Gene

KWMTBOMO08303

Pre Gene Modal

BGIBMGA009251

Annotation

PREDICTED:_histone_acetyltransferase_KAT2A_[Papilio_xuthus]

Location

Bomo_Chr14(-):4776449-4794268      View in EpiBrowser

Full name

Histone acetyltransferase       + More
Histone acetyltransferase KAT2A      

Alternative Name

Histone succinyltransferase KAT2A
Lysine acetyltransferase 2A

Location in the cell

Nuclear   Reliability : 2.798

CDS

ATGTCTCAAGCGACTGACGAAATAGCTGACATAGCAATGACAAGCACAGAGCCAGACTCCTCACAAAATCATACACATGAAGCTACATCAAGCTTAAGTGCAGATGATGCATCATCAAGCAATGCCGGGACTCCTGCAGGCAGTGAAGGACAGGCTTCCCGGCAGTCTAACCTACAAAGGATACAACAAAGAAAACAACAAGTTTTCAACTGGCCCCATAATAAAAAACTACTCAAACTAGCTATATATTCAGCCTGTCAGACACCAGATTGTAACTGCAATGGATGGAAGACTCCAGTAACACAGCATGCGGGCAAGACTCCTCGGGCTGATAATCAGCCCCTTGCCAGCTTCAATGACGTGTGTAGAAACTGCAACCATGTATTAGAGAAACATGTAAGTCAGCTACAAGGTTTGCCTGTAGCAGAAGTGAATAGGCTGCTCGGTGCTGTTGTAGACGTAGAGAACATATTTATGTCGATGCAAAGAGAAGATGACCACAACACTAAACAAGTTTACTACTATTTATTTAAGATACTTCGTAAATGCATCTTAACGCGTTCCCAGCCTCGGATCGAGGGACCACTGGGACAACCTCCATTCGAAAGGCCTTCCATAGCTAAAGCAATAACAAACTTCGTTCTCTACAAGTTCAATTCATTACCACAAAGGGAATGGCAAACAATGTACGATTTGGCCAAGATGTTCCTTCACTGTTTCAATCATTGGAATTTTGAAACGCCCAGCGTCAGGAAGCTGCAAGTTTCAAACCCTGAAGATATATCAGCCTACCAGATTAATTATACGAGATGGCTCGTGTTCTGCCACGTGCCCGCGTTCTGCGACTCGCTGCCCCACTACGACACGTCGCTGGTGTTCGGACGGACGCTGCTGCGCGCCGTGTTCAAGTCCGTGTGCCGCCAGCTCATGGACAAGTGCCACTTGGAGAGGGACAGAATGCCGCCAGAGAAAAGGGTACTGGTTCTGACCCACTTCCCTCGGTTCCTGGCTCTATTGGAAGAAGAAATATTTAGTCCAAACTCTCCGATCTGGGACCCGGACTACAAGCAAGTGCCGCCTAATCATTTACAAGCGATGCTGGATAATAAAACTTCAAGTCGTCGTGTCGGTGAATTTGAACGAGTTACGGCATCCGGAGACAGTAAGGATGGGTTCACGACGGTTACACTGTCATCTGGTTCGATAAAGCAGGAGGGCGTGAAGCGTGCGGGCGTGAGTGTGAGCGGGACGGGCGGCAAGCGGCGCCGCGTGTGCTCTGAGGGCAGCGATGACGTCAGCCAGCGCACGGTGGCCGACATCGTGGCGACTATCTCCGACCCCAACTACATGTGCGGACCGGACGCATTATTCCAAACGCAAGCACCGCGCGACGAGGCGGCCAAAATCGAAGAACAAAGAAAATTAATAGAGTTCCATGTGATCGGCAACTCTCTGACTGGGCCCGTCAACAAACAGACAATGCTATGGTTGATCGGTCTCCACAACGTTTTCTCCCACCAACTACCGGAAATGACTAAAGAATACATATCGCAATTAGTGTTCGATCCGAAACACAAGACATTGGCTCTGATCAAAGAAGGCAGGCCGATTGGTGGCATCTGCTTCAGGACATTCCATTCGCAAGGCTTCAGCGAGATAGTATTCTGTGCGGTCACGTCCAACGAACAAGTGAAAGGATACGGCACTCACCTCATGAACCACCTCAAGGATTACCACATCCGAAACAATATACTGCACTTCCTTACCTTCGCTGATGAATTTGCAATAGGCTACTTCAAGAAGCAGGGTTTCAGTAAAGACATTAAGCTGCCGAGGGCGATGTACCAAGGATACATAAAGGACTACGAGGGAGCAACCCTCATGCACTGCGAATTGAACCCTAGAATAGTATACACACAGTTCACTTCGGTTATTAGGATGCAGAAAGAGATCGTAAAGAAACTTATAGATATGCGACAGAAGGAAGTTAGAAAAATTTATCCCGGCCTCACTTGCTTCAAGGAAGGTGTCCGCAGCCTCCCCCCGGAGTGCATCCCCGGGGCGCGCGAGGCAGGGTGGCGCGCCCCCCCGCCCCCGCACGACCCCGACCCCGACCCCGTCACCCTGCGGAACGTGCTGCACGCAGTAAAGAACCACGCGACGGCCTGGCCGTTCCTGAAGCCGGTCGACAAGGCGGAGGTGCCGGACTACTACGATCACATCAAGTATCCGATGGACTTGCGCACGATGGGGGAACGTCTCAAAGCGCGCTACTACGTGTCCAAGCGGCTGTTCATAGCGGACATGACCCGGATATTCAACAACTGCAGACTCTACAACTCGCCCGACACCGACTACTACAGGTGCGCGAACACACTTGAGAAATATTTCCAAACTAAAATGAAAGAGGTCGGACTGTGGGATAAATGA

