Silkworm Genome Informatics Database

Gene

KWMTBOMO08344

Pre Gene Modal

BGIBMGA009271

Annotation

PREDICTED:_FMRFamide-related_peptides_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr14(+):6302767-6304006 View in EpiBrowser

Full name

FMRFamide-related peptides

Alternative Name

Bommo-FMRFamide

Location in the cell

Nuclear Reliability : 2.976

CDS

ATGAATCACCCTCGATCCATAGCGATGCTTGCTGCGCTGTGGCTGGTTGTTAGTGTCACTTCAACTCCTGTCCGCCGTTCGCCTGACCTTGAAGCTCGTCGTCGCAGTGCTATCGACCGCAGCATGATCAGATTCGGAAGATCCACTCTGCCCGTCGTACCTCCAGCGCAGCCCAGCTTTTTGCAAAGATACAGCGCGTCTCAGCCAGCGGCCCTTACTGCAGATGACCTTATGACTTTCCTCCGAGCCTACGAAGAGGATTACAGCAGTCCCGTGTCCAAAAAGTCGGCTAGTTTTGTGCGATTTGGTCGCGACCCTAGCTTTATCCGGTTCGGAAGGTCAGTCGATGAAGAAAACTCTGGTTATCAAGCTGAAACCAACACTTACCCCCAACGGAGGCACAGAGCTCGCAATCACTTCATCAGGCTCGGAAGGGACAATGAGCTCAGCGAATCCAACGATGAAGACAGATATGAAGTAGAAAGCGAAAGAACAAAAAGATCCGTTGTTGACCCTTGCAATGATTGCGCTTAA

Protein

MNHPRSIAMLAALWLVVSVTSTPVRRSPDLEARRRSAIDRSMIRFGRSTLPVVPPAQPSFLQRYSASQPAALTADDLMTFLRAYEEDYSSPVSKKSASFVRFGRDPSFIRFGRSVDEENSGYQAETNTYPQRRHRARNHFIRLGRDNELSESNDEDRYEVESERTKRSVVDPCNDCA

Description

Regulates ecdysteroidogenesis by direct innervation of the prothoracic gland by reducing cAMP production via the receptor for myosuppressin. The neurons that innervate the prothoracic gland during the fifth instar are most active during days 0-4, after which they reduce and then peak again on day 6. Expression suppresses the biosynthesis of steroid hormones called ecdysteroids that elicit molting and metamorphosis.
In insects, FMRFamide and related peptides have modulatory actions at skeletal neuromuscular junctions, and peptides that are immunologically related to FMRFamide are released into the circulation from neurohemal organs.

Similarity

Belongs to the FARP (FMRFamide related peptide) family.

Keywords

Amidation Cleavage on pair of basic residues Complete proteome Direct protein sequencing Neuropeptide Reference proteome Repeat Secreted Signal

Feature

peptide SAIDRSMIRF-amide

Uniprot

Q1MX22 H9JIC1 A0A2A4JAK9 A0A2W1BHJ2 C0HKT6 M4QCF2 + More
A0A0S1U0B0 A0A3S2NT71 A0A2H1VJ51 A0A385H8V7 A0A194R772 A0A0C5BCR5 A0A194PZR4 U3U8Z6 A0A1B6C1T0

Pubmed

16707581 19121390 28756777 29466015 30171635 26354079 + More
25640113 23932938

EMBL

AB234100 BAE93471.1 BABH01022302 NWSH01002365 PCG68460.1 KZ150121 + More
PZC73175.1 KC340924 AGH25556.1 KT005970 ALM30321.1 RSAL01000226 RVE43954.1 ODYU01002659 SOQ40452.1 MH028085 AXY04254.1 KQ460627 KPJ13507.1 KJ783490 AJM76779.1 KQ459585 KPI98234.1 AB817257 BAO00954.1 GEDC01030069 JAS07229.1

Proteomes

UP000005204 UP000218220 UP000283053 UP000053240 UP000053268

PRIDE

Q1MX22 H9JIC1

Pfam

PF01581 FARP

Interpro

IPR002544 FMRFamid-related_peptide-like

ProteinModelPortal

Q1MX22 H9JIC1 A0A2A4JAK9 A0A2W1BHJ2 C0HKT6 M4QCF2 + More
A0A0S1U0B0 A0A3S2NT71 A0A2H1VJ51 A0A385H8V7 A0A194R772 A0A0C5BCR5 A0A194PZR4 U3U8Z6 A0A1B6C1T0

KEGG

692549 no KO assigned | (RefSeq) Fa, BRFa, FaRPs, RFa; FMRFamide

GO

GO:0005576 GO:0007218

Subcellular location

Secreted Detected at the gland surface. With evidence from 2 publications.

SignalP

Position: 1 - 21, Likelihood: 0.900705

Length:

177

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.39185

Exp number, first 60 AAs:

3.39171

Total prob of N-in:

0.22837

outside

1 - 177

Pi

124.946285

Theta

134.920374

Tajima's D

-0.557073

CLR

178.017418

CSRT

0.223438828058597

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics