Gene

KWMTBOMO08357

Pre Gene Modal

BGIBMGA009231

Annotation

PREDICTED:_cathepsin_O-like_[Bombyx_mori]

Location

Bomo_Chr14(-):6488498-6492406      View in EpiBrowser

Full name

Cathepsin O      

Location in the cell

Extracellular   Reliability : 2.011

CDS

ATGATCGGACCTGTTTTGAATCAAGGAAATTGCAATGGCTGTTGGGCATACAGCATAGTTGAAACCATGGAGTCTATGGCTGTAAAACAGAAAATGAGTCACACACGTCTTAGCATACAGGAATTACTAGACTGCGTTAGTGTCTGTGAGGGCTGTAATAAAGGCCACGTCGAGGAGGCTCTGAATGAAATGTGTATTAATGATACCGTGGTTACAACAGAAGATAGCTATCCTCTTGGGATAAGTCGTGGAAATTGCAACTCCAGTACATTTAAGGGCAGAAAGATAAAGGAGTACTGGCATTACAGTTTTATGGATGAAAATATTTTACGTCGCGTGATAGCCCACCATGGACCCGTCATAGTCAAGGTGAACGCTCAGCCCTGGATAAATTATCTTGGAGGCATCATCCAGCGCGGTTGTATGCGCAGTGAAGACGGAGCCACTTTGGATCACGCCGTTCAAATAGTCGGCTACAACGCGCGGGGCAGTGTACCCTACTATATAGTGCGCAATTCTTACGGTGCCGACTTCGGTATCGGGGGCTATGTAAAGCTCGCCATGTACCGCAACATTTGCGGTGTAGCTGATGATGTGGCATTTTTGACAGTTTATTAA

Protein

MIGPVLNQGNCNGCWAYSIVETMESMAVKQKMSHTRLSIQELLDCVSVCEGCNKGHVEEALNEMCINDTVVTTEDSYPLGISRGNCNSSTFKGRKIKEYWHYSFMDENILRRVIAHHGPVIVKVNAQPWINYLGGIIQRGCMRSEDGATLDHAVQIVGYNARGSVPYYIVRNSYGADFGIGGYVKLAMYRNICGVADDVAFLTVY

Catalytic Activity

The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec.

Similarity

Belongs to the peptidase C1 family.

Keywords

Complete proteome   Disulfide bond   Glycoprotein   Hydrolase   Lysosome   Protease   Reference proteome   Signal   Thiol protease   Zymogen  

Feature

propeptide  Activation peptide
chain  Cathepsin O

Uniprot

J7HLR8   A0A2W1B8K7   A0A2H1VBA2   H9JI81   J7HI12   A0A437BN63   + More
A0A2W1B435   A0A2A4IWR3   A0A2A4JKQ2   A0A2C9JPU1   A0A194PY34   U4U3V2   J3JUX2   N6TT28   N6UR32   A0A212EPL3   A0A3Q8AYZ4   F4WME2   A0A195BSX4   U6JMC8   A0A3S1BWC6   A0A158P1Z3   A0A0P5H6D4   A0A401SW64   A0A2R8Q530   A0A3S3PK68   E7FA09   A0A443SQE0   D2A0S2   V9KZ33   A0A210QAG9   A0A164LEG2   A0A0N8CGR1   A0A0P6DUR6   A0A026W1D4   A0A2R8QDZ6   A0A3B4CWW4   A0A0L8FUN9   A0A0N8DME0   A0A0P5QE26   A0A0P5YPQ9   A0A2T7PMN4   A0A0M8ZTL2   A0A195F3S1   A0A195DC55   A0A2A3ERB9   A0A369SJC0   B3RLZ9   R4WDB3   A0A0B7ATW9   E2AWA7   E9G115   A0A0P5N3F3   A0A088AUI0   A0A151IL61   S4RGW1   V4CPT5   A0A1Y3APM6   A0A0B7ATG4   A0A132ACB0   A0A3L8D6J6   A0A154NZE0   A0A146LY49   W5MNN3   A0A2Y9RK83   A0A1W4ZLU7   A0A293N5B9   A0A401NWW8   A0A0P5DAQ1   G3T124   A0A1S3AHR5   A0A1B0CQA8   W5P9W8   A0A3N0YZV5   K7J8W5   H0WPN5   A0A0B5J1X2   A0A384AA78   G7P6G8   A0A2K6BWC8   A0A3Q7P8N8   A0A2K5U4I7   A0A2K5L851   A0A2K5JKR5   F6RB51   A0A096NQQ3   F1PGK4   G7MS73   A0A452EP08   A0A2K6PMD3   A0A2K6EEJ3   W4ZI04   P43234   A0A287AQD3   A0A0D9S1Q7   E2BJG2   A0A3Q7T5Y0   A0A067R1K0   E1BPI9   A0A341BI86  