Protein

MSQATDEIADIAMTSTEPDSSQNHTHEATSSLSADDASSSNAGTPAGSEGQASRQSNLQRIQQRKQQVFNWPHNKKLLKLAIYSACQTPDCNCNGWKTPVTQHAGKTPRADNQPLASFNDVCRNCNHVLEKHVSQLQGLPVAEVNRLLGAVVDVENIFMSMQREDDHNTKQVYYYLFKILRKCILTRSQPRIEGPLGQPPFERPSIAKAITNFVLYKFNSLPQREWQTMYDLAKMFLHCFNHWNFETPSVRKLQVSNPEDISAYQINYTRWLVFCHVPAFCDSLPHYDTSLVFGRTLLRAVFKSVCRQLMDKCHLERDRMPPEKRVLVLTHFPRFLALLEEEIFSPNSPIWDPDYKQVPPNHLQAMLDNKTSSRRVGEFERVTASGDSKDGFTTVTLSSGSIKQEGVKRAGVSVSGTGGKRRRVCSEGSDDVSQRTVADIVATISDPNYMCGPDALFQTQAPRDEAAKIEEQRKLIEFHVIGNSLTGPVNKQTMLWLIGLHNVFSHQLPEMTKEYISQLVFDPKHKTLALIKEGRPIGGICFRTFHSQGFSEIVFCAVTSNEQVKGYGTHLMNHLKDYHIRNNILHFLTFADEFAIGYFKKQGFSKDIKLPRAMYQGYIKDYEGATLMHCELNPRIVYTQFTSVIRMQKEIVKKLIDMRQKEVRKIYPGLTCFKEGVRSLPPECIPGAREAGWRAPPPPHDPDPDPVTLRNVLHAVKNHATAWPFLKPVDKAEVPDYYDHIKYPMDLRTMGERLKARYYVSKRLFIADMTRIFNNCRLYNSPDTDYYRCANTLEKYFQTKMKEVGLWDK

Description

Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (By similarity). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity). Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). Also acetylates non-histone proteins, such as tbx5 (PubMed:29174768). Involved in heart and limb development by mediating acetylation of tbx5 (PubMed:29174768).

