.1    AAAB01008859    EAA08145.5    APCN01000245    JXLN01012453    KPM08509.1    AHAT01015360    AJWK01023339    MRZV01000740    PIK45009.1   

Proteomes

UP000218220    UP000007151    UP000053268    UP000283053    UP000053240    UP000005203    + More
UP000053097    UP000242457    UP000002358    UP000053105    UP000000311    UP000076502    UP000279307    UP000008237    UP000078540    UP000005205    UP000007755    UP000078541    UP000027135    UP000215335    UP000078542    UP000078492    UP000245037    UP000007266    UP000000305    UP000076858    UP000015103    UP000094527    UP000019118    UP000075809    UP000288716    UP000001555    UP000030742    UP000079169    UP000054359    UP000198287    UP000053454    UP000030746    UP000075880    UP000085678    UP000008820    UP000271974    UP000069940    UP000249989    UP000245119    UP000000673    UP000076407    UP000007062    UP000075840    UP000075882    UP000075903    UP000075902    UP000076408    UP000261640    UP000192224    UP000018468    UP000069272    UP000092461    UP000230750    UP000075920    UP000257160    UP000261400   

Pfam

PF00112   Peptidase_C1        + More
PF08246   Inhibitor_I29
PF01263   Aldose_epim
PF00189   Ribosomal_S3_C
PF07650   KH_2
PF00505   HMG_box
PF03301   Trp_dioxygenase

Interpro

IPR025660   Pept_his_AS        + More
IPR039417   Peptidase_C1A_papain-like       
IPR038765   Papain-like_cys_pep_sf       
IPR013201   Prot_inhib_I29       
IPR000169   Pept_cys_AS       
IPR000668   Peptidase_C1A_C       
IPR011013   Gal_mutarotase_sf_dom       
IPR018052   Ald1_epimerase_CS       
IPR008183   Aldose_1/G6P_1-epimerase       
IPR014718   GH-type_carb-bd       
IPR009019   KH_sf_prok-type       
IPR015946   KH_dom-like_a/b       
IPR004044   KH_dom_type_2       
IPR001351   Ribosomal_S3_C       
IPR005703   Ribosomal_S3_euk/arc       
IPR036419   Ribosomal_S3_C_sf       
IPR009071   HMG_box_dom       
IPR030089   BAF57       
IPR036910   HMG_box_dom_sf       
IPR025661   Pept_asp_AS       
IPR037217   Trp/Indoleamine_2_3_dOase-like       
IPR004981   Trp_2_3_dOase       

SUPFAM

SSF54001   SSF54001        + More
SSF74650   SSF74650       
SSF54821   SSF54821       
SSF54814   SSF54814       
SSF47095   SSF47095       
SSF140959   SSF140959       

Gene 3D

2.70.98.10     3.30.1140.32     3.30.300.20     1.10.30.10    

CDD

cd02248  Peptidase_C1A

ProteinModelPortal

A0A3Q8AYZ4   A0A2H1VBA2   A0A2A4JKQ2   A0A212EPL3   A0A194PY34   A0A437BN63   + More
J7HI12   A0A2A4IWR3   A0A0N1ICZ1   A0A2W1B435   A0A088AUI0   A0A026W1D4   A0A2A3ERB9   A0A1B6F717   R4WDB3   K7J8W5   A0A0M8ZTL2   E2AWA7   A0A154NZE0   A0A3L8D6J6   E2BJG2   A0A195BSX4   A0A158P1Z3   F4WME2   A0A195F3S1   A0A067R1K0   A0A232EN91   A0A151IL61   A0A195DC55   A0A1V1G5H8   A0A2P8XV78   A0A146LY49   A0A1Y1N308   A0A1B6E1M9   D2A0S2   J3JUX2   E9G115   A0A164LEG2   A0A0P6DUR6   A0A0N8CGR1   A0A0P4VPU0   T1HF18   A0A0P5QE26   A0A1D2MWW1   V5G6Y1   N6UR32   A0A151WQZ2   A0A443SQE0   A0A0N8DME0   A0A0P5DAQ1   N6TT28   B7P7I7   U4U3V2   U6JMC8   A0A0B5J1X2   A0A090XF85   R4G394   A0A1S3DEN6   A0A087V0D1   A0A0P5YPQ9   A0A0P5N3F3   A0A1B6LKV5   A0A226E7F2   A0A0L8FUN9   V4CPT5   A0A1Z5L8G2   A0A182IP04   A0A1S3IVU0   A0A293N5B9   Q17P70   A0A3S1BWC6   A0A0P5G700   A0A1Q3FZ96   A0A182H2Y3   A0A1S3IWG8   A0A2T7PMN4   W5JJ47   A0A0B7ATG4   A0A1I8JW56   Q7QCN0   A0A182IIH7   A0A182LE45   A0A182V6I6   A0A182TTT7   A0A132ACB0   A0A182Y400   A0A3Q3SJ83   A0A1W4ZLU7   W5MNN3   A0A182FQY9   A0A1B0CQA8   A0A2G8KAM0   A0A182VZT9   A0A3Q1CT53   A0A3B4ZKG5  

PDB

6CZK     E-value=1.57687e-35,     Score=374

KEGG

101741653    K01374 cathepsin O [EC:3.4.22.42] | (RefSeq) cathepsin O-like

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0005975   GO:0008234   GO:0030246   GO:0016853   GO:0016021   GO:0003735   GO:0006412   GO:0015935   GO:0003723   GO:0005615   GO:0004197   GO:0051603   GO:0005764   GO:0016514   GO:0003677   GO:0043044   GO:0006727   GO:0019441   GO:0004833   GO:0020037   GO:0046872   GO:0006508   GO:0019318   GO:0030145   GO:0016876   GO:0043039  

PANTHER

PTHR46232   PTHR10138  

SignalP

Position:   1 - 26,         Likelihood:  0.822540

 

 

Length:

387

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

20.81586

Exp number, first 60 AAs:

20.53788

Total prob of N-in:

0.97016

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  26

outside

27  -  387

 

 

Pi

198.54699

Theta

176.176307

Tajima's D

0.50459

CLR

0.151759

CSRT

0.515474226288686

Interpretation

Uncertain