EC Number

3.4.22.42

Pubmed

28756777    19121390    15562597    26354079    23537049    22516182    + More
22118469    21719571    25875018    21347285    30297745    23594743    18362917    19820115    24402279    28812685    24508170    30042472    18719581    23691247    20798317    21292972    23254933    26555130    30249741    26823975    20809919    20075255    22002653    17431167    16341006    25319552    25362486    7929457    15489334    24845553    19393038   

EMBL

JN400432    AFQ01135.1    KZ150356    PZC71231.1    ODYU01001628    SOQ38119.1    + More
BABH01022310    JN400433    AFQ01136.1    RSAL01000028    RVE51843.1    PZC71232.1    NWSH01006263    PCG63553.1    NWSH01001237    PCG72013.1    KQ459585    KPI98242.1    KB632077    ERL88569.1    BT127037    AEE61999.1    APGK01020083    APGK01020084    APGK01020085    APGK01020086    KB740160    ENN81213.1    ENN81212.1    AGBW02013432    OWR43445.1    MF155621    ARV79892.1    GL888217    EGI64786.1    KQ976418    KYM89473.1    HG710160    CDJ26736.1    RQTK01000036    RUS90295.1    ADTU01001112    GDIQ01232202    JAK19523.1    BEZZ01000618    GCC34642.1    BX005169    NCKU01001735    RWS11380.1    CR931784    NCKV01000807    RWS29685.1    KQ971338    EFA02812.2    JW871605    AFP04123.1    NEDP02004411    OWF45726.1    LRGB01003146    KZS04034.1    GDIP01133359    JAL70355.1    GDIQ01073595    JAN21142.1    KK107488    EZA49885.1    KQ426357    KOF68348.1    GDIP01019527    JAM84188.1    GDIQ01122133    JAL29593.1    GDIP01056165    JAM47550.1    PZQS01000003    PVD34680.1    KQ435850    KOX70875.1    KQ981855    KYN34827.1    KQ980989    KYN10495.1    KZ288192    PBC34315.1    NOWV01000007    RDD46631.1    DS985241    EDV29612.1    AK417518    BAN20733.1    HACG01037453    HACG01037460    CEK84318.1    CEK84325.1    GL443280    EFN62267.1    GL732529    EFX86715.1    GDIQ01150141    JAL01585.1    KQ977135    KYN05468.1    KB199753    ESP04425.1    MUJZ01066012    OTF70390.1    HACG01037454    HACG01037455    CEK84319.1    CEK84320.1    JXLN01012453    KPM08509.1    QOIP01000012    RLU15874.1    KQ434778    KZC04434.1    GDHC01006146    JAQ12483.1    AHAT01015360    GFWV01022862    MAA47589.1    BFAA01005555    GCB65357.1    GDIP01162802    JAJ60600.1    AJWK01023339    AMGL01038845    AMGL01038846    RJVU01018281    ROL51836.1    AAZX01013133    AAZX01019176    AAQR03182834    AAQR03182835    KP303286    AJF94884.1    CM001280    EHH54036.1    AQIA01056791    JSUE03034811    JSUE03034812    AHZZ02028058    AAEX03010073    JV046275    CM001257    AFI36346.1    EHH26267.1    LWLT01000018    AAGJ04098040    AAGJ04098041    X77383    BC049206    AEMK02000065    AQIB01017599    AQIB01017600    GL448571    EFN84119.1    KK852773    KDR16812.1   

Proteomes

UP000005204    UP000283053    UP000218220    UP000076420    UP000053268    UP000030742    + More
UP000019118    UP000007151    UP000007755    UP000078540    UP000271974    UP000005205    UP000287033    UP000000437    UP000285301    UP000288716    UP000007266    UP000242188    UP000076858    UP000053097    UP000261440    UP000053454    UP000245119    UP000053105    UP000078541    UP000078492    UP000242457    UP000253843    UP000009022    UP000000311    UP000000305    UP000005203    UP000078542    UP000245300    UP000030746    UP000279307    UP000076502    UP000018468    UP000248480    UP000192224    UP000288216    UP000007646    UP000079721    UP000092461    UP000002356    UP000002358    UP000005225    UP000261681    UP000009130    UP000233120    UP000286641    UP000233100    UP000233060    UP000233080    UP000006718    UP000028761    UP000002254    UP000291000    UP000233200    UP000233160    UP000007110    UP000005640    UP000008227    UP000029965    UP000008237    UP000286640    UP000027135    UP000009136    UP000252040   