Catalytic Activity

acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein]
L-lysyl-[protein] + succinyl-CoA = CoA + H(+) + N(6)-succinyl-L-lysyl-[protein]

Similarity

Belongs to the actin family.
Belongs to the acetyltransferase family. GCN5 subfamily.

Keywords

Acyltransferase   Bromodomain   Chromosome   Complete proteome   Cytoplasm   Cytoskeleton   Nucleus   Reference proteome   Transcription   Transcription regulation   Transferase  

Feature

chain  Histone acetyltransferase KAT2A

Uniprot

A0A2A4JMN8   A0A2H1VB08   A0A3S2NZE8   H9JIA1   A0A212EJJ7   A0A067RD75   + More
A0A2J7QY91   A0A232F4Y2   A0A154PA50   K7J6Z6   A0A2A3E2D9   E0VBR8   A0A0L7RDG0   A0A088ARP8   A0A194R6M1   A0A026WTI0   A0A195FW10   A0A195BD79   A0A158P409   A0A195C617   A0A151XA04   A0A195BD90   A0A195DCI4   A0A158P417   A0A151XA17   A0A195FU93   A0A195DCN7   E2A2Q8   E9IZX1   A0A1B6GZZ3   A0A195C6P0   A0A026WW67   E2C3U8   E2C3V0   E2A2Q9   A0A1Y1KV68   A0A0C9S049   A0A0J7KNG1   A0A1B6DZV6   E9J2L2   A0A1Z5LBL9   A0A2R5LNL4   F4WM37   A0A293N5B1   T1JCV1   A0A131XDG5   A0A1S3J1M1   A0A131XYH7   A0A131YP28   A0A224YPL0   A0A0N1ISX5   A0A1E1X2N4   L7LZ38   A0A1B6MUP2   A0A423T0N2   A0A210Q222   K1PM97   A0A182Y8Y6   A0A182XF87   A0A182HYH9   Q7QA53   A0A182W3A5   D6WJN2   U5EJ34   V4ASM6   Q17PA5   A0A1L8DX13   A0A0L8HF23   A0A0L8HFF6   A0A0N8BMA5   A0A2T7PZT0   A0A182Q0K0   A0A182M9T5   A0A0P6BQK2   A7RXH0   S4R481   A0A0N8CDC6   A0A1I8NBC6   A0A1I8NXF8   A0A0B7AGV5   A0A1B0GA51   W4XAH6   A0A1A9WD42   A0A0A1XLE5   A0A1A9ZG16   A0A0K8VDK8   A0A0L0CLC8   A0A2C9K051   T1G2W3   A0A3B1ICG6   A0A1A9UTQ4   A0A1B0AR68   H3D2C5   A0A0R4IXF6   A0A3B3R888   U4UHX1   A0A3Q3NJG8   A0A3Q3BN29   A0A3P9ACY6   A0A3Q2FQ61  

EC Number

2.3.1.48

Pubmed

19121390    22118469    24845553    28648823    20075255    20566863    + More
26354079    24508170    30249741    21347285    20798317    21282665    28004739    28528879    21719571    28049606    29652888    26830274    28797301    28503490    25576852    28812685    22992520    25244985    12364791    14747013    17210077    18362917    19820115    23254933    17510324    17615350    25315136    25830018    26108605    15562597    25329095    15496914    23594743    17997606    29174768    29240929    23537049    25069045   