PRIDE

H9JI81    P43234   

Pfam

PF00112   Peptidase_C1        + More
PF08246   Inhibitor_I29
PF01263   Aldose_epim
PF00505   HMG_box
PF02225   PA

Interpro

IPR000668   Peptidase_C1A_C        + More
IPR025660   Pept_his_AS       
IPR039417   Peptidase_C1A_papain-like       
IPR038765   Papain-like_cys_pep_sf       
IPR013201   Prot_inhib_I29       
IPR000169   Pept_cys_AS       
IPR011013   Gal_mutarotase_sf_dom       
IPR018052   Ald1_epimerase_CS       
IPR008183   Aldose_1/G6P_1-epimerase       
IPR014718   GH-type_carb-bd       
IPR036910   HMG_box_dom_sf       
IPR009071   HMG_box_dom       
IPR030089   BAF57       
IPR025661   Pept_asp_AS       
IPR003137   PA_domain       

SUPFAM

SSF54001   SSF54001        + More
SSF74650   SSF74650       
SSF47095   SSF47095       

Gene 3D

2.70.98.10     1.10.30.10    

CDD

cd02248  Peptidase_C1A

ProteinModelPortal

J7HLR8   A0A2W1B8K7   A0A2H1VBA2   H9JI81   J7HI12   A0A437BN63   + More
A0A2W1B435   A0A2A4IWR3   A0A2A4JKQ2   A0A2C9JPU1   A0A194PY34   U4U3V2   J3JUX2   N6TT28   N6UR32   A0A212EPL3   A0A3Q8AYZ4   F4WME2   A0A195BSX4   U6JMC8   A0A3S1BWC6   A0A158P1Z3   A0A0P5H6D4   A0A401SW64   A0A2R8Q530   A0A3S3PK68   E7FA09   A0A443SQE0   D2A0S2   V9KZ33   A0A210QAG9   A0A164LEG2   A0A0N8CGR1   A0A0P6DUR6   A0A026W1D4   A0A2R8QDZ6   A0A3B4CWW4   A0A0L8FUN9   A0A0N8DME0   A0A0P5QE26   A0A0P5YPQ9   A0A2T7PMN4   A0A0M8ZTL2   A0A195F3S1   A0A195DC55   A0A2A3ERB9   A0A369SJC0   B3RLZ9   R4WDB3   A0A0B7ATW9   E2AWA7   E9G115   A0A0P5N3F3   A0A088AUI0   A0A151IL61   S4RGW1   V4CPT5   A0A1Y3APM6   A0A0B7ATG4   A0A132ACB0   A0A3L8D6J6   A0A154NZE0   A0A146LY49   W5MNN3   A0A2Y9RK83   A0A1W4ZLU7   A0A293N5B9   A0A401NWW8   A0A0P5DAQ1   G3T124   A0A1S3AHR5   A0A1B0CQA8   W5P9W8   A0A3N0YZV5   K7J8W5   H0WPN5   A0A0B5J1X2   A0A384AA78   G7P6G8   A0A2K6BWC8   A0A3Q7P8N8   A0A2K5U4I7   A0A2K5L851   A0A2K5JKR5   F6RB51   A0A096NQQ3   F1PGK4   G7MS73   A0A452EP08   A0A2K6PMD3   A0A2K6EEJ3   W4ZI04   P43234   A0A287AQD3   A0A0D9S1Q7   E2BJG2   A0A3Q7T5Y0   A0A067R1K0   E1BPI9   A0A341BI86  

PDB

3H7D     E-value=1.15336e-22,     Score=260

KEGG

101735448    K01374 cathepsin O [EC:3.4.22.42] | (RefSeq) cathepsin O-like

PATHWAY

04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0008234   GO:0016021   GO:0005975   GO:0030246   GO:0016853   GO:0016514   GO:0043044   GO:0003677   GO:0005615   GO:0004197   GO:0051603   GO:0005764   GO:0016874   GO:0006508   GO:0019318   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR46232  

Subcellular location

Lysosome  

Length:

205

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.06138

Exp number, first 60 AAs:

0.00223

Total prob of N-in:

0.03425

outside

1  -  205

 

 

Pi

21.560728

Theta

25.318317

Tajima's D

-0.56305

CLR

19.620751

CSRT

0.232988350582471

Interpretation

Uncertain