EMBL

NWSH01000976    PCG73317.1    ODYU01001593    SOQ38028.1    RSAL01000016    RVE53043.1    + More
BABH01022185    AGBW02014472    OWR41628.1    KK852714    KDR17903.1    NEVH01009122    PNF33552.1    NNAY01000931    OXU25854.1    KQ434856    KZC08713.1    KZ288427    PBC25867.1    DS235035    EEB10824.1    KQ414614    KOC68839.1    KQ460627    KPJ13463.1    KK107109    QOIP01000008    EZA59370.1    RLU19925.1    KQ981264    KYN44029.1    KQ976519    KYM82154.1    ADTU01001346    KQ978220    KYM96304.1    KQ982353    KYQ57205.1    KYM82155.1    KQ980989    KYN10601.1    KYQ57204.1    KYN44028.1    KYN10602.1    GL436203    EFN72283.1    GL767290    EFZ13882.1    GECZ01001798    JAS67971.1    KYM96305.1    EZA59369.1    RLU19924.1    GL452364    EFN77334.1    EFN77336.1    EFN72284.1    GEZM01073203    JAV65282.1    GBYB01013806    JAG83573.1    LBMM01005053    KMQ91852.1    GEDC01006107    JAS31191.1    GL767895    EFZ12939.1    GFJQ02002191    JAW04779.1    GGLE01007000    MBY11126.1    GL888217    EGI64681.1    GFWV01023229    MAA47956.1    JH432085    GEFH01003964    JAP64617.1    GEFM01004488    GEGO01001420    JAP71308.1    JAR93984.1    GEDV01008377    JAP80180.1    GFPF01008391    MAA19537.1    KQ438551    KOX67158.1    GFAC01005675    JAT93513.1    GACK01007683    JAA57351.1    GEBQ01000358    JAT39619.1    QCYY01002482    ROT70025.1    NEDP02005221    OWF42786.1    JH816697    EKC25097.1    APCN01005372    AAAB01008898    EAA09238.3    KQ971343    EFA04470.1    GANO01002386    JAB57485.1    KB201381    ESO96746.1    CH477193    EAT48526.1    GFDF01003091    JAV10993.1    KQ418303    KOF87863.1    KOF87864.1    GDIQ01163819    GDIP01131937    JAK87906.1    JAL71777.1    PZQS01000001    PVD38897.1    AXCN02000087    AXCM01001209    GDIP01015026    JAM88689.1    DS469550    EDO43844.1    GDIP01142839    JAL60875.1    HACG01033153    CEK80018.1    CCAG010015850    AAGJ04024136    AAGJ04024137    GBXI01002103    JAD12189.1    GDHF01015368    JAI36946.1    JRES01000240    KNC33051.1    AMQM01003841    KB096325    ESO05629.1    JXJN01002267    BX005093    FO818663    DQ017634    KB632364    ERL93579.1   

Proteomes

UP000218220    UP000283053    UP000005204    UP000007151    UP000027135    UP000235965    + More
UP000215335    UP000076502    UP000002358    UP000242457    UP000009046    UP000053825    UP000005203    UP000053240    UP000053097    UP000279307    UP000078541    UP000078540    UP000005205    UP000078542    UP000075809    UP000078492    UP000000311    UP000008237    UP000036403    UP000007755    UP000085678    UP000053105    UP000283509    UP000242188    UP000005408    UP000076408    UP000076407    UP000075840    UP000007062    UP000075920    UP000007266    UP000030746    UP000008820    UP000053454    UP000245119    UP000075886    UP000075883    UP000001593    UP000245300    UP000095301    UP000095300    UP000092444    UP000007110    UP000091820    UP000092445    UP000037069    UP000076420    UP000015101    UP000018467    UP000078200    UP000092460    UP000007303    UP000000437    UP000261540    UP000030742    UP000261640    UP000264800    UP000265140    UP000265020   

PRIDE

H9JIA1    L7LZ38   

Pfam

PF00583   Acetyltransf_1        + More
PF06466   PCAF_N
PF00439   Bromodomain
PF00022   Actin
PF08357   SEFIR

Interpro

IPR000182   GNAT_dom        + More
IPR018359   Bromodomain_CS       
IPR037800   GCN5       
IPR009464   PCAF_N       
IPR001487   Bromodomain       
IPR036427   Bromodomain-like_sf       
IPR016181   Acyl_CoA_acyltransferase       
IPR016376   GCN5/PCAF       
IPR004001   Actin_CS       
IPR020902   Actin/actin-like_CS       
IPR004000   Actin       
IPR013568   SEFIR_dom       

SUPFAM

SSF55729   SSF55729        + More
SSF47370   SSF47370       

Gene 3D

1.20.920.10    

ProteinModelPortal

A0A2A4JMN8   A0A2H1VB08   A0A3S2NZE8   H9JIA1   A0A212EJJ7   A0A067RD75   + More
A0A2J7QY91   A0A232F4Y2   A0A154PA50   K7J6Z6   A0A2A3E2D9   E0VBR8   A0A0L7RDG0   A0A088ARP8   A0A194R6M1   A0A026WTI0   A0A195FW10   A0A195BD79   A0A158P409   A0A195C617   A0A151XA04   A0A195BD90   A0A195DCI4   A0A158P417   A0A151XA17   A0A195FU93   A0A195DCN7   E2A2Q8   E9IZX1   A0A1B6GZZ3   A0A195C6P0   A0A026WW67   E2C3U8   E2C3V0   E2A2Q9   A0A1Y1KV68   A0A0C9S049   A0A0J7KNG1   A0A1B6DZV6   E9J2L2   A0A1Z5LBL9   A0A2R5LNL4   F4WM37   A0A293N5B1   T1JCV1   A0A131XDG5   A0A1S3J1M1   A0A131XYH7   A0A131YP28   A0A224YPL0   A0A0N1ISX5   A0A1E1X2N4   L7LZ38   A0A1B6MUP2   A0A423T0N2   A0A210Q222   K1PM97   A0A182Y8Y6   A0A182XF87   A0A182HYH9   Q7QA53   A0A182W3A5   D6WJN2   U5EJ34   V4ASM6   Q17PA5   A0A1L8DX13   A0A0L8HF23   A0A0L8HFF6   A0A0N8BMA5   A0A2T7PZT0   A0A182Q0K0   A0A182M9T5   A0A0P6BQK2   A7RXH0   S4R481   A0A0N8CDC6   A0A1I8NBC6   A0A1I8NXF8   A0A0B7AGV5   A0A1B0GA51   W4XAH6   A0A1A9WD42   A0A0A1XLE5   A0A1A9ZG16   A0A0K8VDK8   A0A0L0CLC8   A0A2C9K051   T1G2W3   A0A3B1ICG6   A0A1A9UTQ4   A0A1B0AR68   H3D2C5   A0A0R4IXF6   A0A3B3R888   U4UHX1   A0A3Q3NJG8   A0A3Q3BN29   A0A3P9ACY6   A0A3Q2FQ61  

PDB

5TRM     E-value=1.61916e-79,     Score=757

KEGG

101736749    K06062 histone acetyltransferase [EC:2.3.1.48] | (RefSeq) histone acetyltransferase KAT2A

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0004402   GO:0005634   GO:0006355   GO:0005524   GO:0060173   GO:0007507   GO:0061733   GO:0106078   GO:0005737   GO:0005694   GO:0001816   GO:0043966   GO:0048167   GO:0003713   GO:0050863   GO:0005813   GO:0045944   GO:0003682   GO:0007616   GO:0106077   GO:0045589   GO:0018393   GO:0005515   GO:0008080   GO:0030145   GO:0006412   GO:0016876   GO:0043039  

PANTHER

PTHR45750  

Subcellular location

Nucleus  
Chromosome  
Cytoplasm  
Cytoskeleton  
Microtubule organizing center  
Centrosome  

Length:

809

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00414999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00020

outside

1  -  809

 

 

Pi

219.926127

Theta

164.867551

Tajima's D

1.26712

CLR

0.217098

CSRT

0.732363381830908

Interpretation

Uncertain